12/26/25
Featured
- Reinforcer Pathology as a Mechanism for the Increase in Obesity Throughout Childhood: A Conceptual Blueprint for Research.
- RCT: Cardiovascular Outcomes with Tirzepatide Versus Dulaglutide in Type 2 Diabetes.
- Increased Adiposity and Impaired Sleep are Associated with Severity of Greater Trochanteric Pain Syndrome: A Cross-Sectional Study.
Headline vs Study
- Headline: Want a Younger, Healthier Brain? This Type of Exercise Can Help.
- Press Release: The Body Trait That Helps Keep Your Brain Young.
- Meeting Abstract: Cross-Sectional Associations between Body Composition and Predicted Brain Age. No Exercise Studied. Causal Relation of Traits and Brain Youthfulness Not Established. (pdf)
- Headline Critique: Can Muscle Mass Give Us a Younger Brain?
Contrary or Null Findings
- Engagement in More Light Physical Activity and Less Sedentary Time Does Not Protect Against Age-Related Declines in Cerebrovascular Reactivity in Healthy Older Adults.
- Neither Caloric nor Protein Restriction Increases the Male Lifespan of Outbred Short-Lived Fish.
- Obesity Does Not Significantly Impact Clinical Outcomes Following Anterior Cervical Discectomy and Fusion.
- RCT: Eight Weeks of Post-Exercise Local Heating Does Not Improve Cognition and Plasma Brain-Derived Neurotrophic Factor Concentrations.
- Visual and Cognitive Food Stimulation Does Not Affect Salivary Testosterone Concentration in Adult Males.
- Endoscopic Lumbar Decompression in Patients with Obesity Does Not Correlate with Inferior Outcomes.
- Fructose Uptake by Brown Adipose Tissue Is Independent of Carbohydrate Response Element-Binding Protein and Does Not Cause Elevated De Novo Lipogenesis.
- RCT: "The study intervention was unable to yield a detectible improvement in 2nd MTPJ angle" in Foot-specific exercise intervention for forefoot deformity in individuals with type 2 diabetes and peripheral neuropathy.
Basic
- CAPG Enhances Adipogenesis and Inflammatory Cytokine Expression in Adipocytes.
- A Nuclear Hormone Receptor Nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans.
- Hepatic Adaptation to Chronic Metabolic Stress Primes Tumorigenesis.
- Interplay between Enteroendocrine Hormone (Leptin) and Adipokines (Ghrelin and Adiponectin) with Gastric Expression of FTO and MC4R Genes.
Scientific Rigor & Scholarly Dialogue
- Retraction Watch: World Bank Report ‘Removed for Review’ of Nonexistent References After Retraction Watch Inquiry.
- Retraction: Transcriptome Study of Receptive Endometrium in Overweight and Obese Women Shows Important Expression Differences in Immune Response and Inflammatory Pathways in Women Who Do Not Conceive.
- Of Cheese, Saturated Fat, and… Helmets: Only Some of Us Benefit!
Clinical
- Review: A Scoping Review of Sensor-Based Capture of Eating and Drinking Occasions That Could Be Used for Enhancing Personalized Nutrition Interventions in Real-Time.
- Is Light-To-Moderate Alcohol Drinking Associated with the Onset of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Chinese Cohort?
- High Sodium and Low Potassium are Associated with Incident Cardiovascular Disease Among US Hispanic/Latino Adults: Prospective Results from the Hispanic Community Health Study/Study of Latinos.
- RCT: Efficacy of a Digital Health Application for Weight Management in People with Obesity.
Children and Adolescents
- Systematic Review: The Association between Affect and Adiposity in Childhood and Adolescence.
- Meeting Physical Activity Guidelines and Their Association with Cardiometabolic Indicators in Adolescents with Different Weight Status.
- Prospective Associations of Sleep Duration and Screen Time with Transition from Overweight/Obesity to Normal BMI in U.S. Adolescents.
- Blog Post: Smartphones Associated with Depression, Obesity, and Poor Sleep in Adolescents.
- Blog Post: New NHANES Data Demonstrates the Complexity of Risk Factors for Pediatric Obesity.
Surgery
- Cohort Study: Association of Robotic vs Laparoscopic Technique on Postoperative Opioid Consumption Among Patients Who Underwent Bariatric Surgery.
- Cohort Study: Impact of Bariatric Surgery on Metabolic-Dysfunction Associated Fatty Liver Disease in Patients with or without Diabetes.
- Pre-Operative Right Heart Echocardiography in Chronic Obstructive Pulmonary Disease Patients with Obesity Presenting for General Anesthesia: A Case Series on the Role of Ventriculo-Arterial Coupling.
- Meta-Analysis: Effects of Bariatric Surgery on the Pharmacokinetics of Cardiovascular Drugs.
- Review: A Contemporary Perspective on Long-Term Complications of Bariatric Surgery.
- Across Walls: First Intra-Hospital Remote Hugo Robotic Assisted Bariatric Surgery.
Drugs
- Semaglutide and Hospitalizations in Patients with Obesity and Established Cardiovascular Disease.
- Review: Phosphodiesterase-4 Inhibition as a Potential Therapeutic Strategy in the Management of Obesity.
- Beyond Weight Loss: The Gap in Current Drug Development for Obesity.
- Wegovy Becomes First GLP-1 Obesity Med in Pill Form.
Food & Diet
- Betainized Metabolites as Biomarkers of Whole Grain Wheat, Not Oat: Insights from Controlled Crossover Pharmacokinetic and Daily Feeding Studies.
- RCT: Effects of Replacing Solid Fats and Added Sugars with Avocado in Adults with Elevated Cardiometabolic Risk.
Caloric and Dietary Restriction
- Insulin-Like Peptides Play Distinct Roles in Nutrient-Dependent Plasticity in Drosophila.
- Urinary Signatures are Associated with Calorie Restriction-Mediated Weight Loss in Obese Diversity Outbred Mice.
- Caloric Restriction Modifies Small RNA Profiles and Engages Age-Related Molecular Pathways in the CALERIE Trial.
Exercise & Physical Activity
- “Don’t Hold Back”: Swearing Improves Strength Through State Disinhibition.
- Project Head Start to Healthy Lifestyles (HSHL): A Multilevel Intervention to Improve Healthy Eating and Physical Activity Levels Among Head Start Preschoolers and Their Caregivers.
- The Role of Physical Activity Programs in Combating Childhood Obesity: Insights from Physical Education Teachers at a Private School in Abu Dhabi, UAE.
- Effectiveness of a Social Cognitive Theory-Guided, Multi-Component mHealth Intervention on Physical Activity Among Young Adults with Overweight or Obesity.
- Effect of Obesity and Exercise Training on Circulating Lipids in American Indian Adolescents.
- Association between Sedentary Behavior Patterns and Glycemic Outcomes in Women with Overweight and Obesity Under Free-Living Conditions.
Economics & Sociology
- Dissertation: Place, Culture, and Care: a Socioecological Examination of Type 2 Diabetes Among Hispanics in the U.S.
- Review: Integrating Obesity Care Into Chronic Disease Management in Catalonia: Progress and Challenges in Health System Approaches.
- Preprint: Heterogeneous Associations of Socioeconomic Status with Metabolic Disease in Racial and Ethnic Subgroups in the United States: A Cross-Sectional Cohort Study in NHANES and All of Us.
- Commentary: Obesity, Sprawl, and Time Spent in Cars Revisited: Converging Public Health and Transportation Policy.
Epidemiology
- Review: Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.
- Understanding the Impact of Weight on Quality of Life and Willingness to Pay for Obesity Management in the APAC Region.
- Trends and Prevalence of the Metabolic Syndrome Among US Adults.
- A Global Health Crisis in Young Adults: 30-Year Trends in High BMI-Related Early-Onset Cancer Mortality.
Psychology & Neuroscience
- Gastrointestinal Dysmotility and Impaired Gut Peptide-Satiety Coupling in Men with Spinal Cord Injury.
- Tailored Weight Loss Programs for Adults with Serious Mental Illness.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Editorial: Equity, Diversity and Inclusion Is Essential for Rigorous Science and Good for Health.
- Racial and Ethnic Differences in Controlling Risk Factors for Cardiovascular Disease Among Adults with Obesity, 1999-2023.
Stigma
- Awareness of Obesity's Causes Is Not Linked to Less Weight-Related Bias.
- Moderation by Weight Status of the Associations between Positive and Negative Weight Commentary and Body Image-Related Indicators in Young Adults.
- Visible Yet Invisible: Embodied Meanings of Weight Stigma Among Women with Binge Eating Disorder and Higher Weight.
Policy Related
- Review: Obesity and Climate Change: Co-Crises with Common Solutions.
- Review of the Response of the Zimbabwe Sugar Industry to the Sugar Tax Levy -A Case for Health Reform.
Intergenerational Effects
- Central Adiposity, Rather Than in Utero Exposure to Maternal Obesity or Gestational Diabetes, Predicts Metabolic Syndrome Risk in Children Aged 4-10 Years.
- Liver as a Metabolic Sensor in Gestational Diabetes: Implications for Offspring's Liver and Diabetes Risk.
- Review: Incretin Receptor Agonism During Pregnancy: Implications for Mother and Baby.
Ecology, Evolution, & Energetics
- FGF19 May Unlock a Powerful New Brain-Driven Mechanism to Burn Fat and Combat Obesity.
- Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice.
- The Downregulation of Hormone-Sensitive Lipase and Dysregulation of Cholesterol Receptors/Transporter Affect Testicular Lipid Homeostasis and Function in HFD-Induced Oligoasthenospermia Mice.
Methods
- AI-Assisted Assessment of the IFSO Consensus on Obesity Management Medications in the Context of Metabolic Bariatric Surgery.
- Reevaluating the Obesity Paradox Across Diverse Disease Outcomes: A Mendelian Randomization Study.
- Cost-Effectiveness Analysis of Surgical and Non-Surgical Weight Loss Interventions in End-Stage Knee Osteoarthritis and Obesity: A Markov State Model.
- Systematic Review: Large Language Models in Obesity.
- RCT: Implementation and Effectiveness of a Care Process to Prioritize Weight Management in Primary Care.
- Obesity Prediction Using an Explainable Deep Learning Framework Based on LSTM–LIME with Integrated Visualization.
Mathematical and Quantitative
- Community-Based BMI Screening for Overweight and Obesity in Adults Aged 35 Years and Older in Malaysia: Regression Discontinuity Analysis.
- Gradient-Boosting Classifier with Shapley Additive Explanations for Analysis of Obesity Risk in Saudi Arabia.
Commentary
- Podcast: Ologies - Bonus Episode: Nutritional Microbiology (GUT HEALTH & DIET) with Miguel Freitas and Elaine Hsiao.
- Review: Tackling the Complexity of Obesity in the US Through Adaptation of Public Health Strategies.
- Medical Progress, Relaxed Natural Selection, and Adolescent Obesity: Implications for Global Health.
- How Gut Health Became the Foundation of Modern Wellness.
- ‘We Need Intermediary Biomarkers We Can Trust’.
- Is Timing Everything? Study Explores the Best Time for Casein Supplementation in Soccer Players.
- Will Maintain Be the Magic Word in Obesity Care Next Year?
General
- Review: Glucagon-Like Peptide-1 Medicines in Neurological and Psychiatric Disorders.
- An Unbiased Comparison of 14 Epigenetic Clocks in Relation to 174 Incident Disease Outcomes.
- Review: Challenging the principle of "No Presumption of Advantage" with a focus on testosterone and gender eligibility in sports.
- Toward Antifragility - Calling Health Care Systems to Evolve.
- Loss of GLP-2R Signaling in Glp2r-/- Mice Increases the Long-Term Severity of Graft Versus Host Disease.
- Effect of a Partial Loss of Function MC3R Mutation on MC3R+GHSR-1A Heterodimer Activity and RNF11 Regulation.
- Debunking “When Prophecy Fails.”
- Integra and SciScore Partner to Enhance Research Rigor and Editorial Efficiency in Scientific Publishing.
- Food Industry Degrowth as a Public Health Strategy: The Case of Ultra Processed Baked Goods.