12/19/25
Featured
- Researchers Make Strides Toward Preventing Parenteral Nutrition-Associated Liver Disease.
- Real-World Evidence on Weight Loss and Safety with Semaglutide in Obesity Telehealth: A Large Retrospective Cohort Study.
- Dietary Benefits of Pistachio Consumption in Mexico Modeled Using National Health Survey System (ENSANUT) 2012 and 2016 Data.
Headline vs Study
- Headline: Scientists Discover Metabolites That Shape Risk of Obesity and Type 2 Diabetes.
- Press Release: Harvard Gut Discovery Could Change How We Treat Obesity and Diabetes.
- Study: Portal Vein-Enriched Metabolites as Intermediate Regulators of the Gut Microbiome in Insulin Resistance... In Mice.
Contrary or Null Findings
- "In our study, we did not see any preservation of EE [energy expenditure] in our calorie restricted KD [ketogenic diet], with EE declining over time and culminating in a significant reduction after 1 month."
- No Heightened Temporal Attentional Bias Towards Food or Overweight Bodies in Adolescents with Obesity.
- RCT: "In the current trial, altering exposure to sweet-tasting foods did not change sweet taste liking, nor other outcomes. These results do not support public health advice to reduce exposure to sweet-tasting foods, independent of other relevant factors such as energy density and food form."
- "When they looked at the entire group of participants, they did not see meaningful differences in hypertension risk or blood pressure between those who took a daily multivitamin and those who received a placebo"...
- No Clear Relationship between Exercise-Associated Gastrointestinal Integrity Perturbations with Gastrointestinal Symptoms in Response to Exertional-Heat Stress.
- RCT: Supplementation with Ready-To-Use Therapeutic Food Has No Effect on Adverse Outcomes Among Undernourished Children Aged 6-59 months with Severe Pneumonia.
- RCT: "there was no evidence of a meaningful impact of the intervention on glycaemia or other cardiovascular risk factors beyond that achieved with usual care" in trial of a low-carbohydrate digitally-supported weight loss programme for type 2 diabetes.
- RCT: "The proposed intervention resulted in significantly smaller decreases in UPF [ultra-processed food] intake than expected and induced only a statistically, but non-clinically significant, greater weight loss compared to the [generic energy restriction]" in "Effectiveness and metabolic impacts of restricting the consumption of ultra-processed foods in individuals with obesity submitted to energy restriction".
Basic
- Seven Days of Strength Training Reprogram the Hydroxymethylation in Visceral Adipose Tissue of Obese Swiss Mice.
- SerpinA3k Deficiency Ameliorates Experimental Type 2 Diabetes.
- Elevated Adipose Inflammation, but Reduced Hepatic Triacylglycerol Storage in Diet-Induced Obese Plin4-/- Mice.
- Beta-Cell-Specific C3 Deficiency Exacerbates Metabolic Dysregulation and Insulin Resistance in Obesity.
- MiR-494 Deletion Improves Glucose Metabolism Independently of Obesity in Mice.
Scientific Rigor & Scholarly Dialogue
- Blog Post: Correlation Is Not Health. Why a “Gut Health” Score Is Not What You Think.
- 25-Year-Old Paper on Controversial Glyphosate Weedkiller Retracted, After It Turns Out Monsanto Staff Helped Write It.
- Critical Assessment of Glyphosate and Alpha-Lipoic Acid Effects on Granulosa Cells.
- Preprint: Meta-Analyses of Dietary Exposures Must Consider Energy Adjustment: Recommendations from a Meta-Scientific Review.
- Under What Sort of Systematic Reporting Errors Will Science Be Self-Correcting, or Not? And Do Gardening Programs Reduce Obesity?
- Systematic Review: Effect of Interventions Aimed at Reducing or Modifying Saturated Fat Intake on Cholesterol, Mortality, and Major Cardiovascular Events.
- Editorial: Saturated Fats and Cardiovascular Disease: From Avoidance to a Nuanced Recommendation.
- Authors' Response to Editorial In: Free Pass or Failing Grade for Saturated Fats? Review Sets Off Scientific and Political Debate.
Clinical
- Waist-To-Height Ratio as a Non-Invasive Marker of Renal Sinus Fat: A MRI-Based Cohort Study.
- Is Hyperdynamic Circulation a Hallmark of Obesity?
- Predictors of Suboptimal Glycemic Control in People with Type 2 Diabetes and Overweight or Obesity: Insights from Baseline Analysis of a Diabetes-Specific Meal Replacement Study.
- Yes, Telemedicine Is Working in Obesity Care.
- Metabolic Inflammation, Brain Age and Cognitive Functioning in Short- and Long-Term Clinical Weight Loss Trials.
Children and Adolescents
- Food Addiction in Children: A Network Analysis of Nutritional, Metabolic, and Sociodemographic Factors.
- BMI Percentile Cutoffs for Overweight and Obesity are Set Too High in Terms of Adiposity and Metabolic Markers for Asian Children and Adolescents.
Surgery
- Video: Da Vinci Single-Port Surgery in an Obese Woman Affected by Endometrial Cancer.
- Endoscopic Therapeutics for the Management of Obesity.
- Assessing the Impact of GLP-1R Agonists in Post-Sinus Surgery Management.
Drugs
- Glucagon-Like Peptide-1 Receptor Agonist Versus Sodium-Glucose Cotransporter-2 Inhibitor Persistence in Medicare Advantage Beneficiaries with Type 2 Diabetes, Cardiovascular Risk, and Obesity.
- Glucagon-Like Peptide 1 Receptor Agonists and Cardiovascular Disease.
Food & Diet
- Plant-Based Diets, Gut Microbiota, Blood Metabolome, and Risk of Colorectal, Liver and Pancreatic Cancers: Results from a Large Prospective Cohort Study of Predominantly Low-Income Americans.
- RCT: Effects of Replacing Solid Fats and Added Sugars with Avocado in Adults with Elevated Cardiometabolic Risk.
Caloric and Dietary Restriction
- Aging-Linked Systemic Lipid Signature Is Reprogrammed by Caloric Restriction in Rhesus Monkeys.
- Interplay between Ribosomal Gene Deficiency and Calorie Restriction in Shaping Yeast Biosynthetic Capacity.
- Dietary Restriction Reprograms CD8+ T Cell Fate to Enhance Anti-Tumour Immunity and Immunotherapy Responses.
Exercise & Physical Activity
- Effect of Gut Microbiome Modulation on Muscle Function and Cognition.
- Review: Advancing Precision Diagnosis of Sarcopenic Obesity Through Digital Technologies, Wearables and Omics Data.
Economics & Sociology
- Social Risk Factors in Patients with Cystic Fibrosis: Impacts on Exacerbations, Lung Function, and BMI.
- Art Breaks Obesity's Health Information Silos.
- Income-Related Inequities in the Progression from Gestational to Type 2 Diabetes.
- Caught in the Middle: Biomedicine, Social Constructivism and Young People’s Experiences of Obesity in Poland.
Epidemiology
- Obesity in China: Current Progress and Future Prospects.
- Meta-Analysis: Stage-Specific Risk Factors of Cardiometabolic Multimorbidity.
- Out-Of-Home Activity Participation Associated with BMI and Muscle Mass in Community-Dwelling Older Adults.
- Overweight/Obesity Among Health Professionals and Associated Factors.
Psychology & Neuroscience
- Chapter: The Effect of Chronic Hyperglycemia on Aging: Implications in Cognitive Impairment.
- Osteosarcopenic Obesity and the Progression of Physical Frailty, Cognition Function, and Mental Health: First Longitudinal Evidence from ELSA.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Understanding Regional Disparities in Obesity: A Multiscale Geographically Weighted Analysis in the United States.
- Systematic Review of RCTs: School Feeding Programs for Improving the Physical and Psychological Health of School Children Experiencing Socioeconomic Disadvantage.
Stigma
- Examining the Effects of Implicit and Internalized Weight Bias on Physical Activity Cognitions for Women in Larger Bodies.
- The Hidden Pathways to Internalized Weight Bias: From Insecure Attachment to Depressive Self-Schemas.
Policy Related
- US Dietary Guidelines Delayed Until Early 2026.
- Restaurant Availability and Adult Obesity in the United States.
Intergenerational Effects
- Run for Your Sons: Paternal Exercise Boosts Offspring Fitness.
- Sterilization and Contraception Increase Lifespan Across Vertebrates.
- Systematic Review: Strength of Evidence for Paternal Influence on Offspring Epigenome in Observational Human Studies.
Ecology, Evolution, & Energetics
- Different Growth Patterns in Cave-Adapted Sinocyclocheilus Fish Species.
- Aging as the Wound That Fails to Heal: A Bioenergetic Continuum of Resolution Failure.
Methods
- Meta-Analysis: The Effect of Exercise Intervention on the Triglyceride-Glucose (TyG) Index in Adolescents with Overweight or Obesity.
- Chapter: Predicting Adult Obesity Prevalence in Missouri Using Satellite Imagery and Deep Learning.
- Meta-Analysis: Gut Microbiome Research in Malnourished African Populations: A Natural Language Processing Approach.
Commentary
- Podcast: Peter Attia - the Ketogenic Diet, Ketosis, and Hyperbaric Oxygen: Metabolic Therapies for Weight Loss, Cognitive Enhancement, Cancer, Alzheimer’s Disease, Brain Injuries, and More | Dominic D’Agostino, Ph.D.
- Podcast: The Science of Myostatin Inhibitors, GLP-1 Meds and Muscle Mass.
- Fat Cats are Taking Ozempic Now - and It Could Be the Solution to Terminal Feline Illnesses.
- Mapping Out Directions for Weight Bias Research.
- Dietary Fats, Blood Lipids and Atherosclerotic Cardiovascular Disease: Time for Food-Based Approach?
- WHO Issues First Global GLP‑1 Guideline for Obesity Treatment.
- "Muscle quality": rethinking an imprecise term.
- Gradually, Then Suddenly: Nutrition in an Era of Medically Induced Weight Loss.
General
- MBNL Loss of Function in Smooth Muscle as a Model for Myotonic Dystrophy Associated Gastrointestinal Dysmotility.
- Science Sleuths Raise Concerns About Scores of Bioengineering Papers.
- Effects of Crank Length on the Cardiovascular Response in a Rat Model of Motorized Cycling.
- On Connecting Too Many Dots. Ensuring the Integrity of the Associations That Support Our Conclusions.
- Systems Genetics of Lifespan and Senescence in Drosophila melanogaster.
- Neanderthals Mastered Fire - 400,000 Years Ago.
- Sleep Insufficiency and Life Expectancy at the State-County Level in the United States, 2019-2025.
- Stop Treating Code Like an Afterthought: Record, Share and Value It.
- Harvard-Affiliated Dana-Farber [Cancer Institute] to Pay $15 Million to Settle US Claims over Flawed Studies.
Announcements
- BCM to Lead Cardiac Innovation AI-Driven Drug Safety Project.
- The Children's Nutrition Research Center (CNRC) at Baylor College of Medicine Invites Applications for the Competitive CNRC Postdoctoral Fellowship in Pediatric Nutrition.
- Announcing the Third Cohort of the Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research.
- Intrinsic Capacity, Frailty and Sarcopenia Research Conference for Healthy Longevity - Looking Ahead to ICFSR 2026 - Washington, DC - The 2026 Conference Will Be Co-Hosted by Johns Hopkins.