Featured

• Fat Sensory Cues in Early Life Program Central Response to Food and Obesity.
• RCT: Brawn and Brainpower: Acute Resistance Exercise Improves Behavioral and Neuroelectric Measures of Executive Function.
• Meta-Analysis of RCTs: "Resistance exercise exerts selective benefits on cognitive domains in older adults, particularly enhancing overall cognition, working memory, verbal learning, and spatial memory."
• Endothelial Senescent-Cell-Specific Clearance Alleviates Metabolic Dysfunction in Obese Mice.
• RCT: "In conclusion, we demonstrated that the ingestion of LFP [low fat pork] enhanced the stimulation of postexercise rates of myofibrillar protein synthesis compared with HFP [high fat pork] or a CHO [carbohydrate] beverage."

Headline vs Study

• Headline: Most Popular Cooking Oil in America May Directly Contribute to Obesity: Study.
• Press Release: Scientists Find a Hidden Obesity Trigger in Soybean Oil.
• Study: P2-HNF4α Alters Linoleic Acid Metabolism and Mitigates Soybean Oil-Induced Obesity: Role for Oxylipins... In Mice. Nothing Hidden in the Oil.

Contrary or Null Findings

• "Contrary to hypotheses, adolescent-reported family mealtime quality showed slight trending declines among both the intervention and control group" in "Examining Effects of a Cultural and Family Resilience Program on Improving Physical Activity and Eating Behaviors Among Overweight Black Adolescents".
• RCT: "the intervention did not outperform the control in reducing BMI" in A Multicomponent Family Treatment of Childhood Obesity Based on the Planetary Healthy Diet.
• RCT: Vitamin D Supplementation Has No Effect on Bone Mineral Density in Individuals with Chronic Spinal Cord Injury.
• "Despite evidence of positive and statistically significant education-obesity correlations, we cannot reject the null hypothesis that schooling has no overall causal impact on obesity in either study setting."
• "In conclusion, the study by De Jong and colleagues offers robust evidence that low-dose norepinephrine...at extubation is safe for both obese and non-obese patients, challenging the practice of delaying extubation solely due to vasopressor use."
• "Our findings demonstrate no discernible difference in rested-state nor, contrary to our hypothesis, exercise-induced iMyoPS rates between MA and OC. Furthermore, we observed no clear difference in the mTORC1-mediated signaling response to exercise between MA and OC. Taken together, these data suggest that despite divergent long-term exercise habits in MA, OC possess a similar capacity to upregulate intramuscular signaling and iMyoPS in response to unaccustomed exercise contraction."
• RCT: "Short-term probiotic supplementation was safe and well accepted among children but did not produce statistically significant improvements in oral health parameters over 30 days." in Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children.
• RCT: "There were no significant main effects of group and no significant baseline-by-group interactions for SWAN parent ratings of inattention, hyperactivity or total score" in Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD.

Basic

• Burning Fat with Cysteine Depletion.
• Cytochrome P450 1A1 Influences Obesity-Induced Pulmonary Hypertension.
• Deletion of MMP12 Improves Energy Metabolism and Brown Adipose Tissue Function in Mice Prone to Cardiometabolic Disease.
• Cinnamic Acid Improves Insulin Sensitivity in Prediabetic Mice Through Branched-Chain Amino Acid Metabolic Reprogramming.
• Adipocytes Orchestrate Obesity-Related Chronic Inflammation Through β2-Microglobulin.

Scientific Rigor & Scholarly Dialogue

• Podcast: Figuring Out the Perfect Healthy Diet Remains Stubbornly Out of Reach.
• Preprint: The EAT-Lancet 2025 Report: Half a Decade Later, Key Methodological Issues Remain.

Clinical

• Preprint: Mechanistic Insights Into Microbiome-Dependent and Personalized Responses to Dietary Fibre in a RCT.
• RCT: Long-Term Effect of Multivitamin Supplementation on Incident Self-Reported Hypertension and Blood Pressure Changes.

Children and Adolescents

• Change in Weight Status from Childhood to Young Adulthood and Risk of Adult Coronary Heart Disease.
• Using Machine Learning to Identify Predictors of Heterogeneous Intervention Effects in Childhood Obesity Prevention.
• RCT: Effects of High-Intensity Interval Training Combined with Dietary Intervention on Body Composition, Cardiovascular Function, Endothelial Cell Function and Blood Lipid Indexes in Children with Obesity.
• Infant Weight Gain and Motor Development in Relation to Childhood Adiposity and Physical Activity.

Surgery

• Systematic Review: Current Evidence and Future Perspectives on Magnet-Assisted Bariatric Surgery (MABS).
• Cost-Effectiveness of Combined Minimally Invasive Hysterectomy and Bariatric Surgery in Women with Morbid Obesity and Endometrial Hyperplasia or Early-Stage Endometrial Cancer.
• Disparities in Access to Bariatric Surgery Among Adolescents.
• Evaluating Bariatric Surgery in Patients Aged 60 Years and Older: A Retrospective Multicenter Comparison of Sleeve Gastrectomy and Roux-En-Y Gastric Bypass.
• Development and External Validation of a Machine Learning-Based Risk Score for Stent Outcomes in Post-Bariatric Leak Management: The “Alexandria-Bari-Stent” Tool.

Drugs

• RCT: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, for the Treatment of Obesity in People with Type 2 Diabetes.
• Meta-Analysis of RCTs: Efficacy and Safety of Orforglipron in Adults With Obesity With or Without Diabetes.
• Meta-Analysis of RCTs: The Gynecologic Tumor Risk Related to GLP-1 Receptor Agonists and SGLT2 Inhibitors Use.
• Meta-Analysis of RCTs: Metabolic Rebound After GLP-1 Receptor Agonist Discontinuation.
• Effects of Semaglutide in Obesity-Related Heart Failure with Preserved Ejection Fraction Across the Age Spectrum.

Food & Diet

• Plant-Based Dietary Index on the Mediterranean and a Vegan Diet.
• Umbrella Review: The Effect of Resveratrol Supplementation on Obesity Indices.
• Meta-Analysis of RCTs: Can Vitamin D Supplementation Affect Cardiometabolic Factors in Children and Adolescence with Overweight and Obesity?
• Unraveling the Connection between the Mediterranean Diet and Sleep Health.

Caloric and Dietary Restriction

• Post-Intervention Sustainability of Time-Restricted Eating Versus Caloric Restriction: A Secondary Analysis.
• Effect of Caloric Restriction on Cardiovascular-Kidney-Metabolic Health in Young Adults: A Secondary Analysis of the Randomised CALERIE Trial.
• Caloric Restriction Alleviates Anxiety-Like Behaviors by Mitigating Neuroinflammation and Insulin Signaling Dysregulation in a High-Fat Diet-Induced Obesity Mouse Model.
• RCT: Low-Carbohydrate Digitally-Supported Weight Loss Programme for Type 2 Diabetes.

Exercise & Physical Activity

• Exploring the Role of Physical Activity in Obesity Treatment, Body Weight Management, and Related Health Outcomes in Adults: Proceedings of a Workshop - in Brief (2025).
• Sedentary Lifestyle Is Independently Associated with Higher Fat Mass Index Regardless of Physical Activity Level in Patients with Coronary Artery Disease.
• Crosstalk between Skeletal Muscle and the Brain During Physical Activity - In Search of Epigenetic Mechanisms.
• The Integration of Lifestyle Modification Advice and Diet and Physical Exercise Interventions: Cornerstones in the Management of Obesity with Incretin Mimetics. (pdf)
• Concurrent Changes in Diet Quality and Physical Activity and Association with Adiposity in Adults.
• RCT: Effect of a Digital Health Physical Activity Program Integrating Gamification for Obesity Management in Comparison with Usual Care.

Economics & Sociology

• Scoping Review: Life-Course Socioeconomic Status and Obesity.
• Differential Effects of Adolescent Health Behaviours on Adult Cardiometabolic Health by Parental and Neighbourhood Socioeconomic Background.
• Moderating Effects of Walk Score on the Association between Neighbourhood Disadvantage and BMI Among Mid-To-Older Aged Australian Adults.
• Uncovering the Biological Toll of Neighborhood Disorder Trajectories: A Machine Learning Based Weighting Analysis of Biomarkers in Older Adults.
• Time Lag Impacts of Rural Built Environment on Obesity: Mediation Effects of Physical Activity.
• Weight Trajectories Among Youths Following Residential Relocation.
• Dissertation: Injecting Desire: How Weight Loss Pens Create Community, Silence ‘Food Noise’ and Proliferate in Neoliberal Health Markets. (pdf)

Epidemiology

• Association between Shift Work and Insulin Resistance in Women: Implications for Metabolic Health.
• Analysis of Obesity Prevalence and Trend Prediction Among Professional Women in a Hospital from 2010 to 2024: A Weight Management Perspective.
• Obesity Mortality on the Rise: A 54-Year US Perspective.
• Prevalence and Clinical Correlates of Overweight and Obesity Among Adults in Abha, Saudi Arabia.
• Energy Metabolism and Obesity Stratified by BMI: Impact on Lipid Oxidation.
• Meta-Analysis: Unravelling the Obesity Paradox in Cancer: An Umbrella Review of Protective Associations and Evidence Credibility Across 13 Malignancies.
• Central Obesity and Its Association with Youth Physical and Mental Health.
• Prevalence of Clinical Obesity Based on Updated Definitions Among Women by Sexual Identity: Results from 2001 to 2016 National Health and Nutrition Examination Survey.

Psychology & Neuroscience

• Neurophysiological and Executive Function Differences Among Underweight, Overweight, and Normal-Weight Children and Adolescents.
• Mood Disorders, Metabolic Bariatric Surgery, and Weight Loss Pharmacotherapy.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Preprint: Racial and Ethnic Disparities in Adult Obesity Across Food and Physical Activity Environments in the United States.
• Towards Transformative and Equitable Responses to Obesity: Brazil's Systemic Approach.
• Portion Sizes and Caloric Inequity: A Hidden Driver of Obesity Disparities.
• Equity by Design - Using Digital Technology to Overcome Cardiovascular Health Disparities.

Stigma

• Impacts of Internalized Weight Bias and Weight Control Beliefs on Eating Behaviors in Women Losing Weight.
• Addressing Weight Stigma and Communicating with Patients.
• Hypervisibility Meets Hyperinvisibility: Anti-Fatness, Moral Panics, and Mainstream U.S. News Coverage of Fat People Taking Ozempic and Wegovy.

Policy Related

• European Association for the Study of Obesity (EASO) Position Statement on the Diagnosis and Management of Obesity in Older Adults.
• Informing Equitable Noncommunicable Disease Prevention Policies Through Lived Experience.
• World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults.

Intergenerational Effects

• Genome-Independent Transmission of Obesity and Type 2 Diabetes Risk: From Gametes to Early-Life Programming.
• Imprinting Disorders and Epigenetic Alterations in Children Conceived by Assisted Reproductive Technologies: Mechanisms, Clinical Outcomes, and Prenatal Diagnosis.
• Dissertation: Associations between Maternal Diet, Lifestyle and Sociodemographic Factors with Placental and Offspring Outcomes.

Ecology, Evolution, & Energetics

• Kidney Dysfunction Induced by a Hyperpalatable Diet: Role of Sodium/Glucose Co-Transporter Inhibition in Male Mice.
• Sirtuin 1 Overexpression in Mice Preserves Insulin and Thermogenic Responses in Subcutaneous Inguinal White Adipose Tissue Under Proinflammatory Conditions.

Methods

• A Contribution-Interpretable Belief Rule Base Model for Obesity Risk Prediction Using Physical Indicators and Dietary Habits.
• Characterize Disease Progression Subphenotypes in Real World Populations with Overweight and Obesity Using a Graph-Based Neural Network Framework.
• Effects of Computed Tomography Technical Parameters on Body-Composition Analysis.

Commentary

• Losing the Gamble on Semaglutide in Alzheimer’s Disease.
• Internalized Weight Stigma and Eating Disorders.
• Shall We Rationalize Our Thanksgiving Feast as Healthy?
• Fat, Stress, and Survival: Exploring the Secret Life of Adipocytes.
• What are the Implications of More New Mothers Using GLP-1s?
• Why Health Journalism Feels So Misleading.
• The Double-Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health.
• Novo Nordisk Scores a Plausible Win with Amycretin.

General

• Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches.
• Necroptosis Induced by MLKL Overexpression in Liver Triggers Cellular Senescence and Leads to Chronic Inflammation and Fibrosis.
• Do Not Put All of Your Eggs in One Basket: Multiverse Analysis in Applied Psychology.
• Systematic Review: Exercise Modulation of the Myostatin–FOXO Pathway in Murine Models of Cancer Cachexia.
• A Ten-Year Drive to Credit Authors for Their Work - And Why There’s Still More to Do.
• Value-Guided Mentoring Produces Great Leaders.

Announcements

• Houston Scores $120M in New Cancer Research and Prevention Grants.
• The Children's Nutrition Research Center (CNRC) at Baylor College of Medicine Invites Applications for a the Competitive CNRC Postdoctoral Fellowship in Pediatric Nutrition.
• Webinar: The Dietary Reference Intakes Process. December 12, 2025.