Featured

• Vitamin D Is Glucoprotective in Aging Males but Not Females [in Mice].
• Pair-Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study.
• Chemical Modulation of Gut Bacterial Metabolism Induces Colanic Acid and Extends the Lifespan of Nematode and Mammalian Hosts.
• Striatal Dopamine Tone Is Positively Associated with Adiposity in Humans as Determined by PET Using Dual Dopamine Type-2 Receptor Antagonist Tracers.
• RCT: The Effect of Consuming Diets Containing Beef Compared with Plant-Based Beef Substitute on Human Milk Composition in the Study of Nutrition in Postpartum and Early-Life (SUPER) Randomized Crossover Feeding Trial.

Headline vs Study

• Headline: This Food Could Boost Heart Health Without Any Other Changes Needed, Experts Say.
• Narrative Review: Mushrooms and Cardiometabolic Outcomes. Heart Health not Studied. What Would "Without Any Other Changes" Mean?

Contrary or Null Findings

• RCT: No Effect on Diet Quality in Primary School-Based Food Environment Intervention.
• RCT: "There were no significant differences in sitting time …, standing or stepping time between groups" in "The Children – Sit Less, Move More (C-SLAMM) pilot intervention: Feasibility and acceptability of a multi-component school and home-based intervention to promote physical activity".
• RCT: "Surprisingly, the APC-SAS video-a short, animated story video promoting healthy eating-did significantly boost PsyCap, as well as happiness, and this effect was still visible 2 weeks later."
• RCT: "Despite acute glucose suppression, fasting glucose rose modestly after 10 days of high-dose KME supplementation, suggesting possible compensatory metabolic adaptation. This finding underscores the complexity of ketone-glucose interactions and highlights the need for further research into the long-term metabolic effects of chronic ketone supplement use."
• "Surprisingly, the diabetic status of the myoblast donor predicted myoblast fusion, with reduced fusion rates in diabetic myoblasts exposed to conditioned media from all adipose sources. This suggests that IMAT-myoblast signaling may be detrimental to regeneration in diabetes, but that the effect is driven in part by an intrinsic difference in diabetic myoblasts' sensitivity to IMAT secreted factors."
• "Contrary to our hypothesis, neonatal HO [hyperoxia] was associated with lower BP compared to control offspring from lean mothers (males: 105±1 vs. 111±1 mmHg; females: 102±0.4 vs. 108±0.4 mmHg); and also reduced BP and HR in hypertensive obese offspring from obese mothers..."
• Preprint: "Contrary to dogma, hepatic mTORC1 signaling was not elevated in response to diet-induced obesity associated with the phenotypes of type-2 diabetes, including hyperinsulinemia, systemic insulin resistance, and hyperglycemia, and blocking hepatic AKT-TSC-mTORC1 signaling did not prevent these metabolic impairments."
• "The MAD [Modified Atkins diet] was safe but not effective in the treatment of D/EE-SWAS [Developmental and Epileptic encephalopathy with spike-wave activation in sleep] in the short-term, with improvements only seen in seizure control. Its impact on EEG and cognition appears limited in the short-term and poor adherence poses significant challenges."

Basic

• N-Butylphthalide Alleviates Obesity-Induced Cardiomyopathy by Binding Directly to Keap1.
• Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity.

Scientific Rigor & Scholarly Dialogue

• "The previous version of this [systematic review of vitamin D supplementation and maternal and neonatal outcomes] included 30 studies; in this update, we have removed 20 of these studies to 'awaiting classification' following assessments of trustworthiness".
• Lancet Journal Retracts COVID-19 Metformin Paper Nearly 2 Years After Authors Request Correction.
• Beyond Assumptions of Morbidity Compression: Advancing Rigor and Standardization in Geroscience.
• Video: Trustworthiness Before Trust: The Imperative to Embrace the Motto ‘Prevent, Detect, Admit, Correct’ in Scientific Practice.

Clinical

• Steps Toward Better Understanding the Role of Dietary Intake on Development of Complications in People with Type 2 Diabetes.
• Healthful Dietary Patterns and Risks of Microvascular Complications Among Individuals with Type 2 Diabetes: A Prospective Cohort Study.

Children and Adolescents

• Examining Child and Caregiver Perceptions of Environmental Facilitators and Barriers to Healthy Eating and Active Living (HEALth) During the Summer Months in a Neighborhood with a High Hispanic/Latinx Population: A Qualitative Study.
• Potential Benefits of Remission of High Childhood BMI Keep Increasing.
• Review: Childhood Obesity: The Threatening Apprentice of the Adiposity Empire.

Surgery

• Review: Obesity Pillars Roundtable: Better Together - Combined Obesity Medicine and Metabolic Surgery Care for the Treatment of Obesity.
• Propensity Matched Analysis: The Impact of BMI on Short-Term Surgical Outcomes After Robotic Liver Surgery.
• Effect of Glucagon-Like Peptide-1 Agonists on Deep Inferior Epigastric Perforator Flap Breast Reconstruction Outcomes in Patients with Obesity.
• Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Risk-Adjusted Safety Profiles After Previous Fundoplication.
• Difficult Airway Care in Neurological Obesity: Current Strategies and Future Directions.
• Case report: Acute Oxalate Nephropathy Seven Years Post Roux-En-Y Gastric Bypass Surgery Without Excessive Vitamin C Intake.

Drugs

• Editorial: Lessons Learned from Antiobesity Medication Withdrawal Trials.
• GLP1-RAs: Long-Term Use Versus Discontinuation Events of an Emerging Therapy for Obesity and Cardiovascular Diseases.

Food & Diet

• Prevention and Reversal of Hypertension-Induced Coronary Microvascular Dysfunction by a Plant-Based Diet.
• Nutritional Adequacy of the EAT-Lancet Planetary Health Diet: Cross-Sectional Analyses of the United Kingdom National Diet and Nutrition Survey.
• Review: Ultra-Processed Foods and Human Health: The Main Thesis and the Evidence.
• RCT: Eating Rate Has Sustained Effects on Energy Intake from Ultra-Processed Diets.

Caloric and Dietary Restriction

• Methionine Ameliorates Intestinal Injury in Senescence-Accelerated Mouse Prone-8 Mice by Reducing Sulfate-Reducing Bacteria and Enhancing Barrier Function.
• Sulfur Amino Acids, Metabolic Health and Beyond: Recent Advances, Translational Implications, and Future Research Considerations.
• Synergistic Taurine and Methionine Supplementation Enhances Growth and Cholesterol Regulation in Totoaba macdonaldi.

Exercise & Physical Activity

• Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome.
• Barriers to Physical Activity Among Adolescents with Asthma and Obesity: A Qualitative Study of Multiple Stakeholders.

Economics & Sociology

• Impacts of Changing Work from Home Patterns on Health Behaviours and Obesity: Insights from the Late COVID-19 Pandemic.
• An Evaluation of Economic Evidence Included in Published RCTs of Interventions to Prevent Obesity in Children.
• Impact of Dietary Transitions on Overweight and Obesity Burden and Future Trends Among Chinese Adults.
• Health, Wealth, and Nature in Harmony? A Method of Moments Quantile Regression Approach to the Obesity-Income-Environment Trinity in the G7 Panel.
• National Trends in Catastrophic Health Expenditures Among US Adults with Diabetes Aged 18-64 years: 2012–2021.

Epidemiology

• BMI and Colorectal Cancer Recurrence and Mortality: A Nationwide Cohort Study in Denmark.
• Obesity from Childhood to Mid-Adulthood in the United States: A Synthetic Cohort Approach to Measuring Health Trajectories.
• Visceral-To-Peripheral Adiposity Ratio in Proneness to Sarcopenic Obesity: Association with Low Muscle Strength, but Not Low Muscle Mass, in Young Women of South Asian Descent.
• The Prevalence of Prediabetes Is High and Has Rapidly Increased, Independent of the Degree of Obesity, in Finnish Children with Overweight or Obesity.

Psychology & Neuroscience

• Book chapter: Mindful Eating: Awareness-Based Choices for Better Health.
• Book chapter: Artificial Intelligence Techniques in Digital Interventions for Promoting Healthy Eating.
• Perspective: Iron Dyshomeostasis Links Obesity and Neurological Diseases.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• The Intersection of Food Insecurity and Child Health: Implications for Policy and Practice in the Bronx.
• Neighborhood Disparities and Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Overweight or Obesity.

Stigma

• Weight Bias Internalization Among People with Obesity Seeking Consultation for Metabolic and Bariatric Surgery in the Indian Context.
• Weight Discrimination and Up-To-Date Breast and Cervical Cancer Screening in US Women.

Policy Related

• Affordability and Nutritional Challenges for the Future of EAT Diets: An Economic Modelling Analysis.
• RCT: DASH-Patterned Groceries and Effects on Blood Pressure.
• Community-Led Change: Progress Toward Policy, Systems, and Environmental Impacts Through the Catalyzing Communities Initiative.
• Systematic Review: Do the Drivers of Food Choice Differ between Healthier and Less Healthy Foods?
• Long-Term Impact of a Sugar-Sweetened Beverage Tax and Increased Physical Activity on Obesity and Diabetes Burden in Central and Eastern European Countries: A Microsimulation Model.
• Systematic Review: Health Economics Evidence for Food System Policy.

Intergenerational Effects

• Review: Taking a Closer Look at the Early Onset of Childhood Obesity Risk.
• Parental High-Fat/High-Sugar Diets and Their Lasting Impact on Brain Development in Offspring: A Longitudinal Mouse MRI Study.

Ecology, Evolution, & Energetics

• Off-Label Semaglutide & GLP-1 Weight-Loss Medicine Use for Anti-Ageing: A Netnography of Older Bodybuilders’ Experiences and Understandings.
• Abstract: Immunometabolic Reprogramming by Caloric Restriction Leads to Protection from SIV in Rhesus Macaques.

Methods

• AI and Machine Learning in Nutrition: The Promise, the Challenge, and Recommendations.
• Review: Can Artificial Intelligence Uncover the Bioactive Peptides' Benefits for Human Health and Knowledge?

Commentary

• Groundbreaking New Research Challenges 20-Year-Old Theory on Dopamine and Obesity.
• Pro-Inflammatory Diets Linked to Accelerated Brain Aging in Older Adults.
• The Empty Chair: How Eating Alone Can Fuel Declining Health in Older Adults.
• Sucralose’s Effect on Immunotherapy, Benefits of Caloric Restriction on Prostate Cancer Treatment, and More.
• Weight Loss Drugs: What Do We Know About the Effects of Ozempic on Children?
• A New Approach to Understanding Nutrient Intake: An ILSI US & Canada Framework.
• GLP-1s Could End Up Being ‘The First True Longevity Drug’ as the World Battles a Rising Obesity Crisis.
• Orforglipron Pivotal Trial in Diabetes and Obesity Published.

General

• Loss of Molecular Resilience as the Ultimate Outcome of Aging Biology.
• Peter Attia Podcast: #373 - Thyroid Function and Hypothyroidism: Why Current Diagnosis and Treatment Fall Short for Many, and How New Approaches are Transforming Care | Antonio Bianco, M.D., Ph.D.
• Life Lessons from (Very Old) Bowhead Whales.
• Bacteria-Derived Protein Source Shows Positive Results for Health Benefits, Potentially Reducing Cholesterol.
• Meta-Analysis: Cat Ownership and Schizophrenia-Related Disorders and Psychotic-Like Experiences.
• A Multilevel Bayesian Approach to Climate-Fueled Migration and Conflict.
• Oral PCSK9 Inhibitor Provides LDL Reductions Comparable to the Injectables.
• Potential Tool Use by Wolves (Canis lupus): Crab Trap Pulling in Haíɫzaqv Nation Territory.

Video & Audio

• Podcast: Nature Podcast 19 November 2025: Insulin Cream Offers Needle-Free Option for Diabetes.
• Podcast: Brain Beat: Pump Up Your Brain with Exercise.

Announcements

• Registration Open: Your Weight Matters Regional in Memphis, December 6, 2025.
• KU Medical Center Selected as One of 12 Nutrition Obesity Research Centers in the Country.
• The NIH Obesity Research Task Force Is Hosting a Virtual Symposium, Clinical Research Strategies for Sustainable Obesity Care, on Wednesday, December 3, 2025, from 9:00 AM - 3:30 PM ET.