Featured

• Nutritional and Lifestyle Supportive Care Recommendations for Management of Obesity with GLP-1 - Based Therapies: An Expert Consensus Statement Using a Modified Delphi Approach.
• OprahDaily on: "How Loud Is the Food Noise in Your Head? This Tool Can Finally Measure It".
• Life-Extending Interventions Do Not Necessarily Result in Compression of Morbidity: A Case Example Offering a Robust Statistical Approach.
• "Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism".
• TSLP Links Intestinal Nutrient Sensing with Amplification of the ILC2-tuft Cell Circuit.

Headline vs Study

• Headline: Forget Ozempic! Study Reveals Common Kitchen Spice That Can Fight Obesity Naturally.
• Study: Black Cumin Seed (Nigella sativa) Confers Anti-Adipogenic Effects... In 3T3-L1 Cellular Model. No between Group Tests Reported for Lipid-Lowering Properties in Human Subjects.

Contrary or Null Findings

• RCT: "the intervention did not outperform the control in reducing BMI" in "A Multicomponent Family Treatment of Childhood Obesity Based on the Planetary Healthy Diet".
• RCT: "The first of its kind mobile eHealth multicomponent behavioral lifestyle intervention that included guidance to increase physical activity toward national guidelines did not meaningfully impact physical activity outcomes in pregnant women who were enrolled in Louisiana WIC."
• "Contrary to the expected phenotype, HSL-deficient mice and humans exhibit lipodystrophy."
• RCT: "No statistically significant differences between the groups were found in any outcomes at either three or 6 months" in "Effects of aquatic high-intensity interval training on patient-reported outcome measures and quality-adjusted life-years in adults with rheumatic and musculoskeletal diseases".
• RCT: "we found no evidence of effects of a preconception lifestyle intervention on the risk of macrosomia or neonatal body composition."
• RCT: "There were no group benefits of B-GOS supplementation compared with placebo" in "The Effects of 12-Week Prebiotic Supplementation on General Wellness and Exercise-Induced Gastrointestinal Symptoms in Recreationally Trained Endurance Athletes".
• RCT: No "Effect of Oral and Topical Sodium Bicarbonate on Functional Recovery and Soccer-Specific Performance After Exercise-Induced Muscle Damage.
• RCT: "The primary analysis did not meet the prespecified criteria for HbA1c noninferiority" in "INHALE-1: A Multicenter Randomized Trial of Inhaled Technosphere Insulin in Children With Type 1 Diabetes".

Basic

• NLRP3 Inhibition by VTX3232 Tempers Inflammation Resulting in Reduced Body Weight, Hyperglycemia, and Hepatic Steatosis in Obese Male Mice.
• Weight Loss Normalizes Plasma and Adipose Tissue Vitamin D Metabolism, and Gene Expression Involved in the Vitamin D Metabolism in Male Mice with Obesity.
• Crosstalk between Obesogenic Diet and Estrogen Drives Distinct Microbiota Profiles in Ovariectomized Mice.
• Increased Spontaneous Physical Activity in Female MEST-Deficient Mice Protects Against Diet-Induced Obesity.
• Irradiated Obese Adipocytes are Prone to Oxidative Stress, Inflammation, Senescence, and Fibrosis.

Scientific Rigor & Scholarly Dialogue

• Maastricht Uni Retracts €79 Billion Obesity Cost Claim over Conflict-Of-Interest.
• Most Methodological Characteristics Do Not Exaggerate Effect Estimates in Nutrition RCTs: Findings from a Meta-Epidemiological Study.
• Blog Post: Porridge or Coco-Pops? Pitfalls of Measuring Ultra-Processed Food Intake.

Clinical

• RCT: Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases.
• Review: Lifestyle Interventions for the Treatment of Obesity in Workers: An Integrative Review.
• Effect of Lifestyle Intervention on the Mobilization of Fat Depots and Organ Iron Deposition in Individuals with Obesity.
• Cross-Sectional: Lean Mass Index, Not BMI, Is Essentially Associated with Arterial Stiffness in Chinese Adults.

Children and Adolescents

• Meta-Analysis: Effect of Early-Life Protein Supplementation on Childhood Obesity and Related Metabolic Outcomes.
• The Association between Schoolwork Pressure and Overweight/Obesity in Swedish Schoolchildren Across Different Socioeconomic Groups.
• Meta-Analysis: Risk Factors for Adolescent Obesity in LMICs.
• Review: Current Guidelines on Screening, Diagnosis and Management of Dyslipidaemia in Childhood.

Surgery

• Medical Events and Costs Associated with Metabolic Bariatric Surgery Among Adults with Type 2 Diabetes.
• Retrospective Study: Enhanced Recovery After Bariatric Surgery in Patients with BMI ≥50 Undergoing Laparoscopic Sleeve Gastrectomy.
• Roux-En-Y Gastric Bypass Improves Insulin Response and Secretion of GLP-1 and PYY in Response to Postprandial Acute Exercise.
• Long-Term Outcomes of Laparoscopic Sleeve Gastrectomy Versus One-Anastomosis Gastric Bypass.
• PFAS and Altered Glucose Homeostasis in Adolescents Following Bariatric Surgery.

Drugs

• New Drugs for the Treatment of Obesity: Do We Need Approaches to Preserve Muscle Mass?
• Review: Efficacy and Safety of Anti-Obesity Drugs in Metabolic Dysfunction-Associated Steatotic Liver Disease.
• Lifestyle Medicine for Obesity in the Era of Highly Effective Anti-Obesity Treatment.

Food & Diet

• Association between Adherence to EAT-Lancet Diet and Risk of Sarcopenia and Sarcopenic Obesity in Adults.
• Systematic Review: Plant-Based and Sustainable Diet and Obesity.
• Review: Inflammation Diet and the Association with Inflammatory Markers in Individuals with Obesity.

Caloric and Dietary Restriction

• Abstract: Effect of Caloric Restriction on Cardiovascular-Kidney-Metabolic Health in Young Adults: Insights from the CALERIE Trial.
• Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit with Concomitant Aerobic Exercise in Humans.
• Gut-To-Brain Signaling Restricts Dietary Protein Intake During Recovery from Catabolic States.

Exercise & Physical Activity

• Association between Obesity with Physical Activity, Eating Behavior, Sleep Quality, General Health, and the Incidence of Hypertension Among Women: A Study in Rural and Nomadic Population of Western, Iran.
• Memory of Affective Responses to Physical Activity (Study 1) and a Pilot Intervention to Reduce Negative Memory Bias (Study 2) in Adults with Overweight or Obesity.
• Abstract: Integrated Multi-Omics Analysis of Skeletal Muscle in Response to a Bout of Resistance or Endurance Exercise.

Economics & Sociology

• Educational Gradient in Physiological Risk Factors in a Workplace: A Decomposition Analysis of Biomarkers.
• The Uncharted Territory of the New Obesity Drugs in Users Without Obesity: A Sociomedical Perspective.
• Sugar-Sweetened Beverages Consumption Among the Sámi in Sweden: Prevalence and Socioeconomic Risk Factors.

Epidemiology

• The Global Burden of Early-Onset Type 2 Diabetes (1990-2050): An Age-Period-Cohort Analysis of Incidence, Disparities, and Projections.
• Prevalence and Determinants of General and Abdominal Obesity and Overweight Among Older Iranian Adults.
• Newly Defined Clinical Obesity Versus BMI-Defined Obesity: Differential Risks of Overall Death and Adverse Events in a Population-Based Cohort.
• The Epidemiological Features of and Correlation between Central Obesity and Major Cardiometabolic Disease Clustering Among Middle-Aged and Elderly Residents in Xinjiang.
• Triglyceride-Glucose Index and Its Combination with Anthropometric Obesity Indicators are Significant Predictors of Visceral Obesity Among the Newfoundland Population.

Psychology & Neuroscience

• In Defense of Pleasure: We Need to Rethink Food Reward and Obesity.
• The Eveningness Predicts Obesity Through Food Craving and Hedonic Hunger in Young Adults.
• Review: The Role of Top-Down Appetite Self-Regulation in the Development of Healthy Eating Behaviors Among Children.
• What Works for Men? Participant Perspectives from a Mixed-Gender Weight-Management Trial with Incentives.
• The Effect of Intermittent Fasting on Hedonic Hunger: A Pilot Prospective Cohort Study Based on Ramadan Intermittent Fasting.
• RCT: Impact of an MRI Body Fat Imaging Report on Obesity-Related Cardiometabolic Risk.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• RCT: Disparities of Adiposity Explained Ethnic Differences in Insulin Sensitivity and Secretion Traits in Adolescents with Normoglycaemia.
• Rising Mortality from Diabetes and Liver Cirrhosis in the US, 1999 to 2023: Disparities by Race, Gender, and Region.
• Racial and Ethnic Disparities in Clinical Trials for Pediatric Obesity.

Stigma

• Exploring Obesity Bias in Medical Education: A Study of Third-Year Medical Students' Clinical Experiences in the United States.
• Weight Bias, Stigma and Discrimination: A Call for Greater Conceptual Clarity.

Policy Related

• Review: Quality of Evidence of Nutrient Reference Values.
• Integrating Food Loss and Waste Reduction Policies with Global Dietary Shifts: An Economic Modelling Study.
• A Qualitative Exploration of Parent and School Staff Perceptions of Freshly Prepared Meals and Food Waste Implications in California Elementary Schools.
• RCT: Developing Ecolabels to Encourage Sustainable Eating in Restaurants.
• Commentary: An Updated Definition of Global Health.
• Review: Impacts of Nutrition Policy on Food Insecurity and Individual Health in the United States.
• AI Chatbots for Promoting Healthy Habits: Legal, Ethical, and Societal Considerations.

Intergenerational Effects

• The Long-Term Impact of Obesity in Pregnancy on Offspring Hypothalamic Feeding Pathways.
• Neonatal Outcomes and A1C Improved with Real-Time Continuous Glucose Monitoring in Pregnancy with Preexisting Type 2 Diabetes.
• Maternal Carbohydrate-Programming Enhances Carbohydrate Utilization in Zebrafish Offspring by Histone H3K9 Methylation.
• Maternal Overweight During the (Pre)pregnancy Period and the Development of Disordered Eating Behaviors in Adolescent Offspring: Investigating the Role of Amygdala Volume and BMI in Childhood.
• The Multifaceted Roles of Fatty Acids and Their Dysregulation in Obese Mothers: Potential Implications for Infant Development.

Ecology, Evolution, & Energetics

• The Price of Urban Living - Lower Fledging Success Despite Higher Parental Care in Urban House Sparrows.
• PACS2/PKCα/NOX4 Pathway Damaged the Renal Vascular Endothelial Barrier by Promoting ROS Production in Diabetic Nephropathy Mice.
• The Effect of Probiotics on the Improvement of Body Weight and Fat.
• IRX3 Controls a SUMOylation-Dependent Differentiation Switch in Adipocyte Precursor Cells.

Methods

• When “Food Noise” Gets Measured: A Fast, Valid Tool Emerges.
• Is Ultrasound an Accurate Method for Predicting Fat-Free Mass in Resistance-Trained Men?

Commentary

• The Rising Use and Falling Prices of GLP-1 Medicines.
• Award Lecture: The Quest for Trustworthy, Probative, and Creative Research in Geroscience.
• Bridging the Nutrition Guidance Gap for GLP-1 Receptor Agonist Therapy Assisted Weight Loss: Lessons from Bariatric Surgery.
• What Your Patients Should Know About GLP-1s and Melatonin.
• Medical Management of Obesity: A Comprehensive Review of Food and Drug Administration (FDA)-Approved and Investigational Therapies.
• Emphasizing the Potential for Obesity-Related Pregnancy Care Problems: Bringing Attention to the Risk of Obesity-Related Pregnancy Problems.
• The Role of SIRT4 in Obesity: From Molecular Mechanisms to Clinical Implications.
• Pre-print: Challenges of Childhood Obesity and Its Effect on Mental Health.

General

• A Call for Structured Heterodoxy in Medicine and Public Health.
• I like to move it move it - static and dynamic cues in social perception.
• Sex-Specific Parent-Offspring Conflict in Humans.
• Healthspan Research Focuses on Living Healthier, Not Just Longer.
• Houston Zoo's First Vaccine Against Elephant Virus Proves to Be Effective in Other Zoos.
• Effects of Osteopontin Combined with Milk Fat Globule Membrane Proteins on Scopolamine-Induced Learning and Memory Impairment in Mice.
• Gluten Sensitivity Is Common around the World - Explanations are Emerging.

Announcements

• In Memoriam: Bert W. O’Malley, M.D. - Former Advisory Board Member of the USDA Children's Nutrition Research Center at Baylor College of Medicine.
• Jeffrey M. Friedman Awarded the Debrecen Prize for Molecular Medicine.
• "NIH’s Obesity Research Task Force is holding [online] a symposium on December 3rd on Clinical Research Strategies for Sustainable Obesity Care".
• Baylor College of Medicine’s Center for Precision Medicine Models Has Received a Five-Year, $10 Million Grant from the National Institutes of Health to Continue Its Work Using Precision Models to Study Rare Genetic Diseases.
• After an Extensive Worldwide Search, Professor Leanne Redman Has Been Appointed Academic Director of the Charles Perkins Centre (CPC), the University's Largest Multidisciplinary Research Initiative Whose Mission Is to Ease the Burden of Obesity, Diabetes and Cardiovascular Disease and Their Related Health Conditions.