Featured

• Perspective: All That Glitters Ain’t Gold: The Myths and Scientific Realities About the Gut Microbiota.
• Protocol: FLEX: Flight Exercise Training Protocol for the Fruit Fly Drosophila.
• Human Energy Expenditure and Thermoregulation During Persistence Hunting in the Namib.

Headline vs Study

• Headline: This Daily Activity Can Slow Neurodegeneration — Here’s How.
• Study: Association (not Necessarily Effect) of Self-Reported Physical Exercise with Structural Brain Changes and Cognitive Decline in Patients with Early Parkinson Disease. No Specific Activity Identified.

Contrary or Null Findings

• Preprint: "There were no significant differences in change over time of total or self-reported PA between the groups" [in] Feasibility and Physical Health Outcomes of a 1-Year Sport-Based Physical Activity Intervention in Rural Middle School Children.
• Meta-Analysis of RCTs: "yacon use in adults does not lead to significant improvements in lipid profiles or glycemic parameters."
• Much Ado About Nothing: Tirzepatide and Medullary Thyroid Cancer Debunked.
• Mild Hyperbaric Oxygen Does Not Attenuate Mitochondrial Decrease Induced by Detraining in Mice.
• News: “We Were Somewhat Surprised by the Fact That Despite Differences in Receptor Activity and Potency, Dulaglutide, Semaglutide, and Tirzepatide Showed a Remarkably Similar Risk of Serious Gastrointestinal Events.”
• Meta-Analysis of RCTs: "In general, KDs [ketogenic diets] can reduce traditional liver enzyme levels (ALT, AST, ALP, and GGT), but they appear to have no significant effect on liver stiffness."
• Meta-Analysis of Mendelian Randomization Studies: "In MR [Mendelian Randomization] analyses, higher BMI, BFP, WC, and WHR were associated with a reduced risk of cognitive impairment, with WHR also inversely related to mild cognitive impairment."

Basic

• NPFFR2 Deletion Improves Hypothalamic Insulin Sensitivity and Metabolic Outcomes in Mice with Diet-Induced Obesity.
• Soy Isoflavones Prevent Bone Quality Loss Induced by High-Fat Diet in Rats Through Epigenetic Modifications.
• JMJD8 Facilitates Hepatic Lipid Deposition and Metabolic Dysfunction.
• Lactiplantibacillus plantarum Attenuates Diet-Induced Obesity and Insulin Resistance Through Gut Microbiota-Driven PPAR/PI3K-Axis Modulation.
• Preprint: Exercise Training Improves Sarcopenic Muscle Function Via Restoration of Mitochondrial Quality Control.
• AQP7 Deficiency Drives Adipose Tissue Remodeling and Disrupts Homeostasis.

Scientific Rigor & Scholarly Dialogue

• Sometimes Numbers for Obesity Get Fuzzy - “At a press event last week, announcing a deal to make obesity medicines more affordable, CMS Administrator Mehmet Oz told us ‘Americans will lose 135 billion pounds by the midterms’ because of this.”.
• Letter: Doubting Doubly Labeled Water.
• Response: Reply to Uzoigwe: DLW Is Safe and Validated.
• Acknowledge the Merits and Limitations of Exercise Quantification Methods to Better Control the Dose-Response Relationship.

Clinical

• RCT: Curcumin Supplementation Increases Butyrogenic Bacteria in the Gut of Obese Individuals Following a Weight-Loss Diet.
• Non-Randomized Controlled Trial: Interprofessional Nutrition and Dysphagia Management for Care-Dependent Older Adults in Day-Care Services.
• RCT: The VEGPREV Study: Effectiveness of Four Plant-Based Diets on Weight Loss, Metabolic Syndrome Components and Appetitive Traits in Individuals with Overweight or Obesity.
• Dynapenic Abdominal Obesity Is Associated with Long-Term Cognitive Trajectories and Mild Cognitive Impairment.
• Plasma Fatty Acids and the Likelihood of Healthy Aging.

Children and Adolescents

• The Stronger Predictive Role of Early Life Exposures Versus Current Lifestyle Behaviors on the Development of Childhood Severe Obesity and Metabolic Dysfunction.
• Long-Term Effect of a Hospital-Based Intervention Program on BMI Trajectories in Danish Children and Adolescents with Overweight and Obesity: A 6-Year Follow-Up.
• Pilot Study: Testing Implementation Strategies for a Family Healthy Weight Program.
• Meta-Analysis: Prevalence of Obesity Among School-Going Children in India.
• RCT: Personal Activity Trackers and Family Engagement in a Pediatric Obesity Intervention.

Surgery

• Diurnal Rhythm in Meal Responses of Hunger and Appetite in Bariatric Surgery Patients One Year After Vertical Sleeve Gastrectomy.
• Variation of Metabolic and Bariatric Surgery Utilization by Neighborhood Socioeconomic Status in Maryland.
• Review: Are Glucagon-Like Peptide 1 Receptor Agonists and Bariatric Surgery the Answer to Childhood Obesity?
• Binge Eating, Food Addiction, and Body Image Dissatisfaction Before and After Metabolic Bariatric Surgery: Weight Loss Occurs, but the Relationship with Food and the Body May Not Improve in the Long Term After Surgery.
• RCT: Liraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery.

Drugs

• A Hidden Confounder for Microbiome Studies: Medications Used Years Before Sample Collection.
• Meta-Analysis of RCTs: Weight Loss, Obesity Medication, and Risk of Obesity-Associated Cancer.
• People with Lowest Physical Functioning Scores Showed Greatest Improvement After Tirzepatide Treatment.
• News: Merck's Oral PCSK9 Inhibitor Enlicitide Demonstrated Antibody-Like LDL-C Lowering in Adults with HeFH with Safety Profile Similar to Placebo in Phase 3 Trial.

Food & Diet

• The Anti-Inflammatory Effects of Three Different Dietary Supplement Interventions.
• Review: From Soil to Health: Advancing Regenerative Agriculture for Improved Food Quality and Nutrition Security.

Caloric and Dietary Restriction

• Metabolic Biomarkers for Lifespan Extension and Cellular Stress in Saccharomyces cerevisiae During Calorie Restriction and Quercetin Treatment.
• Caloric Restriction Substantially Improves Glucose Regulation in Mice with Hnf1a-Deficient Beta-Cells.

Exercise & Physical Activity

• Ethnography and Ethnohistory Support the Efficiency of Hunting Through Endurance Running in Humans.
• Analysis of RCTs: Effects of Exercise Modalities on Heart Rate Recovery and Its Association with Cardiometabolic Risk in Adolescents with Overweight or Obesity.
• Viewpoint: Personalised Physical Activity Guidelines for Pregnant Women with Overweight and Obesity: A Neglected Priority.
• RCT: Examining the Impact of a Codeveloped Multicomponent Mobile EHealth Lifestyle Intervention on Physical Activity and Its Association with Gestational Weight Gain in Underserved Women.

Economics & Sociology

• Health in Transition: New Evidence on Obesity Dynamics in Post-Soviet Countries.
• (A)symmetries in Beauty-Status Exchange: Spousal Relative Income and Partners’ BMI (at) During Marriage.
• Individual Determinants and Community Moderators of Sports Participation in Adults with Overweight or Obesity: A Hierarchical Linear Model Analysis.
• Dissertation: Consumer Heterogeneity in Demand for Food.

Epidemiology

• Associations between Obesity and the Severity of Occupational Allergic Rhinitis.
• Associations between General and Abdominal Obesity and Oral Health Behaviors.
• Abstract: Epidemiology and Cardiovascular Implications of Preclinical and Clinical Obesity.
• Prevalence and Associated Factors of Obesity, Diabetes, and Hypertension Among University Students in Jordan.
• Obesity, Knowledge, and Perceived Risk: Insights from the ObeCare Project Across Italian Territorial Pharmacies.
• Association between Normal-Weight Central Obesity and Asymptomatic Hyperuricemia in Korean Adults.
• The Combined Impact of Smoking, Alcohol, and Obesity on Past Trends in Educational Inequalities in Life Expectancy in England and Wales, Finland, and Italy, 1990-2017.

Psychology & Neuroscience

• Review: The Role of the Microbiome as a Factor in the Bidirectional Association between Obesity and Depression.
• Review: Psychological and Behavioral Effects of GLP-1 and GIP Agonists in Weight Loss.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Social Determinants of Health and Racial Disparities in Lung Function: Findings from the National Health and Nutrition Examination Survey, 2007-2012.
• The Examination of the Spatial and Contextual Disparities of Determinant Factors of Adult Obesity Among Communities in Chicago.

Stigma

• Internalized Weight Stigma, Metabolic Syndrome, and Inflammation in Postmenopausal Women with Obesity.
• Review: Promoting Resilience in Women's Weight Stigma Management (PRISM): A Model for Enhancing Body Image Resilience.

Policy Related

• Water Promotion for Overweight Prevention in Schoolchildren: For Whom Does It Work Best?
• An Updated Definition of “Healthy” Foods in the United States: How Do They Measure in Nutrient Density, Cost, and Frequency of Consumption?
• Ultra-Processed Food Consumption and Subclinical Cardiac Biomarkers.
• Systematic Review: Towards a Comprehensive School Food Environment Audit Tool in Canada.
• Housing Costs and Food Purchasing Characteristics: The Role of SNAP Participation and SNAP Purchasing Power.
• Review: The ‘Obesity First’ Approach: Redefining the Future of Healthcare.

Intergenerational Effects

• Review: The Impact of Maternal High-Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring.
• RCT: The Impact of Maternal Supplementation of Fish Oil and/or Probiotics During Pregnancy on the Serum Metabolomic Profile from Infancy to Childhood.
• Mendelian Randomization: Causal Relationship between Multiple Modifiable Risk Factors and Gestational Diabetes Mellitus.
• Adverse Perinatal Outcomes Associated with Macrosomia in Nulliparous Women: A Multicenter Cohort Study.

Ecology, Evolution, & Energetics

• The Contribution of Tissue-Specific Mitochondrial Respiration to Individual Variation in Oxygen Uptake During Rest and Exercise by the Gulf Killifish, Fundulus grandis.
• Preprint: Parental Care at the Molecular Level: The Metabolic Division 2 of Labour between Parents and Offspring.

Methods

• Editorial: Stable Isotopes Can Transform Nutritional Epidemiology - If We Let Them.
• Can Speckle Tracking Echocardiography Unmask Cardiac Involvement in Obesity Hypoventilation Syndrome?
• Tissue Engineered Models of Adipose Tissue Dysfunction to Investigate Obesity-Related Comorbidities.
• New Pediatric Waist-To-Height Ratio Adiposity Cutoff Predicts Adulthood Hypertension: Analysis of 7243 Participants from NHANES 2021-2023.
• RCT: Effect of a Mobile Phone Application for Dietary Self-Monitoring on Obesity in Adolescents.
• Evaluating and Comparing the Predictive Ability with Hypertension Risk Among Obesity Indicators: A Prospective Cohort Integrating Mendelian Randomization Analysis.
• Review: Artificial Intelligence for Obesity Management: A Review of Applications, Opportunities, and Challenges.

Commentary

• Obesity, Treatment, and Kidney Function Assessment.
• The Science and Politics of Food Noise.
• Podcast: Ultra-Processed Foods with Dr. Samuel Dicken on Layne Norton Podcast.
• Podcast: "Science Vs: Seed Oils: Should You Switch to Butter?"
• Five Thoughts to Take Home from ObesityWeek 2025.
• Senotherapeutics for Metabolic Disease and Diabetic Complications.
• LinkedIn: Assessing and Addressing Diet in the Real, Multicultural World.
• A Passionate Debate of the Lancet Commission Report.

General

• Early Oldowan Technology Thrived During Pliocene Environmental Change in the Turkana Basin, Kenya.
• Nuances in Fish Combat: Exploring Male and Female Differences in the Agonistic Behavior of an Amazonian Cichlid.
• Sex Differences in Health Burdens Across the Lifespan in Wild Chimpanzees (Pan troglodytes schweinfurthii).
• Preprint: Regulation of the Dependence Period in Booted Eagles: Effects of Nutritional Conditions.
• Long-Term and Regional-Scale Data Reveal Divergent Trends of Different Climate Variables on Fish Body Size over 75 Years.
• Press Release: Some P53 Mutations Could Help Fight Cancer.
• News: Can Bowhead Whales with Their 200-Year Lifespan Help Us to Slow Ageing? Researchers Find the Longest-Living Mammal Is Particularly Good at Fixing Faulty DNA - and Cold Water May Help.
• Coercive Paternalism Vs. Libertarian Paternalism Vs. Antipaternalism: A Triptych.

Announcements

• Applications Open: Excellence in Nutrition Fellow of the American Society for Nutrition (FASN). Due December 1, 2025.
• Texas Voters OK $3 Billion for New Dementia Research Institute.
• Lawrence J. Cheskin Named Recipient of the Obesity Society’s 2025 Atkinson Stern Award for Distinguished Public Service.