10/31/25
Featured
- "...we find that the sense of touch interacts with nutritional state to modulate lifespan in Caenorhabditis elegans."
- Can ‘Food Noise’ Be Measured? A New Psychometrically Validated Scale.
- Ultra-Endurance Athletes and the Metabolic Ceiling.
- New 60 Minutes Episode Featuring Dr. Peter Attia.
Headline vs Study
- Headline: The 8-Year Study That Could Change How We Treat Obesity.
- Study: 4-year findings of RCT: "no difference in BMI [original primary outcome] between the two groups, after adjusting for sex, age, diet, and physical activity".
Contrary or Null Findings
- RCT: "Compared to controls, this home-based obesity prevention intervention had no significant impact on children's or parents' BMI immediately after the intervention or after 1 year of follow-up, indicating that the intervention had no additional effect compared to the control group on children's or parents' BMI over time."
- RCT: "... overall weight loss did not differ significantly between the DTxO and placebo groups..." in Effectiveness of a Digital Therapy on 6-Month Weight Loss in People With Obesity: Digital Therapy to Promote Weight Loss in Patients With Obesity by Increasing Their Adherence to Treatment.
- RCT: "isCGM did not improve QoL scores relative to the control group for overweight individuals with IGT or mild diabetes."
- "These results contrast with earlier observations suggesting TNF inhibition contributes to increased body weight in psoriatic disease. By adjusting for natural weight gain that occurs with age, this study offers a more refined perspective on treatment effects."
- RCT: "In this randomized clinical trial, a monthly food voucher did not have an effect on HbA1c control or objective measures of diet quality but the voucher did increase self-reported vegetable and fruit consumption."
- RCT: Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight.
- “According to previous research, this study examined seven factors that may influence consumer purchase intentions, including food quality, perceived sustainability, conspicuous consumption, perceived food risk, resistance to sales techniques, inadequate marketing strategies and taste anxiety… there were no significant effects, except for food quality and recommendation intention.”
- “Breakfast consumption does not rapidly increase liver or muscle glycogen content in well-trained cyclists.”
Basic
- Cellular Pan-Chain Acyl-CoA Profiling Reveals SLC25A42/SLC25A16 in Mitochondrial CoA Import and Metabolism.
- Methanogenesis Associated with Altered Microbial Production of Short-Chain Fatty Acids and Human-Host Metabolizable Energy.
- Mitochondrial and Lysosomal Signaling Orchestrates Heterogeneous Metabolic States of Regulatory T Cells.
- Effect of Omega-3 Fatty Acids on Adipose Tissue: Histological, Metabolic, and Gene Expression Analyses in Mice Fed a High-Fat Diet.
- Fibulin-7 in Progenitor Cells Promotes Adipose Tissue Fibrosis and Disrupts Metabolic Homeostasis in Obesity.
Scientific Rigor & Scholarly Dialogue
- Video: Trustworthiness Before Trust: The Imperative to Embrace the Motto “Prevent, Detect, Admit, Correct” in Scientific Practice.
- Powering Nutrition Research: Practical Strategies for Sample Size in Multiple Regression.
Clinical
- Under-Documentation of Diagnosis and Follow-Up Procedures for Overweight and Obesity Compared to Other Cardiovascular Risk Factors in Hospitalised Patients.
- Review: Obesity as a Catalyst for Endometrial Hyperplasia and Cancer Progression.
- The Omics Revolution in Obesity: From Molecular signatures to Clinical Solutions.
- Sarcopenic Visceral Obesity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Children and Adolescents
- Prospective and Bidirectional Associations between Caloric Midpoint and Adiposity from 7 to 10 Years of Age.
- Exposure to Sugar Rationing in First 1000 Days After Conception and Long Term Cardiovascular Outcomes: Natural Experiment Study.
- Genetic Polymorphism, Methylation, and IL6 Gene Expression in Children with Obesity.
- Role of Sleep Duration and Timing on Paediatric BMI Across Childhood and Adolescence: Do Both Matter?
- Evaluating the Safety and Efficacy of a Non-Weight-Centric Approach to Obesity Prevention in Rural and Urban Female Adolescents: Quasi-Experimental Study.
Surgery
- Review: Volume-Outcome Relationships in Bariatric Surgery.
- Abstract: Recurrent Cushing Disease Presenting with Obesity Unresponsive to Surgical and Medical Interventions - A Case Series.
- Meta-Analysis: Safety and Efficacy of Single- and Two-Step Metabolic and Bariatric Surgery in the Setting of Obesity With ≥ 50 kg/m2 BMI.
- Cohort Study: Redox Homeostasis and Antioxidant Response After Bariatric Surgery in Severe Obesity.
- Retrospective Study: Stratifying Risk: Complication Rates Across BMI Subgroups of Class III Obesity in Patients Undergoing Hysterectomy.
- Adiposome Lipidomic Shifts Following Bariatric Surgery in Association with Weight Loss and Cardiometabolic Benefit.
Drugs
- Ethical Framework for Weight Loss Medication Use in Youth.
- Dermatologic and Metabolic Benefits of Semaglutide in Psoriasis with Obesity: A Six-Month Prospective Cohort Study.
- Exploring the Role of Adipocytokines in Obesity and Depression.
- Cost-Effectiveness Analysis: Tirzepatide vs Semaglutide and Liraglutide for Weight Loss in Patients with Overweight or Obesity Without Diabetes.
Food & Diet
- RCT: Probiotic Pasta Consumption Improves Lipid Metabolism and Reduces Gut Permeability in Adults with Overweight or Obesity.
- Dietary Urbanization Destabilizes Host-Gut Microbiome Homeostasis and Informs Precision Nutrition for Human Health.
- Development and Validation of a Brief Nutrition Security Screener (NSS) for Clinical and Public Health Settings.
- Trends in Dietary Supplement Use Among U.S. Adults between 2011 and 2023.
Caloric and Dietary Restriction
- Deficiencies in Methionine, Tryptophan, and Niacin Remodels Intestinal Transcriptome and Gut Microbiota in Female Mice.
- Energy Underreporting in Low-Calorie and Carbohydrate-Restrictive Diets: Epidemiological Considerations.
- An Ad Libitum-Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts Via Opposite Effects on the Energy-Splicing Axis.
- Standardizing Caloric Restriction for Preclinical Cancer Research.
Exercise & Physical Activity
- Commentary: Twenty Years of Progress in Human Exercise Metabolism Research.
- Physical Activity Is Directly Associated with Total Energy Expenditure Without Evidence of Constraint or Compensation.
- Effectiveness of Sustained Leisure-Time Physical Activity Strategies for Obesity-Related Cancer Prevention: An Emulated Target Trial in a Prospective US Cohort.
- Social Media in Physical Activity Interventions Targeting Obesity Among Young Adults: Trends, Challenges, and Lessons from Instagram, TikTok, YouTube, and Facebook.
Economics & Sociology
- Costs of Cutting Weight - An Economic Evaluation of GLP-1 Agonists vs Gastric Bypass.
- Exploring Food Insecurity and Nutritional Challenges Among Rickshaw Pullers in Dhaka City, Bangladesh.
- Dietary and Nutrition Transitions in Indigenous Communities: The Role of Income and Market Access in Nagaland, India.
- Preprint: Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis.
Epidemiology
- Prevalence and Determinants of Insulin Resistance Among Middle-Aged Adults in Rural Northern Ghana: An Awi-Gen Cross-Sectional Study.
- Obesity Effects on the Health-Related Quality of Life in Japan.
- Epidemiology of Overweight and Obesity in School Children and Adolescents in Cameroon: A Comparative Study in Urban and Semi-Urban Settings.
- Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.
- Long-Term BMI Trajectories and Epigenetic Age Acceleration.
Psychology & Neuroscience
- Association between Obesity and the Intersection of Depression, Sex, and Race in Brazilian Adults.
- Associations of Metabolic Heterogeneity of Obesity, Cardiometabolic Index with Sleep Trajectory Among Middle-Aged and Older Adults.
- Living Well? The Unintended Consequences of Highly Popular Commercial Fitness Apps Through Social Listening Using Machine-Assisted Topic Analysis: Evidence from X.
- Review: Leptin a Potential Link between Obesity and Depression.
- RCT: An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Racial and Ethnic Disparities in Childhood Cardiovascular Health: Evidence of the Role of Social Disadvantage from NHANES 2013-2018.
- Meta-Analysis: Assessing the Relationship between Cardiometabolic Diseases and the Risk of Developing Aggressive Prostate Cancer.
- Meta-Analysis: Advancing Health Equity Through Telehealth: Remote Vs. In-Person Weight-Loss Interventions Among Black Women with Obesity.
Stigma
- Assessing Weight Stigma in School-Aged Children (Grades 1 to 3) in Palestine.
- Association between Weight Stigma Experiences in Healthcare and Self-Reported Healthcare Avoidance in a National Sample.
- The Prevalence of Negative Weight Commentary in Girls Sport and Associations with Body Image and Well-Being in Young Adulthood.
- Promoting a Turnaround in the Management of Renal Disease in Patients with Obesity.
Policy Related
- Food Parenting Stress Among Caregivers Receiving Government Food Assistance: A Study from the United States.
- Feasibility of an Online Grocery Intervention Pilot to Improve Fruit and Vegetable Purchase and Food Security Among Adults with Children Eligible for SNAP.
- Qualitative: Home-Delivered Nutrition Services for Older Adults Under the Older Americans Act.
- RCT: Ultraprocessed or Minimally Processed Diets Following Healthy Dietary Guidelines on Weight and Cardiometabolic Health.
- Review: First 1000 Days Strategies to Prevent Childhood Obesity.
- The People Behind the Pounds: A Qualitative Exploration of Factors That Help or Hinder Healthy, Sustainable Food Purchases for People Living with Obesity and Food Insecurity in the UK.
Intergenerational Effects
- Review: Nutrigenomics of Obesity: Integrating Genomics, Epigenetics, and Diet-Microbiome Interactions for Precision Nutrition.
- Genetic Ancestry Influences Body Shape and Obesity Risk in Latin American Populations.
- Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring.
- Can Maternal Metformin Protect the Developing Fetal Brain?
- Human Milk Composition Is Associated with Maternal Overweight / Obesity and Low Milk Supply, with Implications for Infant Weight Outcomes: A Cross-Sectional Study.
Ecology, Evolution, & Energetics
- Revisiting Hominin Scavenging Through the Lens of Optimal Foraging Theory.
- Tweet or Treat: Unveiling the Effect of Brood Size on Begging Behaviour in a Songbird and the Importance of Feeding Effort and Diet Quality.
- In Vivo Evidence Supports the Effectiveness of the Longevity-Associated Protein LAV-BPIFB4 in Reducing Adipose Tissue-Derived Mediators of Systemic Inflammation to Prevent Vascular Insult and Atheromatous Change.
- Gut Microbiota Composition Combined with Reduced Intestinal Fatty Acid Uptake Prevents Hepatic Steatosis in Obesity-Resistant Mice Fed a High-Fat Diet.
- Depletion of Myeloid-Derived Zbtb46+ Cells Improves Glycemic Control in Obesity Via the DPP4/GLP-1 Pathway.
Methods
- Time-Resolved Mendelian Randomization Detects Substantial Variation in the Detrimental Effect of Obesity Throughout Life.
- Implementing GRATL and Artificial Intelligence in Experiential Learning of Obesity Physiology and Etiology.
- News Release: Global Scientists Calls for Faster Development of Energy Metabolism Measurement.
- A Mathematical Model for Obesity in Young Women Aged 18 to 25 Years.
Commentary
- Dr. Emily Dhurandhar Discusses Food Noise.
- Diabetes Points to Faith Healing at the Heart of MAHA.
- Exploring the Role of Adipocytokines in Obesity and Depression.
- Obesity and Pregnancy: Obstetric and Neonatal Complications.
- Preprint: Direct Individual Support Is the Missing Element in the Mainstream National Obesity Guidelines.
- Food as Medicine Is a Tricky Business That Doesn’t Always Work.
- Eating Less Protein Could Help You Live Longer. Here's How.
- Heart Benefits of Semaglutide are More Than Weight Loss.
General
- Audio: Can Collagen Supplements Improve Your Skin? Here's What the Research Shows.
- Commentary: Flawed Analysis Invalidates Claim of a Strong Yellowstone Trophic Cascade After Wolf Reintroduction: A Comment on Ripple et al. (2025).
- Educational Attainment as the Primary Socioeconomic Determinant of Heart Failure: A Multivariable Mendelian Randomization Study.
- The Ability of Activity and Cognition in Old Mice to Predict Age of Death.
- How Do Flapping Creatures Achieve Stable Hovering?.
- The Mysterious Rise of Cancer Among Young Adults in the Corn Belt.
- Study Unravels Genetics Behind Why Some Fish Remain Tiny.
- Identifying Key Questions and Challenges in Microchimerism Biology.