Featured

• Remembering Steven N. Blair: A Good Scholar, a Good Man, and a Good Friend Passes.
• Challenges in Undertaking Nonlinear Mendelian Randomization in BMI and Mortality Research.
• "In more thermally demanding conditions female guinea pigs - even under ad libitum food abundance - transfer the higher costs of maintenance and reproduction largely to offspring."
• Energetic Costs of Feeding in 12 Species of Small-Bodied Primates.
• How Narcissism Biases Food Healthiness Perceptions and Consumption.

Headline vs Study

• Headline: Morning Workouts May Be Better for Weight Loss, Study Finds.
• Study: Cross-Sectional Analysis of the Diurnal Pattern of Moderate-To-Vigorous Physical Activity and Obesity. Causation Not Established.

Contrary or Null Findings

• MTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction.
• Gut Transplants from Bees Fed an Antipathogenic Pollen Diet Do Not Confer Pathogen Resistance to Recipients.
• Meta-Analysis of RCTs: "There was no evidence to suggest that commercial exergames are more beneficial for improving cognitive flexibility, inhibitory control, or working memory than conventional exercises."
• In mongooses, "Furthermore, the accuracy of their carer predicted future survival, but not weight gain of the pups and the effect was contrary to expected, with pups that were cared for by less accurate individuals being more likely to survive to adulthood."
• "...no evidence that overall CDS (cognitive disengagement syndrome) symptoms or ADHD symptoms (overall and subdomain) predicted child BMI."
• "Among non-diabetic adults, environmental exposures were not consistently associated with HbA1c."
• RCT: "The intervention did not result in improved diet quality or cardiovascular health as measured by HEI-2015 or LS7" in Evaluation of the SuperShelf Intervention in Choice-Based Food Pantries.
• RCT: "Our results did not show significant differences in body weight, blood sugar, fasting insulin, or lipid profiles between TRE (time restricted eating) plus BE (behavioral economic) interventions, TRE alone, and usual care groups" in Patients with Impaired Fasting Glucose.

Basic

• Glycolytic Reprogramming Fuels Myeloid Cell-Driven Hypercoagulability.
• Knockout of STE20-Type Kinase TAOK3 Does Not Attenuate Diet-Induced NAFLD Development in Mice.
• Angiotensin II Type 1 Receptor-Associated Protein in Immune Cells: A Possible Key Factor in the Pathogenesis of Visceral Obesity.
• Protective Roles of Adiponectin and Molecular Signatures of HNF4α and PPARα as Downstream Targets of Adiponectin in Pancreatic β Cells.
• The Effect of Serum from Calorie-Restricted Mouse on MTOR Signaling in C2C12 Myotubes.
• An Investigation of the Endoplasmic Reticulum Stress in Obesity Exposure in the Prenatal Period.
• Metformin Inhibits Digestive Proteases and Impairs Protein Digestion in Mice.
• Effect of Calorie Restriction on Redox Status During Chemically Induced Estropause in Female Mice.

Scientific Rigor & Scholarly Dialogue

• Retraction Watch: ‘Prompt and Decisive’: Editor Says Obesity Study Will Be Retracted After Critique.
• Retraction Watch: Alcohol Researcher Faked Data in Animal Studies, US Watchdog Says.
• An Ultra-Processed Retraction – Still Processing.
• Error in Weighted Analyses and Reported Prevalence Rates.
• Correction: "Per the National Health and Nutrition Examination Survey, inclusion of the mobile examination clinic (MEC) weights is necessary to make the prevalence data nationally representative."

Clinical

• Umbrella Review: Health Outcomes Associated with Phytosterols.
• Meta-Analysis: The Effects of Time-Restricted Eating vs Habitual Diet on Inflammatory Cytokines and Adipokines in the General Adult Population.

Children and Adolescents

• "Findings of this multi-site study inform the feasibility of partnering with home visiting programs to reach and measure a diverse sample of children and families in need of childhood obesity prevention."
• "Initial visit laboratory values and weight trajectory may allow for risk stratification, whereas fasting plasma glucose is less helpful" for predicting pediatric T2D progression.
• Systematic Review: Nutrient Intake and Status in Children and Adolescents Consuming Plant-Based Diets Compared to Meat-Eaters.

Surgery

• "... bariatric surgery may be associated with a higher risk of gastric and pancreatic cancer and a lower risk of colorectal and liver cancer hospital admission."
• Association of Program-Specific Variation in Bariatric Surgery Volume for Medicaid Patients and Access to Care: A Tale of Inequality?
• Meta-Analysis: Change in Mineral Status After Bariatric Surgery.
• "Food insecure patients had a statistically longer length of stay after primary bariatric surgery but were not associated with an increased risk of 30-d complications."

Drugs

• RCT: Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure with Preserved Ejection Fraction.
• RCT: Efficacy and Safety of Oral Orforglipron in Patients with T2D.
• RCT: " Tirzepatide provided substantial additional reduction in body weight in participants who had achieved ≥5.0% weight reduction with intensive lifestyle intervention."
• RCT: Short-Term Effects of Canagliflozin on Glucose and Insulin Responses in Insulin Dysregulated Horses.

Food & Diet

• Nutrition Education in Medical Schools: What Do Medical Students Think?
• Mid-Life Adherence to the Dietary Approaches to Stop Hypertension (DASH) Diet and Late-Life Subjective Cognitive Complaints in Women.
• Greater Adherence to the Healthy Nordic Food Index Is Associated with Lower All-Cause Mortality in a Population-Based Sample from Northern Germany.
• Red Meat Intake and Risk of T2D in a Prospective Cohort Study of US Females and Males.
• An Unhealthy Plant-Based Diet is Associated with Higher Risk of Hypertension but Not Framingham Risk Score in Adults.

Caloric and Dietary Restriction

• Diet Composition, Adherence to Calorie Restriction, and Cardiometabolic Disease Risk Modification.
• Calorie Restriction Modulates the Transcription of Genes Related to Stress Response and Longevity in Human Muscle.

Exercise & Physical Activity

• The Effect of Heat Stress on Heat Shock Protein Expression and Hypertrophy Related Signaling in the Skeletal Muscle of Trained Individuals.
• Diet Diversity and Food Quality Score in Male Football Players and Healthy Non-Athlete Controls in Relation to Oxidative Stress Biomarkers.
• Editorial: Exercise Intervention for Prevention and Management of T2D.
• Weekly Minutes of MVPA Is Associated with Movement Quality in [Older Adults with Overweight and Obesity], Independent of Age.
• Feasibility and Preliminary Efficacy of a Novel Web-Based Physical Activity Intervention in Adults with Overweight/Obesity.
• Thesis: Effects of Genetic Background and Early-Life Exercise on Adult Traits Related to Exercise Behavior, Morphology, and Physiology. (pdf)

Economics & Sociology

• Parent BMI, Income, and Education Associated with BMI Z-Score of Adolescents with Intellectual and Developmental Disabilities.
• Preprint: A Study of Obesity and Financial Stress in Workers in the US.
• "Tirzepatide...may offer the potential to achieve stringent glycemic goals, weight loss targets, and composite treatment goals at a lower cost per responder compared to semaglutide 1 mg among people with T2D."

Epidemiology

• Mendelian Randomization: Life-Course Adiposity and Severe Liver Disease.
• Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
• Editorial: Coordinating Efforts to Reduce the Global Incidence of Cardiovascular Disease.
• Associations of 10 Trace Element Levels in the Whole Blood with Risk of Three Types of Obesity in the Elderly.
• Correlation Analysis of Obesity Phenotypes with Leptin and Adiponectin.
• Cross-Sectional: Clinical Impacts of Sarcopenic Obesity on Chronic Obstructive Pulmonary Disease.

Psychology & Neuroscience

• Variety and Portion Size Combine to Increase Food Intake at Single-Course and Multi-Course Meals.
• The Cerebellum Plays More Than One Role in the Dysregulation of Appetite.
• Response Inhibition Training as an Intervention to Modify Liking and Wanting for Foods Based on Energy Density.
• Sex-Specific Impulsivity, but Not Other Facets of Executive Functioning, Predicts Fat and Sugar Intake Two-Years Later Amongst Adolescents with a Healthy Weight.
• Two Human Brain Systems Micro-Structurally Associated with Obesity.

Equity and Disparities

• Rural–Urban Differences in Overweight and Obesity, Physical Activity, and Food Security Among Children and Adolescents.
• Amplifying Older Aboriginal and Torres Strait Islander Women’s Perspectives to Promote Digital Health Equity.
• Effect of a Telephone-Based Lifestyle Intervention on Weight, Body Composition, and Metabolic Biomarkers in Rural Ohio.
• Implementation and Evaluation of a Co-Designed, Culturally Tailored Childhood Obesity Community Prevention Program for Māori and Pacific Islander Children and Families.

Stigma

• Comment: Why We Urgently Need to End the Stigma around Body Weight.
• Systematic Review: Compassion-Based Interventions for Individuals Struggling with Body Weight Shame.
• Perspective: Are Current Guidelines Perpetuating Weight Stigma? A Weight-Skeptical Approach to the Care of Patients with Obesity.
• Exposure to Written Content Eliciting Weight Stigmatization: Neural Responses in Appetitive and Food Reward Regions.
• Exploring the Effect of Adding an Interactive Lecture to a Standardized Patient Curriculum on the Attitudes of Third-Year Medical Students About Patients with Obesity.
• Changing the Global Obesity Narrative to Recognize and Reduce Weight Stigma: A Position Statement from the World Obesity Federation.

Policy Related

• Expert Views on High Fat, Salt and Sugar Food Marketing Policies to Tackle Obesity and Improve Dietary Behaviors in the UK.
• Narrative Review: Ultra-Processed Foods and Cardiometabolic Health: Public Health Policies to Reduce Consumption Cannot Wait.
• Changing the Default Order of Food Items in an Online Grocery Store May Nudge Healthier Food Choices.
• RCT: Impact of Taxes and Warning Labels on Red Meat Purchases Among US Consumers.
• Sentiment Analysis of Tweets on Menu Labeling Regulations in the US.
• The Right Advice, from the Right Person, in the Right Way: Non-Engaged Consumer Families’ Preferences for Lifestyle Intervention Design Relating to Severe Obesity in Childhood.

Intergenerational Effects

• Leptin Resistance in Children with In Utero Exposure to Maternal Obesity and Gestational Diabetes.
• Cord Blood DNA Methylation of Immune and Lipid Metabolism Genes Is Associated with Maternal Triglycerides and Child Adiposity.
• "These results suggest that it is important to manage not only blood glucose levels but also pre-pregnancy body weight and gestational weight gain for appropriate fetal growth."

Ecology, Evolution, & Energetics

• Impact of Housing Temperature on Adipose Tissue HDAC9 Expression and Adipogenic Differentiation in High Fat-Fed Mice.
• The Influence of Whole-Body Cryotherapy or Winter Swimming on the Lipid Profile and Selected Adipokines.
• Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights Into Allostery.

Commentary

• New Insights in the Mechanisms of Weight-Loss Maintenance: Summary from a Pennington Symposium.
• The ‘Gas Masks for All’ Approach to Air Pollution: What Could Possibly Go Wrong?
• Have We Tortured BMI Enough?
• A Global View of Weight Stigma.
• Nearly 70% of American Soldiers are Obese or Overweight — Compromising National Security.
• Governing Through Labels: A Comparison of Obesity Prevention and Sustainable Consumption Policies.
• How Your Weight Became Part of the Culture War.
• The Fructose Survival Hypothesis as a Mechanism for Unifying the Various Obesity Hypotheses.

General

• Supplemental Material Precision Medicine for the Population—The Hope and Hype of Public Health Genomics.
• Plants: Re-Evaluating the Driving Force Behind Mutations.
• Take Nutrition Studies with a Grain of Salt.
• Meta-Analysis: The Nocebo Effect Across Health Outcomes.
• "In conclusion, combining almonds with other foods such as chocolate and lettuce influences oral processing behaviour and bolus properties and consequently predicted lipid bioaccessibility of almonds, highlighting the impact of food matrix and consumption context on these aspects."
• Longitudinal Plasmode Algorithms to Evaluate Statistical Methods in Realistic Scenarios: An Illustration Applied to Occupational Epidemiology.
• Prosociality Should Be a Public Health Priority.
• Gender and Retention Patterns Among US Faculty.

Video & Audio

• Peter Attia: Conversation About His Hit Book OUTLIVE, Medicine 3.0, Promoting Healthspan, GLP-1 Drugs and More.

Announcements

• NHLBI Obesity, Nutrition and Physical Activity Seminar: The Relationship between Body Weight, Adiposity, and Cardiovascular Risk among South Asian Americans. November 06, 2023. Virtual (webinar). 11:00 a.m. - 12:00 p.m. ET.