10/17/25
Featured
- Development and Rigorous Multistep Validation of a Psychometric Tool to Measure Food Noise.
- Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs.
- Timing and Duration of Calorie Restriction Determine Its Impact on Ovarian Aging in Female Mice.
- "Overall, our study found inconclusive evidence on the benefits of [Community Based Interventions]." in ... "Systematic review on community-based interventions targeting prevention of overweight and obesity in children and adolescents."
- Why Did Bob Stop Losing Weight? We Need to Talk About Energy Expenditure Compensation.
Headline vs Study
- Headline: Science Confirms Your Daily Brew Really Does Make You Happier.
- Press Release: Your Morning Coffee Really Does Make You Happier.
- Study: Observational study of self-reported caffeine consumption (not necessarily coffee) and reported affect. "[T]he reliance on self-reported measures introduces the potential for bias, and the observational nature of the study limits causal inferences."
Contrary or Null Findings
- RCT: No Significant Effect of a Multifaceted Digital Intervention for the Prevention of Type 2 Diabetes Mellitus in Primary Care (PREDIABETEXT) on Primary Endpoint of HBA1c.
- Preprint: "Contrary to the dominant paradigm and practice in the probiotic field, combining multiple probiotic strains did not necessarily increase efficacy. Simultaneous treatment with EcN and L. murinus V10 was less effective than EcN treatment alone at preventing death from sepsis."
- "Our findings demonstrate that, in accordance with human studies, ActRIIA/IIB blockade holds promise for increasing muscle mass, strength, and muscle insulin sensitivity. However, contrary to the improved glycemic control in humans, ActRIIA/IIB blockade in mice causes severe glucose intolerance and lowers voluntary physical activity."
- RCT: An Enhanced Implementation Support Approach Was Not Superior to Less Intensive Foundational Implementation Support for Promoting Delivery of a Group Physical Therapy Program for Knee Osteoarthritis.
- "Fmr1 KO mice with or without metformin treatment displayed hyperphagia on a HFD, yet did not show higher weight gain than wild type. And, surprisingly, their glucose tolerance was equivalent to that of wild type mice on metformin."
- "Surprisingly, [physically] active women reported more depressive symptoms...".
- RCT: "...even among highly motivated and digitally engaged participants, diet self-monitoring via the app alone did not lead to participants meeting the clinically recommended dietary fiber intake."
- "Contrary to our hypothesis, we observed a downward BMI trajectory back to baseline with the exception of those with residential instability in the post-COVID-19 pandemic period following a statistically significant weight gain during the pandemic."
Basic
- Molecular Signature of Early Obesity-Associated Insulin Resistance: Adipocyte-Derived Extracellular Vesicle Proteins Reveal Stage-Specific Candidates for Metabolic Dysfunction.
- MRAP2 Modifies the Signaling and Oligomerization State of the Melanocortin-4 Receptor.
- Reduced Growth and Inflammation in Lrp5−/− Mice Adipose Tissue.
- Macrophage Plg-RKT Expression Promotes Diet-Induced Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease.
- GHSR Suppression in Neurons Protects Against Aging-Associated Metabolic and Cognitive Impairments.
Scientific Rigor & Scholarly Dialogue
- Correspondence: Interpreting Substitution Models in Nutritional Epidemiology: The Case for the Protective Role of NOVA 1 Foods over the Risk of NOVA 4.
- Article: Effects of Chronic Nitrate Supplementation on Blood Pressure in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
- Letter: The Devil Is in the Details: Reassessing an Isolation Attempt Reveals Methodological Breaches in Dietary Inorganic Nitrate Research.
- Reply: The Light Is in the Details: Transparent Methodology and Scientific Integrity in Systematic Review Design.
- Follow-up Letter: Robustness Is Action, Not Assertion: Reassessing an Isolation Attempt Reveals Methodological Breaches in Dietary Inorganic Nitrate Research.
Clinical
- RCT: Mixed-Meal Challenge Differentially Modulates Metabolic Pathways in Adipose Tissue in Healthy Subjects with Abdominal Obesity who had High Versus Low Liver Fat.
- RCT: The Impact of Smoking Reduction on Food Demand in People with Excess Weight.
- RCT: Reduction of Muscle Damage Indices by Consuming Chlorella vulgaris Along with High-Intensity Interval Training in Men with Overweight.
- RCT: Effect of Weight Loss Through Dietary Interventions on Cardiometabolic Health in Older Adults.
- RCT: Early Weight Loss and Other Factors Associated with Clinically Significant Weight Loss in Two Commercial Weight Loss Programmes.
- Integration of Proteomic and Lipidomic Analysis Reveals Potential Markers of Insulin Resistance in Young Children with Obesity.
- The Skeletal Muscle-Adipose Creatine Metabolic Axis: A Novel Paradigm for Lipid Metabolism Reprogramming and Obesity Management.
- Systematic Review: The Impact of Obesity on Influenza Vaccine Immunogenicity.
Children and Adolescents
- Eccrine Sweat Reveals Normalization of Artificial Sweetener Levels in Children with Overweight After Nutritional Education.
- Overview of Systematic Reviews on Behavioral Determinants of Physical Activity and Healthy Eating in Schoolchildren.
- Thresholds of Fat Mass Index Percentiles and Their Association with Cardiovascular Risk in Adolescents: Results from the EVA4YOU Study.
- RCT: Inulin Supplementation Modulates Gut Microbiota Derived Metabolites Related to Brain Function in Children with Obesity.
Surgery
- Systematic Review: Magnetic Sphincter Augmentation Versus Fundoplication in Gastroesophageal Reflux Disease (GERD) Patients without Obesity.
- Review: Sleeve Plus Procedures.
- The Role of X-Ray Densitometry in Diagnosing Calcium Metabolism Disorders in Patients After Bariatric Surgery.
- A Case Series Analysis of Hospital Volume in a New Era of US Bariatric Surgery Within the Nationwide Readmissions Database.
- Health and Economic Gains from Bariatric Surgery in Portugal: An In-Depth Analysis Using a Markov Model.
Drugs
- Blinded by the Drug? A Vigilyze Signal Linking Semaglutide to NAION [Non-Arteritic Anterior Ischemic Optic Neuropathy].
- "Early metformin treatment in overweight or obese individuals may reduce [post–COVID-19 condition] risk."
- Cost-Effectiveness of Semaglutide 2.4 mg Versus Liraglutide 3 mg for the Treatment of Obesity in Greece.
- Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders.
Food & Diet
- RCT: Effect of Sweeteners and Sweetness Enhancers on Weight Management and Gut Microbiota Composition in Individuals with Overweight or Obesity.
- Review: Tropical Plants to Reduce Chronic Metabolic Diseases in the Obesity Pandemic.
- RCT: Effect Modifiers of the MIND Diet for Cognition in Older Adults: The MIND Diet Trial.
Caloric and Dietary Restriction
- Association between Physical Activity Energy Expenditure and Markers of Healthspan During Prolonged Calorie Restriction in Individuals Without Obesity: Observations from the CALERIE RCT.
- Preprint of Meta-Analysis: Time-Restricted Eating Versus Calorie Restriction for the Management of Metabolic Syndrome.
Exercise & Physical Activity
- RCT: Combined Creatine and HMB Co-Supplementation Improves Functional Strength Independent of Muscle Mass in Physically Active Older Adults.
- A Long-Duration Physical Literacy Intervention to Improve Health Indicators and Physical Activity Levels in Adolescents with Overweight or Obesity.
- RCT: Lemon Myrtle Extract Enhances Muscle Hypertrophy Induced by Low-Load Bodyweight Resistance Training in Older Adults.
Economics & Sociology
- Exploring Maternal Health, Lifestyle, and Socioeconomic Influences on Childhood Obesity in Australia.
- Obesity Indices and Their Sociodemographic, Lifestyle, and Social Isolation Correlates in a Large Spanish Working Population.
- Does Loneliness Impact Intentional Weight Loss? The Role of Obesity-Related Disadvantages and Comorbidities.
Epidemiology
- Obesity and Weight Change During Eight Years in Relation to Asthma Incidence.
- Pooled Prevalence and Factors of Overweight/Obesity Among Women of Reproductive Age in Low and Middle-Income Countries with High Maternal Mortality: A Multi-Level Analysis of Recent Demographic and Health Surveys.
- The Weight of Risk: Epidemiological Trends in Cardiac Arrest Mortality Among Adults with Obesity in the United States (1999-2023).
- Association between Dietary Patterns and Obesity-Related Metabolic Phenotypes in Chinese Middle-Aged and Older Adults.
Psychology & Neuroscience
- Associations of Dietary Mineral Intakes with the Risk of Six Common Mental Disorders.
- A New Lens on Childhood Obesity: Developing and Validating the Obesity-Related Well-Being (ORWB) Scale for Assessing Well-Being in Children and Adolescents with Obesity.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Unfavorable Social Determinants of Health and Obesity: A Double Jeopardy for Premature Mortality.
- Exploring Correlates of 6-Month Weight Loss Among Black United States Veterans Entering Veterans Health Administration Behavioral Weight Management Care.
- The Burden of Inequity: Income Related Disparities in Cardiovascular Risk Factors in Europe.
- The EAT-Lancet Commission on Healthy, Sustainable, and Just Food Systems.
Stigma
- Associations between BMI, Body Size Perception, and Dropout from Upper Secondary Education: A Prospective Cohort Study of 15-19-Year-Old Adolescents.
- Supporting Weight Focused Discussions in Primary Care: Barriers and Facilitators.
- The Weight of Weight: The Salience of Body Weight in the Impression Formation Process.
Policy Related
- RCT: Optimal Design of an Added-Sugar Menu Warning Label.
- Systematic Review: Food Service Professionals' Perspectives on the Barriers and Facilitators to the Implementation of Nutrition Standards for School Food: A Mixed-Methods Systematic Review.
- Analysing Celebrity and Influencer Marketing of Food and Beverages to Adolescents on Instagram.
- Integrating Registered Dietitian Nutritionists’ Medical Nutrition Therapy Benefit Into Existing State Medicaid Coverage and Reimbursement Policy.
- Public Attitudes Towards Obesity Policies on the Island of Ireland; Exploring the Relationship with Biopsychosocial Characteristics.
Intergenerational Effects
- Assessing the Risk Factors and Establishing Multivariable Prediction Models for Singleton Macrosomia.
- Impact of Maternal Obesity on Neonatal TSH Levels.
Ecology, Evolution, & Energetics
- Microbiome Characterization of a Pre-Hispanic Man from Zimapán, Mexico: Insights Into Ancient Gut Microbial Communities.
- The Effect of a Kibble Diet Versus a Raw Meat-Based Diet on Energy Metabolism Biomarkers in Dogs.
- Divergent Selection Alters Metabolism and Body Temperature in Obese Mice.
- Effect of Female Body Size on Courtship Preferences of Males in Two Pierid Butterfly Species: Pieris melete and P. napi.
Methods
- Machine Learning Framework for Predicting Susceptibility to Obesity.
- Obesity Prediction Using Machine Learning Algorithms.
Commentary
- Review: Impact of Anabolic Steroids on Tendons.
- In Favor of a Prediabetes Indication for GLP-1s.
- Novel GLP-1-Based Medications for Type 2 Diabetes and Obesity.
- Weight Loss Drug Stigma Shows Society Still Holds Negative Attitudes Towards Body Weight and Obesity.
- Food Formulation and Precision Nutrition in the Ozempic Era: ‘There’s an Entire Secondary Market That Can Come from Any Breakthrough Technology’.
- Toby Carvery Has Made a Huge Change in All of Its 158 Restaurants Due to New Nanny State Obesity Rules.
- The SWEET Spot for Weight Maintenance.
- Fear, Food & False Claims: How Nutrition Myths & Politics Distract from Real Health.
- The Body Mass Index: What’s the Use?
General
- Association of Genetic Scores Related to Insulin Resistance with Neurological Outcomes in Ancestrally Diverse Cohorts from the Trans-Omics for Precision Medicine (TOPMed) Program.
- Performance of an Automated Sleep Scoring Approach for Actigraphy Data in Children and Adolescents.
- Influence of Varying Proximity-To-Failure on Muscular Adaptations and Repetitions-In-Reserve Estimation Accuracy in Resistance-Trained Individuals.
- Deeper Microchimerism Study Sheds New Light on a Mother’s Cellular Gift.
- Extinct Megafauna Dominated Human Subsistence in Southern South America Before 11,600 Years Ago.
- Density-Dependent Recruitment but Not Survival Drives Cyclic Dynamics in a Field Vole Population.
Video & Audio
- Science vs Podcast: Sugar: How Bad Is It Really?
- Peter Attia Podcast: The Protein Debate: Optimal Intake, Limitations of the RDA, Whether High-Protein Intake Is Harmful, and How to Think About Processed Foods | David Allison, Ph.D.