10/10/25
Featured
- Concerns Regarding the Standard Deviation of Individual Responses for Assessing Treatment Response Heterogeneity.
- Glucose-Dependent Insulinotropic Polypeptide and Glucagon After Weight Loss Induced by Diet or Bariatric Surgery.
- Mitochondrial Coupling Efficiency and Myofiber Type Related to Blood Pressure 22 h After High-Intensity Exercise in Premenopausal Women.
- RCT: "Providing free FVs [fruits and vegetables] without additional intervention does not increase FV intake but does lead to more and larger FV waste events."
- Why Health-Care Providers Don’t Give Nutrition Advice: They’re Not Actually Trying to Keep It from You.
Headline vs Study
- Headline: Junk Food’s Hidden Toll: New Study Reveals It Rewires Your Brain’s Memory in Days.
- Press Release: Junk Food Can Scramble Memory in Just 4 Days.
- Study: Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity... in mice. "Junk food" not studied; rewiring not measured.
- Headline Critique: Junk Food Can Scramble Memory in Just Four Days? Oh My!
Contrary or Null Findings
- "The favourable effects of LTCR [Long-term caloric restriction] on bone health contradict previous negative reports."
- "...orthorexia nervosa moderated the mediating effect of eating attitudes in the relationship between social media use and well-being. Interestingly, the moderating effect was stronger among individuals with low levels of orthorexia nervosa, contrary to initial expectations".
- "Contrary to our expectations, these findings demonstrate that early Homo was still part of the prey spectrum, reinforcing the idea that the transition to dominant predator status occurred later in human evolution or penecontemporaneously to H. habilis through a different hominin taxon."
- ".... contrary to expectations, we do not find a consistently negative relationship between the COVID-19 pandemic and child malnutrition."
- "Contrary to our hypothesis, FAP [fibro-adipogenic progenitors] activation occurred without overt muscle injury, suggesting excessive mechanical loading may directly trigger FAP proliferation and fibrogenesis."
- "Surprisingly, higher snack consumption was associated (AOR: 1.66, CI: 1.24-2.21) with better oral hygiene, contrary to existing literature."
- RCT: "Our study did not demonstrate a clear benefit of EPA [eicosapentaenoic acid] supplementation on weight, BMI, or muscle preservation in patients with locally advanced SCCHN [squamous cell carcinoma of the head and neck] receiving curative-intent treatment."
- Meta-Analysis: "No statistically significant differences in pregnancy outcomes between GLP-1 RA [receptor agonists] and control group, including fetal growth restriction or small for gestational age (p = 0.12), live births (p = 0.10), major birth defects (p = 0.79), miscarriages (p = 0.41), preterm delivery (p = 0.62); and stillbirths (p = 0.09)".
Basic
- Fungal Immunomodulatory Protein FIP-fve Mitigates Airway Inflammation and Metabolic Dysfunction in an Obese Allergic Asthma Model.
- A Long-Term Ketogenic Diet Causes Hyperlipidemia, Liver Dysfunction, and Glucose Intolerance from Impaired Insulin Secretion in Mice.
- Anle138b Improves Insulin Resistance in Mice and Its Possible Signal Pathways.
- D-Allulose Improves Mitochondrial Respiratory Function and Alleviates Obesity-Induced Liver Dysfunction: A Comparative Study with Erythritol in HFD-Fed Mice.
- The MyD88 Inhibitor TJ-M2010-5 Protects Against Obesity in Mice by Suppressing Macrophage-Induced Metabolic Inflammation.
- Eplerenone Improves Kidney Function and Cardiac Performance in Obese Male Mice.
Scientific Rigor & Scholarly Dialogue
- Retraction: Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age.
- Letter: Structural Funding Bias in Red Meat Research: The Elephant in the Room.
- Preprint: Determining Fragility and Robustness to Missing Data in Binary Outcome Meta-Analyses, Illustrated with Conflicting Associations between Vitamin D and Cancer Mortality.
- Magical Mango Thinking About Preventing Diabetes.
Clinical
- Review: Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.
- Weight Trajectories and Access to Weight Management Services in Individuals with Severe Mental Illness in the UK: A Population-Based, Matched Cohort Study.
- Review: Mechanical Interplay between Adipose Tissues and Disease Progression.
- Effects of Weight-Loss Interventions on Bone Health in People Living with Obesity.
- RCT: Adaptive vs Monthly Support for Weight-Loss Maintenance.
Children and Adolescents
- Meta-Analysis: Effects of Aerobic Exercise on Body Composition in Children and Adolescents with Overweight and Obesity.
- The Effect of Smartphone Addiction on Obesity in Children and Adolescents.
- Review: Epigenetic Mechanisms in Childhood Obesity.
- Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls with Excess Weight.
Surgery
- Review: Will Pharmacotherapy Soon Replace Bariatric Surgery as the Gold Standard Treatment for Obesity?
- Meta-Analysis: Changes in the Phase Angle After Bariatric Surgery.
- Changes in Dietary Nutrient Intakes at 6 and 12 Months Following Bariatric Surgery.
- Systematic Review: Bariatric Surgery, Employment, and Productivity Outcomes.
- Commentary: Why Doctors Rarely Refer Patients for Bariatric Surgery.
- Review: Mortality After Bariatric Surgery.
Drugs
- Predictive Factors for HbA1c and Weight Loss Associated with Semaglutide Treatment in Type 2 Diabetes Mellitus: Real-World Clinical Evidence.
- Semaglutide-Associated Drug-Induced Liver Injury: A Case Report and Review of the Literature.
- Systemic and Gut Microbiome Changes with Metformin and Liraglutide in Youth-Onset Type 2 Diabetes.
- Meta-Analysis: The Efficacy and Safety of Pharmacological Treatments for Obesity in Adults.
- Commentary: "High-dose semaglutide drives greater weight loss. Safety remains favorable but needs further study."
- RCT: Efficacy and Safety of Monlunabant in Adults with Obesity and Metabolic Syndrome.
- Artificial Intelligence-Driven Prediction of Glucagon-Like-Peptide-1 Receptor Agonist Eligibility in Obesity.
Food & Diet
- Adaptive Thermogenesis After Hypocaloric Low-Carbohydrate Versus Low-Fat Diets in African American Women.
- RCT: Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women with Obesity.
- BMI Modifies Associations between Diet Quality and Circulating Metabolites.
- "Moderate eating windows (~11-12 h/day) are linked to the lowest mortality risk, with deviations associated with higher risk".
- Association between Dietary Copper Intake and Cognitive Function in American Older Adults.
- Creating a Crave for Local Food: How TikTok Food Review Videos Stimulate Impulsive Visits to Local Restaurants.
Caloric and Dietary Restriction
- Review: The Impacts of Different Dietary Restriction Regimens on Aging and Longevity: From Yeast to Humans.
- "Weight loss through dietary interventions with mild calorie restriction resulted in favorable changes in cardiometabolic risk factors among older adults with overweight and obesity."
- Low Protein-Induced-FGF-21 Signaling Remodels Adipose Tissue on Reduced Markers of Senescence During Aging.
- Dietary Supplementation of Methionine, Tryptophan, and Threonine for Pigs Under Sanitary Challenges: Current Knowledge and Future Directions.
- Meta-Analysis: Effects of Time-Restricted Eating on Body Composition and Metabolic Parameters in Women with Overweight or Obesity.
Exercise & Physical Activity
- Systematic Review: Promotion of Muscle-Strengthening Exercise for Public Health: Real-Life Interventions in Healthy Adults.
- Meta-Analysis: Effectiveness of Aerobic Exercise in Reducing Blood Pressure Among Adults with Obesity.
- Effects of Habitual Endurance and Resistance Exercise on Insulin Action in Primary Human Skeletal Muscle Stem Cells.
- Physical Activity in One-Year-Old Children Predicts Physical Activity Level at Age Three Years Independent of Maternal Activity.
- Review: Short Bouts of Accumulated Exercise: Definition, Efficacy, Feasibility, Practical Applications, and Future Directions.
Economics & Sociology
- Systematic Review: Economic Evaluation of Medications in Prevention and Treatment of Obesity.
- Household Income and Obesity Among Older Adults: The Moderating Role of Race in a Longitudinal Analysis.
- Systematic Review: Relationship of Sleep Quality, BMI, Dietary, and Socioeconomic Attributes Among Young Adults.
- Educational Inequalities in Trajectories of Co-Occurring Behavioral Health Risk Factors over Four Years: A Latent Class Growth Analysis.
- Systematic Review: The Clinical and Economic Burden of Obesity in Low- and Middle-Income Countries.
Epidemiology
- A Body Shape Index Modifies the Association between Air Pollution and Cardiometabolic Multimorbidity.
- Demographic and Socioeconomic Factors Associated with Self-Reported Diet and Physical Lifestyle Patterns in United States Women.
- Excess Adiposity Without Obesity in a High-Risk Population.
- Review: Understanding the Increasing Prevalence of Obesity in Patients with Type 1 Diabetes: Strategies for Improving Clinical Care.
- Association of Longitudinal Trajectory of Body Roundness Index with CVD Risk.
- Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis.
- Review: Heterogeneity of Obesity and Its Predictive Factors.
- Deviation from Genetically Predicted BMI and All-Cause Mortality.
Psychology & Neuroscience
- Association of Loneliness and Social Isolation with Excess Risk of Cardiovascular Events in People with Obesity.
- Commentary: Tiny Cell Messengers in Individuals with Obesity Accelerate Alzheimer’s Linked Plaque Buildup in the Brain.
- Obesity-Induced Cofilin1 Pathway Dysregulation: Possible Molecular Links between Neuroinflammation, Cognitive Decline, and Alzheimer's Disease Biomarkers.
- RCT: Beyond Weight Loss: Digital Therapeutic for Behavioral Change and Psychological Well-Being for Individuals with Overweight and Obesity in a Primary Healthcare Setting.
- The Associations of Objective, Behaviorally Measured Hunger and Weight-Related Variables with Food Craving Inventory Subscales in Adults with Obesity.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Socioeconomic Development Index (SDI) Gradients and High BMI-Driven Pan-Cancer Burden: A Global Burden of Disease Study on Mortality, Disability, and Health Inequities (2015-2021).
- What's the Weight? Estimating Controlled Outcome Differences in Complex Surveys for Health Disparities Research.
Stigma
Policy Related
- Early Childhood Policies: An Evaluation of Their Impact on Maternal and Child Mortality and Nutrition.
- Dissertation: Reducing Childhood Obesity: A Policy Analysis.
- RCT: Front-Of-Package Nutrition Labels in Latino Populations in the US.
Intergenerational Effects
- Association of Maternal Prepregnancy BMI with Offspring Cardiometabolic Outcomes in Childhood.
- Influence of Gestational Weight Gain and Maternal Depression on Offspring BMI Trajectory from Birth to 3 Years.
- Systematic Review: New Developments in GLP-1 Agonist Therapy for Gestational Diabetes.
- In-Utero Exposure to Maternal Diabetes and DNA Methylation Alterations in the Next Generation Birth Cohort.
- Perinatal and Postpartum Insulin Secretion Capacity in Women with Early-Onset and Late-Onset Gestational Diabetes.
Ecology, Evolution, & Energetics
- Sexual Selection Drives Sex Difference in Adult Life Expectancy Across Mammals and Birds.
- Mitochondrial Dysfunction and Defective Quality Control Mechanisms in the Kidney are Not Reversed by High-Fat Diet Withdrawal in Early Obese Mice.
- Disentangling the Impact of Obesity, Diet, Host Factors, and Microbiota on Small Intestinal Antimicrobial Peptide Expression.
Methods
- Bridging the Gap: Development of a Methodology for Retrieving and Harmonising Body Mass Index (BMI) from Population-Level Linked Electronic Health Records.
- Impact of Cut-Point Methods on Classification of Physical Activity and Sedentary Behaviour of Toddlers.
Commentary
- ICARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on Prevention and Treatment of Cardiometabolic Disease.
- Will the EAT-Lancet Sequel Get More Traction This Time?
- Expert Consensus for Regulating ‘Meal Deal’ Price Promotions in Supermarkets: A Policy Delphi Study in Wales, UK.
- Mapping the Risk Landscape of Childhood Obesity: A Narrative Review of Behavioral and Socioeconomic Determinants.
- Human Milk: Insights on Cell Composition, Organoids and Emerging Applications.
- A Festival of Fat Shaming in Political News This Week.
- Eli Lilly Halts Trial Testing Experimental Muscle-Preserving Drug with Zepbound.
- How Weight-Loss Injections are Turning Obesity Into a Wealth Issue.
- The Biggest… Gainer? How Biology Fights Back After Large Weight Loss.
- Is a New Definition for Childhood Obesity Needed?
General
- How Data Can Support a Values-Based Argument for Health.
- Six Journal Rejections and a Major Rethink: Why I’m Happy to Admit to My Research Failures, and You Should Too.
- Sleep-Disordered Breathing Subtypes and Future Diet Quality in the Multi-Ethnic Study of Atherosclerosis.
- Epigenetic Clock Analysis of Sex Chromosome Aneuploidies.
- Disaggregated Substitution Patterns between Plant-Based and Animal Meats: Evidence from U.S. Household Purchases.
- Research Assessment: A Round-Up for Early-Career Researchers.
- How to Find the Papers You Need to Read - and Avoid the Ones You Don’t.
Video & Audio
- From the National Lipid Association: Pharmacotherapy Development and Trends in Lipidology: An Expert Discussion.
- Eating with Intelligence (with Julia Belluz).
Announcements
- Webinar: Low-Carbohydrate Diets and Exercise: What Do We Know?
- Baylor College of Medicine to Offer New Clinical Psychology Degree Program.
- New NIH-Funded Program to Advance Kidney, Urologic, and Hematologic Research Training.
- ASN’s 2026 Science Policy Fellowship Application Submission Is Now Open: Deadline Is December 19, 2025.