10/03/25
Featured
- RCT: The Thermogenic Effect of Mirabegron Ingestion During Cool Conditions.
- Myeloid-Specific CAMKK2 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance by Rewiring Metabolic Gene Expression and Enhancing Energy Expenditure.
- Herbal Terpenoids Activate Autophagy and Mitophagy Through Modulation of Bioenergetics and Protect from Metabolic Stress, Sarcopenia and Epigenetic Aging.
Headline vs Study
- Headline: “Your favourite ramen may pose a higher risk to your health than you think. A new study has found that it can even increase the risk of mortality.”
- Study: No intervention, no randomization, no measure of food intake beyond self-report, no statistically significant association in overall sample (see Table 2). Ergo, No Causal Inference.
Contrary or Null Findings
- RCT: “Contrary to Expectations, There Was a Higher Fall Rate in the Intervention Group Than in the Control Group (0·87 vs 0·64 Falls Per Person-Year; Incidence Rate Ratio 1·33 [95% CI 1·01-1·75; P=0·044]). … This Iyengar Yoga-Based Programme Should Not Be Recommended for Fall Prevention in Its Current Form.”
- "Long baleen whale mothers are more likely to have female calves than males, according to a new study led by the University of Washington. The findings contradict a popular evolutionary theory postulating that strong mammals benefit more from birthing males."
- In mice, "These findings demonstrate that semaglutide reduces muscle size and strength to the same extent as caloric restriction but may be more effective at promoting fat loss."
- Abstract: Changes in Total and Regional Body Composition are Not Predictors of Improvement in Metabolic Health Markers After 12 Weeks of Caloric Restriction (CR) in Adult Chilean Women with Overweight and Obesity.
- RCT: No significant difference in "muscle hypertrophy response between RT performed with free weights (FW) vs. machines (MACH)."
- RCT: "Combined training with fixed intensity improved [visceral adiposity index] but was insufficient to affect metabolic phenotype. These findings suggest minimal differences between fixed intensity and linear increase protocols in reducing the risk of metabolic complications during obesity treatment."
- RCT: No Significant "Effect of a School-Based Physical Activity and Multi-Micronutrient Supplementation Intervention on Cognitive Function and Academic Achievement Among Schoolchildren in Tanzania."
- In This Pediatric Cohort, Contrary to Findings in Adults, We Did Not Find Nutritional Status to Be a Predictor of Anaphylaxis Severity or Presentation.
Basic
- L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
- Microglia/Macrophage-Specific Deletion of TLR-4 Protects Against Neural Effects of Diet-Induced Obesity in a Sexually Dimorphic Manner.
- One Anastomosis Mini-Gastric Bypass Decreases Desacyl Ghrelin and Improves Metabolic Profile in Male Rats with Diet-Induced Obesity.
- Nanomedicine Targeting PPAR in Adipose Tissue Macrophages Improves Lipid Metabolism and Obesity-Induced Metabolic Dysfunction.
- A Two-Strata Energy Flux System Driven by a Stress Hormone Prioritizes Cardiac Energetics.
Scientific Rigor & Scholarly Dialogue
- Authors Defend Retracted Paper on Vitamin D and COVID-19 Critic Called ‘Deeply Bizarre’.
- Study on Apple Cider Vinegar for Weight Loss Retracted After Many Raise Concerns.
- Problematic Obesity Research on Apple Cider Vinegar Retracted.
- "Our results demonstrate that dietary DHA provided as sn-1 LPC-DHA or di-DHA-PC does not increase brain DHA levels compared to NE-DHA or the control group, failing to reproduce prior reports."
- PubPeer Comments On: Efficacy of Oral Folinic Acid Supplementation in Children with Autism Spectrum Disorder: A Randomized Double-Blind, Placebo-Controlled Trial.
- Linkedin Post: Yet Another Invalid Cluster Randomized Trial in the Obesity and Nutrition Domain: We Should Continue to Elevate the Trustworthiness of Our Science If We Ask Others to Trust It.
Clinical
- Qualitative Study: Perceived Barriers and Facilitators to Implementing a Weight Management Programme in a Primary Care Setting in Singapore.
- RCT: Exploring the Effects of High Protein Versus High Fat Snacks on Satiety, Gut Hormones and Insulin Secretion in Women with Overweight and Obesity.
- Meta-Analysis: Probiotics and Synbiotics Supplementation Reduce Inflammatory Cytokines in Individuals with Prediabetes and Type 2 Diabetes Mellitus.
Children and Adolescents
- Review: The Rising Epidemic of Childhood Obesity: Risk Factors, Clinical Outcomes, and Preventive Strategies.
- Cross-Sectional Study: Association between Indoor Light at Night and Obesity Among Children and Adolescents at Different Physical Activity Levels.
- Ostracism, Cortisol Reactivity, and Motivation for High-Calorie Food in Children and Adolescents with Obesity.
Surgery
- Book Chapter: The One-Anastomosis Gastric Bypass Procedure for Severe Obesity: Technical Aspects and Early Outcomes.
- Comparative Analysis: Evaluating Artificial Intelligence-Generated Patient Education Materials for Bariatric Surgery.
- Retrospective Study: Risks and Benefits of Delaying Hernia Repair in Patients with Obesity.
- Cohort Study: Immediate Improvement in Anxiety and Sleep Quality with Delayed Depression Response After Bariatric Surgery.
- Retrospective Cohort Study: Bariatric Surgery and Incident Development of Obesity-Related Comorbidities.
- Obesity Treatment with Bariatric Surgery vs GLP-1 Receptor Agonists.
- Meta-Analysis: Efficacy and Safety of GLP-1 RAs in Children and Adolescents with Obesity or Type 2 Diabetes.
- News: GLP-1 Drugs May Manage Weight Recurrence After Bariatric Surgery.
Drugs
- Commentary: A Salute to Innovation: Exenatide in Diabetes and Obesity Drug Development at Amylin Pharmaceuticals.
- Perspective: The Societal Implications of Using Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Obesity.
- New GLP-1 Drug Delivers Weight Loss in a Pill.
Food & Diet
- Perspective: Dietary Guidance on Plant-Based Meat Alternatives for Individuals Wanting to Increase Plant Protein Intake.
- Editorial: Novel Approaches to Diet, Exercise, and Drugs in Childhood Obesity and Metabolic Diseases.
- The Role of the IL-9 - NLRP3 Axis in Insulin Resistance and Adipose Tissue Inflammation During Diet-Induced Obesity.
Caloric and Dietary Restriction
- Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference.
- Glucagon Receptor Signaling Is Indispensable for the Healthspan Effects of Caloric Restriction in Aging Male Mice.
- Semaglutide Impacts Skeletal Muscle to a Similar Extent as Caloric Restriction in Mice with Diet-Induced Obesity.
- Effects of Graded Calorie Restriction: XXII. Impact of Long-Term Graded Calorie Restriction on Tissue Partitioning, Digestive Efficiency, Bone Health and Coordination in Male C57BL/6J Mice.
Exercise & Physical Activity
- RCT: LIFE-Moms: Effects of Multicomponent Lifestyle Randomized Control Trial on Physical Activity During Pregnancy in Women with Overweight and Obesity.
- RCT: Effects of School-Based Concurrent Training on Body Composition and Cardiorespiratory Fitness in Children with Obesity.
- RCT: Evaluating the Impact of a Physical Activity-Based Behavior Modification Program on Health-Related Fitness in School Boys with Obesity.
- Obesity Drives Temporally Distinct Physical Activity Disruptions in Mice Under a Fixed 24-H Light-Dark Cycle.
- Interventional Study: Effects of Resistance Training and Aerobic Training on Improving the Composition of Middle-Aged Adults with Obesity.
Economics & Sociology
- Cross-Sectional Study: Sociodemographic and Health Determinants of Adipose Tissue Distribution in a Local Community from Eastern Poland.
- The Relationship of Education Level, Lifestyle, and Personality to BMI and Obesity Differs between Men and Women.
- Systematic Review: Associations between Nutritional and Physical Outcomes of Community-Dwelling Older Adults Eating Alone, Versus with Others.
Epidemiology
- Book Chapter: The New Syndemic of Obesity and COVID-19 in Urban Areas.
- The Physiology of the WEight-Reduced State (POWERS) Study: Environmental, Psychological, and Social Determinants of Health.
- BMI and Gastric Cancer Risk: Results from the Stomach Cancer Pooling Project Consortium.
- Age, Sex, BMI, Meal Timing, and Glycemic Response to Meal Glycemic Load.
Psychology & Neuroscience
- Cohort Study: Weight Trajectories and Access to Weight Management Services in Individuals with Severe Mental Illness in the UK.
- Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Opinion: Addressing Food System Determinants of Health Inequalities in Urban Environments: Learnings from the FoodSEqual and FoodSEqual-Health Projects.
- Review: Sex Disparities in Obesity: A Comprehensive Review of Hormonal and Genetic Influences on Obesity-Related Phenotypes.
Stigma
- Examining the Relationship between Weight Stigma, Diabetes Stigma, and HbA1c in Adults with Type 2 Diabetes.
- Addressing Explicit Weight Bias in Medical Students: Contribution of Demographics and Educational Factors.
- Review: Crosstalk between Alcohol Use Disorder and Obesity: Two Sides of the Same Coin?
Policy Related
- Review: Key Action Areas for Transforming the UK Food System: Insights from the Transforming UK Food Systems (TUKFS) Programme Project Portfolio.
- Dietary Profiles and Associated Metabolic Risk Factors in India from the ICMR-INDIAB Survey-21.
- Feature: Africa’s Obesity Crisis Comes Into Focus.
Intergenerational Effects
- Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.
- Review: Parental Diet and Offspring Health: A Role for the Gut Microbiome Via Epigenetics.
- Meta-Analysis: Efficacy of Glyburide Vs. Metformin in Preventing Neonatal Birth Obesity in Pregnancies Complicated by Gestational Diabetes Mellitus.
- Association of a High-Protein and Low-Glycemic-Index Diet During Pregnancy with Offspring Growth and Obesity Until the Age of 18 Years - A Target Trial Emulation.
Ecology, Evolution, & Energetics
- Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota.
- Epigenetic Changes Associated with Obesity-Related Metabolic Comorbidities.
Methods
- Measurement Error in Total Energy Intake in the United Kingdom National Diet and Nutrition Survey (2008-2015).
- Cross-Sectional Study: New Insights Into Total and Resting Energy Expenditure Using State-Of-The-Art Methods in Cancer Survivors.
- Cross-Sectional Study: Association of Eight Anthropometric Indexes Related to Obesity with the Prevalence of Clinical Osteoarthritis Among American Adults.
- Prospective Cohort Study: Body Roundness Index Associated with Cardiometabolic Multimorbidity and Mortality.
- Cross-Sectional Study: Prevalence of Clinical Obesity in US Adults Based on a Newly Proposed Definition.
- Development of a Mechanistic Mouse Model for Understanding Obesity-Associated Early Pregnancy Complications at Maternal-Fetal Interface; A Novel Dual Model Development Method.
- Deep-Learning-Based Radiomics on Mitigating Post-Treatment Obesity for Pediatric Craniopharyngioma Patients After Surgery and Proton Therapy.
- Causal Associations between Pre-Pregnancy Obesity Traits and Hypertensive Disorders of Pregnancy: A Two-Sample Mendelian Randomization Analyses.
Commentary
- EurekAlert! Article Highlight: Baylor Researchers Uncovered How Physical Activity Helps Improve Memory in a Mouse Model of Alzheimer’s Disease.
- News: Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, Stanford University School of Medicine and collaborating institutions provide new insights into how exercise helps lose weight.
- Meeting Report: Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?
- Narrative Review: Is There a Volume Saturation Point for Muscle Hypertrophy in Resistance-Trained Individuals?
- News: This Week Lilly Stopped a Bimagrumab Study Before It Started.
- In Press: Preconception Use of GLP-1 and GLP-1/GIP Receptor Agonists for Obesity Treatment.
- Press Release: "Revita-treated patients lost an additional 2.5% total body weight after stopping GLP-1 drugs vs. 10% regain in sham-treated patients."
- News: GLP-1s: Beyond Diabetes and Weight Loss, Could They Be Next Big Thing in Longevity?
- The Evolution of the Obesity Drug Market.
- Heritage panels call for DGA to promote more meat, fewer carbohydrates.
General
- Religion and Attitudes Toward Xenotransplantation: Results of a Nationwide Survey in the United States.
- Impact of SGLT2 Inhibitors on Glomerular Filtration in Type 1 Diabetes.
- Glucagon-Like Peptide-1 Receptor Signaling Deficiency Exacerbates Hematopoietic Stem Cell Graft Rejection in Mice.
- WNT7A mRNA Lipid Nanoparticles Promote Muscle Hypertrophy and Reduce Fatty Infiltration.
- Whey Protein Hydrolysate Alleviated Acetaminophen-Induced Hepatocyte Pyroptosis by Activating Mitophagy.
- Editorial: Full Stomach and Gastric Ultrasound: Debunking Some Myths.
- Misleading Model: Why the 5% Cancer Risk from CT Scans Is Overstated.
- Frequency of Statistical Mistakes and Associated Article Characteristics: A Cross-Sectional Analysis of Dermatology Journals.