10/02/26
Featured
- Surprising Protein Links Dietary Restriction to Increased Lifespan in Flies.
- A Hypothalamic Neuronal Population Coordinates Metabolic Adaptations to Cold.
- Review: Creatine Monohydrate and Neuronal Methylation in Psychiatric Disorders.
- Podcast: New Study on Creatine During Fat Loss and Body Recomposition: Dr. Drew Gonzalez.
- Creatine for Glucagon-Like Peptide-1-Associated Muscle Loss.
- Is More Protein Always Better?
Headline vs Study
- Headline: Scientists Discover a Molecular "Memory" That Could Make Lost Weight Come Back.
- Press Release: Cleveland Research Team Identifies Biological Mechanism That May Explain Obesity Relapse.
- Study: Adipose TGFβ-Asprosin Memory Promotes Obesity Relapse and Offspring Obesity Susceptibility... In Mice and Cells.
Contrary or Null Findings
- RCT: "Twelve weeks of multispecies probiotic supplementation did not result in statistically significant improvements in glucose metabolism, insulin resistance, or lipid profile compared with placebo."
- RCT: "Heat-killed Bifidobacterium breve B-3 (B-3HK), a postbiotic, has shown muscle-related effects in preclinical studies...[but in this human RCT]...B-3HK did not improve muscle strength in patients with sarcopenia."
- Cold Water Dispersible Resveratrol Supplementation Does Not Alter Recovery Following Flywheel Squat Exercise.
- Nitrate Supplementation Does Not Improve Knee Extensor Fatigability and Exercise Hyperemia in Older Adults.
- When Fiber Does Not Protect: Evaluating Statistical Interaction between Dietary Fiber, Sodium-To-Potassium Ratio, and Metabolic Syndrome in South Korean Adults.
- Endurance Exercise-Induced Cardioprotection Against Metabolic Distress Does Not Require Body Weight Loss in Female Obese Type-2 Diabetic Mice.
- RCT: No Consistent support for primary hypotheses in "Effects of virtual reality-based aerobic exercise versus traditional aerobic exercise training on physical fitness, functional capacity, and quality of life in individuals with Down syndrome."
- Omega-3 Supplementation Modulates Whole-Blood EPA and DHA Without Improving Patient-Reported Outcomes in Youth with Migraine: A Quasi-Randomized Pilot Trial.
Basic
- Review: Cardiovascular-Kidney-Metabolic Syndrome as a Mitochondrial Systems Disorder.
- An RNA Thermogenic Therapy to Preserve Lean Mass and Enhance Metabolic Health During GLP-1 Weight Loss.
- IGF2BP3 Suppresses Adipogenesis Via M6A-Dependent Stabilization of FAM13A MRNA in 3T3-L1 Adipocytes.
- Inhibition of the Translin/Trax Complex by Ellagic Acid Alleviates Metabolic and Affective Behaviors in Obese Male Mice.
- Adipose ILC2s Depend on Acetyl-CoA Carboxylase 1 to Maintain Metabolic Health.
Scientific Rigor & Scholarly Dialogue
- PubPeer Comment: Efficacy of Faecal Microbiota Transplantation for the Treatment of Autism in Children: Meta-Analysis of Randomised Controlled Trials.
- Retraction: Efficacy of Faecal Microbiota Transplantation for the Treatment of Autism in Children: Meta-Analysis of Randomised Controlled Trials.
- Perspectives on the Protein Recommendations in the 2025-2030 Dietary Guidelines for Americans.
- Expert Reaction to Research Looking at Ultra-Processed Food, Physical Activity, Genetic Susceptibility and Type 2 Diabetes, Being Presented at the European Association for the Study of Diabetes (EASD) Conference in Milan.
Clinical
- Preclinical and First-In-Human Evaluation of Ribupatide (HRS9531), a Dual GLP-1/GIP Receptor Agonist.
- Review: The Intertwined Epidemics of Obesity and Obstructive Sleep Apnea: A Comprehensive Analysis.
- Decoding Obesity Through the Lens of Adipose Tissue Inflammatory Regulation: A Comparative Study of Obesity Subtypes.
- RCT: The Effect of an App-Based Nutritional Concept for Weight Reduction and Further Cardiovascular Risk Factors: Insights from the PreVA Study.
Children and Adolescents
- Association between Maternal Shift Work During Pregnancy Child Overweight and Metabolic Outcomes in Early Childhood.
- Knowledge, Attitudes, and Practices in the Management of Childhood and Adolescent Obesity: A Survey of Primary Care Providers in the State of Oklahoma, USA.
- Adiposity Trajectory as a Predictor of Chronic and Multisite Pain in the Transition from Childhood to Adolescence.
- RCT: Caregiver App Use and Child Behavioral Adherence in Relation to Obesity-Related Outcomes in an MHealth App-Assisted Childhood Obesity Intervention.
- Analysis of Factors Associated with Overweight and Obesity Among Preschool Children Based on a Decision Tree Model.
- Review: Diagnostic Approach to Genetic Obesity in Children: From Pathophysiology to Precision Medicine.
Surgery
- Meta-Analysis: The Effect of Bariatric Surgery on Ovarian Reserve Function in Women with Obesity.
- Survey: Morbid Obesity and Lower Limb Arthroplasty: Consultant Practice.
- Splanchnic Vein Thrombosis After Metabolic and Bariatric Surgery: Chilean Position Statement of Hepatology and Bariatric Surgery Societies.
- RCT: Sleeve Gastrectomy with Roux-En-Y Transit Bipartition Versus Sleeve Gastrectomy for the Treatment of Obesity and Reflux.
- Review: Prehabilitation for Patients Undergoing Breast Reduction Surgery.
- Meta-Analysis: Association between Metabolic and Bariatric Surgery and Melanoma Risk.
- Systematic Review: Impact of Surgical Weight Loss Interventions on Urinary Incontinence in Women with Obesity.
Drugs
- Review: GLP-1 Receptor Agonists, Gut Microbiota, and Chronic Pain: Nutritional Signaling at the Gut-Brain Axis.
- News: "Once described as obesity medicines for 'patients,' GLP-1s are increasingly lifestyle drugs for 'customers'."
- GLP-1 Receptor Agonist Coverage for Obesity in Medicaid and Total GLP-1 Receptor Agonist Utilization.
- Indirect Comparative Efficacy and Safety of Tirzepatide vs Semaglutide for the Treatment of Obesity or Overweight in Patients Without Type 2 Diabetes.
- Review: Recent Studies on the Effectiveness and Safety of Anti-Obesity Medications.
Food & Diet
- Meal Timing and Eating Window with All-Cause and Cardiovascular Mortality and Life Expectancy.
- News: Powered by Protein.
- Adherence and Weight Loss with a Total Diet Replacement Programme for Increased Cancer Risk Associated with Obesity: A UK Cohort Study.
Caloric and Dietary Restriction
- Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice.
- Mild Caloric Restriction Accelerates Atherosclerosis Via Dysregulated Cholesterol Homeostasis and Lipogenesis in HCHF-Fed ApoE-Deficient Mice.
Exercise & Physical Activity
- Leisure-Time Physical Activity and Metabolomic Trajectories over the Transition from Late Midlife to Old Age.
- Daily Physical Activity Behavior: A Compensatory Factor to Physical Adaptations Variability Following a 12-Week Power Training in Older Men.
- Effects of Creatine Supplementation with and without Exercise and Diet Intervention on Body Composition, Cognitive Function, and Markers of Health in Middle-Aged and Older Adults.
- Review: Effects of Aerobic Exercise-Based Interventions on Physical and Mental Health in Children and Adolescents with Overweight or Obesity: A Three-Level Meta-Analysis.
Economics & Sociology
- Systematic Review: Cost-Effectiveness Analyses of Weight Loss Interventions for Knee Osteoarthritis.
- Review: Economic Evaluations of Antiobesity Medications.
- Neighborhood Social Fragmentation and Excessive Body Weight Among Children-A View from a Portuguese Inner City.
- Social Physiology: Human Homeostasis Is More Efficient in Social Proximity.
- Review: Digital Health in Obesity Care: Current Evidence, Challenges, and Future Directions.
Epidemiology
- A Cohort Study of Physical Activity, Gut Microbiota, Serum Metabolites, and the Risk of Steatotic Liver Disease.
- Multidimensional Characteristics of Body Composition in Older Adults and Their Relationship to Common Chronic Diseases.
- Associations between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children.
- Report: State of Obesity Report 2026: Better Policies for a Healthier America.
Psychology & Neuroscience
- Family and Community Pressure, Obesity-Related Behaviours, and Psychological Well-Being Among Female Adolescents with Overweight or Obesity: A Qualitative Study.
- Obesity Modulates Mitochondrial Quality Control in Peripheral Blood Mononuclear Cells After Periodontal Treatment.
- Mitochondrial Dysfunction Markers in Paediatric Obesity: DNA Content and Oxidation Damage.
- Autophagy in Hypothalamic POMC and AgRP Neurons: Mechanisms and Therapeutic Implications for Obesity.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions.
- Systematic Review: Pharmacist Involvement in Overweight and Obesity Care: An Equity-Focused Systematic Review.
- Review: The Food Environment as a Cardiometabolic Exposure: Mechanisms, Inequities, and Interacting Environmental Risk.
Stigma
- Review: The Lived Experience of Children and Adults with Overweight or Obesity Engaging in Weight Management Treatments.
- Approaches to Obesity Among Adults with Accurate Body-Size Perception.
Policy Related
- Review: Toward International Dietary Guidance: A Food Guide Pyramid for Human and Planetary Health.
- Commentary: Precision Nutrition Testing Is the Future of Personalized Care: Evidence and Coverage Policies for Equitable Access.
- Remote Services, Benefits, and Program Retention Changes Among Young Children in WIC.
- Systematic Review: Nutrient Profile Models for Front-Of-Pack Nutrition Labelling.
- Systematic Review: Corporate Political Activity and Evidence of Policy Capture in National Obesity Prevention Policies (2000-2025).
Intergenerational Effects
- A Metabolic-Epigenetic Switch Governs Multicellular Cardiac Repair Following Succinate Dehydrogenase Inhibition.
- Associations between Maternal and Cord Blood Leptin Levels and Anthropometry of Mothers and Infants.
- Differential Methylation at Novel Putative Imprinting Control Regions on Chromosome 20 Associated with Childhood Obesity.
Ecology, Evolution, & Energetics
- Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity.
- Resting Energetic Adaptations over the Course of a 10-Month Multidisciplinary Weight Loss Intervention in Adolescents with Obesity: The POWELL-2 Project.
- Early-Life Cardiovascular Programming by Maternal Protein Restriction: Electrophysiological, Structural, and Molecular Alterations in Female Rats.
- Pharmacological Investigation of Beauvericin in High-Fat Diet-Induced Obesity in Rats.
Methods
- Deep Learning from Retinal Images for Prediction of Biomarker-Informed Obesity Subtypes Associated with Cardiometabolic Risk.
- Study of the Genetic Basis of Childhood and Adolescent Obesity with Stress Through the Analysis of Multidimensional Data with Machine Learning and Artificial Intelligence Tools.
- Review: Artificial Intelligence in Obesity Management: Clinical Evidence, Translational Gaps, and Implementation Priorities.
Commentary
- Podcast: The Mortality Effect of Walnuts are Hard to Ignore - Why?
- Podcast: Abbey Sharp Dissects Claims Regarding Saturated Fat & Health.
- Podcast: Heat After Lifting: Better Muscle Growth or Strength? With Aidan Hopper.
- Podcast: Can Creatine Keep Your Brain Sharp After a Sleepless Night? | Dr Ali Gordji-Nejad.
- Review: Why Exercise Does Not Work Equally Well for Everyone: Life-Course Conditions and the Limits of Precision Medicine.
- Podcast: How Much Should You Eat on a Bulk?
- Life and Death: Ultra-Processed Foods Linked to Everything.
- What Do REIMAGINE 5 Toplines Suggest About CagriSema?
- Obesity Science's Fat-Cell Blind Spot.
General
- INSPECT-SR Tool for Assessing Trustworthiness of RCTs.
- Podcast: "Many of us assume that we are visual learners, or we learn by doing or by seeing something on the printed page. ... But it's complete pseudoscience" according to [Dean of Education] Katie Dyer.
- Podcast: Is Moderate Drinking Actually Healthy?
- An Assessment of Data and Code Sharing in Research Funded by the Nathan Shock Centers, 2017-2022: A Meta-Research Study.
- MTORC1-TFEB/TFE3 Signaling Is Associated with Bile Acid Diversification During Hepatic Metabolic Adaptation.
- Diabetes Technology in the School Setting for Preschool-Aged Children.
- Insulin Resistance After Cardiac Arrest: More Than a Glucose Problem.