Featured

• Baylor College of Medicine Awarded an NIDDK Nutrition Obesity Research Center (NORC).
• A Brain Center That Controls Consummatory Responses.
• Meta-Analysis: "These findings indicate that examined parent-focused behavioural interventions are insufficient to prevent obesity at age 24 months (±6 months). This evidence highlights a need to re-think childhood obesity prevention approaches.”
• Cyclopropane Xenolipids Resemble Monounsaturated Fatty Acids and Modulate Peroxisome Proliferator-Activated Receptors.

Headline vs Study

• Headline: Ditching Daylight Saving Time Could Prevent Millions of Obesity Cases and Thousands of Strokes, Study Says.
• Press Release: Study Suggests Most Americans Would Be Healthier Without Daylight Saving Time.
• Study: Circadian-Informed Modeling Predicts Regional Variation in Obesity and Stroke Outcomes Under Different Permanent US Time Policies. Prevention of Outcomes Theoretical and Not Demonstrated.

Contrary or Null Findings

• Meta-Analysis: "In conclusion, resistance training tempo appears to have minimal overall effect on muscle hypertrophy, with potential differences emerging under specific conditions."
• RCT: "Prior research suggests increased stress and reduced mental wellbeing or reduced stress and increased mental wellbeing among individuals following a vegan diet, but this study found no difference in changes in stress and mental wellbeing between participants randomized to vegan or omnivorous diets."
• RCT: "Receiving feedback on excess calories or exercise required to burn excess calories did not significantly impact the total number of calories purchased."
• RCT: No Effects of Adding Repetitive Transcranial Magnetic Stimulation (rTMS) to Home-Based Exercise (HB) over 10 Sessions in Individuals with Parkinson's Disease.
• RCT: "...no significant main effects of sleep duration on any dietary outcome were observed..."
• RCT: "Characteristic food group differences and the accompanying differences in fibre content between a Palaeolithic and a diabetes diet do not cause an effect on glycaemic control."
• Meta-Analysis: No significant "Sex differences in the efficacy of GLP-1 receptor agonists … [in] cardiovascular and renal outcome trials."
• RCT: "a 12-week HIIT intervention did not improve hippocampal integrity or associated cognitive or mental health impairments while people continued to consume cannabis.”

Basic

• FGF21 and GDF15 Act Synergistically to Regulate Systemic Metabolic Homeostasis in Mice Lacking OPA1 in Thermogenic Adipocytes.
• Fatty Acid Profile and Desaturase Activity in Obesity: Roles, Mechanisms, and Clinical Relevance.
• Cranberry Improves Metabolic Syndrome-Related Organ Dysfunction in Rats by Modulating AMPK/SREBP1, ROCK1 and TGF-β1.
• Tirzepatide Retention in IWAT with Mesoporous Polydopamine Encapsulation Enhances Weight Loss Through Leptin Receptor Signaling.
• Cafeteria Diet Increases Approach Behavior and Appetitive Ultrasonic Vocalizations Triggered by a Food-Related Cue in Male Rats.

Scientific Rigor & Scholarly Dialogue

• Letter: Calling Guidance Evidence-Based When It Is Not Is Against the Ethos of Science.
• Response: Reply to GM Tinsley et al.; DB Ibsen et al.; And EJ Dhurandhar et al.
• Retraction: Pre-Infection 25-Hydroxyvitamin D3 Levels and Association with Severity of COVID-19 Illness.
• Blog Post: Cinnamon for Diabetes and Vitamin D for COVID-19.

Clinical

• RCT Preprint: Personalized AI Prompt Generator and ChatGPT for Weight Loss.
• Meta-Analysis: Effects of Non-Nutritive Sweeteners on Body Weight.
• Systematic Review: Effects of a Very Low-Calorie Ketogenic Diet on Energy Metabolism and Inflammation in Obesity Management.
• Meta-Analysis: The Effect of Capsaicin, Capsinoids, and Pepper-Based Interventions on Lipid Profiles in Individuals with Overweight or Obesity.
• The Impact of Personalised Weight Feedback on Heart Attack Incidence: A Regression Discontinuity Approach.
• A Cost-Effectiveness Analysis of Behavioural, Pharmacological, and Surgical Obesity Treatments in Canada.
• Obesity and Hearing Loss: Mechanisms and Future Challenges.

Children and Adolescents

• Meta-Analysis: Parent-Focused Behavioural Interventions for the Prevention of Early Childhood Obesity (TOPCHILD).
• Longitudinal Association between Physical Activity and School Bullying in Adolescents: A Cross-Lagged Panel Model.
• Social and Environmental Correlates of Childhood Obesity Among Southern California Communities.
• The Cost Effectiveness of a Free Summer Day Camp Voucher Program to Prevent Summer Weight Gain Among Children from Disadvantaged Households.
• Childhood Obesity Influences Mid-To-Late Life Bone Health Through Shared Genetic Architecture.
• Associations between Food Insecurity and Child BMI: Cross-Sectional Versus Longitudinal Mediational Analysis of Maternal Weight-Related Parenting Practices and Concerns.
• Meta-Analysis: Prevalence of Overweight/Obesity Among Under-Five Children in Lower Middle-Income Countries and Assessment of the Reported Associated Factors.
• Scoping Review: Parent-Reported Measures of Weight-Related Health Behaviors in Early Childhood.
• Trend in Body Mass Index During Childhood in 460 Girls with Idiopathic Central Precocious Puberty.
• Food Insecurity Associated with Obesity Status Among Adolescents in the United States.

Surgery

• Using Obesity Management Medications Within the First Year After Laparoscopic Sleeve Gastrectomy May Enhance Weight-Loss Outcomes.
• Surgery for Obesity and Related Diseases (SOARD): “Does a Prior Conversion from Adjustable Gastric Banding to Sleeve Gastrectomy Impact the Outcomes of Subsequent Conversion to Roux-En-Y Gastric Bypass?”
• Commentary: Comment on “Oncologic and Perioperative Outcomes Following Robot-Assisted Radical Prostatectomy in Morbidly Obese Patients: A Systematic Review and Meta-Analysis.”
• Preprint: The Impact of Obesity on Postoperative Pulmonary Complications in Patients Undergoing Aortic Surgery.
• Considerations for the Use of Glucagon-Like Peptide-1 Medications for Obesity in a Plastic Surgery Setting.
• Configuring Bariatric Bodies: Exploring Obesity Surgery Beyond the Hospital.
• Retrospective Study: Enhanced Recovery After Surgery Reduces Complications and Length of Stay in Metabolic and Bariatric Surgery: A 1,800-Patient Middle Eastern Study.
• Commentary: Preoperative Use of Liraglutide in Weight Loss Surgery: Limitations and Future Research.
• Quality of Bariatric Surgery at Veterans Affairs Versus Community Care Hospitals.

Drugs

• Cost-Effectiveness of Tirzepatide Versus Liraglutide, Both Adjunct to Diet and Exercise, for Patients with Obesity or Overweight: A UK Perspective.
• Meta-Analysis: Efficacy and Safety of GLP-1 RAs in Children and Adolescents with Obesity or Type 2 Diabetes.

Food & Diet

• Dietary Isoleucine Content Modulates the Metabolic and Molecular Response to a Western Diet in Mice.
• Review: The Impact of Ultra-Processed Foods on Pediatric Health.

Caloric and Dietary Restriction

• Epigenetic Age Acceleration and Cardiometabolic Biomarkers in Response to Weight-Loss Dietary Interventions Among Individuals with Obesity: The MACRO Trial.
• RCT: Effect of Henagliflozin on Aging Biomarkers in Patients with Type 2 Diabetes.

Exercise & Physical Activity

• RCT: Muscle Creatine Levels and Sprint Performance in Young Adult Vegans and Vegetarians After 7 Days of Creatine Monohydrate Supplementation.
• Comparing the Impact of Feedback on Excess Calories and Physical Activity Calorie Equivalent (PACE) Information on Consumer Behaviour in an Online Hypothetical Restaurant Setting.

Economics & Sociology

• The Mediating Role of BMI in the Association of Socioeconomic Status with Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES 2021-2023.
• Structural and Systemic Drivers of Sugary Drink and Water Consumption in Puerto Rico: A Qualitative Participatory Systems Map.
• The Longer You Stay, the Bigger You Get? Evidence from an Australian Longitudinal Study.
• Socioeconomic Differences in the Cost-Effectiveness of a Telephone-Based Intervention for Obesity Prevention in Early Childhood.
• The True Cost of Obesity: A Public Health Problem in Mexico.
• Educational Attainment as a Super Determinant of Diet Quality and Dietary Inequities.
• Women’s Age at Marriage and Obesity in Pakistan.
• Body Mass Index Progression, Development of Complications and Healthcare Costs over 8 Years in UK Individuals Living with Overweight/Obesity.
• Education, Occupation and Income Inequalities in Obesity Among Portuguese Women and Men: Evidence from National Health Surveys (1998-2019).
• Hospital Costs Attributable to Obesity, Diabetes, and Hypertension in COVID-19 Patients in South Africa.
• Neighborhood Retail Food Environment and 6-Year Changes in Cardiometabolic Health in Hispanics/Latinos.

Epidemiology

• Prevalence and Comorbidity Network Analysis of Obesity and Related Complications: A Real-World Study Based on 233,004 Individuals.
• Risk Factors for Overweight/Obesity Among People Living with HIV on Antiretroviral Therapy: An Ambidirectional Cohort Study at a Tertiary Health Facility in Zambia.
• Is Metabolically Healthy Obesity Shaped by Inflammation, Gender Differences, and Fat Distribution?
• Meal Timing Trajectories in Older Adults and Their Associations with Morbidity, Genetic Profiles, and Mortality.
• Prevalence, Demographic and Clinical Characteristics of Individuals with Early Onset Type 2 Diabetes in the USA: An NHANES Analysis 1999-2020.

Psychology & Neuroscience

• Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities.
• Systemic Inflammation Mediated the Association between Body Roundness Index and Depression Among Adults.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Socioeconomic Inequalities in Waist Circumference and Its 12-Year Change: Moderation by Neighbourhood Population Density.
• Toward Health Equity: A Workshop Report on the State of the Science of Obesity Interventions for Adults.

Ethics

• Weighty Matters: Ozempic, Autonomy and the Ethics of Health Reform.

Stigma

• The Effect of Person-First Language on Obesity Stigma.
• "Weight stigma was significantly associated with higher risk of MASLD [Metabolic dysfunction-associated steatotic liver disease] ..., independent of age, sex, social class, and health behaviors."
• The Risk of Intra-Familial Stigmatisation in Family-Based Treatment of Childhood Obesity. A Position Statement of the European Childhood Obesity Group.

Policy Related

• Consensus on the Diagnosis, Treatment, and Follow-Up in Children and Adolescents with Overweight and Obesity of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN).
• Preprint: From Coverage to Consequences: BMI, Health Behaviors, and Self-Rated Health After Medicaid Contraction.
• NCCOR Learning Guides from the workshop series, "Obesity-Related Policy, Systems, and Environmental Research in the U.S. (OPUS)."

Intergenerational Effects

• Genetic Subtyping of Obesity Reveals Biological Insights Into the Uncoupling of Adiposity from Its Cardiometabolic Comorbidities.
• Progress of Infant Obesity Is Associated with Higher Aspartyl-Glutamate and Alanyl-Aspartate in Maternal and Neonatal Blood.
• Assessing Wireless and Wearable Sensors for Continuous Blood Pressure Measurement in Pregnant People with Obesity.
• Early Metabolic Biomarkers in Neonates of Mothers with Diabetes: Predictive Insights from Amino Acid and Acylcarnitine Profiling.
• Obesity and Pregnancy: Impact on Childbirth Timing, Delivery Mode, and Maternal Recovery: An Update.
• Food, Built and Socio-Economic Environments and Maternal-Infant Outcomes: A Geospatial and Structural Equation Modelling of 163 000 Births.

Ecology, Evolution, & Energetics

• Linking Bioenergetics and Radiation Dose in Chornobyl Rodents.
• Organ-Specific Shifts in Aerobic and Anaerobic Metabolism Throughout Metamorphosis Into Adulthood in a Fully Aquatic Amphibian.

Methods

• Perspective: Framework for Developing Prediction Equations for Estimating the Absorption and Bioavailability of Nutrients from Foods.
• Real-World Assessment of Multi-Frequency Bioelectrical Impedance Analysis (MFBIA) for Measuring Body Composition in Healthy Physically Active Populations.
• Preprint: Machine Learning Approaches for Early Detection of Obesity and Associated Comorbidities.

Commentary

• A New Approach to Pain Management in Lipedema.
• It’s Not You. It’s the Food.
• ‘Brain Dial’ Turns Food Consumption On or Off in Mice.
• Podcast: Episode 294: MAHA: A Call to Action - Dr. Kevin Klatt.
• Confusing Opinions with Evidence Yields Scientific Puffery.
• Pill vs Pen: Can Oral GLP-1s Transform the Obesity Treatment Landscape?
• A New National Academies Report Makes Recommendations to Promote and Support Breastfeeding in United States.
• Time to Rethink Early Childhood Obesity Prevention.
• Surgery Beats Medicine for Obesity - Is Anyone Listening?

General

• UWB-Based Watermelon Sweetness Assessment with Smartphones for Everyday Shoppers.
• Review: Obesity-Driven Inflammation and Cancer Risk.
• Review: Diabesity: Unravelling the Synergistic Epidemic of Obesity and Type 2 Diabetes.
• Systematic Review: Impact of Exercise Training During Pregnancy on Maternal Biomarkers.
• Baylor College of Medicine "Dr. Peter Hotez takes the war against science very personally."
• Training Bacteria to Eat Earth's Waste | Ask Me About My Research with Dr. Felipe-Andres Piedra.
• Where Did All the Dogs Come From? Dogs, Ancestors, Breeds and Genomes.
• An Unreliable Ladder: Top-Bottom Self-Placement, Subjective Social Status, and Political Preferences.
• Trends and Characteristics of Early-Onset Colorectal Cancer in the State of Florida, 2002-2021.

Announcements

• Webinar: Strengthening the GRAS Process to Improve Food Additive Safety and Protect Human Health September 25, 2025.