09/11/26
Featured
- Ultra-Wideband Radar to Measure in Vivo Muscle Forces.
- Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship between Potatoes & Colorectal Cancer.
- Preprint: The Energetic Cost of Building Human Skeletal Muscle.
- Preprint: Across 5 European Countries Poodles and Poodle Crosses are "Fussy Eaters" Whereas Labradors "Eat Anything" Compared to Other Breeds and Their Crosses: Results from a Dataset of over 615,000 Canine Records.
Headline vs Study
- Headline: Ozempic Supera Al Ayuno Intermitente: El Fármaco Ayuda Más a Frenar El Envejecimiento (Ozempic Outperforms Intermittent Fasting: The Drug Is More Effective at Slowing Aging).
- Press Release: GLP-1 Treatment Late in Life Extends Lifespan in Animal Model.
- Study: Late-Life Semaglutide Treatment Slows Ageing and Extends Lifespan in Female Mice.
Contrary or Null Findings
- Meta-Analysis: "... the available evidence does not indicate a clear overall advantage of morning over evening/nighttime exercise for most sleep outcomes." in "Effects of morning versus evening exercise on sleep."
- RCT: "At 12 months, the weight loss was -2.5% in the intensive group [frequent nutritional guidance, enhanced diet and exercise therapy, and additional pharmacotherapy] and -1.7% in the standard group, with no significant difference in the primary outcome."
- RCT: Maternal High-Protein/Low-Glycemic-Index Diet During Pregnancy Impairs Offspring Lipid Profile.
- RCT: "A 16-week supervised concurrent exercise program initiated ~ 10 days after bariatric surgery did not improve weight loss compared with usual care."
- RCT: "In GI cancer patients undergoing major abdominal surgery, early SPN [supplemental parenteral nutrition] showed no significant difference in 5-year [overall survival] compared with late SPN. The findings do not support the use of early SPN to improve long-term survival in this patient population."
- RCT: Individualized Targeted Exclusion Diet Based on Confocal Laser Endomicroscopy Does Not Improve Irritable Bowel Syndrome Symptoms.
- Meta-Analysis: "ESG [Endoscopic sleeve gastroplasty] combined with [anti-obesity medications] may enhance early weight loss in selected settings; however, current evidence does not support consistent long-term superiority over ESG alone for weight or glycemic outcomes."
- "BMI has little impact on the EE [energy expenditure] of walking at speeds between 0.89 m/s and 1.79 m/s, and that sex differences in walking EE are eliminated after controlling for height."
- RCT: "There was no difference in [body weight] between Fx [whole fruit feijoa powder] and Placebo over the 6-month intervention. [Fasting plasma glucose] followed the weight loss trajectory in both treatment groups, but with no between-group interaction over 6 months."
Basic
- Review: Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.
- Neutrophil Serine Proteases Inhibit Thermogenic Capacity of Visceral White Adipose Tissue.
- POMC AMPKα1 Deletion Drives Male-Specific BAT Thermogenesis and Obesity Resistance.
- Photic Cycle Shorter Than or Equal to Endogenous Tau Postpones Diet-Induced Obesity in Mice and Shows a Robust Aftereffect.
- Macrophage IgG Recycling Couples Glomerular IgG Accumulation to Podocyte Senescence in Obesity-Related Glomerulopathy.
- Statins Promote Muscle Metabolic Danger and NLRP3-Mediated Myopathy Via Lower Protein-Prenylation and YAP.
- Weight Loss Without Food Intake Suppression Through Size-Dependent Retention of Anti-Inflammatory Nanomedicines.
- Exosome Trafficking Is a Key Regulator of Adipocyte Thermogenesis.
Scientific Rigor & Scholarly Dialogue
- The 109 Percent Problem: What a Flawed Obesity Study Can Teach Us About the Premier League. (pdf)
- Podcast: Is Obesity a Muscle Problem?
- Podcast: Physionic's Nicolas Verhoeven Critically Examines the Evidence for Some Counter-Conventional Thinking on Dietary Fatty Acids and LDL Cholesterol.
Clinical
- Clinical Obesity Beyond BMI Identifies a Large High-Risk Subgroup in UK Adults.
- Meta-Analysis: Effectiveness of Mobile Application-Based Multimodal Behavioral Interventions on Weight Loss in Obesity.
- Meta-Analysis: Treatment Strategies for Functional Hypogonadism in Men with Obesity.
- RCT: Lactococcus lactis Subsp. lactis CAB701 Reduces Body Fat Mass in Adults with Overweight or Obesity.
Children and Adolescents
- RCT: Family-Centered Child Obesity Treatment.
- Trends in GLP-1 Receptor Agonist Prescriptions for Children Ages 8 to 11 with Obesity: 2019-2026.
- Systematic Review: Associations of Sugar-Related Food Parenting Practices and Parental Feeding Styles with Prospective Dietary Behavior of Children and Adolescents.
- Unhealthy Food Television Advertising and Body Weight in Mexican Children.
- Obesity and Severe Obesity Prevalence Among Youth Aged 2-17 in Minnesota, 2020-2025.
- Quantification of Appetite-Regulating Hormones in Children with Hypothalamic and Common Obesity.
- Preprint: Genetic and Behavioural Architecture of Childhood Eating Behaviour and Links to Obesity Risk.
- Comparing Two Diagnostic Frameworks for Obesity in Mexican Children Attending a Pediatric Obesity Clinic.
Surgery
- Excess-Weight Metrics Misrepresent Weight Loss and All Weight Metrics Poorly Predict Early Glycemic Outcome After Metabolic and Bariatric Surgery.
- A 10-Year Cost-Effectiveness Analysis of Metabolic and Bariatric Surgery in Adolescents.
- Extreme Obesity (BMI ≥ 60 kg/m²) Characterization Up to and Beyond 80 kg/m² in 1,262,454 Bariatric Surgery Patients.
- Trends in Metabolic and Bariatric Surgery Among Adolescents, 2016-2025.
- Intestinal HIF1α Is Dispensable for Bariatric Surgery-Mediated Metabolic Benefits but Protects Against Diet-Induced Obesity and Hepatic Steatosis.
- Six-Month Weight Loss and Comorbidity Remission After Sleeve Gastrectomy, Roux-En-Y Gastric Bypass, BPD-DS, and SADI-S: Propensity Score Analysis Using the 2023 MBSAQIP Database.
Drugs
- RCT: Efficacy and Safety of Mazdutide in Adults with Obesity or Overweight.
- Podcast: Baylor College of Medicine Faculty Peter H. Jones, MD, MNLA, and Christie M Ballantyne, MD, MNLA Discuss Plozasiran and the SHASTA-3 & SHASTA-4 Trial Results.
- Meta-Analysis: Comparative Efficacy and Safety of Glucagon-Like Peptide 1 Based Drugs for Weight Loss in Adults with Overweight or Obesity Without Diabetes.
- Comparative Effectiveness of GLP-1 Receptor Agonists Versus Mineralocorticoid Receptor Antagonists as Fourth-Line Pharmacological Therapy in Patients with Resistant Hypertension and Overweight or Obesity.
- Systematic Review: Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acquired Hypothalamic Obesity.
- Meta-Analysis: The Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) on Binge Eating in Patients with Obesity.
- Postmarketing Safety Signals and Medication-Use Risks of GLP-1-Based Therapies in Diabetes and Obesity.
- Meta-Analysis: Comparative Efficacy of Tirzepatide Versus Semaglutide for Weight Loss in Adults with Overweight or Obesity.
Food & Diet
- Systematic Review: "Healthy eating strategies in convenience stores show promise for improving diet-related outcomes."
- Long-Term Weight Maintenance After a Low-Carbohydrate Diet: A Real-World Retrospective Cohort Study.
- Meta-Analysis: "Mediterranean diet produced modest improvements in BMI and triglycerides but did not demonstrate clear superiority over comparator diets for most metabolic or hepatic outcomes"
- RCT: Effects of Cinnamon Supplementation Combined with Exercise Training on Anthropometric Indices and Reproductive Hormones in Women with Overweight or Obesity.
Caloric and Dietary Restriction
- Beyond Weight Loss: Disentangling the Direct Effects of Semaglutide vs Equivalent Calorie Restriction on Reproductive Systems of Male and Female Rats.
- Biological Pathways of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Adults Without Obesity.
- Review: Protein Restriction and the Hallmarks of Aging: A Coordinated Physiological Adaptive Response?
Exercise & Physical Activity
- Long-Term Physical Activity and Risk of Obesity in Australian Women Using Target-Trial Emulation: An OBCT Study.
- RCT: Effects of 12-Week Supervised Combined Aerobic and Resistance Training on Body Composition and Physical Function in Adults with Oveweight or Obesity and Multiple Cardiometabolic Risk Factors.
- Commentary: How Fast Do You Actually Lose Progress When You Stop Exercising?
Economics & Sociology
- Childhood Adiposity and Labor Market Outcomes: Mendelian Randomization Evidence on the Role of Education.
- Preprint: Household Shocks and Child Nutrition: Evidence from Young Lives Study in India.
- Social Media Discussions of Anti-Diabetic Drugs and the Popularity of GLP-1 Therapies: Content Analysis.
- Health and Economic Burden of Obesity and Obesity-Related Health Disorders in Japan.
- Does digital infrastructure improve individuals' body weight? A quasi-natural experiment based on "Broadband China" policy.
- Racialized Incorporation, Migration Timing, and Cardiometabolic Risk Among Afro-Caribbean Immigrants in the United States.
- Multilevel Effects of Socioeconomic Factors on the Somatic Status of Contemporary Youth Across Russian Regions.
- Preprint: Macroeconomic Burden of Six Major Metabolic Diseases in Low- and Middle-Income Countries: A Value of Lost Welfare Analysis Based on the Global Burden of Disease Study 2023.
Epidemiology
- The Relationship between Overweight or Obesity, Elevated Blood Pressure and the Overall Quality of Life in Medical Students, Poland.
- Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice.
- The Cost of Internet Use: An Examination of the Causal Impact on Body Weight.
- BMI Modifies Cardiovascular Risk Across Blood Pressure Categories, Particularly Among Underweight Adults with Hypertension: A 6.3 Million-person Nationwide Japanese Cohort Study.
- Causal Adiposity and Clinical Validation of Regional Fat Distribution in PMOS: A Multi-Modal Analysis Integrating GBD 2021, Mendelian Randomization, and Machine Learning.
- Preprint: Hard to Lose, Easy to Gain; Trends in Obesity and Weight Change Across the Life Course in Four British Birth Cohorts.
- A Multi-Ancestry Polygenic Risk Score for BMI Predicts Longitudinal Weight Change.
- Body Composition Phenotypes Are Key Predictors of Cardiovascular-Kidney-Metabolic Multimorbidity and Long-Term Mortality: Insights from a Population-Based Cohort Study.
Psychology & Neuroscience
- Baseline Mental Health Status and Early Psychiatric Outcomes After Metabolic-Bariatric Surgery.
- Mentalization and Dysfunctional Eating Behaviors: The Mediating Role of Emotional Regulation.
- RCT: Pregnancy Diet Based on Ancestral Patterns Increases Growth in Subcortical Fetal Brain Regions.
- Identification of Cognitive Factors That Predict Behavioural Weight-Loss Intervention Outcomes.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- "The Weight of Place:" Neighborhood Disadvantage in Adolescence and Obesity Trajectories Into Early Midlife.
- Lifestyle Interventions for Obesity Prevention Among Adolescents in Pacific Islands Countries and Territories: A Narrative Review of Outcomes and Sociocultural, Spatial and Temporal Dimensions.
- Childhood Misfortunes and Metabolic Syndrome in Old Age: European Prospective Cohort Study.
Ethics
- Silencing the Sirens: Weight-Loss Drugs, Food Noise, and the Ethics of Effortless Self-Control.
- GLP-1 Receptor Agonists in Dermatology: Ethical Considerations.
Stigma
- Assessing Underlying Processes of Implicit Weight Bias: A Diffusion Model Analysis.
- Challenging Weight Stigmatizing Perspectives in Public Health During Pregnancy by Sharing Positive Stories and Images by Those Who Have Lived Experience.
- Associations between Parental Beliefs About Their Child's Weight Controllability, Negative Weight Comments, and Initiation of Weight Talk with Children.
Policy Related
- Medicare Spending Implications for Semaglutide Under Voluntary Price Agreements.
- Opinion: Potential Effects of Sugar-Sweetened Beverage Taxation on Oral and Systemic Health Outcomes.
- Changes in Semaglutide Fills Following Expanded FDA and Medicare Policies.
- Sugar-Sweetened Beverage Tax and Dental Caries, Periodontitis and Edentulism in Australia: a Modeling Study.
- Review: Public Health Interventions for the Prevention and Management of Overweight and Obesity in Children and Adolescents.
Intergenerational Effects
- Maternal BMI, Gestational Weight Gain, and Cardiovascular Disease in Offspring.
- Impact of Prepregnancy BMI in Low-Risk Pregnancies with Adequate Gestational Weight Gain: Trend and Adverse Outcomes.
- Maternal Consumption of Fruits, Vegetables and Fruit Juices in Relation to Offspring Weight at 4 Years.
Ecology, Evolution, & Energetics
- Visceral Adiposity Is Independently Associated with Hypertension.
- Climate Risks for the European Food System and Policy Preparedness.
- Coping with the Cold: Black-Capped Chickadees (Poecile atricapillus) Use Rapid Facultative Hypothermia to Reduce Fat Loss Overnight.
- Organ Size and Metabolic Rate Co-Vary with Dimensions of the Obstetric Pelvis: The Metabolic Coordination of Childbirth Hypothesis.
Methods
- Simultaneous Prediction of Multiple Dimensions of Food Security.
- Divergent Obesity Classification between the Edmonton Obesity Staging System and the Lancet Commission Model.
Commentary
- Podcast: Should Pregnant & Breastfeeding Women Take DHA? And Should Vegan Women Supplement with DHA During Pregnancy?
- Only 30% of Global Food Supply Calcium Is Bioavailable, Study Finds.
- Podcast: Healthy Beginnings Start with Both Parents: The Emerging Science of Paternal Nutrition with Dr. Kozeta Miliku.
- Podcast: Protein-Maxxing: Is It Actually Bad for Us?
- Podcast: Why Your Brain Thinks You're Full (Even When You're Not).
- GLP-1 Drugs for Aging?
- (Un) Intended Consequences of Mass-Prescribing GLP-1s.
- Obesity Medicines as Disruptive Innovation.
- Do We Need Body Composition Analysis in Patients with Obesity? A Rethinking of Body Composition Assessment in Preclinical and Clinical Obesity.
General
- Podcast: "Scientists stripped a cell down to its most essential genes in order to find out what makes life...alive. What they found was more bizarre than they could have imagined."
- Cellular Senescence Links Muscle Atrophy and Posttraumatic Osteoarthritis After ACL [Anterior Cruciate Ligament] Injury.
- The Knotty Problem of RNA Structure Prediction.
- The Conversations That Move Science Forward.
- Podcast: Industry Innovations | Episode 7: A New Era for FCS: Diagnosis, Daily Life & the Science That's Changing Everything.
- Oxygenaging: A Physiological Framework for Geroscience.
- Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives.
- The Urinary Pathobiont Actinobaculum massiliense Can Generate Androgens Via the DirAB Pathway.
- Gut Microbiota-Derived Imidazole Propionate Promotes Primary Sclerosing Cholangitis Via p38 Signalling.
- When Answers are Instant: Why Mentorship Matters More in the Age of Artificial Intelligence.
Video & Audio
- Podcast: Why Your Body Chooses Sugar over Fat.
- Enriching Clinical Trials with Machine Learning.
- The Sleep-Weight Connection.
- How Hormones Impact Food Noise with Dominique Ludwig - YouTube.