09/05/25
Featured
- RCT: The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women.
- RCT: "Interestingly, the GLP-1 response was larger following PRO [protein] and remained elevated after 240 minutes, whereas the GIP response was larger following CHO [carbohydrates].
- RCT Secondary Outcomes: Effect of Ultra-Processed Food Consumption on Male Reproductive and Metabolic Health.
Headline vs Study
- Headline: Which Food Additives are the Worst -- and Most Likely to Shorten Your Life.
- Study: Associations between categories of 'Markers of Ultra-Processing' estimated from self-reported intake using the Oxford WebQ and all-cause mortality. Yet, "The Oxford WebQ does not assess food ingredient lists..."
Contrary or Null Findings
- RCT: No Effect on Anthropometric Variables When Testing an Adapted Obesity Prevention Intervention in Under Resourced Schools.
- “Higher DI-GM [dietary index for gut microbiota] and UGMS were significantly associated with greater AD [Alzheimer’s Disease] prevalence in US adults. Results challenge prior assumptions that higher DI-GM scores are uniformly linked to health benefits."
- GLP-1R Signaling Does Not Modify the Severity of Experimental Graft Versus Host Disease.
- "We found no strong link between dietary creatine and these hormone levels."
- Eight-Week High Intensity Jump Training Does Not Change Neural Correlates of Executive Functions and Emotion Regulation in Young Adults.
- Meta-Analysis: "current evidence does not strongly support the use of EGCG [Epigallocatechin gallate] as a stand-alone intervention for glycemic control."
- RCT: "Fruit smoothie supplementation over a 16-week period did not impact psychological distress, fatigue, physical fitness, carotenoids, or folate biomarkers among people receiving OAT [opioid agonist therapy]."
- RCT: "Cocoa supplementation did not show significant improvements over the placebo in the measured outcomes."
Basic
- Review: Fatty Acid Transport Protein 2: A Novel Therapeutic Target in Lipid Metabolism and Disease.
- Postbiotic-Mediated Obesity Reduction Via Bioactive Peptide ETLVK and Gut Microbiota in High-Fat Diet Mice.
- Suppression of Adipocyte ABHD6 Favors Anti-Inflammatory and Adipogenic Programs to Preserve Adipose Tissue Fitness in Obesity.
- Investigation of the Effect of Krill Oil on Sortilin in Liver and Adipose Tissue in Obese Rats.
- Synergistic Alleviation of Obesity and Associated Cardiovascular Complications by Combined Modulation of FASN/Arginase/eNOS Uncoupling.
- Abnormal Mitochondrial Structure and Function in Brown Adipose Tissue of SLC35A4-MP Knockout Mice.
Scientific Rigor & Scholarly Dialogue
- Letter: Concern for the Validity of Short-Term Dietary Crossover Trials.
- Reply to: Concern for the Validity of Short-Term Dietary Crossover Trials.
- An Unclean Slate, Discrepancies between Food Input and Recovered Protein Signal from Experimental Foodcrusts.
- Our Preoccupation with Protein Intake.
- Blog Post: New RCT: Oatmeal Is a Healthier Breakfast Than Candy.
- Rigor and Equity in Intervention Study Design in Pediatric Psychology: A Focus on Comparator Conditions from Diabetes Research.
Clinical
- Exploring Optimal Serum Selenium Range for Heart Failure Prevention: A U-Shaped Association and Mediation by Hepatic Steatosis in US Adults.
- Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups with Varying Micro- and Macrovascular Complication Risks.
- Analysis of Long-Term Follow-Up from Assigned Treatments: Estimation of Metformin Effects on Diabetes and Its Complications.
Children and Adolescents
- Dissertation: Predicting Childhood Obesity: Integrating Eating Behavior with Statistical and Machine Learning Approaches.
- Evaluating the Long-Term Effectiveness of a Structured Telehealth Obesity Program in Children and Adolescents.
- Long-Term Health Outcomes in Adolescents with Obesity Treated with Faecal Microbiota Transplantation.
- Cross-Sectional: Neck-To-Height Ratio in Screening for Abdominal Obesity Among Children and Adolescents.
- Testing a Behavioural Intervention Program for the Prevention of Type 2 Diabetes Among American Indian Youth.
- Maternal Outcomes of WIC Recipients Before and During the COVID-19 Pandemic.
Surgery
- Does Robotic-Assisted Surgery Mitigate Risk for Patients with Colorectal Cancer and Overweight or Obesity?
- Use of Glucagon-Like Peptide-1 Agonists Among Individuals Undergoing Bariatric Surgery in the US.
- Implementation of the Enhanced Recovery After Bariatric Surgery Protocol with Clinical Hypnosis.
- Concomitant Laparoscopic Cholecystectomy with Bariatric Surgery.
- Double Roux-En Y Configuration for Managing Chronic Leak After Conversional Roux-En Y Gastric Bypass.
Drugs
- Tirzepatide Leads to Weight Reduction in People with Obesity Due to MC4R Deficiency.
- Lilly's Oral GLP-1, Orforglipron, Is Successful in Third Phase 3 Trial.
- Impact of Tirzepatide Treatment on Participant-Reported Food Craving and Food Preference: Secondary Analyses of a Phase 1 RCT in People with Obesity with Dietary Restriction.
Food & Diet
- RCT: Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes.
- Meta-Analysis: Adolescent Dietary Intake and Breast Cancer in Adulthood.
- RCT: Effectiveness of a Multi-Component Intervention Including Pictorial Warnings to Reduce Sugar-Sweetened Beverage Consumption.
Caloric and Dietary Restriction
- RCT: The Effects of Reverse Dieting on Mitigating Weight Regain After a Caloric Deficit.
- Beta-Hydroxybutyrate but Not NMN Supplementation Mimics Caloric Restriction Reducing Early Mortality in Daphnia.
Exercise & Physical Activity
- Clinician Guidance on the Benefits of Healthy Nutrition and Increased Physical Activity for People with Type 2 Diabetes Following Glucagon-Like Peptide 1 Receptor Agonist Initiation.
- RCT: Effects of Multicomponent Training on Metabolic and Functional Health of Older Women with Obesity.
Economics & Sociology
- The Relationship between BMI, Socioeconomic and Geographic Factors with Somatic Maturation in Mexican Children.
- The Economic Cost of Obesity: A Cost-Of-Illness Study in Greece.
Epidemiology
- Revisiting Obesity Thresholds for Cardiovascular Disease and Mortality Risk in Chinese Adults: Age- and Gender-Specific Insights.
- Trends in BMI, Nutrient Intake and Nutritional Status of Rural Adults in India.
- Obesity, Metabolic Abnormalities and Low-Grade Inflammation: Differential Associations with Subclinical Atherosclerosis.
- Social Determinants of Health and Progression to Cardio-Renal-Metabolic Multimorbidity and Mortality in People with Prediabetes.
- Trends and Disparities in Heart Failure and Heart Failure with Obesity Mortality Among U.S. Adults: A 1999-2020 Analysis of Geographic, Gender, and Racial Variations.
Psychology & Neuroscience
- Methodological Concerns Regarding Feasibility of Online Cognitive-Behavioral Group Therapy Following Metabolic Bariatric Surgery.
- Attitudinal Factors Influencing Willingness to Use Anti-Obesity Medication in Adults with Obesity.
- Understanding Food Addiction in Obesity: A Genetic Perspective.
- Addressing Obesity and Mental Health in Adolescents: Holistic Insights from a Case Report.
- Exploring the Interplay between Mindful Eating and Self-Compassion: Insights from Three Empirical Studies and Future Directions for Research.
- Neural Pathways to Bariatric Success: What Explainable AI Reveals That Conventional FMRI Methods May Miss.
- Association between Childhood Obesity and the Risk of Food Addiction: A Matched Case-Control Study.
Equity and Disparities
- Trends and Disparities in Mortality Due to Hypertensive Disease and Coexisting Obesity in the USA: 1999-2023.
- The Effect of Obesity on Fertility and Assisted Reproductive Therapy Success Among Ethnic Groups.
Stigma
- Beyond Dietary Therapy: Addressing Weight Stigma Awareness in Medical Students.
- Thin-Ideal Internalisation and Weight Bias Internalisation as Predictors of Eating Pathology: The Moderating Role of Self-Compassion.
- Relationship between BMI and Quality of Life Among Malaysian Young Adults: Sequential Mediated Effects of Perceived Weight Stigma and Weight-Related Self-Stigma.
Policy Related
- Healthy Grains in Healthy Diets: The Contribution of Grain Foods to Diet Quality and Health in the National Health and Nutrition Examination Survey 2017-2023.
- The Role of Dignity in Rights-Based Food Policy in the UK.
Intergenerational Effects
- Epigenetic Programming of Estrogen Receptor in Adipocytes by High Fat Diet Regulates Obesity-Induced Inflammation.
- Translating Epigenetics Into Antenatal Care in Australia: Communicating Risk and Intergenerational Health in Practice.
- Review: Maternal Obesogenic Diet Causes Insulin Resistance by Modulating Insulin Signaling Pathways in Peripheral Tissues of Offspring.
- Exploring Continuous Glucose Monitoring in Gestational Diabetes.
Ecology, Evolution, & Energetics
- Bite Size of Caenorhabditis elegans Regulates Feeding, Satiety and Development on a Diet of Live Yeast.
- Scat-Tered Evidence. Understanding the Diet of Forest-Associated Mammalian Mesopredators in a UK Peatland Ecosystem.
- The MUC19 Gene: An Evolutionary History of Recurrent Introgression and Natural Selection.
Methods
- A Comparative Analysis of Generalized Additive Models for Obesity Risk Prediction.
- Shaky Statistical Foundations of BMI in Childhood and Adolescence: Why It Fails and What to Replace It With. (pdf)
- The New Definition of Obesity: An Analysis of a Population-Based Survey in an Andean Country.
- Comprehensive Assessment and Diagnosis of Metabolic and Biomechanical Complications in Obesity.
- Weight Adjusted Waist Index Is a Superior Obesity Index for Predicting Arterial Stiffness in Type 2 Diabetes Mellitus.
- Clarification and Standardization of Dual-Energy X-Ray Absorptiometry Terminology for Accurate Scientific Communication and Clinical Diagnostic Accuracy.
Mathematical and Quantitative
- Using Time-Weighted Averages of Total Daily Energy Expenditure to Estimate Energy Intake During a Weight Loss Intervention.
- The Evolving Burden of Obesity in the US: A Novel Population-Level System Dynamics Approach.
Commentary
- Dual Roles of MTOR in Skeletal Muscle Adaptation: Coordinating Hypertrophic and Mitochondrial Biogenesis Pathways for Exercise-Induced Chronic Disease Management.
- 'Cluelessness About the Potential of Orforglipron'.
- Definitions Matter in Body Composition Science.
- Resistance Exercise in Treating Heart Failure with Preserved Ejection Fraction and Obesity: Targeting Skeletal Muscle Abnormalities and Ectopic Adipose Depots.
- When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity.
- Claudin Proteins: Their Potential Role in Obesity and Adipose Tissue Signaling, Physiology and Disease.
- Commentary: The GLP-1 Era - What Comes After Bariatric Surgery?
- Playing the Long Game: Why Progress on Food, Nutrition & Health Takes Persistence, Patience & Positivity.
General
- Detecting Data Errors: Where are We and What Needs to Be Done?
- ‘Rewilding’ in Argentina Raises Thorny Questions.
- New Statistical Tool Reveals Hidden Genetic Pathways in Complex Diseases.
- When Patients Arrive with Answers.
- RCT: Intervention to Promote Ethical Authorship Practices in Graduate Education.
- How Humans Became Upright: Key Changes to Our Pelvis Found.
- A Response to the Office of Science and Technology Policy Agency Guidance for Implementing Gold Standard Science in the Conduct & Management of Scientific Activities.
- Tutorial: Meta-Analysis Using Time-To-Event Data.