Featured

• Podcast: Barry Sears - Why You Need Higher Doses of Omega-3s Than You Think.
• AgRP Neurons are Required for the Weight-Lowering Effects of GLP-1 Receptor Agonists in Female Mice.
• Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes.
• Patient-Provider Communication Quality: Impact of Patients' Weight, Race and Ethnicity.
• Microbiota-Derived Isovalerate Ameliorates Sex-Specific Gut Barrier Dysfunction in Malnutrition.
• RCT: Apitegromab for Lean Mass Preservation During Tirzepatide-Induced Weight Loss.

Headline vs Study

• Headline: Obesity Weakens Anti-Tumor Immune Response in Lung Cancer - but Exercise May Restore It.
• Study: Exercise Modulates Adiposity-Induced Immune Dysfunction in NSCLC and Non-Tumor-Bearing Lungs... In Mice Implanted with Mouse Lung Cancer.

Contrary or Null Findings

• RCT: "After 4 weeks of herb and spice exposure, postprandial [Flow-Mediated Dilation], lipemia, and glycemia did not differ with acute intake of culinary doses of herbs and spices as part of a higher-carbohydrate, high-saturated-fat meal."
• Ketogenic Diet Mediates Intestinal Tumorigenesis Through Lipids Not Ketones.
• "Contrary to the classic paradigm of unimodal diversity-productivity relationships observed in riverine systems, total phosphorus (TP) positively correlated with biodiversity (edf = 1.00, p = 0.028), while phytoplankton biomass (Chl-a) exerted a negative effect (edf = 1.00, p < 0.001), indicating a decoupling between resource supply and community evenness in riverine ecosystems."
• "Contrary to expectations, cold acclimation induced little to no change in flight muscle structure, mitochondrial density and abundance across all species."
• "The results of this study do not support the hypothesis that dietary iron supplementation increases infection intensity in M. sexta."
• "Contrary to our hypothesis, exposure to these nanoparticles enhanced glucose transport across the placenta."
• RCT: "...exercise in the heat elicited significant thermal strain, fatigue, and inflammation, independent of hydration strategy. Electrolyte composition did not significantly alter responses when fluid intake was controlled..."
• RCT: "Early total enteral feeding did not improve the time to achieve full enteral feeding compared with CEF [conventional enteral feeding]."

Basic

• Transcriptomic Analysis of Bone Marrow Adipose Tissue Reveals Enrichment in Lipid Transport in Response to Western Diet.
• A Novel Solid Beverage RLMCR Prevents Obesity-Related Metabolic Disorders Through the Gut-Adipose Axis.
• An N-Salicyloyl Tryptamine Derivative (Compound 18) Improves Spermatogenic Impairment in Obese Mice Via Regulating Insulin Resistance and Enhancing Sertoli Cell Glycolysis.
• Adipose TGFβ-Asprosin Memory Promotes Obesity Relapse and Offspring Obesity Susceptibility.
• Comparative Effects of Orlistat and PEG-SPIONs on Fasting Glucose, Insulin, and Leptin in Obese Male Mice.
• Obesity-Related Kidney Disease and the Role of Aquaporins: An Overview of Potential Molecular Mechanisms.
• ZRSR1 Protects Against Obesity-Associated Hepatic Lipogenesis Independent of Minor Intron Splicing.

Scientific Rigor & Scholarly Dialogue

• Meta-Analyses of Dietary Exposures Must Consider Energy Adjustment: Recommendations from a Meta-Scientific Review.
• Commentary: Public Health and the Plague of Certainty.

Clinical

• Food Noise as a Missing Piece in Obesity Treatment: Toward an Integrated Intervention Framework.
• RCT: The Effects of Full-Fat and Low-Fat Fermented Dairy Foods on Markers of Cardiometabolic Health in Adults with Overweight or Obesity and Elevated Fasting Triglycerides.
• High Resolution Lipoprotein Subfraction Profiling Identifies Obesity Associated Distributional Changes in LDL and HDL Subfractions and Particle Ratios.
• RCT: The Effect of Reduced Carbohydrate Diet on Cardiometabolic Risk Factors and Gut Microbiota in Children and Adolescents with Obesity.

Children and Adolescents

• Review: Digital Interventions Preventing Childhood Obesity Among Culturally Diverse Families.
• Applying Artificial Intelligence to Childhood Obesity: T2DM and MASLD Risk Predictive Models.
• Meal Time and Meal Regularity: Is It Associated with Pediatric Obesity?
• Systematic Review: Family Matters? A Systematic Review of Interventions Addressing Family-Level Mechanisms in the Treatment of Childhood and Adolescent Obesity.

Surgery

• Association of Age and Gender with the Efficacy of Metabolic Surgery in Patients with Obesity and Type 2 Diabetes.
• Comparison of Preoperative and Postoperative Intraperitoneal Nebulised Ropivacaine in Laparoscopic Gastric Bypass.
• The Value of Adding Obesity Medications After Bariatric Surgery.
• Association of Obesity with Clinical, Physiologic, and Durability Outcomes After Antireflux Surgery in a 2388-Patient Cohort.
• Systematic Review: Impact of Bariatric Surgery on Cardiovascular Pathology.

Drugs

• RCT: Elecoglipron, an Oral Small Molecule GLP-1 Receptor Agonist in Adults with Obesity or Overweight (VISTA).
• RCT: Orforglipron for Maintenance of Body Weight Reduction.

Food & Diet

• RCT: High Animal Protein and High Plant Protein Meals Differentially Alter Postprandial Plasma Amino Acid Concentrations but Not Glucose Homeostasis in People with Overweight/Obesity in a Single-Meal Study.
• Choline and Metabolic Health, a Missing Link in a Critical Chain.
• Vegan Diets and Dietary Energy Density a Secondary Analysis of a RCT.

Caloric and Dietary Restriction

• Six- and Twelve-Month Changes in Body Composition and 24-H Energy Expenditure After a Very Low-Calorie Ketogenic Diet.
• Meta-Analysis: Do Ketogenic Diets Produce Greater Weight Loss Than Higher-Carbohydrate Diets Under Comparable Prescribed Energy Conditions?

Exercise & Physical Activity

• Meta-Analysis: Acute Effects of Interrupting Prolonged Sitting with Short Bouts of Physical Activity on Postprandial Metabolism in Sedentary Adults.
• The Combined Associations of Physical Activity and BMI on the Prevalence of Functional Difficulties Among 29,343 Individuals Living with Subjective Cognitive Decline: A Cross-Sectional Study.

Economics & Sociology

• Negotiating Body Self-Concept in Iranian Women Living with Obesity: A Qualitative Phenomenological Study.
• Healthcare Cost Impacts of Telehealth-Delivered Nutrition Therapy Among US Adults with Type 2 Diabetes or Obesity: A Matched Difference-In-Differences Analysis.

Epidemiology

• New Obesity Definition and Clinical Obesity Prevalence for Global Metabolic Bariatric Surgery.
• Operational Approach to the Lancet 2025 Obesity Framework in Mexican Adults: Prevalence and Clinical Characteristics.
• The Association between Obesity Class and Cause-Specific Mortality by Age and Sex in US Adults.
• The Weight of Risk: Epidemiological Trends in Mortality Involving Cardiac Arrest and Obesity in the United States (1999-2023).

Psychology & Neuroscience

• Mental Health in Individuals Who Have Undergone Metabolic Bariatric Surgery: A Cross-Sectional Mediation Analysis.
• Obesity Is Associated with Greater Variability of Reward Signals in the Nucleus Accumbens.
• Ventral Tegmental Area Sync State Incorporates Gastrointestinal Feedback and Reflects an Active Interoceptive Learning State in Mice.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Review: Climate Change and Cardiovascular Diseases: Systemic Challenges, Policies, and Management Strategies.
• Perspective: Cardiovascular Risk Prediction in Africa: Why Global Tools Fail and What We Must Do.
• Trends in Publicly Subsidized and Private Access to GLP-1 Medicines Indicated for Type 2 Diabetes in Australia, 2020-2025.
• Preprint: Culturally Adapted Collaborative Care for Asian Americans with Type 2 Diabetes: Cardiometabolic Outcomes, Effect Modification, and Return on Investment.

Stigma

• Commentary: Weight Stigma Internalization in the Medical School Curriculum.
• Review: GLP-1 Receptor Agonists and the Emergence of Treatment-Related Stigma: A Call for Conceptual Clarity.
• Compounding Stigma: An Experimental Study Comparing Perceptions of an Individual Using Ozempic, Bariatric Surgery, or Behavior Modification.

Policy Related

• Review: State-Level Promotion of Plant-Based School Meals in the United States.
• Knowledge and Intake of Sugary Drinks: A Cross-Sectional Study from the International Food Policy Study.
• Reimagining School Meals from a Systems Thinking Perspective: A Case Study of School Meal Supply Chain Collaboration in California.
• SNAP Disruption During a Government Shutdown and Implications for Chronic Disease Self-Management: A Qualitative Study.

Intergenerational Effects

• Parental BMI and Offspring Childhood Body Size and Eating Behaviour.
• The Association of Prenatal Adiposity Characteristics with Early Childhood Overweight and Obesity.

Methods

• Review: Artificial Intelligence, Wearable Technologies, and Virtual Reality in Precision Nutrition and Obesity Management.
• Review: Methodological Standards for Body Composition Assessment - An Expert-Endorsed Guide for Research and Clinical Applications.

Commentary

• Podcast: Are "Everyday Toxins" Really Making You Sick? Dr. Joe Zagorski Separates Fact from Fiction.
• Podcast:  Science VS Weight Cycling.
• Podcast: MOT-C Explained by USC Gerontology Professor Dr. Changhan David Lee.
• Podcast: Creatine Supplementation in Women Across the Lifespan.
• Podcast: You've Got Rhythm - Coffee, Caffeine, and Your Body - Dr. Thomas Merritt.
• Sugar Tax Has Failed to Reverse Obesity.
• Podcast: Resistance Training and Cardiovascular Health in Postmenopausal Women.
• What If Inflammation Is Not Exactly What We Thought?

General

• Genomic Data Describe Population Structure but Struggle to Estimate Directed Connectivity Networks.
• Podcast: "Dismissing pseudoscience is too easy. Understanding why it spreads so quickly is harder. It can teach us why real science works and how to spot the difference between the two."
• Podcast: PHYSICS WORLD - Motivation Is Key to the Public’s Trust in Science, Study Reveals.
• A Cluster Randomized Trial of HEPA Filters Is Strikingly Negative.
• Podcast: 14 Million Deaths or Zero Deaths? The Impact of the USAID Cuts.
• Meeting Report - a National Institute on Aging Workshop on Sex Differences in Health Across the Lifespan.
• Fetal Microchimeric Cells: Today’s Enemies, Tomorrow’s Friends.

Announcements

• NIDDK-Sponsored: Registration for the 18th Annual Isotope Tracers in Metabolic Research Course Is Still Open! This Week-Long Course (Oct. 19 - 23) on the Theory and Practice of Stable and Radioactive Isotopic Tracers for the Study of Metabolism in Human, Animal, and Cell Models Will Take Place in Nashville, TN.
• "Researchers at Baylor College of Medicine have developed a drug called CS18 that disrupts the ability of cancer cells to survive therapy."