Featured

• "Garvey selected to earn highest honor from AACE."
• The Effects of Graded Calorie Restriction XVII: Multitissue Metabolomics Reveals Synthesis of Carnitine and NAD, and tRNA Charging as Key Pathways.
• Dietary Inflammatory Index and Cardiometabolic Risk in Ecuadorian Women.
• Eight Fold Increase in the Dietary Supplement Related Liver Failure Leading to Transplant Waitlisting over the Last Quarter Century in the US.

Headline vs Study

• Headline: AU Study: Some Fat Actually Beneficial in Fighting Dementia.
• Press-Release: Beige Fat 'Indispensable' in Protecting the Brain from Dementia.
• Study: Beige Adipocytes Mediate the Neuroprotective and Anti-Inflammatory Effects of Subcutaneous Fat... In Mice.
• HvS Study: What’s Not in the News Headlines or Titles of Alzheimer Disease Articles? #InMice.

Contrary or Null Findings

• RCT: "DeskCyclesTM were not an effective intervention for physical activity or behavioral outcomes in this classroom setting."
• "High coffee consumption is associated with low risk of mortality, cardiometabolic diseases, some cancers and gallstones in observational studies, with no evidence to support causality from Mendelian randomization studies for most diseases except gallstones."
• RCT: No Significant Effect of 12-Weeks Elastic Band Resistance Training on MyomiRs and Osteoporosis Markers in Elderly Women with Osteosarcopenic Obesity.
• RCT: "In contrast to findings from previous studies in younger adults and those with pre-existing hypertension, measures of vascular function in this cohort of healthy postmenopausal women were not impacted by supplemental watermelon juice."
• "Nut consumption has no effect, positive or negative, on weight or adiposity parameters in people with T2D."
• RCT: "Multi-modal exercise training improved body composition and some appetite outcomes, although changes were inconsistent and largely independent of exercise-timing. In the absence of dietary manipulation, the effect of diurnal exercise timing on appetite and body composition appear trivial compared to the overall benefits of exercise participation."
• "Contrary to bariatric surgery, only limited evidence indicated that site and type of surgery, the approach to the abdominal cavity (laparoscopic vs. open), institutional factors, and the type of perioperative care such as ERAS protocols may play a role in determining postsurgical complications in obese patients."

Basic

• Impact of Obesity on Day-Night Differences in Cardiac Metabolism.
• Depletion of Microglia Mitigates Cerebrovascular Dysfunction in Diet-Induced Obesity Mice.
• Low-Molecular Alginate Improved Diet-Induced Obesity and Metabolic Syndrome Through Modulating the Gut Microbiota in BALB/c Mice.
• Iron Overload Protects from Obesity by Ferroptosis.
• The Effects of Mirabegron on Obesity-Induced Inflammation and Insulin Resistance are Associated with Brown Adipose Tissue Activation but Not Beiging in the Subcutaneous White Adipose Tissue.
• Adipocyte NR1D1 Dictates Adipose Tissue Expansion During Obesity.
• Brown Adipose Tissue Is the Key Depot for Glucose Clearance in Microbiota Depleted Mice.

Scientific Rigor & Scholarly Dialogue

• Concerns About Chocolate Consumption and Indicators of Adiposity.
• Article: Do Lower-Carbohydrate Diets Increase Total Energy Expenditure? An Updated and Reanalyzed Meta-Analysis of 29 Controlled-Feeding Studies.
• Letter: Overestimated Impact of Lower-Carbohydrate Diets on Total Energy Expenditure.
• Response: Letter to the Editor: Reply to Guyenet and Hall.
• Causes and Consequences of Interindividual Response Variability: A Call to Apply a More Rigorous Research Design in Acute Exercise-Cognition Studies.

Clinical

• MRI Based Validation of Abdominal Adipose Tissue Measurements from DXA in Postmenopausal Women.
• Modeling the Influence of Chronic Sleep Restriction on Cortisol Circadian Rhythms, with Implications for Metabolic Disorders.
• RCT: Advancing Therapy in Suboptimally Controlled Basal Insulin–Treated Type 2 Diabetes: Clinical Outcomes with IGlarLixi Versus Premix BIAsp 30.
• RCT: Effectiveness of Combining Antiobesity Medication with an Employer-Based Weight Management Program for Treatment of Obesity.
• RCT: Novel Lifestyle Intervention Compared with the Diabetes Prevention Program for Weight Loss in Adult Dependents of Military Service Members.

Children and Adolescents

• Monogenic Diabetes in Youth with Presumed Type 2 Diabetes: Results from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.
• Thinness, Overweight, and Obesity Among 6- to 17-Year-Old Malaysians: Secular Trends and Sociodemographic Determinants from 2006-2015.
• Dissertation: Examination of the Efficacy of the Healthy Hunger-Free Kids Act to Reduce High School Childhood Obesity Rates System.
• Recent Trends in Overweight and Obesity in Adolescents Aged 12 to 15 years Across 21 Countries.
• Meta-Analysis: Interventions to Treat Obesity in Mexican Children and Adolescents.
• Exploring the Importance of Diversified Physical Activities in Early Childhood for Later Motor Competence and Physical Activity Level: A Seven-Year Longitudinal Study.

Surgery

• The Need and Safety of Mineral Supplementation in Adults with Obesity Post Bariatric Surgery-Sleeve Gastrectomy (SG).
• Obesity and Perioperative Outcomes in Older Surgical Patients Undergoing Elective Spine and Major Arthroplasty Surgery.
• Toll-Like Receptor-4 (TLR4) and MyD88 are Required for Gastric Bypass-Induced Metabolic Effects.
• Cost-Effectiveness of Procedure-Less Intragastric Balloon Therapy as Substitute or Complement to Bariatric Surgery.
• Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight-Loss.
• Systematic Review: Impact of Bariatric Surgery-Induced Weight Loss on Ovarian Reserve in Women with Obesity.
• Examining the Rates of Obesity and Bariatric Surgery in the United States.
• Patient Reported Outcomes After Metabolic Surgery Versus Medical Therapy for Diabetes.

Drugs

• RCT: Effects of Liraglutide on Visceral and Ectopic Fat in Adults with Overweight and Obesity at High Cardiovascular Risk.
• Targeting Visceral Adiposity with Pharmacotherapy.
• Metformin for Pediatric Obesity and Insulin Resistance: A Retrospective Study Within an Integrated Health Care System.
• Obesity-Induced Changes in Human Islet G Protein-Coupled Receptor Expression: Implications for Metabolic Regulation.
• Managing Obesity and Related Comorbidities: A Potential Pharmacological Target in the Adenosine System?

Food & Diet

• Meta-Analysis: Adherence to the Mediterranean Diet, Five-Year Weight Change, and Risk of Overweight and Obesity.
• Meta-Analysis: Decreased Iron Intake Parallels Rising Iron Deficiency Anemia and Related Mortality Rates in the US Population.
• Comparative Study of the Anti-Obesity and Gut Microbiota Modulation Effects of Green Tea Phenolics and Their Oxidation Products in High-Fat-Induced Obese Mice.
• Improvement Effect of Sweet Basil (Ocimum basilicum l.) Powder Intake on Obese Mice Fed a High-Fat and High-Sucrose Diet.
• Trends in Consumption of Ultraprocessed Foods Among US Youths Aged 2-19 Years, 1999-2018.
• RCT: Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease.

Caloric and Dietary Restriction

• RCT: Changes in Cardiometabolic Risk Among Older Adults with Obesity: An Ancillary Analysis Investigating Exercise Plus Weight Maintenance and Exercise Plus Intentional Weight Loss by Caloric Restriction.
• Weight Loss from Caloric Restriction vs Roux-En-Y Gastric Bypass Surgery Differentially Regulates Systemic and Portal Vein GDF15 Levels in Obese Zucker Fatty Rats.
• Abstract: Short-Term Carbohydrate and Lipid Restriction Impact on Obese Gerbil.

Exercise & Physical Activity

• Exercise in the Maintenance of Weight Loss: Health Benefits Beyond Lost Weight on the Scale.
• Physical Activity and the Risk of SARS-CoV-2 Infection, Severe Covid-19 Illness and Covid-19 Related Mortality in South Korea.
• RCT: Two Weekly Sessions of High-Intensity Interval Training Improve Metabolic Syndrome and Hypertriglyceridemic Waist Phenotype in Older Adults.
• Microcirculatory Responses to Muscle and Tendon Exercises in Individuals with and Without Type 2 Diabetes Mellitus and the Association between Microcirculatory and Exercise Performance.
• Gender Differences in the Association between Physical Activity and Obesity in Adults with Vision and Hearing Losses.
• Systematic Review: The Impact of Yoga on Components of Energy Balance in Adults with Overweight or Obesity.

Economics & Sociology

• Area-Level and Family-Level Socioeconomic Position and Body Composition Trajectories: Longitudinal Analysis of the UK Millennium Cohort Study.
• Rational Addiction and Other Purchasing Dynamics Across Obesity Status Groups.
• Obesity Is Associated with Lack of Access to Dental Care and Physical Activity Among Older Adults: A Cross-Sectional Study.
• Diabetes Drug’s New Weight Loss Formula Fuels Cost-Benefit Debate.
• The Economic Burden of Obesity in Italy: A Cost-Of-Illness Study.

Epidemiology

• Early Mortality and Cardiovascular Disease, Varied Association with BMI and Its Changes in Insulin-Treated Diabetes: A Nationwide Study.
• Anthropometric Indices and Age at Natural Menopause: A 15-Year Follow-Up Population-Based Study.
• Comparative Analysis of Metabolic Syndrome Diagnostic Criteria and Its Effects on Prevalence in a Multiethnic Population.
• Validation of Obesity-Related Diagnosis Codes in Claims Data.
• Low Protein Intakes and Poor Diet Quality Associate with Functional Limitations in US Adults with Diabetes: A 2005–2016 NHANES Analysis.
• Diabetes, Disability, and Dementia Risk: Results from the Hispanic Established Populations for the Epidemiologic Studies of the Elderly.

Psychology & Neuroscience

• Confinement During the COVID-19 Pandemic After Metabolic and Bariatric Surgery-Associations between Emotional Distress, Energy-Dense Foods, and BMI.
• Relationship between BMI and Alcohol Consumption Levels in Decision Making.
• Leptin Brain Entry Via a Tanycytic LepR–EGFR Shuttle Controls Lipid Metabolism and Pancreas Function.
• Gut Cytokines Modulate Olfaction Through Metabolic Reprogramming of Glia.
• Unlocking the Causal Link of Metabolically Different Adiposity Subtypes with Brain Volumes and the Risks of Dementia and Stroke: A Mendelian Randomization Study.
• Review: Top-Down Control of Appetite.
• Factor Structure and Measurement Invariance of the Attitudes Toward Persons with Obesity (ATOP) Scale in a Preoperative and Postoperative Bariatric Surgery Sample.
• Association between BMI, Its Change and Cognitive Impairment Among Chinese Older Adults: A Community-Based, 9-Year Prospective Cohort Study.

Equity and Disparities

• Weight Discrimination Experienced Prior to Enrolling in a Behavioral Obesity Intervention Is Associated with Treatment Response Among Black and White Adults in the Southeastern U.S.
• Racial, Ethnic, and Gender Differences in Obesity and Body Fat Distribution: An All of Us Research Program Demonstration Project.
• Twelve-Month Efficacy of an Obesity Prevention Program Targeting Hispanic Families with Preschoolers from Low-Income Backgrounds.
• The State of Disparities in Pediatric Diabetes Care.
• Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association with Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes.

Stigma

• Factors Linking Perceived Discrimination and Weight Bias Internalization to Body Appreciation and Eating Pathology: A Moderated Mediation Analysis of Self-Compassion and Psychological Distress.
• Coping with Weight Discrimination: Findings from a Qualitative Study.
• Role of Weight Bias and Patient–physician Communication in the Underutilization of Bariatric Surgery.

Policy Related

• Competitive Food and Beverage Policies and Obesity Among Middle School Students: Variability by Urbanicity in California.
• Projecting the Impacts of Sugar-Sweetened Beverage Warning Labels and Restaurant Menu Labeling Regulations on Energy Intake, Weight Status, and Healthcare Expenditures in US Adults: A Microsimulation.
• Physical Activity May Mitigate COVID-19 Infections in People with Obesity: A Call to Action.
• Perspective: The Influence of Front-Of-Package Nutrition Labeling on Consumer Behavior and Product Reformulation.
• Exploring Attitudes Toward Taxation of Sugar-Sweetened Beverages in Rural Michigan.
• Stakeholder Views on Taxation of Sugar-Sweetened Beverages and Its Adoption in the Netherlands.

Intergenerational Effects

• Mapping a Prevention Strategy to Reduce Medically Indicated Preterm Births: A Trio of Low-Risk Modifiable Factors for the Triad of the Mother, Fetus, and Placenta.
• Differences in Biomarkers of Cardiac Dysfunction in Cord Blood between Normal Pregnancies and Pregnancies Complicated by Maternal Diabetes.
• Maternal Obesity: A Focus on Maternal Interventions to Improve Health of Offspring.

Ecology, Evolution, & Energetics

• Obesity Genes Open New Avenues of Research.
• Glacier Ice Archives Nearly 15,000-Year-Old Microbes and Phages.
• Gut Microbiota: A Target for Intervention in Obesity.

Methods

• Reliability of Measurements of Energy Expenditure and Substrate Oxidation Using Whole-Room Indirect Calorimetry.
• Establishing Growth Charts for Proposed Body Shape and Size Index of the Pakistani Population, Using Quantile Regression Approach.
• Pragmatic Evaluation of Older Adults’ Physical Activity in Scale-Up Studies: Is the Single-Item Measure a Reasonable Option?

Mathematical and Quantitative

• Can “VAI” Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey.
• A Body Shape Index (ABSI) and Hip Index (HI) Adjust Waist and Hip Circumferences for BMI, but Only ABSI Predicts High Cardiovascular Risk in the Spanish Caucasian Population.
• Pathways to “5-A-Day”: Modeling the Health Impacts and Environmental Footprints of Meeting the Target for Fruit and Vegetable Intake in the United Kingdom.

Commentary

• Eat More Plants, Suffer Less Heart Disease? Not Exactly.
• Changing Diets Mean More Americans are Anemic Now.
• Better Pregnancy Outcomes After Bariatric Surgery?
• An Anti-Obesity Immunotherapy?
• Transpulmonary Pressure-Guided Invasive Ventilation in Patients with Morbid Obesity: Another Brick in the Wall of Personalized Medicine.
• Public Policy Based on Anger and Fear.
• Childhood Obesity Beyond COVID-19.
• Obesity and Hypertension in Asia: Current Status and Challenges.
• Innovation and Competition in Obesity Gains Momentum.
• Shifting from More to Better in Food Systems.

General

• Parkinson’s Disease Reversed by Farnesol in Mice.
• Amazing Insights into the Farthest Moving Species in the World.
• Male Age Alone Predicts Paternity Success Under Sperm Competition When Effects of Age and Past Mating Effort are Experimentally Separated.
• Senescent Cells in Cancer Therapy: Why and How to Remove Them.
• Senotherapeutics: Targeting Senescent Cells for the Main Age-Related Diseases.
• A Mathematical Estimation of the Physical Forces Driving Podocyte Detachment.
• Chocolate Consumption and All-Cause and Cause-Specific Mortality in a US Population: A Post Hoc Analysis of the PLCO Cancer Screening Trial.
• What Does It Mean to Be Dead Last in Healthcare?

Video & Audio

• Podcast: #171 - Steve Austad, Ph.D.: The Landscape of Longevity Science: Making Sense of Caloric Restriction, Biomarkers of Aging, and Possible Geroprotective Molecules.

Announcements

• Metabesity 2021 Conference: Meet Steve Austad PhD.
• Food Insecurity, Neighborhood Food Environment, and Nutrition Health Disparities: State of the Science, September 21‒23.
• Survey: AIN-93G/M: Tell Us What’s New in Rodent Nutrition!
• Short Course: Strengthening Causal Inference in Behavioral Obesity Research: September 10th to October 1st, 2021.
• Nutrition Science Tenure/ Tenure-Track: Full/Associate/Assistant Professor Search.
• Non-Tenure-Track: Clinical Full/Associate/Assistant Professor; Senior Lecturer or Lecturer Search.