Featured

• You are when you eat: How food synchronizes liver clocks.
• Podcast: Is It Really Just Calories In, Calories Out? Metabolism, Insulin, Hormones and Why Counting Fails.
• Editorial: Inconvenient for the Investigator but Convenient for Science: Trial Registration in the American Journal of Clinical Nutrition.
• Reframing Basic Experimental Studies in Humans - Implications for Nutrition Science.

Headline vs Study

• Social Meta Title: Scientists Studied What Fathers Eat Before Conception. It Showed Up in Their Babies.
• Study: Associations between fathers' self-reported intake and neonatal anthropometric outcomes. Whether it "showed up in their babies" was not measured. "It is important to emphasize the need for additional research to determine the causality of the associations observed..."

Contrary or Null Findings

• "Amenorrheic athletes did not demonstrate cardiovascular disease risk factors compared with eumenorrheic athletes, contrary to what has been observed in prior studies of adult athletes."
• "...contrary to our predictions, this high-quality dietary supplementation resulted in lower vaccine responsiveness."
• "Greater adiposity was associated with shorter QTcF, contrary to the conventional paradigm."
• "Contrary to the study hypothesis, this study suggests no differential effects of the intervention [dietary counseling] across educational groups."
• "Contrary to hypotheses, ADHD diagnosis did not moderate these associations, suggesting shared neural pathways linking early adiposity and brain structure independent of diagnostic status."
• RCT: Betaine Supplementation Has No Effect on Sex Hormones in Premenopausal Women with Overweight or Obesity.
• Meta-Analysis: Number of Sprint Repetitions in a Sprint Interval Training Session Does Not Moderate Improvements in V̇O₂max with Training.
• Unintentional Weight Loss Does Not Predict Poor Outcomes in Zenker Diverticulum.

Basic

• Sucralose Is Accumulated in Adipose Tissue and Plasma, but Minimally Impacts Inflammation in Lean and Obese Mice Available to Purchase.
• BMI Normalization Is Associated with Lower Risk of Progression to Type 1 Diabetes, Primarily in Youth.
• Oral Co-Delivery of Quercetin and Anthocyanins Via Dual-Ligand Nanoparticles Alleviate Obesity and Associated Metabolic Disorders.

Scientific Rigor & Scholarly Dialogue

• Podcast: Effectiveness of Chiropractic Spinal Manipulation for Headache Treatment.
• Discrepancies between Validated and Selected Dietary Exposures for Association Analysis: A Meta-Research Study of Cohorts Examining Diet-Cardiovascular Disease Associations.
• Expert Reaction to Unpublished Study Suggesting That Diet Quality Matters More Than Food Processing Level.

Clinical

• RCT: Influence of Protein Intake During Obesity Reduction on Physical Function and Body Habitus in Older Men with Prediabetes.
• Sugar Rationing During the First 1000 Days and Early-Onset Cancer: A Natural Experiment.
• Interpreting Lower HDL-C in Plant-Based Diets: Mechanisms and Clinical Implications.
• Declines in Plasma Erythritol Levels and Improvements in Insulin Sensitivity and Glucose Metabolism: POUNDS Lost Trial.
• Commentary: Are We Measuring the Same Disease? Clinical Obesity as a Definition-Dependent Construct.
• Real-World Data-Driven Insights in Obesity: A Comparative Cross-Sectional Analysis of General Practice and a Specialized Obesity Clinic in Belgium - An IMI2 SOPHIA Study.

Children and Adolescents

• Association of Early Childhood Lifestyle Patterns with Overweight in Preschoolers and Timing of Adiposity Rebound.
• Identifying Eating Behaviour Phenotype Cut-Off Scores for Childhood Obesity: An Individual Participant Data Meta-Analysis Using the Child Eating Behaviour Questionnaire (CEBQ).
• Infections in Infancy and Association with Long-Term Weight Gain and Obesity in Children, Southern California, USA.
• Review: Unravelling the Obesity Epidemic Among Young People in Qatar.
• Physical Activity Participation and Obesity-Related Risk Behaviors Among Male Saudi Adolescents.
• Association of Parental Moderate-To-Vigorous Physical Activity with Child Overweight/Obesity, Physical Fitness and MVPA Guideline Adherence: Dose-Response Analyses Among Schoolchildren.
• Associations between Physical Activity and Physical Fitness in Preschool Children: Gender and Age Differences.
• Increasing Trend in Prediabetes and Obesity Among Adolescent School Children in Chennai City in Southern India.

Surgery

• Associations between Obesity-Related Comorbidities and Weight Loss After Bariatric Surgery.
• Meta-analysis: An Updated Systematic Review, Meta-Analysis, and Network Meta-Analysis of Breast Cancer Incidence After Metabolic and Bariatric Surgery.
• Commentary: Beyond Blood Pressure Reduction- the Potential Cardiovascular Risk Reduction Benefits of Weight Loss Surgery.
• Bariatric Surgery in Adolescents with Obesity: Weight and Cardiometabolic Outcomes-Real-World Data.

Drugs

• Orforglipron: First Approval.
• Glucagon-Like Peptide-1 Receptor Agonists and Risk for Anterior Ischemic Optic Neuropathy.

Food & Diet

• RCT: Grazing Suppresses Meal-Induced Dietary Preference in Rodents and Humans.
• Toddler Diet Quality: A Factor Associated with Childhood Growth?

Caloric and Dietary Restriction

• Caloric Restriction Enhances Radiosensitivity of Colorectal Tumors Through the CGAS-STING Pathway Activation.
• High-Fat Diet Triggers Chemerin-Dependent Immune Reprogramming That Exacerbates Acute Kidney Injury.

Exercise & Physical Activity

• Leisure-Time Physical Activity on Age-Modelled Trajectories of BMI and Obesity Risk Throughout Life: Multivariable Regression and Mendelian Randomization Analyses Using Electronic Health Record Data from the CORDELIA-Catalunya Study.
• Body Appreciation and Social Anxiety: Exploring Within-Person Associations and the Moderating Role of Physical Activity.
• Physical Activity Relates to Adolescent Social Anxiety: Evidence from a Structural Equation Model Involving Resilience and Self-Efficacy.
• Systematic Review: Association between Sensor-Based Physical Activity, Sedentary Behaviour, Sleep, and Mental Health in University Students.
• Meta-Analysis: Comparative Effectiveness of School-Based Physical Activity Interventions on Moderate-To-Vigorous Physical Activity in Children and Adolescents.
• Mediation Analysis of Fundamental Movement Skills, Physical Activity, Fitness, and BMI in Primary School Children.
• Exploring the Associations Among Physical Activity, Social Adaptation, and Emotional Intelligence in Adolescents: A Network Analysis Study.

Economics & Sociology

• Dissertation: Investigating the Interrelationships of Alcohol Consumption, Physical Activity, Socioeconomic Status, and Obesity: A Multi-Method Approach.
• Socioeconomic Inequalities in Obesity Among Korean Adults: The Role of Lifestyle Factors in KNHANES 2022–2024.
• Systematic Review: Socioeconomic Position and the Hair Cortisol-Obesity Association.
• The Economic and Social Burden of Obesity in Bulgaria.
• GLP-1-Induced Weight Loss and the Female Obesity Penalty.

Epidemiology

• Clinical Value of the New Obesity Definition for Cardiovascular Events in a Middle Eastern Population.
• Prediabetes Phenotypes and Adiposity Patterns: Findings from a Population-Based Study.
• The Degree of Obesity Correlates with the Severity of Acute Pancreatitis.
• Global Burden of Gout Attributable to High BMI (1990-2021) and Causal Link with Obesity: A GBD and Mendelian Randomization Study.

Psychology & Neuroscience

• Psychophysiological Pathways Linking Physical Activity and Mental Health in Adolescents: A Narrative Review of Autonomic Regulation, Hypothalamic-Pituitary-Adrenal Axis Function, Neuroplasticity, and Sleep Rhythms.
• Letter: Distinct Brain Regions Mediate Regulation of Food Intake in Response to GIPR Agonism or Antagonism.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Local Community Environment Drive India’s Obesity Epidemic: A Multilevel Analysis of Geographic Variations Using Asian-Specific BMI Criteria.
• Engaging Stakeholders to Define Research Priorities and Build a Research Community to Reduce Obesity Among Hispanic Women in the Southeastern United States.
• Sleep Duration and BMI Among Adolescents: Variation by Age and Race/Ethnicity.
• Existing Geographical Disparities in the Utilization of Counseling Services by Pediatric Patients with Obesity.
• Global, Regional, and National Trends in the Morbidity Gap and Contributing Diseases, Injuries, and Risk Factors, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023.

Stigma

• Attitudes, Stigma and Knowledge on Obesity in Mexico: A National Cross-Sectional Survey of the General Population and Healthcare Professionals Living with or Without Obesity.
• Review: Weight Stigma in Latin America and the Caribbean: Regional Evidence and a Call to Action by ABESO.

Policy Related

• Support for an Added-Sugar Menu Labeling Policy Among Key U.S. Population Groups in a Cross-Sectional Sample.
• Perspective: Informing the Next Chapter of SNAP Policy: Lessons from SNAP Participants’ Experiences in the Aftermath of the Emergency Allotment Expiration.
• Systematic Review: Implementation Strategies Used in Effective Policies to Combat Obesity in Socioeconomically Disadvantaged Communities.
• State Supplemental Nutrition Assistance Program Policies and Cardiovascular Mortality.
• Mexico’s Soda Tax as a Public Health Lever: A Case Study on Tackling Obesity and Diabetes Through Fiscal Policy.
• Changes in Physical Fitness in Chinese Primary Schools Following the “Double Reduction” Policy Based on Policy Instrument Theory.

Intergenerational Effects

• Effect Modification by Ambient Temperature on the Association of Ambient Ozone Exposure with Diet-Controlled and Insulin-Treated Gestational Diabetes Mellitus.
• Temporal Trends and Determinants of Gestational Diabetes Mellitus and Perinatal Outcomes in Tuscany, Italy (2010-2021).
• Weight-Gain-For-Gestational-Age Z-Score in Twin Pregnancies in China and Its Association with Preterm Birth: A Retrospective Cohort Study.
• Maternal Vitamin B12 Deprivation Exacerbates Offspring Obesity by Reducing Early-Life Colonization with Bifidobacterium pseudolongum.
• Hypertensive Disorders of Pregnancy: Heterogeneity in Risk Factors and Maternal and Neonatal Outcomes Across Subtypes - A 6-Year Retrospective Cohort Study.

Ecology, Evolution, & Energetics

• Diet-Microbiome Synergy Underlies Obesity-Associated Immunotherapy Efficacy.

Methods

• Systematic Review: Applications of Artificial Intelligence in Cardiovascular Risk Detection and Prediction Among Adults with Obesity.
• News: New AI Body Map Reveals Obesity’s Hidden Attack on Facial Nerves.
• Generative AI-Enhanced Ensemble Model for Predicting Adolescent Obesity in India: A School-Based Study in Two Southern Districts of Karnataka.
• Same Child, Different Risk: Demographic Bias in Childhood Obesity Attribution by Large Language Models.

Mathematical and Quantitative

• A Social Influence-Driven Compartmental Model of Obesity Dynamics with Multi-Class Severity and Relapse.

Commentary

• Podcast: Catching Up with Dr. Mary Newport | Ketosis, Cholesterol and Brain Health.
• Podcast: GLP-1 Therapy and Bone Density: Separating Signal from Noise with Dr. Sandra Cortina.
• Podcast: Are Your Peptides Illegal?
• Let's Not Throw the Baby Out with the Bath Water-Next Steps for Child Obesity Prevention in Early Life.
• Transforming Screen Time Into Active Time: Digital Health Interventions for Childhood Obesity.
• Review: Diagnosis, Staging and Management of Obesity: A Synthesis of Contemporary Guidelines.
• Ketogenic Diet, in a First Randomized Trial, Correlates with Symptom Improvement in Schizophrenia & Bipolar Disorder with Psychosis.
• Obesity Ad Wars: Only in America.

General

• Podcast: Are You Still Assuming Every Newborn Got Vitamin K?
• Podcast: Are We Too Afraid of the Sun?
• The Best of Both Worlds - Using Clinical Trial and Observational Data to Evaluate Vaccine Protection.
• Geroprotective Insights Into the Natural Metabolite Spermidine in Aging and Age-Related Diseases. (pdf)
• "Contrary to our hypothesis, testosterone declined more in fathers who reported higher alignment with traditionally masculine beliefs, and among those who did not identify as the child's primary caregiver."
• Caffeine and Cardiovascular Disease: A Scientific Statement from the American Heart Association.
• Orcas Seen Ramming Prey So Hard It Explodes May Be Playing Game.
• An Automated Approach to Improve Clinical Trial Registration and to Identify Outcome Changes on ClinicalTrials.gov.
• "...62% of U.S. adults self-report having little to no idea what statistics or statistical concepts like p-values are, but 90% of them would base decisions on reported statistics at least sometimes if they understood them better."

Announcements

• Childhood Obesity Advancing Editorial Processes.