07/24/26
Featured
- A Cold-Induced GDF15-Secreting Adipocyte Subpopulation Regulates Energy Homeostasis Through Endocrine Signaling.
- RCT: "Incorporating 1 avocado per day into habitual diets for 26 weeks reduced the concentration of atherogenic LDL particles without affecting other lipoprotein particles and subclasses in adults with abdominal obesity."
- Podcast: Is Your Protein Aging You? What the Longevity Science Gets Wrong.
- Video: Gary Taubes - NIH Scientific Freedom Lecture Series: Energy Balance or Fuel Partitioning? A History Lesson in the Science of Obesity Pathogenesis, and Its Implications.
Headline vs Study
- Headline: Fish over Meat: Why a Pescatarian Diet May Help People with Obesity Live Longer.
- Study: Associations between mortality and being categorized as a meat eater, fish eater, or vegetarian/vegan based on self-reported dietary intake. Causation not established. "[P]escatarian diet was associated with better survival outcomes [compared to meat eaters], whereas vegetarian and vegan diets did not," which would be "Fish over Non-Fish."
Contrary or Null Findings
- RCT: "The ME [mindfulness-based eating] group showed no clear improvement in inhibitory control on the food Go/No-Go task," the primary endpoint.
- Systematic Review: "Nutrition education may be effective for intermediate outcomes such as nutrition knowledge and dietary behaviors, but evidence for effectiveness in physiological and biochemical outcomes remains inconclusive."
- RCT: "No significant group-by-time interactions were identified in the intention-to-treat analyses" in "Effects and moderators of a 16-week intervention on contextual physical activity in adults with moderate to severe depressive symptoms."
- Meta-Analysis: "There was no evidence of increased respiratory harm associated with weight-loss drugs compared with placebo, suggesting a reassuring respiratory safety profile in the general population."
- RCT: "Prolonged self-paced cycling in the heat produced a reproducible neuromuscular response dominated by slowed twitch relaxation. However, 6% CHO ingestion did not clearly attenuate these changes compared with PLA, suggesting that the principal impairment reflected exercise and heat load rather than CHO availability or delivery mode."
- RCT: "In elderly patients with chronic HF and malnutrition or at risk of malnutrition, a pragmatic nutritional intervention did not reduce major clinical outcomes."
- RCT: "In this randomized clinical trial of adults undergoing radical cystectomy, perioperative specialized immunonutrition did not reduce 30-day complications compared with standard oral nutrition. Differences in 2-year survival favored immunonutrition but were not statistically significant."
- RCT: In adults with RA and obesity, diet-induced weight loss reduced adiposity without evidence of disproportionate muscle loss.
Basic
- Combined Time-Restricted Feeding and Physical Exercise Attenuate ER Stress and Improve Liver Inflammation and Collagen Deposition in Aged Mice.
- Sleeve Gastrectomy Induces Adipose Browning Via Suppression of Asprosin and Activation of the ATF3-Nrf2/HO-1 Axis.
- ASK1-Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice.
- Reduced Platelet Count in Mice Protects Against Glucose Intolerance and Beta Cell Loss During a Long-Term High-Fat Diet.
Scientific Rigor & Scholarly Dialogue
- PubPeer Comments On: Social Stress Shortens Lifespan in Mice.
- Editorial: WHO's Misguided Push for Complementary and Alternative Medicine.
Clinical
- Review: From Obesity to Healthy Longevity: A Consensus-Based Clinical Framework for Obesity Diagnosis, Staging, and Treatment.
- Systematic Review: Dietary Strategies and Nutritional Management in Patients Receiving GLP-1 and Dual GIP/GLP-1 Receptor Agonists as Adjuncts to Lifestyle Interventions.
- Perspective: Rethinking Cardiometabolic Therapy Thresholds in Individuals with Obesity.
- Central Obesity and Recurrent Cardiovascular Events in Patients with Obstructive Sleep Apnea.
- RCT: Longitudinal Association of Dietary Spermidine with Hepatic Function Indexes and Cardiometabolic Traits in Older Adults with Metabolic Syndrome.
Children and Adolescents
- Research Letter: GLP-1 Receptor Agonist and Bariatric Surgery Utilization Among Adolescents and Young Adults.
- Branched Chain Amino Acid Metabolism and Microbiome in Adolescents with Obesity During Weight Loss Therapy.
- Nutritional and Behavioral Determinants of Overweight and Obesity Among School-Aged Children in Shandong Province, China.
Surgery
- Perceptions and Attitudes Towards Obesity and Metabolic and Bariatric Surgery for Weight Loss in Children and Adolescents: A Survey Among a Subset of Chinese Residents.
- Optimal Timing of GLP-1 Receptor Agonist Initiation in Patients with Obesity Eligible for Metabolic Bariatric Surgery.
- Pilot Study: Bariatric Surgery and Patient Reported Outcomes of Heart Failure in Women.
- A Modified POSE 2.0 Double Helix Megaplication Endoscopic Gastroplasty Pattern for Obesity: Initial One-Year Outcomes in Japan.
- Evolving Utilization of Bariatric Surgery Since the Rise of Semaglutide and Tirzepatide.
- Intraoperative Liver Biopsy During Metabolic and Bariatric Surgery: Diagnostic Yield, Safety, and National Trends.
- Postoperative Changes in Eating Behavior After Sleeve Gastrectomy are Associated with IL-10 Independent of Anthropometric Changes.
Drugs
- RCT: Short- and Long-Term Effects of Semaglutide 2.4 mg on Energy Intake, Appetite, and Food Reward.
- RCT: Once-Weekly Semaglutide in Adults with Alcohol Use Disorder.
- Post-Shortage Compounded GLP-1 RA Market in 2 States with Potentially High Demand.
Food & Diet
- RCT: Lipoprotein(a) Lipidome and Diet: Responses to Reducing Saturated Fat Intake in African Americans.
- RCT: Replacing Red Meat with Non-Soy Legumes Alters Choline Metabolites but Not Systemic Inflammation or Proxies of Gut Barrier Function in Healthy Males.
- RCT: Comparison of Two Nutritional Protocols in Body Re-Composition of Resistance-Trained Participants.
Caloric and Dietary Restriction
- Defining a Ketone Threshold for Weight Loss: Evidence from 14 Day Daily β-Hydroxybutyrate Monitoring in 217 Subjects on a Ketogenic Diet.
- RCT: Time-Restricted Eating During a Bulking Phase Is Associated with Reduced Fat Accumulation, While Muscle and Strength Gains are Maintained.
Exercise & Physical Activity
- Changes in Self-Esteem, Body Dissatisfaction, and Body Appreciation During Face-To-Face and Digital Supervised Physical Activity Interventions in Women with Obesity.
- Associations of Demographic, Socioeconomic, Lifestyle Factors and Comorbidity with Accelerometer-Measured Physical Activity in Adults with Cardiovascular Diseases.
- Meta-Analysis: Muscle-Strengthening Activities are Associated with Lower Risk and Mortality in Major Non-Communicable Diseases.
- Long-Term Resistance Training with All-Cause and Cause-Specific Mortality: Assessing Dose-Response and Joint Associations with Aerobic Physical Activity.
- Dose-Dependent Association between Muscle-Strengthening Activities and All-Cause Mortality.
Economics & Sociology
- Associations of Educational Attainment with Cardiometabolic Markers and Health Behaviors.
- Changing Dynamics of the Education-Overweight Relationship in Indonesia: An Instrumental Variables Analysis.
- Obesity Related Out-Of-Pocket Expenditure and Productivity Loss: Evidence from Cross-Sectional Study in Bangladesh.
Epidemiology
- Preprint: Effectiveness of Telehealth Low-Carbohydrate Intervention in Preventing Chronic Kidney Disease.
- Meta-Analysis: Impact of BMI on All-Cause Mortality in Adults.
- Association between Metabolic Obesity Phenotypes and Alcohol-Associated Fatty Liver Disease Among US Adults.
Psychology & Neuroscience
- Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity-2026.
- Pooled Analysis: Prolonged Short Sleep and Its Effect on Body Weight and Composition.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- The Impact of Physical Activity on Health Inequality Among Older Adults: Evidence from China.
- Systematic Review: Cost-Effective Somewhere, Decision-Relevant Everywhere? A Global Systematic Review of Economic Evidence for Newer Type 2 Diabetes Therapies.
- The Burden of Cardiovascular-Kidney-Metabolic Syndrome in High Versus Upper-Middle-Income Countries: Integrated Analysis of Trends, Inequality, and Risk Factors.
- When Skin Color/Race and Education Matter: Disparities in Obesity Among Brazilians (2013-2019).
Stigma
- Binge-Spectrum Eating Disorders and Higher BMI are Associated with Greater Negative Attitudes Towards Obesity.
- Maternal Weight Discrimination Experiences and Restrictive Feeding Practices are Associated with Child Body Dissatisfaction and Drive for Thinness.
Policy Related
- Perspective: Relevance and Implications of Precision Nutrition to Nutrition Education and Behavior Research, Practice, and Policy.
- Ten High-Priority Areas for Health Policy Research in 2026-2027.
Intergenerational Effects
- Metabolites Co-Correlating with Maternal Obesity and Gestational Weight Gain and Offspring Childhood Obesity.
- Review: Maternal Obesity During Lactation as a Hypertensive Cardiovascular Risk Factor in the Offspring.
- Association of Maternal Overweight/Obesity Metabolic Phenotypes with Longitudinal Foetal Anthropometric Measurements.
- Evaluation of Family History Burden in Obesity Among 6-7-Year-Old Children at Pre-School Screening in Southern Russian Cities.
Ecology, Evolution, & Energetics
- Coping with Lactation by an Ephemeral Forager as Pups Get Bigger: Energy Expenditure, Water Flux, Diet and Foraging Activity of Lactating Fish-Eating Myotis (Myotis vivesi).
- Acceptability and Impact on Health-Related Markers of a Sustainable Dietary Pattern.
Methods
- Exposure to Processing from Ultraprocessed Diets and in Feeding Studies.
- Transforming Obesity Medicine with Artificial Intelligence: Personalization, Precision and the Path Ahead.
- Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories.
Commentary
- Bad Idea #40 "The food system is fundamentally broken" with Jan Dutkiewicz.
- Podcast: How Does the Gut-Brain Connection Work?
- US Obesity Crisis: Not Losing Weight Despite Exercising? American Heart Association Study Reveals the Surprising Truth About Your Health Beyond the Scale, Blood Pressure and Cholesterol.
- Non-Pharmacological Interventional Strategies for the Management of Obesity in Aging.
- Role of Calorie Restriction Mimetics in the Management of Obesity in Aging.
- Lost Sleep Affects Weight, and Obesity Is Multifactorial.
- Metabolic Memory in the Gut: The Microbiota-Epigenetic Crosstalk Orchestrating Obesity Onset and Novel Therapeutic Landscapes.
- Building Health from Childhood: One Health Strategies for Obesity Prevention and Nutritional Education in Italy.
General
- Podcast: The Surprising Lack of Breakthroughs in Life Extension Science over 40 Years | Siim Land.
- Targeting Cellular Senescence in Dermatology: Senolytic and Senomorphic Strategies.
- Characterization and Potential Functions of Milk Fat Globule Membrane and Exosome Proteins in Donkey and Bovine Milk: A Comparative Data-Independent Acquisition Proteomic Analysis.
- Podcast: SSRI-Ously? Separating Fact from Fiction on SSRIs.
- Historic Drought in Northern Kenya Shifts Diet and Mobility Away from Traditional Pastoralism as Resource Security and Nutrition Falter.
- Multiomic Profiling of Responses to Clinical and Novel Bisphosphonates Reveals Extraskeletal Effects on Ageing Related Signatures.
- Podcast: Why Do Some People Eat Dirt?
- Researchers Uncovered a Novel Pathway That Causes Epilepsy.