Featured

• Rod Bain and Agriculture Under Secretary for Research, Education, and Economics Scott Hutchins Discuss USDA Research Priorities.
• Cognitive Demands of Bipedal Locomotion During Human Foraging.
• "…limiting a single nutrient, the amino acid methionine, in the diet destabilized DNA organization and led to cancer cell death and increased animal survival."
• Treating Acquired Hypothalamic Obesity.
• The Impact of BMI on All-Cause Mortality Worldwide: A Mathematical Demonstration of Clinical Bias Regarding Causal Risk from Body Composition Measures.

Headline vs Study

• Headline: Yeast Food Supplement Helps Immune Cells Fight Cancer More Effectively.
• Study: Yeast β-Glucan Supplementation Supports Immunometabolic Anti-Tumor Responses and Reverses Obesity-Induced Dysfunction Via Trained Hematopoiesis... In Mice.

Contrary or Null Findings

• Meta-Analysis: "Current evidence indicates that fasting and CR exert minimal to no statistically significant impact on reproductive hormones in adults."
• RCT: "Maternal high-protein/low-glycemic-index diet during pregnancy impairs offspring lipid profile."
• RCT: "This kindergarten-family intervention showed directionally favorable but statistically uncertain effects on BMIz gain after small-sample correction..."
• RCT: No Compelling Evidence of Deleterious Effect of Three Daily Servings of Full-Fat Dairy for 12 Weeks on Body Weight, Body Composition, Energy Metabolism, Blood Lipids, and Dietary Intake of Adults with Overweight and Obesity.
• RCT: Recess Did Not Affect Physical Activity.
• RCT: "...no evidence to support that the administration of fluralaner to domestic dogs diverts the feeding profile of T. infestans to humans at 10 months post-intervention."
• RCT: "No significant group by time interaction was found for depressive symptoms" in “Resistance exercise training compared to a low-intensity sham for depressive symptoms in young women with analogue generalized anxiety disorder.”
• Meta-Analysis of RCTs: "Magnesium supplementation does not appear to improve insulin resistance in individuals with diabetes or prediabetes significantly."

Basic

• Skin Acetone as a Clinical Diagnostic Biomarker of Ketosis.
• Stress-Coping Phenotypes Shape Adipose Tissue Function and Plasticity and Modulate Metabolic Resilience.
• Myeloid MMP14 Couples Extracellular Proteolysis to Inflammatory and Metabolic Remodeling During Obesity.
• Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice Via Extracellular Vesicles.

Scientific Rigor & Scholarly Dialogue

• Preprint: A Systematic Review to Critically Appraise Methodological Rigour in Research on Ultra-Processed Food and Cardiovascular Disease and Hypertension.
• Judge Dismisses Splenda Lawsuit, Says Courts Wrong Place for Research Debate.
• Clark Atlanta University Walks Back Study on Waffle House Workers.

Clinical

• Ecnoglutide: First Approvals.
• Impact of Surgery-To-Conception Interval on Maternal and Perinatal Outcomes Following Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study.
• The Role of Endocrine Factors in Childhood Obesity.
• New Open Access Book: Body Mass Index in Clinical Practice Edited by Samy I. McFarlane.

Children and Adolescents

• A Longitudinal Cohort Study of the Costs of Adolescent Obesity Into Young Adulthood.
• Effects of Positive Childhood Experiences in Adolescence on Obesity in Women.
• Longitudinal Examination of the Family Food Environment and Weight Status Among Children.
• Systematic Review: Risk Factors in the First 1000 Days of Life Associated with Childhood Obesity.

Surgery

• Meta-Analysis: Improvement of Obesity-Related Comorbidities After Bariatric Procedures.
• Review: Obesity and Cardiovascular Disease: Mechanistic Insights and Multimodal Management Strategies.
• What Bariatric Surgery Can Teach Us About Glucagon-Like Peptide-1 Agonist Weight Loss Therapy: Improving Long-Term Outcomes and Patient Care.
• Review: Advanced Robotic Liver Surgery.
• Analysis of the Outcomes and Postoperative Complications of Patients Undergoing Body Contouring Plastic Surgery After Weight Loss.

Drugs

• Kailera’s Oral GLP-1 Asset Sees 11% Weight Loss, Hits Goals in Chinese Phase 3 Obesity and Diabetes Trials.
• Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.
• A New GLP-1 Pill for Diabetes, Semaglutide with Amylin, Data from China, and More from ADA 2026.
• Single Dose Creatine Improves Cognitive Performance and Induces Changes in Cerebral High Energy Phosphates During Sleep Deprivation.
• Review: The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Objective Physical Activity in Adults.

Food & Diet

• Five-Year Patient-Reported Outcomes of Individualized Nutrition Therapy Supporting Nutritional Ketosis in Adults with Type 2 Diabetes.
• Validation of a New Self-Administered Dietary Salt Intake Questionnaire in Patients with Chronic Kidney Disease.
• Ultraprocessed Food Versus Diet Quality in Relation to Cardiometabolic Health and All-Cause Mortality: NHANES 1999-2018.
• Heyehui Attenuates Diet-Induced Obesity Via Regulating LEP/AMPK/ACC Axis and Restoring Intestinal Function in Mice.

Caloric and Dietary Restriction

• RCT: Caloric Restriction Improves Glycemic Control Via the Adiponectin-Ceramide Axis in Men and Women without Obesity.
• Methionine Restriction Plus Vitamin B12 Antagonism Overcomes Methionine Independence for Cancer Therapy.
• RCT: Marked Changes in One-Carbon Metabolism on a Low-Carbohydrate High-Fat Diet.
• Meta-Analysis: The Effects of Fasting and Caloric Restriction on Reproductive Hormones.

Exercise & Physical Activity

• Adverse Pregnancy Outcomes and Sedentary Behavior, Light-Intensity Physical Activity, and Daily Steps.
• In Obesity Treatment, Physical Activity’s Benefits Go Beyond Weight Loss, Says AHA.
• Physical Activity and Quality of Life in Children: Findings from the Health Oriented Pedagogical Project (HOPP).
• Meta-Analysis: Impact of High-Intensity Interval Training on Cardiometabolic Risk Factors in Youth with Overweight/Obesity.

Economics & Sociology

• The Association of Socioeconomic Status and Response to Pediatric Health Behavior and Lifestyle Obesity Treatment in Germany and Sweden.
• Obesity as a Potential Explanatory Factor in the Association between Socioeconomic Position and Multidimensional Cardiometabolic Risk.
• Inhibitory Control Mediates the Association between Perinatal PM2.5 Exposure and Childhood Obesity in Children in the PROGRESS Cohort, Mexico City.
• Exploring the Development and Prevention of the Childhood Obesity Epidemic in Barbados Using the Socio-Ecological Framework: A Qualitative Study.

Epidemiology

• NLRP3 Inflammasome Partially Mediates Genotoxic E. Coli Infection in Lean but Not in Genetically Obese Mice.
• Compositional Analyses of Accelerometer-Measured 24-H Movement Behaviors Among Adults with Normoglycemia, Pre-Diabetes Phenotypes, and Diabetes: A Population-Based Study.
• The Joint Association of Health-Enhancing Walking and Healthful Diet with Central Obesity: A Longitudinal Repeated-Measures Study.
• Metabolically Healthy Obesity Is Independently Associated with 20-Year Incidence of Cardiovascular Disease: Findings from the ATTICA Cohort Study (2002-2022).

Psychology & Neuroscience

• Food Neophobia Is Associated with Lower Self-Reported Physical and Mental Health.
• Diet Quality, Nutrient Adequacy, and Symptom Associations in ADHD: A Case-Control Study of Australian Adolescents.
• Association between Physical Activity and Mental Health in Primary School Children.
• What are the Experiences, Perceptions and Expressed Needs of Adolescents Living with Obesity and Their Mothers in Indonesia? A Qualitative Multi-Method Study.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• RCT: Integrating Executive Function Training with Health Behavior Intervention for Preschool Obesity Prevention in China.
• GLP-1 Drug Announcements and Food Sector Equity Returns: Evidence from a Structural Demand Shock.
• Sustainable Diets and Functional Foods for the Prevention of Cardio-Metabolic Diseases and Sustainable Development Goals of the UNO.
• Where You Live Shapes Diabetes Risk: Multilevel Determinants of Type 2 Diabetes in the East South Central United States.
• Global, Regional and National Intake of Plant-Based Foods Among Youth in 185 Countries (1990-2018): Findings from the Global Dietary Database.

Ethics

• Shocking ‘Leblouh’ Tradition: Fattening Farms in Mauritania, Girls Were Force-Fed Up to 10,000 Calories Per Day to Become ‘Ideal Brides’.
• Prevention of childhood obesity from a bioethical perspective.

Stigma

• Is Agreement with the Statement “Obesity Is a Disease” Helpful or Harmful? Insights from a National Cross-Sectional Survey.
• The Mediating Role of Physical Activity Avoidance in the Association between Weight Stigma and Physical Activity.
• Longitudinal Associations between Weight Self-Stigma, Physical Exercise, and Social Anxiety Among Adolescents: Between-And Within-Person Effects.

Policy Related

• Review: Integrating Policies That Enable Minimally Processed Foods with Policies That Restrict Ultra-Processed Foods for Obesity and Noncommunicable Disease Prevention.
• RCT: Eco-Focused Menu Labels on Full Meal Orders from Fast-Food Restaurants.
• Alternative Breakfast Service Models are Associated with Greater Student School Breakfast Participation. Evidence from Middle and High School Students Across 8 States.
• Out-Of-Pocket Insulin Spending Before and After the Inflation Reduction Act Across Demographic Subgroups.
• Review: Cross-Sector Policies for Achieving Equitable Obesity Prevention and Food Security.

Intergenerational Effects

• Joint Associations of Maternal Smoking and Pre-Pregnancy BMI with Term Low Birthweight and Small-For-Gestational-Age Births: A Cross-Sectional Analysis of 2024 United States Birth Data.
• Association between High Maternal Haemoglobin Levels in the First Trimester and Gestational Diabetes Mellitus: A Prospective Birth Cohort Study.
• How Maternal Diet Shapes Offspring Mitochondrial Physiology.
• Association of Iron Status with Gestational Diabetes and Preeclampsia in an Obesogenic Context: Results from a Cohort of Pregnant Chilean Women.

Ecology, Evolution, & Energetics

• The Endogenous Ghrelin Antagonist, LEAP2, Accelerates Puberty Onset in Conditions of Early Obesity.
• Capsinoids Treatment Reduces Steatosis with Consequent Attenuation in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease in Obese Rats.
• Dietary Glucoraphenin Ameliorates Obesity and Steatotic Liver Disease Associated with Gut Dysbiosis Induced by a Western Diet in Mice.
• Burgers, Brains, and Evolution: Biological and Philosophical Roots of Fat Craving.

Methods

• Systematic Review: Applications of Traditional Machine Learning and Deep Learning Algorithms in Obesity Prediction or Classification.
• An Optimized Ensemble Learning Model for Interpretable and Efficient Obesity Classification.
• Reliability and the Hidden Translational Gaps in Multidisciplinary Clinical Psychological Science.
• Integrative Multi-Omics Analysis of DNA Methylome and Transcriptome in a Tyrosine Kinase Inhibitor LPM4870108-Induced Rat Model of Obesity.

Commentary

• Podcast: No More Raw Cookie Dough with food scientist Roxi Smith.
• Podcast: GLP-1 Muscle Loss and Creatine, Bulking vs Cutting, One-Hour Training, & Detraining.
• Podcast: First RCT of Keto for Schizophrenia & Bipolar Disorder: Results & Future Directions.
• Podcast: Dietary Guidelines and the Gap in Cardio-Protective Flavanol Intake.
• Does Metabolically Healthy Obesity Really Exist: Going Toward New Definitions.
• Creatine a Supplement with a Rare Commodity: Evidence.
• Moral Panic About GLP-1s at Wimbledon.
• GLP-1s Meet Culture and Things Get Complicated.

General

• Intermittent Hypoxia Induces Reversible Epigenetic Age Acceleration in Old Mice.
• Immune Aging Biomarkers for Clinical Trials.
• Meta-Analysis: Risk Factors for the Development of Food Allergy in Infants and Children.
• JAMA Medical News Director Jennifer Abbasi and Associate Managing Editor Kate Schweitzer discuss "Testosterone Therapy: Does New Evidence Warrant Broader Prescribing?"
• Genome Editing in Rats Enables More Accurate ER+ Breast Cancer Models.
• How Healthy Is Your Brain? We Now Know How to Find Out.
• Food Without Fire: Environmental and Nutritional Impacts from a Solar Stove Field Experiment.

Announcements

• Secretary Rollins Announces Growing Momentum Behind USDA’s Product of USA Label with 10 New Companies Joining Initiative.
• USDA, HHS, EPA Join Forces to Bolster Consumer Protections from Heavy Metals and Other Contaminants in Food.
• The Translational Research Institute for Space Health (TRISH) at Baylor College of Medicine Has Released a New Solicitation Seeking Proposals to Address Venous Thromboembolism (VTE), a Critical Risk to Human Health During Spaceflight.