Featured

• Review: Effects of Dietary Protein Quantity, Source, and Type on Plasma Lipids and Lipoproteins and Their Roles in Dyslipidemia Management in Humans.
• "Bad Air" or the Tobacco Industry Playbook? Which is the better metaphor for the controversy over ultra-processed foods?
• Paternal Dietary Macronutrients Affect the Seminal Vesicle Fluid Proteome and Fetal Development: A Geometric Framework for Nutrition Study in Mice.
• Review: Macronutrient Mixtures - Interactions in Health and Disease.
• Appetite Suppression by GLP-1 Receptor Agonists: Role of Delayed Gastric Emptying.

Headline vs Study

• Headline: Protein Source Key for Weight Loss After Menopause.
• Study: Secondary Analysis of RCT Designed to Compare Two Completely Different Diets (Vegan Diet with 86g Cooked Soybeans to a Usual Diet) for Hot Flashes in Postmenopausal Women. Study Does Not Test Specific Effects of Protein Source.
• Headline Critique: Solid Soy + Hot Flash Data. Weak Protein Claim.

Contrary or Null Findings

• RCT: "[N]o significant group or group × time interaction effects were observed, indicating that probiotic supplementation did not provide measurable additional benefits beyond CER for the outcomes assessed."
• RCT: "No statistically significant difference was observed between the two groups in terms of body weight, BMI, waist circumference, systolic and diastolic blood pressures, serum fasting glucose, and lipid profile at the end of week 12" in “Effects of synbiotic supplementation on cardiometabolic risk factors in overweight or obese calcium oxalate stone formers.”
• "However, contrary to the original brain lag hypothesis, the brain/body ratio does not converge back on the allometric regression line, but continues to evolve beyond it."
• "Contrary to our hypothesis, fiber-fed horses appeared to elicit a more robust acute inflammatory response to exercise than starch-fed horses despite an altered gastrointestinal microbiome."
• "Contrary to our hypotheses, disordered eating behaviors were more strongly associated with emotion regulation difficulties at lower levels of urgency."
• "[D]uring insecticide exposure food consumption by larvae was reduced, but it increased after exposure at least in females, suggesting sex-specific compensatory feeding. Contrary to our predictions, we mostly found additive effects of the combined exposure, but an interactive effect on female relative consumption rate."
• "Contrary to our hypothesis, obesity was associated with significantly lower postoperative opioid use over the total inpatient stay following PSF with LB."
• "Contrary to conventional assumptions favoring standardized conditions, high-quality consumer smartphone photography significantly outperformed controlled laboratory imaging..." for diet nutrition measurement.

Basic

• Fish Oil and Evening Primrose Oil Have Ameliorative Effects on Obesity-Associated Complications in Olanzapine-Administered Rats.
• Impact of Simulated Obesity in Animals on RANK/RANKL/OPG Pathway During Orthodontic Tooth Movement.

Scientific Rigor & Scholarly Dialogue

• Correspondence: Concerns with the Statistical Analysis in “Effect of Combined GLP-1 Analogue and Bupropion/naltrexone on Weight Loss: A Retrospective Cohort Study”.
• Podcast: So You Want to Stop Falling for Nutrition and Fitness Misinformation.
• Video: Statistical Critique of Keto-CTA Preprint.

Clinical

• Very-Low-Energy Ketogenic Therapy Modulates the Metabolic–Antioxidant Axis in Patients with Obesity and Type 2 Diabetes: A Non-Randomized Clinical Trial.
• RCT: Survodutide in Adults with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease.

Children and Adolescents

• Cross-Cultural Adaptation and Preliminary Validation of the Adolescent Obesity Environmental Questionnaire (AOEQ) in LMICs: Family, School, and Peer Contexts.
• Ecological Predictors of Daily Dietary Intake in Black Adolescents with Overweight and Obesity in the Families Improving Together (FIT) for Weight Loss Trial.
• The Use of BMI Polygenic Risk Score (BMI-PRS) in a Paediatric Population with Obesity.
• Adolescent BMI as a Strong Predictor of Pre-Pregnancy Obesity in Arkansas Mothers.
• Childhood and Adolescent Obesity Prevention: From Evidence to Implementation in Complex Systems.
• Review: Family-Based Dietary Counselling in Pediatric Obesity: A Proposed System-Oriented Framework Integrating Home, School, and Social Environments.
• Longitudinal Associations of Neighborhood Food Access with Child BMI and Obesity.

Surgery

• Obesity Attenuates the Association between the Modified Five-Item Frailty Score and Mortality in Septic Surgical Patients.
• High and Low BMI and 90-Day Postoperative Outcomes in Patients with Crohn’s Disease Undergoing Abdominal Surgery.
• Observational Study: The Influence of Emotional Dysregulation on Bariatric Surgery Outcome.
• Robotic-Assisted Primary Total Hip Arthroplasty Is Not Associated with Superior Clinically Meaningful Patient-Reported Outcomes or Complication Rates in Patients with Obesity.
• Transcriptomic Signatures for Personalised Obesity Treatment: Insights from Adipose and Blood Tissues.
• Bilateral Manual Subcutaneous Fat Retraction to Facilitate Landmark Guided Spinal Anaesthesia in Patients with Morbid Obesity - A Case Series.
• Outcomes of Metabolic and Bariatric Surgery Among Adolescents and Young Adults in Southern Louisiana.
• Maternal and Neonatal Outcomes After Bariatric Surgery in Pregnancy: A Cohort Study Comparing Women with and Without Prior Bariatric Surgery.

Drugs

• RCT: Orforglipron and Markers of Insulin Sensitivity and Beta-Cell Function by Prediabetes Status in Adults with Obesity: A Post Hoc Analysis of the ATTAIN-1 Trial.
• Systematic Review: The Efficacy of Antidepressant Therapy on Obesity.
• Shifting the Goalposts in Obesity Drug Development.
• Correspondence: Are GLP-1 Receptor Agonists Gerotherapeutics or Just Treatments for Obesity?

Food & Diet

• Changes in Food Patterns over a 10-Year Period in the UK Adult Population; Findings from the National Diet and Nutrition Survey.
• RCT: Effect of Incorporating 1 Avocado Per Day on Lipoprotein Particle Concentrations Compared to Habitual Intake in Adults with Abdominal Obesity.
• Listening to Children with Obesity: Lived Experiences of Hunger, Cravings, and Satiety.
• Natural Approaches to Appetite Suppression in Obesity: Mechanisms, Evidence, and Clinical Integration.
• Systematic Review: Linking Diet and Obesity Among Young People Living in Sub Saharan Africa.

Caloric and Dietary Restriction

• RCT: D-Allulose as a Low-Calorie Sweetener: A 30-Day Study on Gastrointestinal Tolerance and Systemic Safety to Support Its Application in Healthy Diets.
• Maternal Undernourishment Impairs Murine Placental Development During Pregnancy.
• Loss of the Calorie Restriction Response Protein DEPP1 Worsens Diet-Induced Obesity.
• Meta-Analysis: Response of FTO Gene Polymorphisms to Continuous Caloric Restriction Diets on Lipid and Glycemic Biomarkers in Adults with Overweight or Obesity.

Exercise & Physical Activity

• Physical Activity in Women with Obesity: Fatigue, Knee Symptoms, and Functional Capacity.
• Physical Activity Among Active-Duty US Military Servicemembers with Overweight and Obesity.
• Review: Physical Exercise and MiR-146a in Type 2 Diabetes and Obesity.
• Association of Anthropometric Measures, Physical Activity, and C-Reactive Protein Level with Musculoskeletal Symptoms in Children with Excess Weight.
• Meta-Analysis: Aerobic and Resistance Exercise Improves Glucose Metabolism and Insulin Resistance in Children and Adolescents with Overweight or Obesity.
• Commentary: Strengthening the Metabolic Alliance: Exercise as an Essential Partner of Obesity Pharmacotherapy.

Economics & Sociology

• Preprint: Trends in Obesity and Socioeconomic Status in the Peruvian Population between the Years 2015-2024: An Analysis of a National Survey.
• The Burden of Obesity in Argentina (2005–2022): The Role of Socioeconomic Status and Gender in Shaping BMI Trends.

Epidemiology

• Sociodemographic Determinants and Prevalence of the Metabolic Risk Factors and the Metabolic Syndrome Among Women 20-49 in Kirinyaga County, Kenya.
• A Body Shape Index Is a Better Predictor of Overall and Cardiovascular Mortality Than BMI.
• Report: Obesity, Severe Obesity, and Abdominal Obesity in US Youth and Adults from 1999 to 2023.
• Metabolic Traits in Obesity and Normal BMI in Industrialised Countries: A Multi-Country Analysis of National Population-Based Studies.
• Understanding the Impact of the Follow-Up Period on the Association between Excess Body Weight, and Cardiovascular Events and Mortality.
• Review: Diagnosis and Evaluation of Sarcopenic Obesity.

Psychology & Neuroscience

• Obesity-Related Circulating Endothelial Extracellular Vesicles Negatively Affect Cerebral Microvascular Cell Function.
• The Joint Association of Obesity and Low Handgrip Strength with Cognitive Impairment and Probable Dementia: A Cross-Sectional Study.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Circulating mRNA and miRNA Signatures Used as Predictive Markers of Lifestyle Modification Outcomes in Pediatric Obesity Management.
• Socioeconomic Inequalities and Trends in the Prevalence of Childhood Obesity Phenotypes in Iran from 2000 to 2030.

Stigma

• Review: Wounds of the Body, Wounds of the Self: Addressing Shame in the Care of Patients Living with Obesity and Chronic Wounds.
• Weight Discrimination and Cardiometabolic Health in Underrepresented US Adults.

Policy Related

• Changes in Sugar-Sweetened Beverage Intake from Before to After Nutrition Labeling Policy Implementation: A Comparison of Mexico and the United States.
• Child-Directed Marketing on Product Packages of Sweet Snacks, Cereals, and Yogurts: Content Analysis and Association with Nutrition Quality.
• Review: Using Early and Periodic Screening, Diagnostic, and Treatment (EPSDT) to Improve Access to Obesity Pharmacotherapy: A Practical Guide for Clinicians Caring for Youth with Obesity Across United States Medicaid Programs.
• State Insulin Out-Of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.
• Predictors of Voucher Redemption in Produce Prescription Programs in a Primarily Low-Income Population with Type 2 Diabetes.
• What Unhealthy Food and Beverage Advertisements Appeal To- and Promote Obesity Amongst- Adolescent Children in Urban South Africa?
• Online Food Delivery and Body Weight: Quasi-Experimental Evidence from China.

Intergenerational Effects

• "...lactation was the period of greatest vulnerability to dehydration...Heat stress and droughts exacerbate maternal and infant health risks..."
• Umbilical Vein Blood Flow in Macrosomic Fetuses with and without Pre-Gestational Diabetes.
• Obstetrical and Medical Outcomes Following GLP-1 Receptor Agonist Exposure in Pregnancy.

Ecology, Evolution, & Energetics

• Parent-Offspring Conflict Drives Selection for Integrated Egg Traits in the Male-Incubated Emu Egg.
• Metabolic pathways fueling human spermatozoa capacitation and hyperactivation: a roadmap for spermatozoa bioenergetics.

Methods

• Adherence of Artificial Intelligence Models to Brazilian Guidelines for Obesity in Primary Health Care.
• Decision Tree-Based Prediction of 5-Year Weight Trajectories After Bariatric Surgery in Adolescents and Young Adults: A Retrospective Cohort Study from France and Sweden.
• Trends and Themes in Artificial Intelligence Applications for Obesity: A Bibliometric Mapping Study.
• An Interactive Web-Based Tool for Computing BMI Standard Deviation Scores in Italian Children and Adolescents Using National Growth References.

Commentary

• Podcast: Special Edition: Medications in the Pipeline for Cardiometabolic Disease.
• Excuses to Continue Neglecting Obesity Care.
• #398 ‒ AMA #86: GLP-1 RAs and Muscle Loss: New Data, Better Questions, and How to Preserve Muscle During Weight Loss.
• Why Prenatal Vitamins Matter.
• Webinar: Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health.
• One ‘Bad’ Fat Is Making Longevity Researchers Think Twice.
• Podcast: Is the Protein RDA Too Low for You? What 40 Years of Studies Show - Dr. Don Layman & Dr. Heather Leidy | GLS #214.
• Podcast: GLP-1s & Novel Peptides in Obesity, Diabetes & Metabolic Health | Katrin Svensson | Episode 298.

General

• Brain Activity Under Anesthesia Challenges What We Know About Consciousness.
• Evaluating the Accuracy of Large Language Models in Selecting Appropriate Statistical Tests for Healthcare Research.
• Podcast: Dr. Amy Boddy Explains Microchimerism: How Much of You Is Actually You?
• Letter: Longitudinal Changes in Epigenetic Clocks Predict Survival in the InCHIANTI Cohort.
• More Flowers, More Pollinators, Less Fruit: Drought Increases Insect Visitation but Reduces Yield in Cucumber.
• Podcast: How Does Ketchup Work?
• Podcast: That's Pediatrics: Breast Milk Antibodies and the Prevention of Necrotizing Enteritis in Premature Infants with Timothy Hand, MD.
• Podcast: #612: Does Sweet Taste Exposure Actually Develop Preference? - Prof. Katherine Appleton.

Announcements

• New Investigator Takes Off Running: Dr. Olivia Ginnard.
• The Wonder We Share; The Responsibility We Carry.