06/26/26
Featured
- RCT: The Effects of Acute Ketone Monoester Supplementation on Brain Insulin Responsiveness and Cognitive Performance.
- A Ratiometric Photoacoustic Nanoprobe for Dynamic Profiling Energy Metabolism in Liver Injury and Caloric Restriction-Based Cancer Therapy.
- "The latest benefit of obesity drugs: boosting testosterone and sperm quality. Preliminary study finds that testosterone levels increase or stabilize in people taking GLP-1 medications."
- Chug, Run, Repeat: A Statistical Analysis of Beer-Mile Performance.
Headline vs Study
- Headline: Body Mass Index Found to Drastically Underestimate Obesity Levels in the United States.
- Study: Differences between Two Definitions of BMI (BMI-Based vs Lancet Commission). 'Underestimate' Assumes the Lancet Commission Is the Only 'Correct' Definition.
Contrary or Null Findings
- Semaglutide (Ozempic) Linked to Fewer Bone Fractures Despite Greater Weight Loss.
- Preprint of RCT: "In the entire cohort, there were no differences between diet conditions in brain response" to a 2 week cross-over of a UPF vs non-UPF diet.
- RCT: "None of the peptides or metabolic markers changed significantly after the intervention diet. Even though glucose, insulin and C-peptide levels decreased following the diet intervention, none of the values reached statistical significance" in "A Healthy Diet Intervention Alters Food Preferences and Eating Behaviours Without Changing Appetite, Adipokines or Glucose Homoeostasis."
- "Current evidence is insufficient to determine whether structured step aerobics improves psychological well-being in nonclinical populations."
- Meta-Analysis of Clinical Trials: "Taken together, the present study found no significant overall effects of oral L-carnitine supplementation on cardiometabolic risk factors in HD patients."
- RCT: No Effects of Ganoderma lucidum Polysaccharide Peptide on Inflammatory and Metabolic Biomarkers in Patients with Obesity and Cardiometabolic Syndrome.
- "Contrary to common clinical assumptions, traditional host-related risk factors such as gender, obesity, and diabetes do not consistently predict adverse outcomes after abdominal wall hernia repair when clinical heterogeneity is rigorously accounted for."
- "Our model of Stegoceras validum-the first for any pachycephalosaur-suggests that its feeding performance was much closer to that of basal ornithischians and ornithopods than expected for a derived Late Cretaceous taxon and contrary to the derived feeding performance of Psittacosaurus lujiatunensis, another marginocephalian."
- "Contrary to predictions, we found no evidence that higher temperatures increased the growth (mass or total length) of Eastern Hellbenders. ... These results challenge assumptions about the role of temperature in captive rearing outcomes and suggest that future research focus on other variables (e.g., diet, density) that might enhance captive-rearing efficiency."
- "...impaired inhibitory processing, rather than exaggerated reward signaling, may underlie excessive weight gain in chronic pain patients."
Basic
- Deletion of Tgf-β1 from CD206+ M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.
- Puerarin Ameliorates Obesity-Induced Spermatogenic Dysfunction by Targeting GRP78/StAR to Increase Testosterone Synthesis.
- Adiponectin Exerts Sex-Dependent Effects on Lipid, Amino Acid, and Glucose Metabolism During Caloric Restriction.
- CD300e Modulates Metabolic Programs in Adipose Tissue Macrophages During Obesity.
Scientific Rigor & Scholarly Dialogue
- Classification Without Calibration: The Internal Logical Incoherence of Nova and Its Conflict with Dose-Dependent Biological Reasoning.
- Podcast: Statistical Sleuthing of a High-Carb/Endurance Paper.
- Is the US worse than North Korea for malnutrition deaths?
- Precision Exercise, Personalized Exercise, and Exercise Non-Responders: Still No Black Cat.
- Article: Sustainable Diets Reduce Diet-Related Greenhouse Gas Emissions and Improve Diet Quality: Results from the MyPlanetDiet Randomized Controlled Trial.
- Letter: Teaching to the Test and Differential Reporting Bias Undermine Inferences from the MyPlanetDiet Randomized Controlled Trial.
- Reply: To L Veras et al.
Clinical
- Beyond Inflammation - A Multidisciplinary Approach to Managing Obesity and Cardiometabolic Risk in Inflammatory Bowel Disease.
- RCT: Impact of Weight Loss and Reduction of Ultra-Processed Foods on Liver Fat Content in MASLD.
- Triglyceride-Glucose-Waist-To-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People with Sarcopenic Obesity.
- Does β-Hydroxy-β-Methylbutyrate (HMB) Have an Anti-Inflammatory Impact in Critically Ill Patients? A Secondary Post Hoc Analysis of an RCT.
- Role of Systemic and Epicardial Adipose Tissue in Cardiometabolic Disease.
Children and Adolescents
- The Role of the Pediatrician to Promote Effective Approaches for Child and Adolescent Nutrition in Schools: Policy Statement.
- Are Energy Expenditure and Substrate Oxidation Implicated in the Control of Energy Intake in Adolescents with Obesity?
- The Association of Parental Depression with Adolescent Obesity.
- Obesity and Self-Perception in Adolescents: Investigating the Psychological Burden Beyond Metabolic Risks.
- Exposure to Food Additives, Dietary Indicators, and Adiposity in Chilean Preschool Children.
Surgery
- Reversal of Obesity-Related Spinal Epidural Lipomatosis After Metabolic and Bariatric Surgery: A Case Suggesting the Role of Ectopic Fat Reduction. (pdf)
- Toward an Intergenerational Model of Metabolic and Bariatric Surgery: Reframing the Household as the Unit of Care.
- Perceptions of Obesity and Treatment Decision-Making Among Hispanic-Latino Adults: Barriers to Metabolic and Bariatric Surgery.
- Preprint: When BMI Exceeds 50: What Ten Years of Follow-Up Reveal After Bariatric Surgery (BARI-10-POL Study).
Drugs
- Negative Effects of Semaglutide on Bone in Obese Mice.
- Experience with Tirzepatide and Weight Management During and After a Clinical Trial in Japanese Patients with Obesity Disease: A Qualitative Study.
- Pharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants with Obesity or Overweight.
Food & Diet
- Preprint of RCT: Comparison of a Ketogenic Diet Program to the ADA Standards of Care in Patients Living with Diabetes.
- The Pharmacological Window Hypothesis: How Emerging Obesity Medications May Realize Decades of Plant-Forward Dietary Recommendations.
- A Critical Review of the Science on “Highly” Processed Food Intake and Body Weight.
- Are There Age-Related Differences in Glycaemic Response and Glycaemic Index?
Caloric and Dietary Restriction
- Effect of an Acute Prolonged Overnight Fast on Skeletal Muscle Insulin and Anabolic Sensitivity in Healthy Men.
- RCT: Time-Restricted Eating Versus Dietetic Guidance on Glycaemic Outcomes in Adults at Risk of Type 2 Diabetes.
- RCT: Effect of Time-Restricted Eating on Metabolic Adaptation in Adults with Severe Obesity During Early Phase of Weight Loss.
- Meta-Analysis: Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity.
Exercise & Physical Activity
- Endurance Exercise Elicits Temporal and Sexual Dimorphic Multi-Omics Remodeling of Liver Metabolism Revealed by MoTrPAC.
- Sprint-Interval Training with Post-Exercise Blood Flow Restriction Increases Mitochondrial Content and Respiration.
- Excessive Training Does Not Induce Mitochondrial Dysfunction or Impair Insulin Signalling Within Skeletal Muscle.
- Preprint: Acute Aerobic Exercise in Individuals with Obesity Abolishes Amino Acid-Stimulated Muscle Protein Synthesis in the Immediate Postexercise Period.
Economics & Sociology
- What Happens to Adults, from Different Socio-Economic Backgrounds, Who Join a Community Weight Management Programme? Long-Term Outcomes Up to Nine Years After First Joining.
- Area-Level Socioeconomic Status and Children’s Body Weight: Examining the Role of Unhealthy Food Environments.
- Female Obesity and Socioeconomic Gradients in Small Island Developing States.
- The Impact of Working from Home on Obesity in Australia.
Epidemiology
- Obesity Prevalence Varies Markedly by Definition.
- Trends in Overweight Prevalence Among University Freshmen and the Impact of the COVID-19 Pandemic.
- Real-World Obesity Prevalence and History in 79 271 Patients Receiving Systemic Anticancer Therapy Across 13 Cancer Types in England.
Psychology & Neuroscience
- Preprint: Interconnected Influences of Diet, Gut Microbiome, and Metabolome on Cognition Across Three Metabolomics Platforms.
- Emotions, Emotion Regulation, and Eating Behavior in Women with a Healthy Weight and Women with Obesity: A Daily Life Study.
- RCT: Ghrelin Predicts Food Consumption Up to Three Hours Prior to Eating.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Area-Level Socioeconomic Inequalities in Adiposity Among Older Adults: The Moderating Effect of Neighborhood Walkability.
- Cardiometabolic Burden and Diabetes Medication Acquisition Among Adults with Diagnosed Diabetes in Peru: A National Survey Analysis, 2022-2024.
- Perceptions of Obesity and Treatment Decision-Making Among Hispanic-Latino Adults: Barriers to Metabolic and Bariatric Surgery.
Stigma
- Stigmatizing Attitudes and Misconceptions About Obesity Among Spanish Healthcare Professionals.
- Addressing Weight Stigma in Healthcare Settings Using an Obesity Checklist.
Policy Related
- Tackling the Social Determinants of Childhood Obesity in the United States: Policy Brief and Lessons for Developed and Emerging Economies.
- Obesity Prevention and Sustainable Food Systems: Rethinking the Nexus Through a Health in All Policies Approach.
- Can Public Data Openness Enhance Public Health Resource Allocation Efficiency? Evidence from the Launch of Chinese Government Data Platforms.
Intergenerational Effects
- Prenatal Cell-Free DNA Methylome Detects Association with Autism and Maternal Obesity.
- Elevated Non-Esterified Fatty Acids in Women with Obesity and Late-Onset Preeclampsia: A Cross-Sectional Study.
- How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future.
Ecology, Evolution, & Energetics
- The “Novelty-As-Scarcity” Hypothesis: An Evolutionary Hypothesis to Partially Explain the Global Obesity Epidemic.
- Regulators of Appetite in Mammals - Old and New Players.
Methods
- Preprint: Accuracy of Body Fat Predictive Equations in Adolescent Boys Using Deuterium Dilution Method as Reference: Comparisons Across Nutritional and Physical Activity Profiles.
- Food Substitution Modelling Approaches: A Methodological Study.
- Qualitative Research: A Needed but Neglected Form of Inquiry in Nutrition.
- A Novel Method to Evaluate Insulin Sensitivity by Combining Continuous Glucose Monitoring and Urinary C-Peptide Excretion.
Commentary
- Podcast: BITESIZE: The New Protein Guidelines Reignited the Plant Vs. Animal Debate.
- Fatty Acids, Their Food Sources, and Cardiovascular Disease: Current Evidence and Controversies Surrounding the 2025-2030 Dietary Guidelines for Americans.
- Podcast: Raw Milk.
- Podcast: Vinay Prasad - Longevity Episode 2 - Nutrition Science.
- Podcast: Lisa Richardson - Ins and Outs of Infant Formulas (Bowel Sounds Podcast Collaboration).
- "Overweight and with a metabolism out of whack? Here’s the mathematical model for a personalised diet. The system estimates the energy intake from food more accurately."
- Exercise Decreases Among People Taking GLP-1 Medication.
- Evidence Over Enthusiasm in Maternal and Child Nutrition.
- Does Tirzepatide Activate Brown Fat?
General
- Podcast: OBS Studies vs RCTs - Trial Emulation - RCT Duplicate - We Debate Recent JAMA Paper.
- Podcast: Inside the Lab Taste-Testing the World's Chocolate.
- Simulating Store Management and Competition in Food Retailing.
- Podcast: Is Hyperbaric Oxygen Therapy a Cure-All?
- Colostrum as a Protective Factor Against Peanut Allergy: Evidence from a Birth Cohort.
- Protein Intake & Cancer Risk in Human Observational Studies.
- The ‘Truth Machine’ That Is Changing Math.