06/12/26
Featured
- The Anabolics are Coming: RCT - Apitegromab for Lean Mass Preservation During Tirzepatide-Induced Weight Loss.
- Tracking Changes in Body Composition in Athletes: Are Rapid Four-Compartment Models Valid?
- Podcast: Ozempic, Yo-Yo Diets & the Science of Weight Loss, with Dr. David Allison.
- Drosophila Disengage Systemic Protein Storage as an Evolutionary Response to Chronic Larval Malnutrition.
- Ultraprocessed Foods and Obesity: Interpreting the Evidence.
- Systematic Review: Evaluating the Safety of Creatine Monohydrate in Adolescents.
Headline vs Study
- Headline: Could a Gut Microbe Help Reduce Weight Regain After Dieting? New Study Suggests It Might.
- RCT: Pasteurized (i.e., Dead and Processed) Akkermansia muciniphila MucT Supplement Resulted in Better Weight Loss Maintenance in People with Overweight and Obesity.
Contrary or Null Findings
- RCT: "A 24-week intervention with freeze-dried blueberries had no effect on serum p-tau181 and serum NFL in older adults."
- RCT: "In ELBW infants, providing an additional 1 g/d of parenteral amino acids for 5 days after birth has little to no effect on survival without neurocognitive impairment at school age and may have adverse effects on strength and psychosocial functioning."
- Meta-Analysis: "Vitamin B12 supplementation (alone or when supplemented with other micronutrients) in children may have little to no effect on growth (i.e. height/length), cognitive function (e.g. attention), development outcomes (e.g. motor skill development), or anaemia, compared to placebo, no intervention, or the same supplements without vitamin B12."
- RCT: No Apparent Impact of a Prenatal Nutrition Package with Balanced Energy Supplementation on Gestational Weight Gain in Amhara, Ethiopia.
- "Contrary to our hypothesis, higher BMI was associated with poorer CAT and cognitive performance among participants with HIV."
- "Results are contrary to the established links between executive function and time spent outdoors..."
- Umbrella Review: "Testosterone therapy improved lean muscle mass and strength without adverse effect in older men...There was no effect demonstrated on major cardiovascular events or all-cause mortality."
- "...high-intensity systematic training significantly decreases Body Mass Index and significantly increases osteocalcin levels, whereas other training types had no effect [association]."
Basic
- 15-PGDH Inhibition Promotes Muscle Repair and Strength Recovery During GLP-1 Receptor Agonist-Induced Weight Loss.
- Effects of Changes in Fat Metabolism by Particulate Matter on Endometrium and Infertility.
- STAU1 Fine-Tunes Adipose Thermogenesis by Regulating Ucp1 mRNA Stability.
- Targeting Hypothalamic SIK3 to Promote Weight Loss and Improve Glycemic Control in Mice.
Scientific Rigor & Scholarly Dialogue
- Article: Evaluating Agreement between Individual Nutrition Randomised Controlled Trials and Cohort Studies - a Meta-Epidemiological Study.
- Letter: Concordance between Nutritional Cohorts and Randomized Trials: Biological Confirmation or Statistical Consequence? A Re-Analysis of Stadelmaier et al.
- Response to: Matters Arising in Relation to “Evaluating Agreement between Individual Nutrition Randomised Controlled Trials and Cohort Studies - A Meta-Epidemiological Study”.
Clinical
- Patient Preferences for Pharmacological Treatments for Obesity: The VOICE Study.
- Association of Post-Oral Glucose Tolerance Test Hypoglycaemia with Clinical Features, Incident Diabetes and Mortality.
- Clinical Intervention Following Detection of Incident Diabetes Within a Large Psychiatric Service System: A Chart Review Study.
Children and Adolescents
- Systematic Review: Adolescent Obesity and Risk of Serious Chronic Morbidity and Mortality in Young Adulthood.
- Healthy Lifestyle Synergy and Its Association with Overweight and Obesity Among Parent-Child Dyads.
- Meta-Analysis: Childhood Obesity and Age-Related Diseases.
- What Is Driving Energy Intake After Weight Loss? A Longitudinal Mediation Analysis in Adolescents with Obesity.
- Relationship between Triglyceride-Glucose-Derived Obesity Indices and NAFLD in Adolescents.
Surgery
- Metabolic and Bariatric Surgery Vs. Dietary Counseling in Adults with Severe Obesity: Risk of De Novo Malignancy in a Propensity-Matched Multicentered Real-World Analysis.
- ‘Bridging Therapy’ as a Preoperative Strategy for Bariatric Surgery in Super-Super Obesity: A Report of Two Cases.
- Scoping Review: The Application of Large Language Models in Bariatric Surgery.
- Tirzepatide for Recurrent Weight Gain After Bariatric Procedures: Real-World Evidence of Efficacy and Safety.
- Bariatric Surgery in Adolescents with Obesity: Weight and Cardiometabolic Outcomes - Real-World Data.
Drugs
- Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events in Adults with Obesity and Autoimmune Disease: A Target Trial Emulation.
- Scoping Review: Do GLP-1 Receptor Agonists Sabotage Fat Grafts? GLP-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer.
- Semaglutide Slows Epigenetic Aging in RCT of HIV-Associated Lipohypertrophy.
Food & Diet
- Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance.
- Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.
- Whole-Body Protein Balance During Arctic Military Training Is Unaffected by Dietary Essential Amino Acid or Energy Density.
- Anti-Obesity Mechanisms of Adzuki Bean Saponin.
Caloric and Dietary Restriction
- Dietary Energy Level Modulates Dietary Silver Nanoparticle Toxicity in Zebrafish (Danio rerio): Growth, Oxidative Stress, Fatty Acid Composition, and Bioaccumulation.
- Time-Restricted Feeding Extends Healthspan in Both Sexes and Lifespan in Male C57BL/6 J Mice.
- Untargeted Metabolomics Reveals Effects of Calorie Restriction on Skeletal Muscle in Older Female and Male Rats.
- RCT: 12 Weeks of Caloric Restriction with a Novel Diet in Overweight Cats with Diabetes Mellitus.
- Do the Effects of Early Time-Restricted Eating Vary by Cardiometabolic Phenotype, Age, Sex, or Race?
Exercise & Physical Activity
- Preprint: Ageing Blunts the Phospho-Proteomic Response to Resistance Exercise in Humans.
- Exercise-Induced Changes in Systemic Inflammatory Biomarkers in Populations with Overweight or Obesity.
Economics & Sociology
- The Role of Social Food Infrastructure in Addressing SNAP Participation Gaps: Evidence from Linked Administrative and Ground-Sourced Data.
- Projecting the Macroeconomic Burden of Type 2 Diabetes Mellitus Attributable to High Body-Mass Index in Southeast Asia.
- Abstract: Associations and Interactions of Genetic Predispositions for Taste Preferences and Socioeconomic Status with Hyperpalatable Food Intake.
Epidemiology
- Prepregnancy BMI in Ontario from 2012 to 2022.
- Socioeconomic Development, Longevity and Prevalence of Obesity and Overweight.
- Prevalence and Associated Factors of Obesity Among the Staff of the University Hospital Center of Owendo.
- Dietary Intake of Polybrominated Diphenyl Ethers (PBDEs) and the Risk of Obesity in the French E3N Cohort.
- Review: Epidemiology of Cardiometabolic Multiple Long-Term Conditions.
Psychology & Neuroscience
- Obesity and Depressive Disorders Among U.S. Adults with Disabilities: The Mediating Role of Healthcare Access and the Moderating Effect of Physical Activity.
- Deletion of Neurosecretory Proteins GL and GM Drives Dual Anti-Obesity Effects Via Appetite Suppression and Enhanced Energy Expenditure.
- Adipose Tissue as a Systemic Modulator of Brain Aging: Mechanistic Links between Metabolism, Inflammation and Neurodegeneration.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Association of Lifestyle Behaviours and Socioeconomic Disparities with Overweight and Obesity Among School-Aged Children and Adolescents: A Population-Based Cross-Sectional Study.
- Attenuating the Mortality Risk of Socioeconomic Deprivation in Type 2 Diabetes: Minimum and Compensatory Physical Activity Estimates.
Stigma
- Interventions to Reduce Implicit Weight Bias: A Focus on Mechanisms and Individual Differences.
- Weight Stigma in Cancer Care.
- Internalized Weight Bias Is Associated with Dysregulated Affect and Binge Eating in Daily Life Among Adults of High Body Weight with and Without HIV.
Policy Related
- Examining the Relationship between Meal Costs and the Redemption of the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Benefits in Oklahoma: An Instrumental Variables Method.
- Reducing Unhealthy Consumption While Balancing Health Inequality: The Dual Effects of Explicit Sugar Taxes.
Intergenerational Effects
- Role of Parental Characteristics and Feeding Practices in Childhood Obesity.
- Preprint: BMI Decline and Cognitive Trajectories in Mild Cognitive Impairment: The Role of Maternal History of Alzheimer's Disease.
Ecology, Evolution, & Energetics
- Chapter: Foraging Ecology, Nutrition, and Energetics.
- Nutrient-Driven Histone Acetylation Underlies Energy Storage and Mobilization.
- Auditory Prey Specialization Sustains Fat-Deposition-Free Winter Survival in Morpho-Acoustically Adapted Bats.
- Strong Pleiotropic Effects of a Fatty Acid Synthase on Energy Storage, Sexual Signalling and Reproduction in a Parasitic Wasp.
Methods
- A Deep-Learning Framework Reveals Whole-Body Perturbations at Cell Level.
- Optimizing Machine Learning Models for Obesity Risk Prediction Through Hyperparameter Tuning.
- Reducing Bias and Enhancing Equity in AI-Enabled Precision Nutrition: Addressing Measurement Error Across Wearables, Multiomics, and Dietary Data.
- Carbon Isotope Ratios as Biomarkers for Added Sugar Intake: Fundamental Limitations That Constrain Valid Application.
- Construction and Validation of a Machine Learning Model to Predict the Sarcopenic Obesity Population.
- Examining the Invariance of a Common Household Food Insecurity Measure Across Various Adult and Child Characteristics.
Commentary
- A Global Commitment to Addressing Chronic Liver Disease.
- Podcast: Are Food Preservatives Raising Your Blood Pressure? A New Study Explained.
- What the Ultra-Processed Foods Debate Still Gets Wrong.
- Shouldn't Where We Get Fat (and When) Tell Us Something About Why?
- The Evidence Against 10,000 Steps for Weight Loss Exercise Has Important Health Benefits, but Diet Drives Meaningful Weight Change.
- Dairy Byproducts Hold Promise for Human Nutrition.
- Biomea Fusion Presents New Clinical and Translational Data for Icovamenib at the American Diabetes Association (“ADA”) 86th Scientific Sessions and Announces Expansion of Ongoing Phase I BMF-650 Study.
- Is It Time to Reassess the View of Linoleic Acid and Inflammation?
- Why Should Nutrition Research and Innovation Be Integrated with Environmental Science?
- Benefits Beyond Weight Loss with Survodutide.
General
- AI-Assisted Teams Outperform AI-Led Teams but Not Human-Only Teams in Assessing Research Reproducibility in Quantitative Social Science.
- Preprint: Automating Reproducibility Checks Using Large Language Models.
- Podcast: Peakspan: Defining and Extending the Boundaries of Human Performance.
- Podcast: The Measure of Motion with Dr. Christine Harper.
- Why Psychopathology Researchers Should Avoid Studying One Mental Disorder at a Time: An Intergenerational and Developmental Evidence Base for Understanding ‘p’.
- Data Sharing in Stepped-Wedge Cluster RCTs: Suboptimal Data Availability Despite “Data Available upon Request”. (pdf)
- Data Available upon Request - Time to End the Charade?
- From Replication Crisis to Research Rigor: What Applied Sport Science Can Learn from Psychology.
- OLD DOG - Validating the Dog as an Animal Model for Human Aging Studies.
- Does the Biodiversity of Urban Green Spaces Impact on Human Health.
Video & Audio
- Podcast: Obesity, Liver Disease, and the Patient Voice.
- Podcast: Ketones - Aitor Viribay Energy Series.