Featured

• Podcast: Your Doctor Is Watching the Wrong Number. LDL, ApoB & Heart Risk Explained. - Dr. Kevin Maki.
• Standardising Rodent & Other Animal Diets: A Call for Global Action.
• From Chow to Conclusions: Why Standardising Laboratory Animal Diets Is Essential for Rigor, Reproducibility, and Translational Relevance in Nutrition Research.
• Protein Decoys, Alcohol, and Energy Intake: Testing a Mechanistic-Ecological Model.
• An Appetite for Protein.

Headline vs Study

• Headline: Molecular Switch in Mice Links Energy Burning and Bone Health.
• Press Release: Discovery of Fat-Burning ‘Switch’ Could Lead to Advances in Bone Disease Treatments: In the Longer Run, Obesity Research Also Stands to Benefit from This Breakthrough.
• Study: Discovery of Glycerol Is an Allosteric Activator of Tissue-Nonspecific Alkaline Phosphatase. No Human Bone Treatments or Obesity Breakthroughs Reported.

Contrary or Null Findings

• Meta-Analysis: "Creatine supplementation does not significantly reduce inflammatory biomarkers in humans based on current evidence."
• "These findings are ... contrary to general expectations that higher resource availability should favor larger and more female-biased offspring" in bees.
• "Contrary to expectations, neither self-love nor body image significantly predicted self-acceptance directly. Furthermore, body image did not mediate the relationships between self-love or self-compassion and self-acceptance."
• "Contrary to previous findings, individuals in this sample appeared to be more motivated by alcohol misuse than disordered eating to engage in drunkorexia behavior."
• "Contrary to our expectations, social desirability did not moderate the effect of messages, suggesting that the findings are not attributable to self-presentation strategies" in “The effect of persuasive messaging on attitude and intention to reduce meat consumption - a mediation analysis.”
• "Our meta-analysis of randomised controlled trials comparing home-based interventions with control conditions suggests that home-based physical exercise is feasible and improves aerobic capacity, but does not confer significant benefits for functional capacity, muscle strength or quality of life in children and adolescents with chronic diseases."
• RCT: "In conclusion, this study showed that priming exercise did not improve performance when water polo players were analyzed as a whole group."
• RCT: "These findings do not support a neuroprotective effect of progressive aerobic exercise..." in Parkinson's Disease.
• RCT: "In older patients with overweight and persistent AF [atrial fibrillation], a low-calorie diet and behavioral support program was associated with significant weight loss at 8 months with no safety concerns but did not affect AF symptoms, AF burden, cardiac remodeling, or the need for further rhythm control interventions."

Basic

• Adipocyte-Specific NIK Depletion Enhances Energy Metabolism and Glucose Tolerance in Mice.
• C2orf74 Orchestrates Germ-Leydig Crosstalk to Inhibit White Adipose Tissue Browning in Male Mice.
• Gdf15 Expression in Thermogenic Adipocytes Regulates Diet-Induced Weight Gain in a Sex-Dependent Manner.

Scientific Rigor & Scholarly Dialogue

• Retraction Watch: Widely Criticized Keto Diet Study Retracted.
• Reassessment of Antibody-Based Detection of the Murine T Cell GLP-1 Receptor.
• A Call for Methodological Rigour: Suspending Systematic Reviews and Meta-Analyses of Observational Studies on Ultra-Processed Foods.
• Best (but Oft Forgotten) Practices: Applying the Target Trial Framework in Nutrition Research.
• Letter: Comment on Liu et al. Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies.
• Response to: Comment on Liu et al. Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies.

Clinical

• GLP-1 Agonists in Orthopedic Surgery: A Narrative Review of Bone Health and Surgical Implications.
• Factors That Influence the Implementation of Obesity Support in Dental Settings: An Observational Study in Texas.
• Meta-Analysis: Effectiveness of Pre-Pregnancy Weight Loss Interventions on the Risk of Gestational Diabetes Mellitus in Women with Overweight or Obesity.
• Systematic Review: Virtual Reality Interventions in Obesity and Eating Disorders.
• End-Of-Life Care for Hospitalized Patients with Severe Obesity.

Children and Adolescents

• Evaluation of a Behavioral Intervention to Support Adolescents Undergoing Bariatric Surgery Using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework.
• Systematic Review: Effects of Behavioural Interventions for Preventing Obesity in Young Children from Ethnic Minority Backgrounds.
• Prevalence of Overweight and Obesity Among Children in Greenland: A Growing Concern.
• Association of Birth Weight with General Obesity, Central Obesity, and MASLD in a Nationally Representative Sample of US Adolescents.
• Childhood BMI Trajectories and Risk of Overweight and Obesity in Young Adulthood.
• Early Life Socio Dietary Clusters and Later Overweight and Obesity Up to Age 15 in Australian Children: Evidence from the Longitudinal Study of Australian Children.

Surgery

• Impact of BMI on Two-Year Outcomes Following Meniscal Repairs and Meniscectomies in Pediatric and Adolescent Patients.
• Metabolic - Bariatric Surgery in Elderly Patients - Safety and Effectiveness in a Single-Center Cohort.
• Initiation of GLP-1 Receptor Agonists Treatment After Bariatric Metabolic Surgery and Major Adverse Cardiac Events.

Drugs

• RCT: Tirzepatide for Maintenance of Bodyweight Reduction in People with Obesity.
• RCT: Semaglutide Versus Placebo in Individuals with Poor Weight Loss After Bariatric Surgery.
• Weight Loss by Sodium-Glucose Co-Transporter 2 Inhibitor Canagliflozin Is Followed by Rebound in db/db Mice but Maintained in Fat-Fed Mice Via Circadian Rises in Body Temperature and Locomotor Activity.

Food & Diet

• RCT (Preprint): Ketogenic Diet or Exogenous Ketone Supplementation Restore Menstrual Activity in Women with PMOS: Preliminary Findings.
• The Emerging Role of Branched-Chain Amino Acid Metabolism in Obesity.
• Type I Corn Resistant Starch Attenuates Obesity in High-Fat Diet-Induced Mice by Modulating the Gut Microbiota, Appetite and Lipid Metabolism Genes.

Caloric and Dietary Restriction

• Methionine Restriction Extends Yeast Lifespan By Activating Non-Nitrogen-Starvation-Induced Autophagy Through Limiting Methylation of Protein Phosphatase 2A.
• Metabolic and Urinary Profiles in Normal-Weight, Overweight and Obese Dogs: Clinical Response to an Individualised Weight Loss Programme.
• Meta-Analysis: Effects of Calorie Restriction with and without Strength, Endurance or Mixed Training on Fat-Free and Skeletal Muscle Mass in Individuals with Overweight or Obesity.

Exercise & Physical Activity

• Meta-Analysis: Effects of Prenatal Exercise Interventions on Physical Activity, Sedentary Behaviour, Maternal Health, and Pregnancy Outcomes.
• The Mediating Effect of 24-H Movement Behaviors in the Association between Obesity-Related Comorbidities and Depression: Evidence from a Large-Scale Cohort Study.

Economics & Sociology

• Body Size, Cardiometabolic Risk, and Educational Disparities in Mortality Among U.S. Adults, 1988-2019.
• Association of Socioeconomic Status and Lifestyle Factors with Incident Diabetes Among Individuals with Prediabetes.
• Physical Stature as Human Capital: Consequences of Globalisation and Rising Injuries.

Epidemiology

• Inflammation Does Not Mediate Relationships between BMI/BMI-For-Age Z-Score and Retinol or Retinol-Binding Protein in Adult Women or Young Children Without Underweight, Wasting, or Malaria.
• Meta-Analysis: BMI and Activities of Daily Living Impairment.
• Prolactin in High-Metabolic Risk Pregnancies: Associations with Maternal Obesity and Metabolic Health.
• Antibiotic Use in the First 2 Years of Life Is Related to Longitudinal BMI Trajectories from 0 to 18 Years.
• Association between Obesity and Frailty: A Two-Sample Mendelian Randomization.
• Exome-Wide Association Study of Blood Lipids in 1,158,017 Individuals from Diverse Populations.
• Association between BMI and Mortality in Intensive Care Unit Patients with Sepsis.
• Optimal Dietary Patterns for Lower Weight Gain and Risk of Obesity Surrounding Menopause.
• Prevalence of Excess Adiposity Among US and Canadian Adults with and Without BMI-Defined Obesity.
• Association of BMI with Lower Extremity Long Bone Fracture Location.
• Review: Obesity and Biological Aging Across the Life Course.

Psychology & Neuroscience

• Associations between Food Addiction Symptoms, Food Intake and BMI-For-Age in Children from a Low-Income Region.
• Semaglutide Drives Weight Loss Through cAMP-Dependent Mechanisms in GLP1R-Expressing Hindbrain Neurons.
• Neurobiological Mechanisms of Second-Generation Antipsychotic-Induced Obesity: Interactions between Ghrelin Signaling and Neurotransmitter Systems.
• Meta-Analysis: Influence of Reward-Related Genetic Variants on BMI and Predisposition to Obesity.
• Central Nervous System Adaptation Mechanism of Obesity Induced by High-Fat High-Sucrose Diet: Differences in Brain Function between Obese and Obese Resistant Rats Based on fMRI.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Characterizing Disparities in GLP-1 Receptor Agonist Use Among US Adults with and without Diabetes.
• Health Inequities in Older Adults with Type 1 Diabetes: A Nationwide Registry Analysis of Sociodemographic and Clinical Profiles for Glycaemic Control and Complications.
• Associations of Social Determinants and Lifestyle Factors with Incidence and Dynamic Progression of Type 2 Diabetes in the Chinese Population.
• Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.
• Distribution of Adult Certified Bariatric Surgery Centers in the United States: Are We Meeting the Needs of the People?
• Associations of Racialized Economic Segregation with the Prevalence of Unhealthy Behaviors and Poor Mental Health in the United States.

Stigma

• Weight Stigma Is Associated with Reduced Dietary Diversity in Women and Older Adults with Diabetes.
• Beyond Body Size: Gender Specific Associations between Self-Perceived Body Shape and Experienced and Internalized Weight Stigma.

Policy Related

• Systematic Review: The Impact of Front-Of-Pack Labeling on Social Inequality in Sugar Consumption and Purchase.
• Using Systems Archetypes to Understand System Behaviour and Identify Leverage Points for Change in Local Obesity Prevention in the Netherlands.
• U.S. Consumer Preferences for FDA Healthy Vs. Generic Healthy Food Labels: The Influence of Trust.
• RCT: The Impact of Restaurant Menu Eco Labels on Consumer Meal Selections.

Intergenerational Effects

• Early Maternal Obesity Shapes Offspring Development Through Immune Mechanisms.
• Maternal Obesity and the Embryonic Rewiring of Feeding Circuits: Beyond the Hypothalamus.
• Association between Pre-Pregnancy BMI and Neonatal Outcomes in Women Undergoing Assisted Reproductive Technology.

Ecology, Evolution, & Energetics

• Exploration of the Mechanism of Lipid Droplets Regulating Animal Adipose Tissue Thermogenesis.
• Jump Now, Pay Later: Saltatory Behavior Trades Off with Body Mass and Facilitates Shelter Repair in a Seed-Dwelling Insect.

Methods

• The (ab)use of Food Frequency Questionnaire Data in Substitution Modelling in Nutritional Epidemiology.
• Cross-Cultural Adaptation and Psychometric Validation of the Mindful Eating Scale in Chinese Individuals with Overweight or Obesity.
• Development and Validation of an Explainable Machine Learning-Based Risk Prediction Model for Obesity in Chinese Children and Adolescents.

Commentary

• How Do Fatty15 Gummies Help with Healthy Aging?
• Is Weight Cycling Clinically Harmful?
• Prof Emeritus Arne Astrup, Dairy Foods, Saturated Fats, and the Matrix.
• Scientists Discover How a Father’s Obesity Affects His Children’s Metabolism.
• Retatrutide Results Suggest a Change in the Order of Things.
• The Obesity Epidemic at a Crossroads Progress and Pitfalls.
• Exploring Nutritional Myths and Fake News: Impact and Counteractions.
• Clinical Trial Design Considerations to Improve Equitable Anti-Obesity Medication Access for Youth.
• The Weird Politics of Access to Obesity Care.
• Ultra-Processed Foods: Challenging Corporate Power and Promoting Local Food Systems to Reclaim Health.

General

• Reciprocal Cross-Feeding between Bacteria Can Limit the Emergence of Metabolic Dependencies.
• A Compendium of Reporting Guidelines for Traditional, Complementary, and Integrative Medicine from the Enhancing the QUAlity and Transparency of Health Research (EQUATOR) Network.
• National Academies Unveil a Roadmap for U.S. Statistical Science Through 2035.
• In Math, Rigor Is Vital. But are Digitized Proofs Taking It Too Far?
• Blueberries, Exercise, Memory, and Memories: Combining Open-Minded, Promising Inquiry with Rigorous, Trustworthy Scientific Research.
• Bottlenose Dolphin Reliance on Trawlers in Prey-Depleted Adriatic Sea Regions.
• Peroxisomes Orchestrate Metabolic Flexibility and Longevity Via an Interorganelle Cascade.
• Future of Continuous Ketone Monitoring and Its Utility for Safe Use of Sodium-Glucose Cotransporter-2 Inhibitors in Type 1 Diabetes.
• The Effect of Chronic Exogenous Ketone Use on Aortic Responses in Male and Female HFpEF Rats.

Video & Audio

• Podcast: Obicetrapib: The CETP Inhibitor with Cardiovascular Benefits and Potential Alzheimer's Prevention.
• Webinar: Understanding Metabolic Flexibility: Methods, Mechanisms, and Links to Cardiometabolic Disease.
• Podcast: How Do Clinical Trials Work, and Who Can Participate?

Announcements

• New Podcast Series from Stu Phillips.