Featured

• Nutrition Science Must Be Strictly Scientific: Sugars Terminology Is Not.
• Caloric Restriction Reprograms Skeletal Muscle Molecular Pathways in Non-Human Primates: Potential Relevance to Human Aging Biology.
• Obesity Rise Plateaus in Developed Nations and Accelerates in Developing Nations.
• RCT: Orforglipron for Maintenance of Body Weight Reduction.

Headline vs Study

• Headline: 90-Year-Old Nursing Home Residents Increased Muscle Mass by 174% in Just 12 Weeks. Here’s What They Did 3 Times a Week.
• Study: High Intensity Resistance Training (Not “High-Intensity Interval Training”) in Nonagenarians Showed Pre-Post Increase (Not Control-Corrected Effect Estimate) of 174% in One-Rep Maximum (Not Muscle Mass); Mid-Thigh Muscle Mass Increased 9%.

Contrary or Null Findings

• "Contrary to expectations, adherence to plant-based diet did not mitigate the negative effects of unhealthy supper choices on cognitive function."
• RCT: "No clinically significant changes were observed in body weight, BMI, hematological indices, or renal function in Safety of Lactiplantibacillus plantarum K014 in Healthy Adults."
• "Contrary to our hypothesis, we found no change in fasting blood glucose levels or in the area under the curve with the GTT, indicating that the HF diet and OVX together had no effect on glucose handling in the hypertensive BPH/2J mice."
• "[C]ontrary to our initial hypotheses, core temperature seems to reduce more rapidly in males, skin temperatures appear to be similar between the sexes, and higher metabolic rates in males cannot solely be attributed to body morphology, especially to BSA-to-mass ratio."
• "[C]ontrary to our hypothesis, plasma calcium levels were elevated after three days at high altitude (ANOVA main effect p=0.026; SL: 4.8±0.98 mg/uL; HA: 5.6±0.77 mg/uL) but did not differ across Acetazolamide and placebo treatments (p=0.32)."
• "Contrary to our predictions, succinate concentrations increased 39-fold during torpor, peaked early during arousal but declined in IBE… These results suggest that hibernation presents a hypoxic challenge with potential for oxidative stress upon reoxygenation during arousal."
• "Contrary to predictions that resting should remain invariant as an energetic baseline, resting was the most responsive activity to environmental variation, functioning as a behavioural buffer that absorbs fluctuations in resource availability and thermal conditions, although this flexibility is constrained above a critical temperature threshold with implications for population resilience under projected climate warming."
• "Contrary to our expectations, changes in fecal bacterial composition did not affect innate immunity and body composition with regard to fat and lean mass and bone mineral density."

Basic

• Preprint: High-Fat Diet-Induced Obesity Differentially Alters Circadian Gene Expression Across Peripheral Tissues.
• Neuronal Surface P Antigen (NSPA) as a Novel Regulator of Energy Homeostasis and Adipose Tissue Metabolism.
• Low Dose Systemic AAV-Exendin-4 Gene Therapy for Prader-Willi Syndrome and Dietary Obesity.
• Persistent Adipose Inflammation Despite Metabolic Recovery Reveals Tissue-Specific Immunomodulation by Tirzepatide.
• Caloric Restriction and Aerobic Exercise Differentially Counteract Muscle-Tendon Dysfunction Following Diet-Induced Obesity in C57BL/6J Mice.
• Conditions Mimicking Obesity Result in Mitochondrial Dysfunction in Three-Dimensional in Vitro Cardiovascular Spheroid Models.

Scientific Rigor & Scholarly Dialogue

• New Horizons for the Ro Allison Indiana Dhurandhar Food Noise Inventory: Response to a Letter to the Editor.
• "Half of laboratory mice are not what scientists think they are, a genetic analysis of hundreds of strains that are distributed globally for animal research has found."
• "But how real are “blue zones”? And has the concept’s commercialization drowned out its scientific value?"
• Improve Genetic Quality Control to Increase Rigor and Reproducibility of Mouse Research.
• ‘Comically Bad’ Datasets Used to Train Clinical Models for Stroke and Diabetes.

Clinical

• RCT: Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes (PRISM).
• Narrative Review: Nutraceuticals as Modulators of Genetic, Epigenetic and Hormonal Factors in Obesity.
• Effect of Obesity and Endocrine Therapy on the Prognosis of Premenopausal Women with HR+HER2-Breast Cancer.
• Prevalence of Pre-Clinical Obesity Among US Adults Receiving Medical and Surgical Obesity Treatment.

Children and Adolescents

• Longitudinal Associations between Adherence to 24-H Movement Guidelines and Physical Fitness and Body Composition in Pediatric Overweight and Obesity.
• Genetic Variants in the Leptin-Melanocortin Pathway and Their Joint Effects with Physical Activity and Sleep Duration on Risk of Childhood Obesity.
• Cumulative Effects of Excess Weight, Sleep Quality, and Depressive and Anxiety Symptoms in Chinese Adolescents.

Surgery

• Targeting Hepcidin to Restore Oral Iron Efficacy After Vertical Sleeve Gastrectomy.
• Metabolic and Body Composition Shifts After Adrenalectomy in Unilateral Primary Aldosteronism.
• Meta-Analysis: Effects of Semaglutide on Dumping Syndrome and Reactive Hypoglycemia After Bariatric Surgery.

Drugs

• RCT: Tirzepatide for Maintenance of Bodyweight Reduction in People with Obesity in the USA.
• Effectiveness and Safety of Semaglutide in Type 1 Diabetes: A Danish Nationwide Cohort Study (2018-2024).
• RCT: Ixekizumab with or Without Tirzepatide in Adults with Psoriasis and Overweight or Obesity.

Food & Diet

• The 5:2 Diet Induces Male-Specific Weight Loss and Sex-Independent Enhancement of Lipid Storage in Mice Via Activation of GHSR.
• Highly Processed and Ultra-Processed Foods and Health: Balancing Evidence and Everyday Eating.
• RCT: The Effect of Pre-Exercise Protein Sources Compared to Fasted and CHO on Substrate Metabolism During Sub-Maximal Exercise and 4 km Time-Trial Performance.
• Decoding the Sweetpotato Proteome: Proteogenomic Insights Into Development, Metabolism, and Stress Responses.
• Narrative Review: Artificial Sweeteners and Gut Microbiota: Mechanistic Insights and Implications for Metabolic Health.

Caloric and Dietary Restriction

• Exploring the Impact of Intermittent Fasting Plus Time-Restricted Eating Versus Calorie Restriction on Eating Behavior, Mood, Sleep, Quality of Life in Adults with Obesity.
• Planetary Health Diet Adherence Improves Weight and Body Composition During Energy Restriction.
• Meta-Analysis: Effects of Calorie Restriction with and without Strength, Endurance or Mixed Training on Fat-Free and Skeletal Muscle Mass in Individuals with Overweight or Obesity.

Exercise & Physical Activity

• Scoping Review: Multimechanistic Actions of Functional Factors in Enhancing Physical Strength and Endurance.
• Meta-Analysis: Impact of Physical Activity and Exercise Interventions on White Matter Integrity in Populations with Overweight or Obesity.
• Effects of Hybrid-Type Multicomponent Exercise Training on Cardiopulmonary Capacity, Resting Metabolic Rate, and Muscle Strength Following Bariatric Surgery.

Economics & Sociology

• The Health Cost of Convenience: Food Delivery Platform Expansion and Obesity.
• RCT: Effectiveness and Cost-Effectiveness of Text Message and Financial Incentives for Weight Management in Men with Obesity.
• Entrepreneurial Intention and Action in Response to Obesity: The Roles of Health and Psychosocial Experience.

Epidemiology

• Nationwide Trends in Overall and Abdominal Obesity Among Korean Adults, 2007-2022: An Age-Period-Cohort Analysis.
• Meta-Analysis: Global Prevalence of Underweight and Overweight/Obesity Among Migrant Workers.
• Association of Visceral Obesity Indices with Survival Among Cancer Survivors.
• Metabolomic Pathways Distinguishing Metabolically Healthy and Unhealthy Obesity from Normal-Weight.
• Adiposity-Based Obesity Classification and Cardiometabolic and Kidney Outcomes: A Longitudinal UK Biobank Analysis.

Psychology & Neuroscience

• Binge Eating, Multimorbidity and Sociodemographic Characteristics are Associated with a High Prevalence of Depression and Anxiety in Adults with Class II and III Obesity.
• Fasting Ghrelin as Mediator between Obesity and Depressive Symptoms: A Pre-Registered Study.
• Altered Effective Connectivity between the Prefrontal Cortex and Caudate in Children with Overweight and Obesity.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Obesity Has Risen in All Countries - But at a Faster Pace in Poorer Ones.
• Determinants of Obesity: The Role of Sociodemographic Factors, Health Behaviors, and Quality of Life in Spanish Workers.
• Dissertation: Dietary Acculturation, Dietary Inflammatory Potential, and Metabolic Syndrome Among Immigrants in the United States: A Mixed-Methods Approach Using NHANES and Qualitative Data.
• Obesity and Cardiovascular Risk in Down Syndrome: Challenges and Updated Management.

Stigma

• Changing Internal Medicine Residents' Attitudes Towards Managing People with Obesity Using an Interactive Educational Session with Lecture and Embedded Real-Life Patients' Experiences.
• RCT: The Effect of Online Fitness Combining Dietary Intervention on Body Composition, Body Shame and Self-Esteem in Young Adults.
• RCT: Exercise-Based Obesity Simulation Reduces Weight Bias and Improves Clinical Decision-Making in Health Professions Students.
• The Weight of Society: A Qualitative Study on How Social Norms Shape Body Size and Weight Ideals.

Policy Related

• Factors Associated with SNAP Online Fruit and Vegetable Purchasing Among Produce Incentive Program Participants.
• Who are the Long-Term and Short-Term Users of Meals on Wheels Services in the 65+ US Population?
• Scoping Review: Serving Size and Consumption Frequencies in Food-Based Dietary Guidelines: A Global Scoping Review.
• Effect of Social Media Advertisements on Adolescents' Sugar-Sweetened Beverage Choices: A Randomized Field Experiment.

Intergenerational Effects

• Review: Parental Microbiome Programming of Early-Life Neurodevelopment: Multi-Niche Contributions Through the Microbiome-Gut-Brain Axis.
• Potential Impact of Revising the Diagnostic Criteria for Gestational Diabetes on Maternal Pregnancy and Infant Perinatal Outcomes.

Ecology, Evolution, & Energetics

• Altered Mitochondrial Bioenergetics in Skeletal Muscle of Horses with Pituitary Pars Intermedia Dysfunction.
• Rapid Adaptive Increase of Amylase Gene Copy Number in Indigenous Andeans.

Methods

• A New Way to Define Obesity.
• Does the European Association for the Study of Obesity New Definition Better Capture the Risk of Functional Limitation?

Commentary

• Webinar: A Recipe for Creativity in [Nutrition] Research: Cross-Fertilization, Credulity, Constraint, Contrarianism, Conversation, Courage.
• Plenty of Food Noise in Istanbul at ECO2026.
• On the Importance of Including Both Sexes in Animal Studies - Insights from Home-cage Monitoring.
• ECO2026: Rigor on Obesity and Eating Disorders.
• Framework for the Pharmacological Treatment of Obesity and Its Complications from the European Association for the Study of Obesity (EASO): 2026 Update.
• "A protein called HSL, long believed to simply release stored fat when the body needs energy, turns out to have a second job deep inside the nucleus of fat cells—helping keep those cells healthy and balanced. Even more surprising, people and mice missing this protein don’t become obese as expected."
• Obesity Pharmacotherapy: An Urgent Need for Progressing Science, Access, and Equity - JACC: Advances Expert Panel.
• Expert Reaction to an Analysis of Global Obesity Trends.

General

• Compassion for Animals in Scientific Research.
• Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics.
• Neuronal Ketone Body Utilization Couples Exercise and Time-Restricted Feeding to Cognitive Enhancement [in Mice].
• Rightsizing Brand Names: The Effects of Brand Name Length on Brand Name Attitude and Recognition.
• How Does Prior Infection and Vaccination Relate to the Risk of Incident SARS-CoV-2 Infection/Reinfection? A Prospective Cohort Study Among Nine Clinical Sites in the USA, February 2021 to January 2023.
• Intermittent Fisetin Treatment Improves Vascular Endothelial Function and Suppresses Cellular Senescence in Older Adults: Role of Reduced Mitochondria-Related Oxidative Stress.
• Review: SIRT1, Resveratrol and Aging.

Announcements

• Palatin Is Betting on the Next Generation of Obesity Drugs (NYSE: PTN).
• New Analysis of Global Obesity Trends.