Featured

• The Antimetastatic Effects of Calorie Restriction are Negated by Voluntary Exercise in an Aggressive Breast Cancer Mouse Model.
• GLP-1R - GIPR - PPARα/γ/δ Quintuple Agonism Corrects Obesity and Diabetes in Mice.
• When Size Goes Inside: Visceromegaly in Bodybuilders Is Not Attributed to High Protein Intake but More Likely Associated with the Use of Appearance- and Performance-Enhancing Drugs.
• Human Body Surface Area Scales Linearly with Height and Mass and Is Largely Independent of Body Composition: A 3D Laser Scanning and Body Composition Study.
• Mind the Plateau: A Mathematical Modeling Analysis of Long-Term GLP-1 Receptor Agonist Treatment.

Headline vs Study

• Headline: Braunes Fettgewebe Kann Vor Infarkt Schützen [Brown Adipose Tissue Can Protect Against Heart Attacks].
• Press Release: Brown Fat Could Help Protect Against Cardiovascular Disease in Obesity.
• Study: Active Brown Adipose Tissue Is Associated with Reduced Arterial Inflammation and Less Atherogenic Circulating Factors in Individuals with Obesity... In a Cross-Sectional, Acute Cold-Exposure Study. No Cardiovascular Disease Studied.

Contrary or Null Findings

• Thesis: "The review concludes that school-based obesity prevention programmes are unlikely to achieve sustained impact in isolation." (pdf)
• RCT: Null and Iatrogenic Findings in Labelled Cash Transfers for Uptake of Care for Chronic Conditions Among Middle-Aged and Older Adults in Burkina Faso.
• Diet-Based Weight-Loss Intervention Is Not Associated with a Meaningful Change in Lean Soft Tissue.
• RCT: Creatine Supplementation Dose and Duration are Not Associated with Increased Side Effects: A Structured Review and Study-Level Dose-Response Analysis of RCTs.
• Meta-analysis of RCTs: No Adverse Effect of Creatine Supplementation on Kidney Function.
• "Findings challenge assumptions that more AHS [allied health service] automatically improves HM outcomes and highlight the need to evaluate how allied health resources are integrated, coordinated, and aligned with family-centered lactation support in the NICU."
• RCT: Contrary to Our Hypothesis, Mental Fatigue Was Not Mitigated Following Acute Exercise.
• "Although both KD [ketogenic diet] and KS [exogenous ketone salts] effectively reduced fasting glucose levels, the KD, contrary to its typical weight-reducing effect in humans, significantly increased body weight and mesenteric fat, whereas KS did not alter adiposity relative to the control diet" in rats.

Basic

• SLC33A1 Exports Oxidized Glutathione to Maintain Endoplasmic Reticulum Redox Homeostasis.
• Thesis: Obesity-Induced Hypertension : The Role of PXR-4βHC-LXR Axis, a Novel Regulatory Pathway.

Scientific Rigor & Scholarly Dialogue

• Article: Processed Meat Intake and Changes in Weight, Waist, Body Mass Index, and Fat Mass: Systematic Literature Review, Meta-Analysis, and GRADE Assessment of Cohort Studies Of Adults.
• Letter: Conceptual Confusion About “Processed Meat”.
• Reply to: Conceptual Confusion About “Processed” Meat.
• "The recent article by Xu et al. (1) concludes that creatine supplementation has positive effects on cognitive performance... However, certain aspects of the statistical approach have introduced a unit-of-analysis error."
• Article: The Effect of the Participatory Heat Education and Awareness Tools (HEAT) Intervention on Agricultural Worker Physiological Heat Strain: Results from a Parallel, Comparison, Group Allocated Study.
• Letter: Mislabeling and Inappropriate Analysis Render Interpretations from “The Effect of the Participatory Heat Education and Awareness Tools (HEAT) Intervention on Agricultural Worker Physiological Heat Strain: Results from a Parallel, Comparison, Group Randomized Study” Unreliable.
• Reply to: ‘Mislabeling and Inappropriate Analysis Render Interpretations from “The Effect of the Participatory Heat Education and Awareness Tools (HEAT) Intervention on Agricultural Worker Physiological Heat Strain: Results from a Parallel, Comparison, Group Randomized Study” Unreliable’.
• Correction: The Effect of the Participatory Heat Education and Awareness Tools (HEAT) Intervention on Agricultural Worker Physiological Heat Strain: Results from a Parallel, Comparison, Group Allocated Study.

Clinical

• Advancing Personalized Strategies for Obesity Prevention Through Biologically and Behaviorally Tailored Interventions: The Strategic Framework for the BETTER4U Initiative.
• RCT: Virtual Weight Management and Continuous Glucose Monitoring in Patients with Type 2 Diabetes.

Children and Adolescents

• Cross-Sectional: Can Breastfeeding Practices Explain Sociodemographic Disparities in Childhood Obesity and Healthy Eating?
• RCT: Mindfulness Intervention for Parent Stress and Childhood Obesity Risk.
• Effects of SHOW Intervention Program on Physical Activity and Fatness of Children with Overweight or Obesity.
• Multiregional Survey of Chinese Pediatricians: Compliance with WHO Guidelines on Physical Activity, Sedentary Time, and Sleep.

Surgery

• Meta-Analysis: Short-Term Outcomes of Concurrent Magnetic Sphincter Augmentation During Bariatric Surgery: An MBSAQIP Analysis.
• Systematic Review: Impact of Weight Bias, Stigma and Discrimination on Physical, Mental, and Quality of Life Outcomes of Metabolic and Bariatric Surgery.
• Abstract: Is There a BMI Threshold for Recurrence After Paraesophageal Hernia Repair?
• Propensity Matched Analysis: Acute Care Outcomes in Patients Admitted for Atrial Fibrillation Who Had Prior Metabolic Surgery.
• Preoperative Weight Trends in Adolescents Undergoing Metabolic and Bariatric Surgery.

Drugs

• The Case for Primary Prevention of Obesity in the Era of GLP-1 Therapies.
• Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide.
• News: Patients Taking GLP-1s are Often Unprepared for How the Weight-Loss Drugs Can Affect Their Enjoyment of Food.

Food & Diet

• Review: Concerns About the Health Effects of Industrially Produced Seed Oils are Without Scientific Foundation: A Scoping Narrative Review of the Clinical and Observational Evidence.
• Mice on a High-Fat Diet Have Reduced Immunopathology and an Altered Immune Response During Respiratory Syncytial Virus Infection.

Caloric and Dietary Restriction

• Commentary: Holy Anomaly, Batman! What? Exercise May Actually Make Cancer Worse in Mice?
• Time in Range During Caloric Restriction in Type 2 Diabetes with Obesity.
• RCT: Effects of Time-Restricted Eating with Calorie Restriction Versus Calorie Restriction on Health Outcomes in Patients with Weight Regain Post-Sleeve Surgery.

Exercise & Physical Activity

• Review: Exercise Timing and Circadian Regulation of Metabolism in Type 2 Diabetes.
• BDNF Relates to Prefrontal Cortex Activity in the Context of Physical Exercise.
• RCT: Cardiorespiratory and Hematological Responses to High-Intensity Interval Training in Adolescent Girls with Overweight or Obesity.
• Improved Physical, Emotional, and Social Well-Being in People Living with Obesity Treated with Semaglutide: A Plain Language Summary.
• Meta-Analysis: The Effect of Behavioral Sleep Interventions on Measures of Obesity, Dietary Intake and Physical Activity in Adults with Poor Sleep Health.
• Differences in Physical Activity, Eating Habits and Risk of Obesity Among Indonesia Adolescent Boys and Girls.
• Review: Non-Digital Interventions Based on Play and Physical Activity in Children and Adolescents with ADHD.

Economics & Sociology

• Obesity in Late Adolescence and Healthcare Costs in Young to Mid- Adulthood.
• Public Housing Redevelopment and Childhood Obesity.
• Estimating the Healthcare Costs of Overweight and Obesity Amongst Australian Children.

Epidemiology

• Prevalence and Factors Associated with Severe Obesity Among U.S. Adults.
• Abstract: Associations of Lifestyle Behaviors with Overweight and Obesity.
• Beyond BMI: The Integrated Impact of Obese-Metabolic-Anthropometric Phenotypes on Chronic Kidney Disease Risk.

Psychology & Neuroscience

• Temporal Relationship between Physical Activity, Social Anxiety, and Internet Addiction Among Adolescents: A Cross-Lagged Analysis.
• Editorial: Impact of Physical Activity on Health and Behavioral Risks in Adolescents.
• Obesity and Its Health Implications: The Role of Metabolic and Bariatric Surgery in Improving Physical, Mental, and Psychosocial Well-Being.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Decomposing the Rural-Urban Disparities in the Prevalence of Diabetes Among Older Adults in India.
• Dissertation: The Role of Dollar Store Proliferation in Influencing Diabetes and Obesity Rates in West Virginia.
• Reframing Obesity as Collective Vulnerability in Black Churches in the USA: Implications for Clergy Leadership, Health Equity, and Pastoral Identity.

Stigma

• Body Image in the Age of GLP-1s: Emerging Questions for Research and Practice.
• A Longitudinal Study Exploring the Influence of Weight Bias Internalization and Weight-Based Discrimination on Pathological Eating After Metabolic and Bariatric Surgery.
• Development and Validation of the EDIT Weight Stigma Reduction Checklist.

Policy Related

• RCT: Impact of the Food and Drug Administration’s Proposed Front-Of-Package Label and Alternative Designs on Consumer Understanding.
• Review: Is the Experimental Evidence on Ultra-Processed Food and Obesity Reliable?
• Review: Investing in Nutrition Throughout the First 8000 Days of Life: A Multisectoral Approach to Supporting Well-Being and Creating Future Human Capital.
• Clinical Obesity in Asian People: Bridging the Gap between Adiposity and Disease.
• Systematic Review: Associations between Ultra-Processed Food (UPF) Consumption and Weight Change and Obesity Risk Among Consumers of Plant-Based Diets.
• Review: Leadership in Obesity Care: Strategies to Support Healthcare Professionals in Effective Decisions, Communication, and Solutions.
• Review: A Viewpoint Review of Recent Policy Changes and Public Health Initiatives to Combat Obesity.
• Viewpoint: Harms of Framing Obesity as a Disease of Individuals.

Intergenerational Effects

• Preprint: Impact of Pre-Gestational Obesity on the Clinical Presentation and Perinatal Outcomes of Gestational Diabetes Mellitus.
• A Higher Paternal Ultra-Processed Food Consumption Is Directly Associated with Parameters of Neonatal Anthropometry.
• Maternal High-Fat High-Energy Diet Impairs Surfactant Maturation in the Non-Human Primate Fetal Lung.

Ecology, Evolution, & Energetics

• An Independent Center for the Origin of Bread Wheat in the Neolithic Period of Georgia in the South Caucasus.
• Metabolic Acclimation to Captivity in Highveld Mole-Rats (Cryptomys hottentotus pretoriae) Is Driven by Sex-Specific Body Mass Increases.

Methods

• Data-Driven Prioritization of High-Risk Individuals for Weight Loss Interventions.
• Multi-Omic Definition of Metabolic Obesity Through Adipose Tissue-Microbiome Interactions.

Mathematical and Quantitative

• A Data-Driven Risk Stratification Framework for Clinical Obesity.

Commentary

• Is U.S. Leadership on Food and Nutrition Science Fading?
• Measuring Eating Patterns in Real Life Reveals High Variability in Timing and Choices.
• Pharma Bets a Little-Known Form of Cholesterol Will Underpin Its Next Blockbuster Heart Drugs.
• Zepbound Soars and Lilly Advises Patience on Foundayo.
• The 2025-2030 Dietary Guidelines for Americans: A Pediatric Review of Recommendations for Children Under 5 Years.
• Food as Medicine’s Missing Metric: Of Management, and Measurement.
• Current Application and Future Directions for the Sarcopenic Obesity Global Leadership Initiative (SOGLI) Diagnostic Algorithm.
• Study of Food Noise Aims to Account for Lived Experience.

General

• Exercise Advice for Long Covid May Be Doing More Harm Than Good.
• Modeling Population Status and Demographic Rates of Baleen Whales Using Historical Whaling Data.
• Halal Foods in the United States Present Opportunities and Challenges.
• C15 Fatty Acid, Dolphins, and Anti-Aging.
• Multi-Reflectance-Spectroscopy, Part III: In-Line Monitoring of Milk Fat Globule Size Via Sauter Diameter Using an Optical Sensor.
• A Review of Omega-3 Fatty Acids from Marine Source Supplements and Enhanced Food Effects on Children's Development, Neurological and Metabolic Disorders and General Health.
• Bad Stats: A Regular Series Exploring Slip-Ups, Snafus and Salutary Lessons from the World of Statistics.

Announcements

• PCORI Is Seeking Public Comments on a Comprehensive Update to Its Methodology Standards for Patient-Centered Comparative Clinical Effectiveness Research (CER).