Featured

• Severe Obesity in Human HFpEF Alters Contractile Protein Function and Organization.
• Ethics and Data in Precision Nutrition: A Roadmap for Responsible Innovation.
• RCT: The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety.

Headline vs Study

• Headline: This Type of Sugar May Cause Metabolic Disease, Study Finds.
• Press Release: New Report Highlights Fructose as a Key Driver of Metabolic Disease.
• Study: Review Article About Fructose. Not a New Study.

Contrary or Null Findings

• RCT-Thesis: High Resistance Training Volume During Caloric Restriction Among Resistance-Trained Individuals Does Not Seem to Further Enhance FFM Retention During a 40% CR.
• "These findings suggest that the long-standing reliance on allometric power-law equations reflects historical convention rather than biological necessity, and that simple linear formulas may suffice for clinical body surface area estimation within the range of body sizes studied here."
• "Analysis showed association between EBF and overweight/obesity in children was not statistically significant (p = 0.068)."
• Study Challenges Decades-Old Puzzle About Childhood Body Fat.
• "Contrary to prevailing assumptions, no gender differences emerged in psychological distress, suggesting BID-related [body image disorder] psychological burden is equitably distributed across genders."
• "Contrary to our hypothesis and patterns observed in other species, orphaned African savanna elephants exhibited a younger DNA methylation age than non-orphans, no accelerated aging, and only limited differential methylation at CpG sites."
• RCT: "Muscle mass and strength: No intergroup differences were found in changes of ASM or handgrip strength (p > 0.05)" in "The Impact of Oral Whey Protein and Yeast Protein Supplementation for 6 Months on Skeletal Muscle Mass, Strength, and Function in the Elderly."
• RCT: "Vitamin D supplementation successfully increased serum levels but failed to provide additional benefits for muscle mass or metabolic markers compared to resistance training alone."

Basic

• FGF21 Signals Through Hindbrain Neurons to Alter Food Intake and Energy Expenditure During Dietary Protein Restriction.
• Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal.
• Defined Microbiota Modulates Host Metabolome and Skeletal Adaptation to Diet-Induced Obesity.
• Postweaning Diet Affects Offspring Metabolic Outcomes More Than Maternal Diet in Male and Female Mice.
• IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction Via Impaired BCKDHA-Dependent BCAA Catabolism.

Scientific Rigor & Scholarly Dialogue

• Article: Circadian-Informed Modeling Predicts Regional Variation in Obesity and Stroke Outcomes Under Different Permanent US Time Policies.
• Letter: The Sum of Absolute Circadian Shifts: Questioning the Metric Linking Daylight Saving Time Policy to Stroke and Obesity.
• Letter: Challenges of County-Level Circadian Modeling for Time-Policy Debates.
• Response: Reply to Erren et al. And Martin-Olalla and Mira: What Constitutes Circadian Burden? An Empirically Grounded Approach to Long-Term Summary Metrics.

Clinical

• RCT: The Influence of Short-Term, Severe Low Energy Availability with Varying Protein Content on Substrate Metabolism, High-Intensity Exercise Performance and Subjective Responses in Young Adults.
• RCT: Effectiveness of Tailored Multichannel Interventions on Weight Loss Among Adolescents.

Children and Adolescents

• The Double Edged Sword of Digital Development A Global Bayesian Analysis of ICT and Obesity in Children and Adolescents Aged 5 to 19 Years.
• Association between Physical Activity and Mental Health (Emotional and Peer Problems) in Children and Adolescents, a National Follow-Up Study.

Surgery

• Review: American Society for Metabolic and Bariatric Surgery Statement on the Treatment Options for Patients with Non-Response and Weight Recurrence After Metabolic and Bariatric Surgery.
• Review: Implementation of Preoperative Very Low-Calorie Diets in Preparation for Metabolic and Bariatric Surgery.
• Bariatric Surgery and Subsequent Weight Loss Lead to a Reversal of Peripheral Blood Monocytosis in Obesity.
• Short-Term Weight Control and Complications in Patients with Obesity Following Laparoscopic Sleeve Gastrectomy.

Drugs

• The Weight-Loss-Independent Hepatoprotective Benefits of Semaglutide are Orchestrated by Intrahepatic Sinusoidal Endothelial GLP-1 Receptors [in Mice].
• Efficacy, Safety and PK of Once-Daily Oral Semaglutide 25 mg for Obesity with and without Type 2 Diabetes in Comparison with Subcutaneous Semaglutide 2.4 mg: A Model-Informed Drug Development Approach.
• Meta-Analysis: GLP-1 Agonists and Changes in Body Mass and Composition in Adults with Overweight or Obesity with or without Type 2 Diabetes Mellitus.
• Review: Improving Incretin-Mediated Body Weight Loss Via Energy Expenditure.
• Semaglutide 2.4 mg Cardiometabolic Long-Term Effects in Patients with Obesity or Overweight in a Real-World Setting.

Food & Diet

• Review: Effects of Diet Strategy and Nutrients on the Progression and Prevention of Diabetic Cardiomyopathy.
• Review: Phytochemicals and Obesity: A Mini Review from the Dietary Phytochemical Index Perspective.
• High-Protein Diets Increase Microbiota Associated P-Cresol Production in the Colon and Reduce Gut Barrier Function in a Sex-Dependent Manner [in Piglets].

Caloric and Dietary Restriction

• Caloric Restriction Exerts Site-, Sex-, and Duration-Dependent Effects on Skeletal Structure and Bone Marrow Adiposity [in Mice].
• Metabolomics Identified Caloric Restriction-Associated Glycerophospholipid Alterations in ApoE−/− Mice.

Exercise & Physical Activity

• L-Shaped Association of Plasma Creatinine with Frailty in Oldest‑old.
• Review: Impact of Yoga on Cardiometabolic Health in Adults with Overweight or Obesity.

Economics & Sociology

• The Weight of a Hug: Abdominal Obesity as a Barrier to Health and Human Connection.
• Neighborhood Socioeconomic Disadvantage and Early Overweight of Very Preterm-Born Children.

Epidemiology

• Obesity, Metabolic Health Status, and Adverse Outcomes in Men and Women.
• Clinical Value of Visceral Fat Rating in Assessing Liver Fibrosis in Women with Obesity - LUCAS 1.3 Study.
• Real-World Weight Loss Is Associated with a Reduction in Cancer Risk.

Psychology & Neuroscience

• Review: Lifestyle Behaviours and Risk of Early-Onset Non-Communicable Diseases Among Young Adults.
• Gut Microbiota Reshapes Host Energy Metabolism to Modulate Depressive Behaviors.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Decomposing the Rural-Urban Variation in Obesity Prevalence Among Indian Men.
• Generational Status, Family Structure, and Phenotypic Severity of Obesity in Children Attending a Pediatric Obesity Clinic.
• The Conditional Effect of Income Inequality on Obesity.
• Using the WHO Health Equity Assessment Toolkit to Investigate Changes in Rural vs Urban Malnutrition Inequality for Low- and Middle-Income Countries.

Stigma

• Discrimination of Persons Living with Obesity by Healthcare Professionals.
• "A substantial portion of MBS [metabolic and bariatric surgery] patients in this study experienced residual weight stigma following weight loss, and higher internalized weight bias was associated with less weight loss."
• The Relationship between Weight Stigma and Physical Activity Avoidance Among College Students.

Policy Related

• Impacts of a Produce Prescription Program on Food Security, Diet Quality, and Psychosocial Health of Adults with Medicaid and Chronic Health Conditions.
• Complex, Contradictory and Confusing: Exploring Consumer Dilemmas in Navigating Sustainable Healthy Nutrition Knowledge.
• Commentary: A Critical Perspective on the Dietary Guidelines for Americans 2025-2030: Methodological, Conceptual, and Communication Challenges.
• From Science to Policy: Discovering Technology Hotspots in Policy Documents.
• Policy on Paper Compared with Policy in Practice: A Study of Healthy Default Beverage Implementation and Enforcement in the United States.
• Perceptions of Ultra-Processed Foods, Food Processing and Food Healthfulness Among a Cross-Sectional National Sample of US Adults: Do Perceptions Align with the Evidence?

Intergenerational Effects

• Impact of Maternal BMI on the Performance of Non-Invasive Prenatal Testing.
• Differences in Association between Gestational Weight Gain and Perinatal Outcomes According to Pre-Pregnancy BMI Categories and Gestational Diabetes Mellitus Status.
• Parental Obesity Exacerbates Cognitive Dysfunction and Cardiac Vulnerability in Offspring of an Alzheimer Disease Model.

Ecology, Evolution, & Energetics

• Mitochondrial Fission Mediates an Evolutionarily Conserved Antibacterial Defense Response.
• Review: Insights Into Human Adaptation from Ancient DNA.
• Fifteen Thousand Years of Bioarchaeological Data Reveal Life History Trade-Offs Among Europe’s First Farmers.

Methods

• An Optimized Protocol for Efficient Derivation of Pancreatic Islets from Multiple Human Pluripotent Stem Cell Lines.
• Secular Trends and Prognostic Value of the Body Shape Index in U.S. Adults.

Mathematical and Quantitative

• Enhancing Economic Modelling in Obesity: Integrating Novel Type 2 Diabetes Progression & Obstructive Sleep Apnea Remission - A UK Case Study.
• Review: Mapping Digital Nudges and Recommender Systems for Obesity Prevention.

Commentary

• Overweight and Obesity in Children and Adolescents: Causes and Strategies for Prevention.
• What Is Food Noise? Causes, Symptoms and How to Stop Constant Cravings.
• Challenges of Placebo Arms in Weight-Loss Drug Trials.
• Obesity Treatment: Still Judging After All These Years.
• Study Suggests Meal Timing May Matter More Than You Think.
• You Don’t Need to Stretch to Stay Mobile - Why Lifting Weights Can Be Just as Effective.
• Podcast: Why Exogenous Ketones?
• Podcast: Why Exogenous Ketones are the Metabolic Game Changer | Dr Eric Plaisance.

General

• The Mechanosensitive Adhesion G Protein-Coupled Receptor 133 (GPR133/ADGRD1) Enhances Bone Formation.
• For Young Adults, Recollection of Alcohol Addiction May Differ from Reality.
• Youth Suicides Drop.
• Repeated Measurements of Vitamin D: Common and Very Unlikely to Indicate Deficiency.
• Podcast: Vaping and Cancer.
• Physicists Refute Famous 2025 Study Claiming Daylight Saving Time Poses Severe Health Risks.
• Predicting Achilles Tendon and Patellofemoral Joint Forces During Running with Consumer-Grade Wearable Sensor Data.
• Brain Motion Is Driven by Mechanical Coupling with the Abdomen [in Mice].

Announcements

• University of Aberdeen and SIAT Launch Joint Laboratory to Advance Global Energy Metabolism Research.
• Webinar: Ultra-Processed Foods and Health Outcomes: State of the Research to Inform Practice. May 4, 2026.
• "Join us July 23-25 in Orlando, Florida for a powerful weekend dedicated to support, education and advocacy at the Your Weight Matters National Convention, hosted by the Obesity Action Coalition (OAC)."
• Invitation to Participate in a Survey on Laboratory Animal Nutrition.
• Webinar: Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health. May 28, 2026.