Featured

• DiMarchi & Tschöp Light It Up Again! - Researchers Behind GLP-1 Obesity Drugs Advance New Approach: Drop GLP-1 as a Target.
• Can Milk Membrane Lipids Benefit Older Adults’ Brain Health?
• Meta-Analysis: Creatine Supplementation in Young Men Under Resistance Versus Non-Resistance Training: Strength, Performance, and Lean Mass.
• The Puzzle of the Pill: Loyal & LOY-002.

Headline vs Study

• Headline: Researchers Found Out Why Bread Makes You Gain Weight Even If You Don’t Eat Extra Calories.
• Press Release: Scientists Discover Why Bread Can Cause Weight Gain Without Extra Calories.
• Study: "Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice." Yes, the authors appropriately added "in mice" to their own title!

Contrary or Null Findings

• Meta-Analysis: "Financial incentives showed no statistically significant improvements in weight or cardiometabolic outcomes in young people with obesity."
• Meta-Analysis of RCTs: No Ergogenic effect of β-Alanine on Repeated Sprint Ability.
• "Contrary to expectations under selective harvests, we observed an increase of almost 2 years in age and 1.7 cm in skull size among harvested bears over the 37-year period."
• "Contrary to hypotheses, preschool EC [executive control] was not significantly associated with activity metrics during adolescence..."
• "Contrary to prior clinical observations, Tirzepatide elevated mean blood pressure (197.4 ± 16.6 vs. 153.7 ± 5.4 mmHg at Day 28; TZP vs. VEH-PF, n = 9 vs. 8; p < 0.05) and increased heart rate, accompanied by left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function" [in rats].
• "Contrary to canonical doctrine, GSH [glutathione] depletion unexpectedly protects against MASLD by substantially decreasing hepatic lipogenesis and fibrosis without triggering an oxidative stress response."
• RCT: "Findings revealed no significant difference in mean weight loss between groups..."
• "Eating pattern is not associated with altered body mass composition in patients presenting for weight loss."

Basic

• Overnutrition in Mice Impairs Thyroid Hormone Biosynthesis and Utilization, Causing Hypothyroidism, Despite Remarkable Thyroidal Adaptations.
• Ammoniated Beef Improves Metabolic Outcomes and Adipose Functions in Diet-Induced Obese Male and Female Mice.
• Txnrd2 Loss in Skeletal Muscle Causes Muscle Atrophy and Drives Leanness and Obesity Resistance.
• Chia Oil Supplementation Attenuates Obesity-Induced Hepatic Steatosis, PVAT Inflammation, and Endothelial Dysfunction in Mice.
• Exercise Ameliorates Adipose Tissue Insulin Resistance by Activating the Lactate/GPR81 Signaling Pathway in DIO-IR Mice.
• Adipocyte Small Extracellular Vesicle-Derived MicroRNA-30a-3p Exacerbates Hepatic Steatosis in High Fat Diet-Fed Male Mice.
• The Plant Hormone, 6-Benzylaminopurine, Ameliorates Obesity in Male and Female Mice While on a High-Fat Diet.

Scientific Rigor & Scholarly Dialogue

• Retraction: Association between Vitamin D and Mortality Risk in Gout Patients.
• Letter: Stopping Spin at the Source: Learning from an Example in Obesity.
• Response To: “Stopping Spin at the Source: Learning From an Example in Obesity."
• PubPeer Comments On: The Effects of Omega-3 Supplementation on Stress, Anxiety, Depression, Sleep Quality, and Everyday Memory in Individuals with Psychological Distress: A Randomized, Double-Blind, Placebo-Controlled Trial.
• Retraction: The Effects of Omega-3 Supplementation on Stress, Anxiety, Depression, Sleep Quality, and Everyday Memory in Individuals with Psychological Distress: A Randomized, Double-Blind, Placebo-Controlled Trial.
• Controlling Confounding in Nutrition Research: Methodological Strategies, Software Implementation, and Reporting Guidelines. (pdf)
• Interview: Christopher Borgert on an Infamous Glyphosate Paper.

Clinical

• Beyond Weight: Systems Biology and Precision Medicine Redefine Obesity as a Multidimensional Disease.
• RCT: Neurocognition and Food Cue-Related Brain Reactivity After Fiber Supplementation Within a High-Protein, Plant-Based Diet in Individuals with Overweight and Prediabetes.
• Cinnamon Supplementation Improves Uric Acid Levels in Adolescents with Obesity: Secondary Metabolic Outcomes from RCT.
• Meta-Analysis: Comparison of the Effects of Different Models of Nutrient Supply on Nutritional Status and Clinical Outcomes in ICU Patients.

Children and Adolescents

• Meta-Analysis: Assessing the Effectiveness of Healthy Weight Interventions in the Early Years of Childhood: Evidence from High-Income Countries.
• Longitudinal Changes in General Overweight and Obesity, and Central Obesity from Birth to Early Adolescence.
• Predicting Childhood Overweight and Obesity at School Entrance Using Healthcare, Demographic, and Socioeconomic Data.
• Nature vs Nurture of Glucose Homeostasis Trajectories in Children from the ALSPAC Study.

Surgery

• A Single Center Comparison of Obesity Management Medications and Metabolic Bariatric Surgery in Patients with Left Ventricular Assist Device and Obesity.
• Pre-Post study: Self-Esteem, Depression and Anxiety After Surgery for Obesity.
• Book Chapter: Robotic Metabolic and Bariatric Surgery: Current Evidence and Status.

Drugs

• Widespread Exposure to GLP-1RAs and Weight Loss-Related Discourse: Considering Potential Public Health Implications.
• Self-Reported Side Effects of Semaglutide and Tirzepatide in Online Communities.
• Systematic Review: Effect of Incretin-Based and Nonpharmacologic Weight Loss on Body Composition.
• GIPR:GCGR Co-Agonism Restores Normal Weight in Obese Rodents.

Food & Diet

• Review: Is Obesity the Missing Link? Ultra-Processed Foods and Metabolic and Reproductive Outcomes.
• Review: The Influence of Cultural Dietary Patterns on Global Obesity Trends.
• Avocado Intake and Cardiometabolic Risk Factors in a Representative Survey of Australians: A Secondary Analysis of the 2011-2012 National Nutrition and Physical Activity Survey.
• Scoping Review: Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function.
• Association between Dietary Patterns and Cardiometabolic Health in Children: Findings from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS) Cohort.

Caloric and Dietary Restriction

• Meta-Analysis: Effects of Lifestyle Interventions in Older People with Obesity (Effective SLOPE).
• Calorie-Restricted Diet Reshapes Gut Microbiota to Alleviate Obesity Potentially Via SCFAs-UCP2-AMPK Signaling Pathway.
• Energetic Adaptations in Response to Moderate Calorie Restriction-Induced Weight Loss in Normal-Weight Adults.
• RCT: The Effect of Integrated Lifestyle Intervention Incorporating Calorie-­ Carbohydrate Restriction with or without Time-­Restricted Feeding for Remission of Type 2 Diabetes (DIREM).
• Circadian Reprogramming by Combined Time-Restricted Feeding and Exercise Improves Metabolic Homeostasis in Diabetes.

Exercise & Physical Activity

• Exercise-Induced Protein Lactylation: From Molecular Mechanisms to Precision Health Applications.
• Optimizing Strength and Hypertrophy: The Combined Effect of Intensity and Velocity Loss Thresholds in Bench Press Training.
• Volume vs Intensity of Physical Activity and Risk of Cardiovascular and Non-Cardiovascular Chronic Diseases.
• Meta-Analysis: Effects of Exercise on Multiple Health Outcomes in Children and Adolescents with Overweight or Obesity.
• Effects of a Year-Long Aerobic Exercise Intervention on Neuroendocrine, Autonomic, and Neural Correlates of Stress, Emotion, and Cardiovascular Disease Risk in Midlife Adults.

Economics & Sociology

• Agricultural Technology-Critical Analysis on the Cultural Shifts in Obesity Subsidy Concentration with the Consumption of High Fructose Corn Syrup.
• Very Low Birth Weight Infants Among Latinx Women in the United States: Is the Paradox Lost?
• Opportunities and Challenges in Integrating Family Planning and Nutrition Services in Tanzania: A Mixed-Methods Study.

Epidemiology

• Weight Trajectories and Obesity Onset between 17 and 60 Years of Age, and Cause-Specific Mortality: The Obesity and Disease Development Sweden (ODDS) Pooled Cohort Study.
• Review: Obesity, Type 2 Diabetes and Cancers of the Digestive System.
• Comparison of the Prevalence of Obesity and Overweight Among Adults with HIV and the Adult General Population in Korea.
• Trends and Disparities in Obesity-Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968-2025).

Psychology & Neuroscience

• Meta-Analysis: Effectiveness of Exercise and Nutrition Interventions for Cognitive Function in Older Adults.
• Plant-Based Dietary Patterns and Risk of Alzheimer Disease and Related Dementias in the Multiethnic Cohort Study.
• Report: Online and in Doctors’ Offices, People are Finding That GLP-1s May Help with Everything from Arthritis to Addiction to Migraines.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Racial and Ethnic Disparities in Type 2 Diabetes: Does Visceral Fat Play a Role? Evidence from the MESA Study.
• MIDO First Childhood: Assessment of Growth and Development in Early Childhood Among Vulnerable Mexican Communities.
• Preprint: The Invisible 3.45% GDP Drain: Presenteeism and Gendered Care Burdens as Primary Drivers of Obesity Costs in Uruguay - A Benchmark for the Americas.
• Vitamin D Status, Adiposity, and Insulin Resistance Among U.S. Non-Hispanic Black Women.

Stigma

• Mapping Weight Stigma in Food-Based Dietary Guidelines Across Thirteen Countries in Latin America and the Caribbean.
• Systematic Review: Intersectionality in Weight Stigma Research.

Policy Related

• Predictors of Overweight and Obesity in Early Childhood Leaders in the United States.
• Obesity Transitions by Age, Period, and Cohort: A Population-Based Application of the Lancet Commission Framework in the United States and Korea.
• Shifting New Jersey Adolescents Toward Sustainable Diets: Factors That Influence Their Food Choices and Views on Environmental Sustainability.
• Children with Disabilities in Nutrition Programmes: Thematic Analysis of Training and Guidelines.
• National Policies for Improving Micronutrient Intake in School Meals: A Global Cross-Sectional Study.
• Identifying Barriers and Facilitators of the Implementation of Nutrition Guidelines in Food Banks Using the Consolidated Framework for Implementation Research.

Intergenerational Effects

• Polycystic Ovarian Syndrome and Perinatal Outcomes: A Population-Based Pooled Cross-Sectional Study.
• Effects of Pregnancy and Lactation-Associated Osteoporosis on Children: Analysis Using Linked Mother and Child Data.
• Correlation of Red Blood Cell Parameters with Glycated Hemoglobin (HbA1c) in Gestational Diabetes Mellitus.
• Trends in Overweight and Obesity Among Reproductive-Age Women in Bangladesh: Analysis of Nationally Representative Surveys over a Decade.

Ecology, Evolution, & Energetics

• Diet-related energetics of honeybee larvae (Apis mellifera L.).
• North Atlantic Right Whale Energetics in a Changing Environment.
• Ecological Impact and Metabolic Food Waste of Adults with Overweight or Obesity in Northern European and Mediterranean Countries.
• Review: The Impact of Artificial Sweeteners on Bacterial Physiology and the Microbiome.

Methods

• Development and Validation of a Clinical Prediction Model for Postoperative Weight Regain After Bariatric Surgery Using Inflammatory, Metabolic, and Ferritin Biomarkers.
• Health Prediction Using Hybrid Deep Learning Models: A Transparent and Interpretable Approach.
• An International Consensus on Core Reproducibility Items in Research.

Commentary

• Podcast: Peptides - Evaluating the Science, Safety, and Hype in a Rapidly Growing Field.
• Podcast: 76% of People Don’t Get Enough Omega-3 - and It Affects Your Brain | Philip Calder.
• Is Dark Chocolate Good for You?
• Podcast: Coffee vs Matcha | Andrew Kojima & Prof Tim Spector.
• Adding the Trendy Supplement Methylene Blue to Creatine May Not Help Your Body or Brain.
• Strong Feelings on Sweeteners Don’t Match the Data.
• Podcast: Why Your Body Fights After Weight Loss with Rudy Leibel.
• Nutrition Science: Let Those Familiar with Mathematics Enter Here.
• The WHO Essential Medicines List Can Help to Unlock Access to GLP-1 Therapies for Metabolic Syndrome.

General

• Running: Will It Wreck Your Body?
• Podcast: What are Blue Foods? | Stats + Stories Episode 384 /April 9, 2026.
• Food Noise: Integrating Experience and Evidence.
• A Third of People May Have Low Levels of C15 Fatty Acid.
• Epigenetic Resilience to Early-Life Maternal Loss in African Savanna Elephants.
• Letter to the Editor: Special Vision Considerations for GLP-1 Receptor Agonists Use Among Military Aircrew Members.
• β-Alanine Is an Unexploited Neurotransmitter in the Pathogenesis and Treatment of Alzheimer's Disease.
• Differential DNA Methylation Clock Ages Across Buffy Coat (BC), Peripheral Blood Mononuclear Cells (PBMC), and Saliva in Individuals in Early-To-Mid Adulthood.
• Effects of Exposure to Extreme Artificial Light at Night on Liver Oxidative Damage and Gut Microbiota During Pregnancy and Lactation in Mice.
• Investigating Intraspecific Attacks in Brown Bears (Ursus arctos) Using a Forensic Approach: Evidence from Northern Italy.

Announcements

• WellSCAN's Ranking Technology Can Be Accessed Via the WellSCAN Website or Inventory Tool.