Featured

• Weight Loss with GLP-1 Medicines Does Not Result in a Disproportionate Loss of Muscle Mass or Function in Obese Mice and Humans.
• Rethinking Obesity Prevention: A Call for Strategic and Operational Clarity.
• RCT: "High-dose KME [ketone monoester] administration for 31-days …increased cognitive function and oxygen uptake during maximal graded exercise even after ketone administration stopped…"
• An Acyl-Activating Enzyme (AAE) 3 Homolog Encodes an Oxalyl-CoA Synthetase in Bradysia Coprophila.
• Peptide-Functionalized Gold Nanoparticles Lowered Diet-Induced Obesity in Rats by Reducing White Adipose Tissue Mass.

Headline vs Study

• Headline: U of T Study Finds That Whole-Fat Milk Lowers Risk of Child Obesity.
• Study: Associations between Parent-Reported Child Milk Fat Consumption and Child Anthropometry. Got Causation?

Contrary or Null Findings

• "Results from this exploratory multisite study found no evidence that CBT-T was less acceptable or effective for participants in higher-weight bodies."
• "Contrary to expectations, jasmonate-deficient fad mutants did not support enhanced larval performance, whereas dietary n3-PUFA supplementation significantly promoted caterpillar growth and pupation success."
• "Contrary to our initial hypothesis, postweaning solid feed digestibility was not impaired" in “Pre- and postweaning feeding strategies on growth and digestion of female Holstein calves.”
• "Contrary to our hypothesis, this hunger-induced increase in wanting was less pronounced for food odors than for food pictures (p < 0.001)."
• Exogenous Ketosis Does Not Alter Oxygenation, Oxygen Uptake Kinetics or Whole-Body Efficiency During Submaximal Exercise in Early High-Altitude Acclimatization.
• Maximal Exercise at High Altitude Does Not Exacerbate Inflammation in the Human Brain.
• The Measure It! Very Brief Physical Activity Measurement Intervention Delivered 6-Weekly by Cardiac Rehabilitation Clinicians over 24-Weeks Did Not Statistically Increase MVPA.
• No Statistically Significant Long Term Effects of Lifestyle Intervention Among Arab Women with Obesity: A 12-Year Follow-Up.

Basic

• Hepatic MiR-93 Promotes the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease by Suppressing SIRT1.
• Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity.
• Blue Light Exposure Exacerbates Obesity in High-Fat Diet-Fed Mice by Inducing Mitochondrial Dysfunction in the White Adipose Tissue.
• Leucine Catabolic Enzyme AUH Regulates BAT Thermogenesis Via PPARγ HMGylation and RNA-Binding Function in Male Mice.
• Exposure to a High-Fat Diet Compromises Gut Health, Behavior, and HPA Axis Function, with Partial Reversal When Limited to Adolescence.

Scientific Rigor & Scholarly Dialogue

• Stopping Spin at the Source: Learning from an Example in Obesity.
• Predatory Publishing in Nutrition and Dietetics: Risks, Impacts, and Collaborative Solutions.
• ‘We Want to Retract Our Own Paper ... in the Journal of the American College of Cardiology: Advances, titled “Longitudinal Data From the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not”.”’

Clinical

• Associations between Extreme Temperature Events and Daily Step Counts by Weight Status and Modifying Effects of Socio-Demographic Factors: A Longitudinal Study.
• The Potential Mediating Role of High-Density Lipoprotein Cholesterol Levels in the Association between Physical Activity and Depression: A Nationwide Population-Based Study.
• The Effect of Including One Avocado Daily in a Habitual Diet on the Glycemic Index and Glycemic Load in Free-Living Adults with Overweight/Obesity.

Children and Adolescents

• Adiposity, Fat-Free Mass Index, and Muscular Strength in Children: Independent Effects on Functional Performance in a Tertiary Pediatric Endocrinology Cohort.
• Meta-Analysis: Effects of Probiotic and Synbiotic Supplementation on Metabolic and Hepatic Outcomes in Children and Adolescents with Obesity, Including Those with Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease.
• Predicting Childhood Overweight and Obesity at School Entrance Using Healthcare, Demographic, and Socioeconomic Data in Wales, UK.

Surgery

• Association of Obstructive Sleep Apnea and Postoperative Complications in Bariatric Surgery: How Crucial Is Preoperative CPAP Compliance?
• Cohort Study: Preoperative GLP-1 Receptor Agonist (GLP-1 RA) Exposure Is Associated with Postoperative Initiation of GLP-1 RA Following Metabolic Bariatric Surgery.
• Bariatric Surgery Reverses Blunted Blood Pressure Reactivity to Cold-Induced Stress in Patients with Severe Obesity.

Drugs

• Genetic Predictors of GLP1 Receptor Agonist Weight Loss and Side Effects.
• Prohormone Cleavage Prediction Uncovers a Non-Incretin Anti-Obesity Peptide.
• Review: Directions in the Medical Treatment of Obesity.

Food & Diet

• 2026 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement from the American Heart Association.
• Multi-Omics Reveal Vitamin D Regulation of Immune-Gut Microbiome Interactions and Tolerogenic Pathways in Inflammatory Bowel Disease.
• Ultra-Processed Foods and Muscle Fat Infiltration at Thigh MRI: Data from the Osteoarthritis Initiative.

Caloric and Dietary Restriction

• RCT: Weight Loss and Metabolic Improvements Dominate the Microbiome Response in the MIND Diet Intervention.
• Compound-Specific Stable Isotope Analysis Improves the Association between Dairy Fatty Acid Biomarkers and Dairy Intake: A Secondary Analysis.
• Exoproteome of Calorie-Restricted Humans Identifies Complement Deactivation as an Immunometabolic Checkpoint Reducing Inflammaging.

Exercise & Physical Activity

• Meta-Analysis: Acute Effects of “Exercise Snacks” During Prolonged Sitting on Hemodynamics and Peripheral Vascular Function.
• RCT: Weekly Frequency of School Based HIIT Improves Adiposity and Fitness in Children with Obesity.
• American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews.

Economics & Sociology

• Population Trends in Nutritional Status and Socioeconomic Divergence in Extreme Obesity in Peru: Geospatial Dynamics and Intergenerational Risk.
• Social Perceptions of Weight Loss with Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Black and White Women with Obesity.
• Trends in GLP-1 Receptor Agonist and SGLT2-Inhibitor Utilization and Expenditure between 2017-2023: Demographic, Income, and Insurance Associations.

Epidemiology

• Milk Fat Intake, Adiposity, and Obesity in Canadian Children: Findings from the Prospective Canadian CHILD Cohort Study.
• Review: Prevalence of Obesity and Its Associated Factors Among Healthcare Workers in Malaysia.
• Patterns of Dietary Supplement Use for Weight Loss Among U.S. Adults with Obesity.

Psychology & Neuroscience

• Evaluating an Incentive-Based mHealth App for Physical Activity Promotion Using the Obesity-Related Behavioral Intervention Trial Model: Small Cohort Study.
• An Examination of African Immigrants with Overweight or Obesity: Weight, Lifestyle Behaviors, and Body Image Following Immigration.
• Are There Any Effective Behavior Change Strategies for Communicating Genetic Risk in Obesity Prevention and Body Weight Reduction Interventions?

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Association between Socioeconomic Status and the Prevalence of Metabolic Diseases.
• Obesity, Physical Activity, and Gene-Environment Interactions: A Natural Experiment Framework.
• Systematic Review: Socioeconomic Inequalities in Exposure to Neighborhood Environments for Physical Activity.

Ethics

• Public Perceptions of AI in Medicine and Implications for Future Medical Education: Cross-Sectional Survey.

Stigma

• The Impact of Excess Body Mass on Employment Prospects in Australia.
• "Results partially supported our hypotheses, suggesting both enacted weight/transgender stigma and internalized weight stigma are significantly associated with utilization of health care services in a gender diverse sample."

Policy Related

• Viewpoint: State Actions to Define Ultraprocessed Food for Policy - Opportunities and Challenges.
• Addressing Childhood Obesity: Resources, Social Drivers of Health, and Pediatric Guidelines.
• Work- and Hydration-Related Health Outcomes Prevalence Among USA Construction Workers: Evidence from the National Survey.

Intergenerational Effects

• Transgenerational Effects of Heat Shock on Gene Regulation and Fitness-Related Traits in Natural Drosophila Populations.
• Skeletal Muscle Mitochondrial Bioenergetics in Pregnancy: A Comparison of in Vivo and in Vitro Outcomes.
• Meta-Analysis: Evidence for a Perinatal Origin of Childhood Obesity.

Ecology, Evolution, & Energetics

• Isotopic Insights Into Long-Term Socio-Economic Transformations in Prehistoric Kuyavia, Poland.
• Vitamin B3 Rescues Mitochondrial Homeostasis in Dexamethasone-Induced Skeletal Muscle Atrophy by Reducing Oxidative Stress.

Methods

• Beneficial Outcome Pathways: A New Mechanistic Framework to Map the Health Effects of Fasting in Metabolic Dysfunction-Associated Steatotic Liver Disease.
• Determination of Per- and Polyfluoroalkyl Substances in Food and Feed by Enhanced Matrix Removal LC-MS/MS Method: Single-Laboratory Validation, First Action 2025.11.

Mathematical and Quantitative

• Estimating the Health, Economic, and Social Benefits of Obesity Treatment Using Microsimulation Modeling.

Commentary

• Precision Nutrition for Better Clinical Outcomes.
• Podcast: To Mark Sigma Nutrition's Milestone 600th Episode (and 12-Year Anniversary), Danny and Alan Examine Several Areas in Which Their Views Have Changed, Softened, Strengthened, or Remained Stable over the Lifespan of the Podcast.
• Once- or Twice-Yearly Injection for Weight Loss?
• Addressing Childhood Obesity: Resources, Social Drivers of Health, and Pediatric Guidelines.
• Is Berberine Really “Nature’s Ozempic”?
• Cold Exposure and Metabolic Health: Therapeutic Potential for Obesity, Diabetes, and Beyond.
• How Animals Allocate Resources between Growth, Maintenance, and Reproduction Is a Fundamental Question. In This Issue of PLOS Biology, Pradhan and Colleagues Show That Maternal Nutrient Sensing Regulates Ribosome Deposition Into Embryos, Shaping the Early Growth Dynamics in the Next Generation.
• Tastiness Is Not Why People Overeat.
• Steak Night: How Healthy Is This Houston Staple?
• "What Dolphins Can Teach Us About Aging Better, According to a Surprising Navy Discovery."

General

• Systematic Review: The Benefits and Harms of Screening for Prostate Cancer in Adults Aged 18 Years and Older.
• Video: Restoring Trust in Science: Storytelling, AI, and Integrity in Scholarly Publishing (Mar. 26, 2026, 10:00 Am ET) - Ivan Oransky.
• Podcast: Is the Testosterone Crisis Real? The Numbers Behind the Headlines.
• RCT: Effect of Calorie Restriction on Thyroid Antibodies and Symptoms in Hashimoto’s Thyroiditis Patients. (pdf)
• Dietary Restriction Shapes Intergenerational Ribosome Abundance and Early Growth of Caenorhabditis elegans Offspring.
• Longevity Medicine, and Decisions Amidst Shadows.
• Storytelling: Sharing the Impact and Awe of Science.
• Novel Approach to Clearing Brain Waste Shows Promise for Alzheimer's.
• 14 Things Our PhD Supervisors Got Right and Why It Mattered.

Announcements

• Texas Children’s Lands $5M Gift from LeGrange Family for Children’s Behavioral Health.
• From Congress: Investigations and Oversight Subcommittee Hearing - the State of Scientific Publishing: Assessing Trends, Emerging Issues, and Policy Considerations.
• ObesityWeek Abstract Submissions Due April 20.