Featured

• Quasi-Experiment: Public Housing Redevelopment Was Associated with a Significantly Lower Increase in Childhood Obesity Prevalence Within Its First 2 Years.
• Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss [in Mice].
• Are Ultra-Processed Foods Too Tasty? Toward a Metabolic Framework for Diet and Obesity.
• Defining and Characterizing Postprandial Reactive Hypoglycemia.

Headline vs Study

• Headline: Want to Lose Weight? Try Eating the Same Meals on Repeat.
• Study: Associations between self-reported dietary repetition and 12-week weight loss. "Future work should confirm these findings with experimental manipulations..."

Contrary or Null Findings

• "Chia seed supplementation …did not impact primary obesity indicators under obesogenic conditions" [in rats].
• RCT: "among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, IRVR, or both did not result in statistically significant differences in improvements in cognitive function over 24 months."
• Dietary Inflammatory Index and Objective Disease Activity in IBD: No Association Found.
• "Contrary to earlier reports, our study demonstrates that neither GLS1 inhibition nor PD-1 blockade significantly reduced p16INK4a-positive cell burden or improved aging-related health parameters. Although we do not seek to discredit prior work, our results underscore the need for rigorous design, standardized protocols, and independent validation to ensure reliable senolytics before clinical translation."
• “Contrary to Expectation, HMTBa Did Not Alleviate MFD, nor Did It Cause Changes in Trans-10 FA Concentrations in Rumen and Milk or in Mammary De Novo FA Synthesis. …The Involvement of Cis-9 16:1 and Cis-11 18:1 in Marine Lipid-Induced MFD Is Therefore Challenged and the Previously Described Relationship Would Not Be Causative, but Probably a Confounding Effect” [in Sheep].
• Preprint: "The results of this study do not support the hypothesis that dietary iron supplementation increases infection severity in M. sexta" [Tobacco Hornworm].
• "Contrary to characterizations of the placenta as a transcriptomic void, we find transcriptional breadth and complexity comparable to adult tissues, with high splicing diversity of obesity- and growth-related gene transcripts, including 108 distinct CSH1 (placental lactogen) isoforms."
• "Contrary to expectations, meal consumption did not reduce isotonic lingual endurance."

Basic

• The Conjugation-Resistant Bile Acid NorUDCA Cures Liver Fibrosis but Impairs Systemic Energy Metabolism.
• Bisphenol S and High-Fat Diet Drive Structural and Inflammatory Remodeling of the Colon in C57Bl/6 Male Mice.
• Irisin Ameliorates Obesity and Insulin Resistance Via Adipose Tissue IL-33 and Regulatory T Cells.
• Oligomeric Peptides LLRLTDL and GYALPCDCL Alleviate Obesity Through HO-1/Nrf2-Dependent Pathways in High Fat Diet-Induced Mice.
• Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude.

Scientific Rigor & Scholarly Dialogue

• "A kidney researcher and former dean of a medical school has now had six papers retracted and one marked with an expression of concern in a little more than a year."
• Increasing the Rigor of Body Composition and Adiposity Measurement in Multiple Sclerosis Research.

Clinical

• Do the Effects of Early Time-Restricted Eating Vary by Cardiometabolic Phenotype, Age, Sex, or Race?
• Maternal Nutrition and Hypothalamic Programming of Offspring Metabolic Health.
• Risk Factors and Clinical Nomogram for Fatty Pancreas in Adults with Obesity: A Case-Control Study.

Children and Adolescents

• Mothers’ Perspectives on the Healthy Change Early Childhood Obesity Prevention Programme.
• Transitions from Overweight to Obesity and the Rising Severe Obesity Burden Among Children and Adolescents in China.
• Review: The Role of the Gut Microbiome in Childhood Obesity: Mechanistic Insights and Community-Based Interventions.

Surgery

• The Effect of Weight-Loss Surgery in Patients with Obesity on Adipose Tissue Mesenchymal Stem Cells Versus Circulating Endothelial Progenitor Cells.
• Weight Loss Independent Outcomes in Type 2 Diabetes Mellitus and Other Metabolic Comorbidities After Roux-En-Y Gastric Bypass and Sleeve Gastrectomy.
• Meta-Analysis: Ten-Year Follow-Up for Sleeve Gastrectomy Versus Roux-En-Y Gastric Bypass.

Drugs

• Cardiovascular, Metabolic, and Mortality Outcomes with Semaglutide Versus Tirzepatide in Patients with Obesity and Hypothyroidism: A Real-World Analysis.
• Natural Carb Blockers: Emerging Nutritional Strategy, or Overhyped Nutraceuticals?
• Pharmacological Administration of FGF21 Reverses Obesity Through a Parabrachial-Projecting Neuron Population in the Hindbrain.

Food & Diet

• Food Environment with High Plant-Based Fat Supply Is Associated with Attention-Deficit/Hyperactivity Disorder (ADHD) Protection: A Global Study with More Than 150 Countries.
• The Low-Fat Milk Recommendation for Young Children: Time for a Re-Evaluation.
• Should the Dietary Guidelines for Americans Include Sustainability? A Critical Perspective.

Caloric and Dietary Restriction

• Adherence and Metabolic Outcomes of Early and Late Time-Restricted Eating with Energy Restriction Vs. Energy Restriction Alone: A 6-Month Follow-Up.
• RCT: Effect of Caloric Restriction on Organ-Specific Biological Aging.

Exercise & Physical Activity

• Muscular Strength and Mortality in Women Aged 63 to 99 Years.
• Associations of Physical Activity, Sedentary Behavior and Sleep with Obesity Markers in Chinese College Students: A Compositional Data Analysis.
• Aerobic Physical Activity Among Adults Age 18 and Older.
• RCT: Greek Yogurt Versus Whey Protein Supplementation in Adolescent Athletes Throughout a Competitive Season.

Economics & Sociology

• Understanding the Experience of Women Living with Obesity and Reproductive Pathology.
• Dissertation: Relative Socioeconomic Status and Decision-Making an Application to Eating Behaviors.

Epidemiology

• Obesity Prevalence: Comparison of Traditional and New Classification Approaches in a Swiss Population-Based Study.
• Obesity Trajectories Based on the European Association for the Study Diagnostic Framework and Their Associations with Cardiovascular Disease: Evidence from Two Longitudinal Cohorts.
• Sex-Specific Links between Dietary Fat Intake, Dementia Risk, and Cognitive Decline in Central Obesity.
• Beyond the 24-Hour Recall: Aligning Dietary Diversity Metrics with Nutrient Physiology.

Psychology & Neuroscience

• Movement Behaviors, Psychosocial Well-Being and Childhood Obesity.
• The Association between Childhood Traumatic Events and Weight Restoration in Adult Anorexia Nervosa Inpatient Treatment.
• Gender Differences in Working Memory Impairment and Metabolic Characteristics Among Patients with Stable Schizophrenia: A Cross-Sectional Study.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Food Insecurity and Adolescent Obesity in the United States: A Social Ecological Analysis of Multi-Level Risk Factors and Structural Inequities.
• Understanding the Socio-Economic and Health Burden of Obesity: A 10-Year Retrospective Analysis of Population-Wide Administrative Healthcare Data ​.
• Obesity Pharmacotherapy: An Urgent Need for Progressing Science, Access, and Equity - JACC: Advances Expert Panel.
• Preprint: The Temporal Relationship between Socioeconomic Vulnerability, Dietary Intake and Childhood Obesity: Longitudinal Results from the Feel4Diabetes-Study.
• Community Clinic Blood Pressure and BMI Control in Black Americans with Hypertension: A Retrospective Chart Review.
• Responses to GLP-1RA in White and Black Adults with Obesity: Insights from Generalized Additive Mixed Models of EHR Data.
• Evaluated Childhood Obesity Prevention and Management Programs in Europe, 2015–2024: A Structured Narrative Review of Behavioral and Anthropometric Outcomes.
• Cold-Induced Metabolic Flexibility Explains Ethnic Disparities Among Individuals with Obesity and Insulin Resistance.

Stigma

• It Is a Matter of Size-Manipulating Body Size with Virtual Reality Modulates Reward Sensitivity.
• Development and Validation of the EDIT [Eating Disorders in Weight-Related Therapy] Weight Stigma Reduction Checklist.
• Exploring the Link between Internalized Weight Stigma and Meal Skipping Behavior in Black Young Adult Women.
• An Experimental Investigation of the Stigmatization of Weight Loss and Regain from GLP-1 Receptor Agonist Use and Cessation.

Policy Related

• Promoting Climate-Resilient Agriculture and Food Security Through School Feeding.
• Translating Nutrition Science Into National Policy: Comparative Assessment of the 2025-2030 U.S. Dietary Guidelines and the Italian Mediterranean-Based Guidelines.

Intergenerational Effects

• Associations between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age.
• Early-Life Programming of Hypothalamic Circuits by Maternal Obesity: Implications for Neuroendocrine Disorders.
• Maternal Pre-Pregnancy BMI and Early Childhood Adiposity Trajectories: Longitudinal Evidence from the Taiwan Birth Cohort Study.

Ecology, Evolution, & Energetics

• Evolution of Competitiveness During Wheat Domestication.
• Global Human Population Has Surpassed Earth’s Sustainable Carrying Capacity.

Methods

• Machine and Deep Learning Models for Preoperative Prediction of Suboptimal Clinical Response One Year After Metabolic Bariatric Surgery: Findings from the Tehran Obesity Treatment Study.
• Interpretable Machine Learning for Identifying Adolescent Obesity Risk and Identifying Key Determinants.

Commentary

• Podcast: High BMI and Causal Risk for Vascular-Related Dementia.
• Podcast: Food and Weight Loss | Dr Kevin Hall.
• Credit Where Credit Isn't Due.
• Building Muscle and Measuring Muscle for a Healthier Life: Bring the D3‑Creatine Method Online at Our Center.
• "HHS presents new protein-forward dietary guidelines, turning the food pyramid upside down. The Kennedy guidelines are mum on cancer risks associated with red meat and alcohol."
• Podcast: Protein, Creatine and "Skinny Teens?": Nutrition Science on Steroids.
• What Will Approval of Foundayo GLP-1 Tablets Bring?

General

• VIBES: A Multiscale Modeling Approach Integrating Within-Host and Between-Hosts Dynamics in Epidemics.
• First Three Outcomes Papers Published for SCORE: Systematizing Confidence in Open Research and Evidence.
• Why Selection for Mitochondrial Quality Drives the Evolution of Sexes.
• Airline Websites Vary on Info for Passengers with Obesity.
• Editorial: A Preamble to the Pathology of Humanized Mouse Models.
• Metabolic Psychiatry Targeting Metabolic Dysregulation in Mental Health.
• Investing in Agricultural Research to Sustain Growth and Competitiveness of US Agriculture.
• Podcast: Aging Clocks - What They Measure, How They Work, and Their Clinical and Real-World Relevance.

Announcements

• "Baylor College of Medicine invites applications for an innovative and highly interdisciplinary Postdoctoral Associate position focused on decoding how infection leaves durable epigenetic and transcriptional scars that shape long term immunity, inflammation, and lung repair."