Featured

• Professor Sadaf Farooqi of the University of Cambridge in the UK is the 2026 recipient of the European Association for the Study of Obesity (EASO) – Novo Nordisk Foundation Obesity Prize for Excellence.
• Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging's Intervention Testing Program Data.
• RCT: Beneficial Effects Observed on Emotion Regulation in the Two-Year-Old Offspring of Pregnant Persons in a Diet-and-Exercise Intervention.
• Weaning Drives Microbiome-Mediated Epigenetic Regulation to Shape Immune Memory in Mice.

Headline vs. Study

• Headline: Pitt Study Could Lead to New Way to Lose Weight.
• Press Release: Two Key Enzymes Drive Fat Loss While Preserving Muscle: New Pathway May Lead to Safer Obesity Treatments.
• Study: Focal Adhesion Kinases Regulate Leptin Action and the Weight Reducing Effect of HDAC6 Inhibition... In Mice.

Contrary or Null Findings

• High Meat Consumption Linked to Lower Dementia Risk in APOE4 Carriers.
• RCT: "...long-term almond consumption (50 g/day) did not enhance cognitive performance in overweight/obese individuals with prediabetes. Moreover, brain vascular function was unaffected."
• Astaxanthin, Meclizine, Mitoglitazone, Pioglitazone, Alpha-Ketoglutarate, Mifepristone, Methotrexate, and Atorvastatin-Telmisartan Do Not Increase Lifespan in UM-HET3 Mice.
• RCT: "Wholegrain rye versus refined wheat foods as part of a hypocaloric diet did not result in larger weight loss."
• RCT: "Intention-to-treat and per-protocol analyses revealed no statistically significant between-group differences in any biomarker" in Effects of a Modified Otago Exercise Program on Metabolic, Cellular, and Epigenetic Biomarkers in People Living with Dementia.
• RCT: "There were no statistically significant differences found between those in the TRE and ER groups" in Relative Effects of Time-Restricted Eating, Energy-Restricted Eating, and Unrestricted Eating on Eating Patterns and Dietary Intake.
• RCT: "In people with HIV and obesity, switching from an INSTI+TAF/FTC regimen to DOR/FTC with either TAF [tenofovir alafenamide] or TDF [tenofovir disoproxil fumarate] did not produce clinically meaningful differences in weight change or metabolic health after 48 weeks."
• RCT: "Vitamin K2 supplementation had no effect on muscle strength, physical function, muscle soreness, or inflammatory responses in the recovery period after a bout of resistance exercise."
• RCT: "The findings of this study suggest that a 12-week 8-hour time-restricted eating intervention was not associated with reductions in body mass or body composition and sleep parameters evaluated by a portable monitoring device."
• "Maternal fat-soluble vitamin levels were not independently associated with birth weight, suggesting that vitamin status during mid-to late pregnancy may not be a major determinant of fetal growth in this metabolically high-risk [overweight or obesity] population."

Basic

• Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant from Donors Subjected to Diet-Induced Obesity.
• A Nutrient-Hormone Axis Pivots an Energy Trade-Off between Resting Thermogenesis and Movement Expenditure.
• HIF-1α Reinforces PPARγ-Dependent Metabolic Rechanneling to Support Lipid Accumulation in Adipocytes.
• Commensal Enteric Virome Regulates Intestinal Carbohydrate Digestion and Absorption.
• Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging.
• Visceral, Not Abdominal Subcutaneous, Fat Cell Size Associates with Metabolic Dysfunction-Associated Liver Disease in Severe Obesity.

Scientific Rigor & Scholarly Dialogue

• Expert Reaction to Study Looking at Meat Consumption and Measures of Cognitive Health by APOE Genotype, as Published in JAMA Network Open.
• Impact of Investigator Bias in Nutrition Research.
• Expert Reaction to Observational Study of Older People Preparing Home Cooked Meals and Risk of Dementia.

Clinical

• Prevention of Weight Regain After GLP-1 Receptor Agonists Cessation with Oral TIX100.
• RCT: Family-Based Time Limited Eating to Treat Obesity.
• RCT: "Compared to a red meat-based supplemented diet, a plant-based meat supplemented diet led to significantly lower TMAO [Serum Trimethylamine N-oxide] levels, suggesting that replacing red-meat with a plant-based diet may lead to a more favourable metabolic risk profile."
• RCT: Evaluation of Organic Versus Synthetic Derived Multivitamin and Mineral Supplementation on Circulatory Concentration in Healthy Humans.
• RCT: Semi-Targeted Metabolomics Analysis of Biomarkers of Low to Moderate Alcohol Intake in the Postmenopausal Women’s Alcohol Study.
• RCT: Effect of an mHealth-Assisted Multifaceted Lifestyle Intervention on BMI, Hepatic Fat Content and Stiffness in Children with Overweight or Obesity.

Children and Adolescents

• Long-Term Cardiometabolic Outcomes in Children with Metabolically Healthy and Unhealthy Obesity.
• Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.
• Longitudinal Relationships between Parental Support and Physical Activity Behavior Among Hispanic Children with Overweight/Obesity.

Surgery

• Impact of Bariatric Surgery on the Gut Microbiota and Metabolomic Profile of the Enterohepatic Axis in an Experimental Model of Obesity.
• Review: Application of Bariatric Surgery in Pediatric Obesity.

Drugs

• Meta-Analysis: Efficacy and Safety of GLP-1 Agonists in Pediatric Obesity.
• Meta-Analysis: Trajectory of Weight Regain After Cessation of GLP-1 Receptor Agonists.
• Meta-Analysis: Suboptimal Therapeutic Responses Associated with Semaglutide in Type 2 Diabetes and Obesity.
• Review: Losing Weight and Gaining Wrinkles: The Impact of Weight Loss Drugs on Facial Aesthetics.

Food & Diet

• Association between Ultraprocessed Food Consumption and Cardiovascular Disease Risk.
• RCT: The Independent and Combined Effect of Price Increase and Price Labelling on Sugar-Sweetened Beverage Vending Machine Sales.
• "Higher UPF intake was significantly associated with lower odds of fertility in the fully adjusted model (OR = 0.32; 95% CI: 0.14, 0.75)".

Caloric and Dietary Restriction

• An Obligatory Role for AgRP Neurons in Maintaining Body Temperature During Time-Restricted Feeding.
• Dietary Sulfur Amino Acid Restriction Elicits a Cold-Like Transcriptional Response in Inguinal but Not Epididymal White Adipose Tissue of Male Mice.
• Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin–IGF-1 Nutrient-Sensing Pathway.
• RCT: Effect of Caloric Restriction on Organ-Specific Biological Aging.

Exercise & Physical Activity

• "Reductions in basal metabolism, improved movement efficiency, and selective remodeling of metabolically active organs may collectively limit exercise-induced weight loss."
• Impact of the National Steps Challenge Physical Activity Programme on Obesity and Type 2 Diabetes Prevalence in Singapore to 2050: Simulation-Based Forecasting Analysis.
• [CORRECTION] WHO Did Not Update Childhood Obesity Prevention Guidelines for Daily Physical Activity for Children Aged 5-17 in 2026.
• The Utility of Measures of Physical Behavior, Function, and Fitness as Predictors of Mortality.
• Impact of Physical Activity and Frailty on Mortality and Healthcare Utilization Among Middle-Aged and Older Adults in South Korea.

Economics & Sociology

• The Cost-Effectiveness of Placement Restrictions of Unhealthy Food and Drinks at End of Aisles and Checkouts in Australian Supermarkets.
• Disrupting the Path to Cardiovascular Disease: Stress-Related Coping and Onset of Hypertension and Obesity.
• Systematic Review: Healthcare Resource Utilisation and Cost of Obesity and Related Complications in the United States.

Epidemiology

• Meta-Analysis: Major Risk Factors of Obesity in China and Recommendations for Future Prevention and Control Efforts.
• Association of BMI, Waist Circumference, Overweight and Obesity with Sex- and Age-Specific Cognitive Function over Time.
• DXA-Derived Abdominal Adiposity and Obesity-Related Cancer Risk Among Postmenopausal Women in the Women's Health Initiative.
• Prevalence of Childhood Overweight and Obesity in Slovakia from 2018 to 2022.
• Changes in Cardiometabolic Risk Factors and Ischaemic Heart Disease Mortality between 2000 and 2015: A Global Ecological Analysis.

Psychology & Neuroscience

• The Mediating Role of Depressive Symptoms in the Relationship between Obesity-Related Triglyceride-Glucose Index and Cognitive Status Among Middle-Aged and Elderly Adults.
• Associations between Meat Consumption and Depression are Small and Unlikely to Be Causal.
• "...greater adherence to the MIND diet was associated with slower brain structural atrophy, particularly regarding grey matter loss and ventricular enlargement".

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Cause-Specific Years of Life Lost Attributable to Non-Optimal BMI by County, Sex, Race, and Ethnicity in the USA.
• Temporal Variations and Sociodemographic Differences in No Muscle-Strengthening Exercise Among Adolescents: A 10-Year Repeated Cross-Sectional Study.
• Diet Quality by Race and Ethnicity in Adult Cancer Survivors: An NHANES 2011 - 2020 Study.

Stigma

• "43.2% viewed obesity as a cause for shame", Social Perception of Obesity - Nationwide Cross-Sectional Survey Among Adults in Poland.
• Weight Bias Internalization Is Inversely Associated with Adherence to the Mediterranean Diet.
• Weight Self-Stigma, Weight Bias Internalization, and Eating Attitudes in Relation to Body Appreciation.
• Misconceptions About Obesity and Weight Stigma in Brazilian Healthcare Professionals.

Policy Related

• Review: Barriers and Facilitators for Implementation of Lifestyle Related Blended Care Interventions for Overweight, Obesity and Type 2 Diabetes Mellitus.
• Food Policies and Initiatives Targeting Ultra Processed Food Consumption in Sub-Saharan Africa.
• The Intersection of Education and Health: Schools as a Catalyst for Childhood Obesity Prevention.
• Dissertation: The Role of School Nutrition Policy in the Prevention of Dental Caries and Obesity in Public Primary School Children, Riyadh, Saudi Arabia.

Intergenerational Effects

• Blood Serum from Women with Obesity Raises ROS Production by Neural Stem Cells.
• Per- and Polyfluoroalkyl Substances in Umbilical Cord Serum and Key Intermediate Metabolites in Relation to Preterm Birth.
• Pregnancy-Associated Metabolic Adaptations in Circulating Monocytes and Macrophages Favor Clearance Functions.
• "Children born to mothers with overweight or obesity showed persistently higher BMI trajectories and an earlier adiposity rebound than those of mothers with normal weight."

Ecology, Evolution, & Energetics

• Update and Classification of Feeding Habits of Armadillos (Xenarthra, cingulata): A 40-Year Review.
• Systematic Review: Socio-Economic Pathways Driving Food Systems Transformations.

Methods

• Diet, Physical Activity, All-Cause and Cause-Specific Mortality: Repeated Measures Considerations.
• Methodological Standards for Body Composition Assessment - An Expert-Endorsed Guide for Research and Clinical Applications: Bioimpedance, Dual-Energy X-Ray Absorptiometry, Computerized Tomography, and Ultrasound Methods.
• A Sequential Deep Learning Model for Predicting People with Obesity in Adults Aged 18-64 Using Physical Fitness Variables.
• Growth Charts for Grown-Ups? BMI-For-Age Percentile Curves to Measure Obesity Status: An Analysis of Data from the Canadian Longitudinal Study on Aging.
• "The newly proposed BMI cutoff points (≥24.0 kg/m2 for males and ≥23.5 kg/m2 for females) optimize the detection of excess body fat and are more effective than traditional thresholds."

Commentary

• New Study Challenges Dietary Advice on Sweet Foods and Obesity.
• Milk Consumption Linked to Higher Parkinson Disease Risk, Especially in Men.
• HD Wegovy Approval Marks More Dosing Flexibility.
• Council for Responsible Nutrition Says Nutrition Is Foundational for Health Care.
• Are Grotesque Burgers Having a Moment?
• When Drugs Meet Disease: Disentangling Diabetes, Obesity, and Periconceptional GLP-1 Receptor Agonist Safety.
• Using Feeding Trials to Establish Skin Carotenoid Score as a Biomarker of Fruit and Vegetable Intake.
• Myth of 'Fat But Fit': Major Study Confirms There's No Such Thing as 'Healthy' Obese Person.
• Collagen Vs. Whey: Marketing Hype or Scientific Reality?

General

• Organization of Neuropeptide Systems in the Human Brain.
• An Atlas of Exposome-Phenome Associations in Health and Disease Risk.
• RCT: Combined Resistance Exercise and Essential Amino Acid Intake Enhance Follistatin/Myostatin Ratio and Muscle Fitness in Older Women.
• RCT: When Does Food Act as a Social Surrogate? The Interplay of Need to Belong and Social Context.
• What Can We Learn from Network Meta-Analyses Published in Top Medical Journals.
• Pharmacological Complexities of Herbal Medicinal Extracts: A Review of Bioavailability, Interactions, and Standardization.
• Limited Consensus in Expert Opinions on Studies Evaluating the Design, Conduct, Analysis, or Reporting of Health Research.
• Elsevier Expands Check Integrity Tool Across 2,000 Journals.
• Commentary: How AI Use in Scholarly Publishing Threatens Research Integrity, Lessens Trust, and Invites Misinformation.

Video & Audio

• Podcast: Is Fluoride Safe? The Science Behind Dental Health (NIH Director's Podcast).
• Podcast: Obesity Medications and the Coming Revolution in Care with Louis Aronne.

Announcements

• "The prestigious European Association for the Study of Obesity (EASO) and the Novo Nordisk Foundation named Dr I Gusti Ngurah Edi Putra the winner of the New Investigator Award in Public Health."