Featured

• Mapping the Causal Chain from Genetic Risk Variants to Lipid Dysmetabolism in Parkinson’s Disease.
• Ameliorative Effects of Tallow and Olive Oil on Hyperlipidemia-Induced Atherogenesis in Male Albino Rats.
• RCT: Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults.
• Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight-Loss in Diet-Induced Obese Mice.

Headline vs Study

• Headline: Dietary Melatonin May Lower Obesity and Depression Risk.
• Study: The Content of Dietary Melatonin in 119 Self Reported Food Items and Cross-Sectional Relationship with Self Reported Chronic Diseases.

Contrary or Null Findings

• RCT: "A moderate, fat-dominant preload consumed before a mixed meal did not alter nadir or overall postprandial glucose in adults without diabetes after SG."
• RCT: Limited to No Effects Detected in Preplanned Analyses of Primary Endpoints in the Effect of a Supervised Exercise Program Throughout Pregnancy on Longitudinal Lipid Profile Changes.
• RCT: "In this relatively small study, providing a modified, low-protein infant formula during the first months of life did not affect hormonal and metabolic markers during early childhood".
• "Contrary to expectations, placing larvae in hypoxia a day before they reached the critical weight delayed the molt significantly, suggesting that hypoxia is not a trigger for the initiation of metamorphosis. Nevertheless, an increase in lactate levels in the second half of the final instar, and the leveling off of metabolic rate, indicate that a metabolic shift occurs at the critical weight."
• "Contrary to the general belief of the dominance of Lactobacillus in the human endometrium, our study suggests that the endometrial microenvironment may be harbouring DNA fragments and/or cells of lactobacilli originating from the lower reproductive tract. Our study results indicate a need to re-consider/re-analyse the endometrial microbiome in health and disease."
• "Contrary to our hypothesis, we find dietary benefits in individuals with lower ADHD PGS, necessitating replication."
• "Contrary to the persistent assumption that hippos rest in water by day and graze on land all night, hippos in this study fed during only a quarter of the night and were active for a similar proportion of the day."
• "Strikingly, and in contrast to prevailing expectations based on metabolic improvements, this shortened lifespan in females occurred despite marked enhancements in metabolic health, including reduced body weight and adiposity, preferential glucose oxidation, elevated metabolic rate, and enhanced glucose tolerance and insulin sensitivity throughout adulthood."

Basic

• An Oral, Liver-Restricted LXR Inverse Agonist for Dyslipidemia: Preclinical Development and Phase 1 Trial.
• Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis.
• Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice.
• Neomycin-Sensitive Gut Bacteria-Derived Brassicasterol Mediates the Anti-Obesity Effects of Cordyceps militaris Polysaccharide.
• Early-Life Dietary Long-Chain Polyunsaturated Fatty Acid Consumption Promotes Immune Function and Reduces Systemic and Adipose Inflammation in a Sex-Specific Manner in Obese Wistar Rats.
• High-Fat and Choline-Deficient Western Diets Disrupt the Ovarian Microenvironment in Mice.
• Central FGF19 Reduces Hypothalamic Inflammation and Improves Leptin Signaling in Obese Mice.

Scientific Rigor & Scholarly Dialogue

• A Framework for Assessing the Trustworthiness of Scientific Research Findings.
• Reproducibility and Sources of Variation of Urinary Biomarkers of Food Intake of Fruits, Vegetables, and Chocolate in European Children and Adolescents.
• Rapid Response: Re: Misleading Narrative of “Healthy” Ultraprocessed Foods.

Clinical

• RCT: Oral Multi-Enzyme Supplementation Alters Postprandial Plasma Nutrient Concentrations After a Mixed Meal in Healthy Middle-Aged and Older Adults.
• Review: Digestible and Metabolizable Energy Intake in Humans.
• Obesity-Driven Hypertension: Exploring the Mechanisms and Modern Treatment Strategies.

Children and Adolescents

• Infant Diet Is Associated with BMI Later in Childhood.
• Cross-Sectional: Relationship between Body Adiposity and Glycemic Control in Children and Adolescents with Type 1 Diabetes.
• Review: Participatory Approaches with Girls in Physical Activity Contexts.
• Body Roundness Index Outperforms Traditional Obesity Metrics in Predicting Cardiometabolic Risk Among Children and Adolescents.
• Interrelationships between Sarcopenia, Bone Mass and Metabolic Parameters in Pediatric Obesity.
• Multicomponent Intervention Improves Gut Microbiome and Cardiac Autonomic Function in Childhood Obesity.

Surgery

• Optimizing Safety and Outcomes in Metabolic/Bariatric Surgery: A Conceptual Framework for Staged Minimally Invasive Treatment.
• RCT: Preoperative Glucagon-Like Peptide-1 Therapy in Bariatric Surgery Patients with Morbid Obesity.
• The Role and Effects of Metabolic and Bariatric Surgery on Endometrial Cancer Care.

Drugs

• Review: Pharmacological Management of Obesity in Pregnancy: A Review of Current and Emerging Therapies.
• Pediatric Use of Compounded GLP-1 Agents: Benefits, Risks, and Equity.
• Lean Mass Loss in Glucagon-Like Peptide-1/GIP Therapy: Clinical Implications for Obesity and Cardiovascular Care.

Food & Diet

• Maternal Mediterranean Diet During Pregnancy and Adiposity from Early Childhood Through Preadolescence.
• RCT: Eating Rate Has Sustained Effects on Energy Intake from Ultraprocessed Diets.
• RCT: The Impact of Restaurant Menu Eco Labels on Consumer Meal Selections.
• RCT: Diet Quality and Nutritional Adequacy During a 2-Year Calorie Restriction Intervention.

Caloric and Dietary Restriction

• A Very-Low-Energy Fast Involves Increased Adipose Inflammatory Gene Expression.
• Effects of 1-Month Very-Low-Calorie Ketogenic Diet on 24-Hour Energy Metabolism and Body Composition in Women with Obesity.
• Preprint: Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults Without Obesity.
• Content of Fatty Acid and Eicosanoids in Muscle and Intestinal Tissue of C57BL/6 Mice Subjected to Long-Term Caloric Restriction.

Exercise & Physical Activity

• Resistance Training as a Key Strategy for High-Quality Weight Loss in Men and Women.
• Leisure-Time Physical Activity Is Associated with Reduced Risks of Mortality in Adults with General or Abdominal Obesity in Mexico.

Economics & Sociology

• Preprint: Evaluation of the Experience of People Referred Under the NHS Enhanced Service Incentive for Obesity to the NHS Digital Weight Management Programme.
• Associations between Historical Redlining and BMI: Potential Indirect Pathways Through Neighborhood Socioeconomic and Environment Factors and Their Associated Lifestyle Behaviors in CARDIA.
• Burden of Obesity in Local Health Systems: A Comparative Analysis Across Three Integrated Care Boards in England with a Focus on Type 2 Diabetes.

Epidemiology

• Adult Obesity and Risk of Severe Infections: A Multicohort Study with Global Burden Estimates.
• The Impact of the Lancet Commission Definition of Obesity on Its Prevalence and Implications on Long-Term Cardiovascular-Kidney-Metabolic Outcomes in East Asians.
• Genetics Identifies Obesity as a Shared Risk Factor for Co-Occurring Multiple Long-Term Conditions.
• Cross-Sectional: The Association between Serum α1-Acid Glycoprotein and Obesity and Abdominal Obesity in Women.

Psychology & Neuroscience

• Adolescent Depressive Symptoms, Physical Activity, and Core Self-Evaluation in Chinese Adolescents.
• A Ketogenic Diet for Treatment-Resistant Depression.
• The Impact of Adverse Childhood Experiences on Gut Microbiota and Markers of Inflammation Is Mediated by Obesity and Depression.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Fifteen-Year Trends in Behavioral Risk Factors and Metabolic Health Conditions for Non-Communicable Diseases: Persistent Race and Gender Inequalities in Brazil.
• Racial and Ethnic Disparities in Postnatal Growth of Infants Born Before 30 Weeks of Gestation.
• Review: Socioeconomic Position and the Gut Microbiota.
• Pre-print: Obesity, Urbanization, and Food Access in Wisconsin: The Intersection of Healthcare Provider Access and Population Health Outcomes.
• Review: Social Determinants of Health Associated with Perinatal Health Outcomes in Different Racial/Ethnic Groups.
• Disparities in Adolescent and Young Adult Obesity Medication Dispensing.

Stigma

• Contraceptive Care for Patients with Bigger Bodies in the US: Evaluation of a Provider Training Intervention.
• Internalized Weight Stigma, Breastfeeding Difficulties, and Self-Efficacy as Mediators between Pre-Pregnancy Overweight/Obesity and Exclusive Breastfeeding at 6 Months Postpartum.

Policy Related

• Nanotechnology in Food Systems: Opportunities and Risks for Human Health.
• From Tobacco to Ultraprocessed Food: How Industry Engineering Fuels the Epidemic of Preventable Disease.
• Burden of Obesity in India: Need for Policy Changes to Attain Highest Possible Level of Health and Well-Being.
• Digitalization of the Retail Food Environment: Modernizing Food Access, Highlighting Health Equity, and Identifying Opportunities for Future Research and Practice.
• Review: Addressing Childhood Malnutrition in Europe: Policy Approaches to Promote Healthy Eating in Young Children.

Intergenerational Effects

• NASEM Proceedings: Prepregnancy BMI and Gestational Weight Gain: New Evidence, Emerging Innovations, and Policy Implications.
• Pre-print: Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling.
• Effects of Maternal High-Fat Diet During Pregnancy and Lactation on Behaviour and Hypothalamic Orexin Neurons in Mice Offspring.
• Impact of Obesity and Preconceptional Bariatric Surgery on Feto-Placental Unit in a Rat Model.
• Associations of Maternal Prenatal Inflammation with Child Adiposity.
• Maternal and Fetal Genetic Predispositions to Insulin Deficiency and Resistance Affect Fetal Growth Through Distinct Pathways.

Ecology, Evolution, & Energetics

• Energetics link long-term environmental variations to breeding success in a wild penguin population.
• The cheeky ape hypothesis: Is rosacea the evolutionary price of human buccal fat?

Methods

• A Novel Electrochemical Glucose Biosensor Based on MnO2/Carboxylated Graphene Oxide/Glucose Oxidase for Sensitive Glucose Biosensing.
• Preference-Informed Cluster Randomized Design for Pragmatic Clinical Trials.
• Identifying Genome-By-Childhood Trauma Interactions for Depression Using a Forest-Based Approach.
• Explainable Machine Learning for Depression Risk Prediction in Adults with Obesity: Development of an Online Tool.
• Integrating Body Composition Analysis and Machine Learning for Non-Invasive Identification of Metabolic Dysfunction-Associated Fatty Liver Disease.

Commentary

• Podcast: How Body Fat Affects Your Metabolic Health and Risk of Metabolic Disease | Dr Robert Eckel.
• Podcast: Study Deep Dive: Does Aspartame Increase Insulin?
• Podcast: Can We Define Hyper-Palatable Foods? And Is Processing Actually the Problem? - Tera Fazzino, PhD.
• Unintended Risks of Sarcopenic Obesity During Weight-Loss Interventions in Older People.
• Podcast: Dr. Gabrielle Lyon Sits Down with Dr. Donald Layman, One of the World’s Leading Protein Researchers and a Key Contributor to the Newly Released U.S. Dietary Guidelines.
• "A longevity researcher [Steve Austad] changed his routine after visiting an island 'Blue Zone' where people live to 100."
• Do GLP-1s Have Deleterious Effects on Muscle?
• The Next Wave of GLP-1 Drugs are Coming - And They’re Stronger Than Wegovy and Zepbound.

General

• Commentary Urges Balance between Research Integrity and Technology Transfer in Biomedicine.
• Not Eating Red Meat Is Associated with Reporting the Environment and Climate Change as a Top Concern.
• Richard DiMarchi: "The biggest reward is the people you produce,” he said. “I’ve contributed technology and drug candidates to the world, but I’ve also contributed the next generation of scientists capable of continuing to improve the world."
• How Gene Loss and Monogamy Built Termite Mega Societies.
• "A team of researchers at Baylor College of Medicine and Texas Children's Hospital has discovered a connection between a genetic variant, disruptions in lipid metabolism, and the development of Parkinson's disease."
• Comparing Cross-Sectional and Longitudinal Study Designs for Accurate Viral Dynamics Estimation: Insights from the NBA Cohort Data.
• Review: Nudges for Enhancing Agricultural Policy.
• Norovirus Growth Breakthrough Using Mini-Gut Organoids.

Announcements

• The Division of Nutrition, US Department of Agriculture (USDA) Agricultural Research Service (ARS) Children’s Nutrition Research Center (CNRC), in the Department of Pediatrics at Baylor College of Medicine and Texas Children's Hospital Seeks Applicants for an Appointment at the Assistant Professor (Tenure-Track), Associate Professor (Tenured) Level, or Professor (Tenured) Level Who Will Also Serve as Director of the Body Composition Unit.