Featured

• Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation.
• Nanogel-based Nasal Ghrelin Vaccine Prevents Obesity [in Mice].
• [Low] Methodological Quality, Completeness of Reporting and Use of Systematic Reviews as Evidence in Clinical Practice Guidelines for Paediatric Overweight and Obesity.

Headline vs Study

• Headline: World Might Come to an End for Nutella Lovers: Study Suggests It Could Cause Cancer.
• Report: Evaluation of Risks Associated with Potential Chemical Byproducts of the Processing of an Oil Used in Nutella (and Many Other Things); No Mention of Nutella, No Observations in Humans.
• Evaluation of Headlines: Does Nutella Cause Cancer? A Deeper Look.

Contrary or Null Findings

• Accelerometer-measured Physical Activity is Not Associated with Two-year Weight Change in African-origin Adults From Five Diverse Populations.
• "Our findings provide little evidence to support a strong causal intrauterine effect of incrementally greater maternal BMI resulting in greater offspring adiposity."
• RCT: L-arginine Supplementation (2g Per Day) ...in Male Athletes, ...had No Effect on Anthropometric Measurements, Including BMI, BFM and LBM.
• RCT: 24-month Intervention with a 1-credit College Course on Healthy Weight Behaviors and a Social Networking and Social Support Website …was Not Successful in Achieving BMI Differences Between Treatment Groups.
• The Authors Find No Association Between Changes in Sprawl and the Changes in BMI for Movers.
• RCT: "The results of this study suggest that, in nonmetabolic obese persons, a hypoallergenic-LCD diet for 1 mo showed no advantages compared with an LCD."
• Contrary to the Reports of a Salutary Effect of Honey in Diabetic Humans and Rodents, Our Results Showed that Consumption of Honey Caused No Significant Changes in Body Weight, or Glucose and Insulin Concentrations.
• "Surprisingly, the excess of fatty mass seems not to be related to atherosclerotic burden in very elderly individuals."
• Brown Adipose Tissue Does Not Seem to Mediate Metabolic Adaptation to Overfeeding in Men.

Basic

• Increased Ghrelin Signaling Prolongs Survival in Mouse Models of Human Aging Through Activation of Sirtuin1.
• Alcoholic Fatty Liver is Enhanced in CYP2A5 Knockout Mice Via the PPARa-FGF21 Axis.
• Effects of Varying Protein and Lipid Levels and Protein-to-Energy Ratios on Growth, Feed Utilization, and Body Composition in Juvenile Croakers.
• Store-Operated Ca2+ Entry (SOCE) Controls Induction of Lipolysis and the Transcriptional Re-Programming of Lipid Metabolism.
• Increased Expression of Triggering Receptor Expressed on Myeloid Cells-1 in the Population with Obesity and Insulin Resistance.
• Interspecies Organogenesis Generates Autologous Functional Islets.
• Mild and Short-term Caloric Restriction Prevents Obesity-induced Cardiomyopathy in Young Zucker Rats Without Changing in Metabolites and Fatty Acids Cardiac Profile.
• Hindbrain DPP-IV Inhibition Improves Glycemic Control and Promotes Negative Energy Balance.
• Celastrol Ameliorates Liver Metabolic Damage Caused By a High-fat Diet Through Sirt1.
• Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome.
• Deletion of P22phox-dependent Oxidative Stress in the Hypothalamus Protects Against Obesity By Modulating ß3 - Adrenergic Mechanisms.
• Effects of G6pc2 Deletion on Body Weight and Cholesterol in Mice.

Scientific Rigor & Scholarly Dialogue

• Critical Evaluation of Nutrition Research.
• Comment On: Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention.
• Response to Comment On: Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention.
• Letter: What is a Favourable Risk-Benefit Profile Concerning Metabolic Surgery for Patients with Type 2 Diabetes?
• Letter: Is It Justified to Have a Lower BMI Cutoff for Metabolic Surgery for Asians with Type 2 Diabetes?
• Response To: Why Fat Suits do Not Advance the Scientific Study of Weight Stigma.
• Comment On: A Meta-analysis of GLP-1 Receptor Agonists Versus Insulin Treatment From Head-to-head Studies in Type 2 Diabetic Patients.

Clinical

• RCT: Effect of Shortened Sleep on Energy Expenditure, Core Body Temperature, and Appetite.
• Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease.
• Role of Insulin-Stimulated Adipose Tissue Perfusion in the Development of Whole-Body Insulin Resistance.

Children and Adolescents

• Overweight in Adolescent, Psychiatric Inpatients: A Problem of General or Food-specific Impulsivity?
• Sweetened Beverage Intake in Association to Energy and Sugar Consumption and Cardiometabolic Markers in Children.
• Dietary Patterns in Infancy are Associated with Child Diet and Weight Outcomes at 6 Years.
• Cardiac Autonomic Regulation as a Predictor for Childhood Obesity Intervention Success.
• Three Interventions that Reduce Childhood Obesity are Projected to Save More than They Cost to Implement.
• Systematic Review: Involvement of Fathers in Pediatric Obesity Treatment and Prevention Trials.

Surgery

• Vertical Sleeve Gastrectomy Reduces Blood Pressure and Hypothalamic Endoplasmic Reticulum Stress in Mice.
• Gastric Plication Improves Glycemia Partly By Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and Liver.
• Mechanisms Behind Reduced Appetite for Fat After Gastric Bypass Uncovered.

Drugs

• Beneficial Effects of Naringenin and Indomethacin on White and Brown Adipocytes.
• Associations of Prenatal and Childhood Antibiotic Use with Child BMI at Age 3 Years.
• Pharmacological Efficacy of FGF21 Analogue, Liraglutide and Insulin Glargine in Treatment of Type 2 Diabetes.
• RCT: Efficacy and Safety of Once-weekly Semaglutide Monotherapy Versus Placebo in Patients with Type 2 Diabetes.

Food & Diet

• RCT: Effect of Mouth Rinsing and Ingestion of Carbohydrate Solutions on Mood and Perceptual Responses During Exercise.
• RCT: The Relative Reinforcing Value of Sweet Versus Savory Snack Foods After Consumption of Sugar- or Non-nutritive Sweetened Beverages.
• How Nutritious are Children's Packed School Lunches? A Comparison of Lunches Brought From Home and School Lunches.
• Saturated Fat Consumption and Risk of Coronary Heart Disease and Ischemic Stroke: A Science Update.
• Long-term Dietary Supplementation with Low-dose Nobiletin Ameliorates Hepatic Steatosis, Insulin Resistance, and Inflammation Without Altering Fat Mass in Diet-induced Obesity.
• Protection Against High-Fat-Diet-Induced Obesity in Mice Due to Reduced P53 Activity and Enhanced Energy Expenditure.
• Bovine Milk Oligosaccharides Decrease Gut Permeability and Improve Inflammation and Microbial Dysbiosis in Diet-induced Obese Mice.

Caloric Restriction

• The Effects of Graded Levels of Calorie Restriction: IX. Global Metabolomic Screen Reveals Modulation of Carnitines, Sphingolipids and Bile Acids in the Liver of C57BL/6 Mice.
• Calorie Restriction Attenuates Terminal Differentiation of Immune Cells.

Exercise & Physical Activity

• Systematic Review: The Impact of Interventions that Integrate Accelerometers on Physical Activity and Weight Loss.
• Regular Exercise Shapes Healthy Gut Microbiome. (pdf)
• Behavior Change with Fitness Technology in Sedentary Adults: A Review of the Evidence for Increasing Physical Activity.
• Plasma Irisin Modestly Increases During Moderate and High-Intensity Afternoon Exercise in Obese Females.

Economics & Sociology

• Using the Protein Leverage Hypothesis to Understand Socioeconomic Variation in Obesity.
• Height, BMI, and Relative Economic Standing in Children From Developing Countries.
• Measures of the Food Environment: A Systematic Review of the Field, 2007–2015.

Epidemiology

• CEBP Focus: The Obesity Paradox in Cancer: Evidence and New Directions.
• SNAP Participation and Diet-Sensitive Cardiometabolic Risk Factors in Adolescents.

Psychology

• Portion Size Tells Who I Am, Food Type Tells Who You Are: Specific Functions of Amount and Type of Food in Same- and Opposite-sex Dyadic Eating Contexts.
• Food Cravings Prospectively Predict Decreases in Perceived Self-regulatory Success in Dieting.
• Parent-adolescent Influences on Everyday Dietary Practices: Perceptions of Adolescent Females with Obesity and Their Mothers.
• Contextual Factors Associated with Eating in the Absence of Hunger Among Adults with Obesity.
• Adolescent Weight Status: Associations with Structural and Functional Dimensions of Social Relations.
• BMI Moderates the Relationship Between C-reactive Protein and Depressive Symptoms.
• Volitional Regulation of Brain Responses to Food Stimuli in Overweight and Obese Subjects: A Real-time FMRI Feedback Study.
• Self-Expansion is Associated with Better Adherence and Obesity Treatment Outcomes in Adults.

Equity and Disparities

• Race Effects of Perceived Weight Status and Its Relationship with Unmet Health Care Need.
• Social Disparities in Obesogenic Behaviors in Adolescents.
• Commentary: Urban Place and Health Equity:Critical Issues and Practices.

Stigma

• Association Between Weight Bias Internalization and Metabolic Syndrome Among Treatment-seeking Individuals with Obesity.
• Can Legislation Prohibiting Weight Discrimination Improve Psychological Well-Being?
• Eating Moderates the Link Between BMI and Perceived Social Connection.
• Internalized Weight-stigma and Binge Eating Behaviors in Portuguese Women with Overweight and Obesity.
• The Damaging Effects of Weight Bias Internalization.

Policy Related

• Taxing Sugar-sweetened Beverages: Impact on Overweight and Obesity in Germany.
• Junk Food, Junk Diets, and Junk Policy for Obesity.
• Taking Measures in Times of Crisis: The Political Economy of Obesity Prevention in Spain.

Intergenerational Effects

• Adverse Metabolic Phenotype of Female Offspring Exposed to Preeclampsia in Utero: A Characterization of the BPH/5 Mouse in Postnatal Life.
• Maternal Pre-Pregnancy Obesity is Associated with Altered Placental Transcriptome.
• Associations of Maternal Pre-pregnancy BMI and Gestational Weight Gain with Birth Outcomes in Shanghai, China.

Ecology, Evolution, & Energetics

• Energetics of Being a Healthy Sith Lord [updated link 2017-12-13].
• Morphological Asymmetry and Habitat Quality: Using Fleas and Their Rodent Hosts as a Novel Experimental System.
• Comparative Genomics Reveals Convergent Evolution Between the Bamboo-eating Giant and Red Pandas.

Mathematical and Quantitative

• Qualitative Stability Analysis of an Obesity Epidemic Model with Social Contagion.
• Mathematical Investigation of Diabetically Impaired Ultradian Oscillations in the Glucose-insulin Regulation.
• Evaluation of Serum High Molecular Weight Adiponectin and Lipid Profiles in Predicting the Risk of Coronary Artery Disease Among CAD Patients.(pdf).

Commentary

• Ingestive Classics: Stanley Schachter and Obesity and Eating.
• Professor: ‘Indulgent’ Foodie Blogs Sexually Objectify Women.
• Big Studies Clash Over Fetal Growth Rates.
• What Not to Eat: ‘The Case Against Sugar’.
• Why Sugar is Bad for You.
• Esther Cepeda: White-knuckled Fear of Sugar Isn't the Sweetest Solution to Our Overconsumption.
• The Case Against Sugar.
• What's Making Us Fat? Inside the Sugar Wars. Experts Disagree on What's Really Driving the Obesity Epidemic.
• Government Should Not Regulate Sugar Like Alcohol or Tobacco to Curb Obesity.
• Think Sweet ~ Stay Slim.
• Nutritional Studies Swayed By Popular Opinion, Researchers Say.
• Commentary on Low-Calorie Sweetened Beverages Misses the Mark.
• ‘Chocolate Found to Stave Off Death!’ Analyzing the Scientific Evidence Behind Health Headlines.
• EU Panel Concludes Organic Food May Offer Limited Health, Sustainability Advantages.

General

• The Clear and Present Menace of SciLence.
• Webcast Recordings and Speaker Presentations From the ILAR Roundtable Workshop on Animal Models for Microbiome Research: Advancing Basic and Translational Science are Now Available.
• John Arnold's War on Bad Science.
• Academia's Failure to Retain Data Scientists.
• "This study did not find strong evidence of a protective relationship between family activities and school problems."
• Pomegranate for Prevention and Treatment of Cancer: An Update.
• Loss of Merlin Induces Metabolomic Adaptation that Engages Dependence on Hedgehog Signaling.
• Performance of Predictive Equations Specifically Developed to Estimate Resting Energy Expenditure in Ventilated Critically Ill Children.
• Vacuum Transfer Advance Will Help Redefine Kilogram Next Year.

Video & Audio

• Video: Studying Mitochondrial Structure and Function in Drosophila Ovaries.
• Audio: Is Your Smartphone Weighing Down Your Workout?

Announcements

• Announcing: Glucose Clamping the Conscious Mouse: A Laboratory Course September 11-15, 2017.
• 12th Annual Building Healthy Lifestyles Conference February 10-11.
• UAB's Nutrition Obesity Research Center (NORC) invites you to join us at our NIH-funded short course on “The Mathematical Sciences in Obesity;" Applications due March 3rd.
• UAB Invites You to Join Us at Our NIH-funded Short Course on “Strengthening Causal Inference in Behavioral Obesity Research;” Applications Due March 31st.
• National Academy of Sciences Sackler Colloquium “Reproducibility of Research: Issues and Proposed Remedies”, March 8 - 10, 2017.
• UAB’s NORC seeks post-doctoral fellows in obesity research.