Featured

• Nutritional and Lifestyle Supportive Care Recommendations for Management of Obesity with GLP-1 - Based Therapies: An Expert Consensus Statement Using a Modified Delphi Approach.
• Meta-Analysis of RCTs: "Exercise may be moderately more effective than a control intervention for reducing symptoms of depression. Exercise appears to be no more or less effective than psychological or pharmacological treatments…"
• Evaluation of the Effects of a New Standard Equation for Doubly Labeled Water Studies.
• Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging.
• Nucleotide Metabolic Rewiring Enables NLRP3 Inflammasome Hyperactivation in Obesity.

Headline vs Study

• Headline: Losing Weight in Midlife May Have a Hidden Brain Cost.
• Press Release: Weight Loss to Treat Midlife Obesity: Protecting the Aging Brain May Be Key.
• Study: Weight Loss Aggravates Obesity-Induced Hypothalamic Inflammation... In Mid-Aged Mice.

Contrary or Null Findings

• RCT: "...the kindergarten-based obesity prevention intervention showed no overall effect on BMI z-score or overweight risk at the population level..."
• RCT: No Demonstrated Effectiveness of a Just-In-Time Micro-RCT on the Physical Activity and Sedentary Time of Young Children and Their Parents: The Active Family M-Health Intervention.
• RCT: "In conclusion, twelve 10-minute sessions of short-HIIT performed at the beginning of physical education classes over six weeks did not alter executive function or inhibitory control in adolescents..."
• RCT: Lesser Effects from Low-Load Blood-Flow Restriction Training Versus High-Load Resistance Training on Neuromuscular Performance and Neuromuscular Activation.
• RCT: "We observed no changes in markers of insulinemia, inflammation, or PSA from a 16-week at-home walking intervention vs. control in individuals with low-risk [prostate cancer]."
• RCT: "In this ... trial of diabetes-free individuals with obesity and MASLD, a 6-month berberine treatment at a daily dose of 1 g had an excellent safety profile but did not reduce VAT area or liver fat content."
• RCT: "In this relatively small study, providing a modified, low-protein infant formula during the first months of life did not affect hormonal and metabolic markers during early childhood."
• RCT: No apparent "efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart disease who had completed a phase II CR program."

Basic

• Genetic Variation Shapes the Chromatin Accessibility Landscape and Transcriptional Responses in Mouse Adipose Tissue.
• High-Dose Neonatal Riboflavin Remodels Energy Metabolism and Brain Mitochondrial Ultrastructure in Rats Exposed to Maternal High-Fat Diet.
• Mechanistic Insights Into the Anti-Obesity Effects of Gondoic Acid: Regulation of AMPK Signalling and Obesity Related Gene Expression in Obese Mice.
• α1-Acid Glycoprotein Mitigates MASLD Progression by Modulating Liver and Adipose Tissue Function.
• Metabolic Beneficial Effects of Targeting a Long Non-Coding RNA, Lnc-Megacluster, in Obesity.
• Epoxy-Oxylipins Direct Monocyte Fate in Inflammatory Resolution in Humans.
• MiR-874-3p Suppresses TNF-α-Induced Inflammation in Adipocytes by Targeting Nucleolin.
• Cajanolactone a Alleviates High-Fat Diet-Induced MAFLD by Modulating Liver De Novo Lipogenesis, Inflammatory Signaling, and Bile Acid Composition in the Gut-Liver Axis.

Scientific Rigor & Scholarly Dialogue

• Retraction: Effect of Combined GLP-1 Analogue and Bupropion/Naltrexone on Weight Loss: A Retrospective Cohort Study.
• Conclusions are Not Supported by the Published Statistical Analysis. Comment on López-Toledo et al. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial. Nutrients 2025, 17, 709.
• Article: Effect of Ultra-Processed Food Consumption on Male Reproductive and Metabolic Health.
• Letter: Confusion About Energy and Energy Density in a 3-Week Trial of Ultra-Processed Food.
• Letter: Disentangling the Effects of Food Processing from Those of Diet Quality.
• Reply: On the Mechanisms of Ultra-Processed Diet Effects.
• Article: Ketone Ester Ingestion Impairs Exercise Performance Without Impacting Cognitive Function or Circulating EPO During Acute Hypoxic Exposure.
• Letter: Individual Responses: Transparency Is Welcome, but Inference Needs Replication and Modeling.
• Editorial Expression of Concern: High Triglyceride‑Glucose Index and Stress Hyperglycemia Ratio as Predictors of Adverse Cardiac Events in Patients with Coronary Chronic Total Occlusion: A Large‑scale Prospective Cohort Study.

Clinical

• Navigating the Benefits and Harms of GLP-1 and GLP-1/GIP Agonists in Obesity.
• What to Know About the Wegovy Pill for Obesity.
• One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.
• Exome-Wide Analysis Identifies a Rare EXD3 Missense Variant Associated with Diabetic Kidney Disease.

Children and Adolescents

• Circulating Spexin and Adiponectin as Early Biomarkers of Insulin Resistance in Pediatric Obesity.
• Review: Understanding How Childhood Obesity Influences Educational Outcomes.
• Body Composition Changes and Their Associations with Physical Activity and Screen Time in a Sample of Italian Early Adolescents over a 3-Year Period.
• Association between Fundamental Movement Skills and Weekday/Weekend Physical Activity Among Preschool Children in China: A Cross-Sectional Study.

Surgery

• Surgical Intervention for Adolescent Obesity: Evolution of the Scientific Agenda from 1980 to the Present.
• Bariatric Surgery and Renal Function: A Mid-Term Prospective Analysis of Estimated Glomerular Filtration Rate Dynamics in Adults with and without Diabetes Mellitus.
• Long-Term Mortality After Bariatric Surgery Versus Matched Controls: A National Health and Nutrition Examination Survey-Based Study.
• Personalizing Bariatric Metabolic Surgery: Predictors of Weight-Loss Success and Risk of Weight Recurrence.

Drugs

• ENT1 Inhibition Enhances Weight Control and Metabolic Health in Diet-Induced Obesity.
• Glucagon-Like Peptide-1 Medicines and Cancer.
• Glucagon-Like Receptor Agonists and Next-Generation Incretin-Based Medications: Metabolic, Cardiovascular, and Renal Benefits.
• Cryo-EM Structures of GPR75 Reveal an Occluded Orthosteric Pocket Challenging Conventional Drug Discovery Paradigms for an Anti-Obesity Target.
• Longitudinal Trends in Non-Insulin Pharmacotherapy for Type 2 Diabetes in Australian Women of Reproductive Age: Implications for Planned and Unplanned Pregnancies.

Food & Diet

• Systematic Review: Bamboo Consumption and Health Outcomes: A Systematic Review and Call to Action.
• Choline Adequacy and Health Outcomes in Vegetarian and Vegan Diets.
• Global Food Policies and Obesity: Lessons from Selected Country Experiences.
• Fish Oil Ameliorates Glycolipid Metabolism Disorders Induced by Long-Term Potato Chip Diet Through Gut-Liver Axis [in Mice].

Caloric and Dietary Restriction

• Review: Fasting as a Multisystem Health Modulator: A Narrative Review of Metabolic, Cardiovascular, Immune, Neurocognitive, and Psychospiritual Effects.
• Calorie Restriction Suppresses Premature Ageing in Pro-Apoptotic Yeast Mutants Through an Autophagy-Independent Mechanism.
• Structure of the Lysosomal KICSTOR-GATOR1-SAMTOR Nutrient-Sensing Supercomplex.
• Meta-Analysis: Effects of Caloric Restriction Combined with Exercise on Lipid Metabolism and Blood Pressure.

Exercise & Physical Activity

• Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults.
• Meta-Analysis: Does Physical Activity Really Improve Anxiety and Depression in Children or Adolescents with Overweight or Obesity?
• Family Nutrition and Physical Activity Practices Associated with Overweight and Obesity in Children: A Cross-Sectional Study.
• Association of Chronic Disease Risk and Physical Activity Measured by Wearable Devices in the All of Us Program.

Economics & Sociology

• Trends in Adults BMI Related to Changes in Socioeconomic Status of 201 Large Latin American Cities.
• Modification of the Association between Obesity Phenotypes and Cardiovascular Disease by Social Determinants of Health.
• Nationwide Real-World Assessment of the Economic Impact of Obesity in Spanish Healthcare Settings (ECC-OS).
• Low Socioeconomic Status as a Major Risk Factor for Early-Onset Type 2 Diabetes with Limited Lifestyle Mediation: Cross-Sectional Evidence from US and South Korean Populations.

Epidemiology

• Linear Inverse Association between Triglyceride Glucose-BMI and Osteoporosis in Patients with Type 2 Diabetes Mellitus.
• Review: Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction.
• Review: Comprehensive Review of Carbonated Soft Drink Consumption Rates and Their Public Health Importance.
• Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study.

Psychology & Neuroscience

• Cognitive Flexibility Versus Stability Via Activation-Based and Weight-Based Adaptations.
• Nutrition Patterns, Metabolic and Psychological State Among High-Weight Young Adults: A Network Approach.
• Endurance Training Mitigates Obesity-Induced Hippocampal Impairment by Enhancing Neurotrophin Signalling, Synaptic Plasticity, and Cellular Responses in a Female Rat Model.
• Commentary: Ultra-Processed Food Addiction: A Growing International Concern.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Impact of Telemedicine on Improving Access to Metabolic/Bariatric Surgery Care in Minority and Other Underserved Patients with Obesity.
• Socioeconomic and Structural Barriers to Addressing Obesity in Communities: A Scientific Statement from the American Heart Association.
• Same Diagnosis but Different Outcomes: The Gender Gap in Heart Failure Persevered Ejection Fraction with Obesity.
• Sex Matters in HFrEF: Unraveling Gender Disparities in In-Hospital Outcomes.

Stigma

• The Association between Higher Body Weight and Stigmatizing Language Documented in Hospital Birth Admission Notes.
• Exploring How Weight Stigma Relates to Psychological Distress, Physical Activity, and Eating Behaviors over Time.
• Gender Disparities in Outcomes of Hospitalized Adults with Obesity and Heart Failure with Reduced Ejection Fraction: Insights from a National Analysis.

Policy Related

• Commentary: Identifying Ultra-Processed Foods for Policy.
• Equal School Meals for All - Differentiation of School Meals According to School Social Index.
• Commentary: Beyond Fresh: Implications of Produce Prescription Policy for Food Systems Transformation.
• Exploring Sociodemographic and Nutrition-Related Correlates of Meal-Kit Use Across Five Countries: Findings from the International Food Policy Study.
• Review: Integration of Lifestyle Medicine Into Primary Care: A Comprehensive Review.

Intergenerational Effects

• Preprint: Maternal Cardiometabolic Dysfunction and Fetal Sex-Specific Alterations to Uterine Vascular Reactivity in an Ovine Model of Diet-Induced Obesity During Pregnancy.
• Investigating the Influence of Maternal Prenatal BMI and Perinatal Depressive Symptoms on Neonatal Brain Network Dynamics.
• Interaction between Maternal Obesity and Metabolic Dysfunction in Gestational Hypertension and Preeclampsia: A Prospective Birth Cohort Study.
• Risk Factors and Pregnancy Outcomes of Twin Pregnancies with Gestational Diabetes Mellitus: A Comparison Based on Chorionicity.

Ecology, Evolution, & Energetics

• Paternal Microplastic Exposure Alters Sperm Small Non-Coding RNAs and Affects Offspring Metabolic Health in Mice.
• Sex-Based Differences in the Enteroendocrine System and Food Intake Regulation Due to Dietary Protein Replacement by Alphitobius diaperinus in Rats.

Methods

• Perspective: Guiding Principles for Science-Based Food Classification Systems Focused on Processing and Formulation.
• Aggregated Data, Hidden Realities: Challenges in the Analysis of Obesogenic Environments.
• Standardizing the Analysis and Visualization of Human Energy Expenditure Data.
• Machine Learning Insights Into Age-Related Sex Differences in Blood Pressure: Influence of Diabetes and BMI.
• Feasibility of Dynamic Structural Equation Modeling for Capturing Micro-Level Temporal Dynamics in Adolescent Physical Activity.

Commentary

• Study Explores the Relationship between Universal School Meal Policies and Student Stigma.
• A Window Into Activation of Inflammation in Obesity.
• Senotoxins Target Senescence Via Lipid Binding Specificity, Ion Imbalance and Lipidome Remodeling.
• The Growing Public Health Problem of Sugar-Sweetened Beverage Consumption and Promising Strategies to Reduce Its Burden.
• How Fit Do We Really Need to Be?
• Glucagon-Like Peptide-1 Receptor Agonists for Obesity: Growing Popularity Met with Growing Questions over Safety.
• Calorie Restriction Slows Brain Aging in Primates.
• The New Food Pyramid: the Good, the Bad, and the Ignored.
• Podcast: Why Your Brain Won't Stop Thinking About Food with Emily Dhurandhar.
• Podcast: Ultra-Processed Food and Nutrition Policy: What We're Getting Wrong | Dr. David Ludwig | the Metabolic Link Ep. 85.
• Podcast: EP 69: UPFs and the Queston of Hyper-Palatability, Revisiting Reusable Packaging with Richard Mattes.
• Podcast: Is the Nutrient Density of Crops Declining? – Edward Joy, PhD.

General

• Restricted Mean Survival Time in Cluster RCTs with a Small Number of Clusters: Improving Variance Estimation of the Intervention Effect from the Pseudo-Values Regression.
• Podcast: Can Marty Makary Fix the F.D.A.?
• Is the Human Mind Massively Modular? Good and Bad Faith Debates around Evolutionary Psychology.
• Minimum Combined Sleep, Physical Activity, and Nutrition Variations Associated with LifeSPAN and HealthSPAN Improvements: A Population Cohort Study.
• Meta-Analysis of RCTs: Oral and Topical Peptides as Anti-Aging Agents.
• A GDF-15 - GFRAL Axis Controls Autoimmune T Cell Responses During Neuroinflammation.
• Stratification of Viral Shedding Patterns in Saliva of COVID-19 Patients.
• Association between Cagemate Number and Risk of Death in Mice - a Time-Varying Covariate Analysis Using Cox Frailty Models.
• Enhancing Trust in Science: Current Challenges and Recommendations for Policymakers, the Scientific Community, Media, and Public.

Announcements

• Baylor College of Medicine Names Minnesota Med School Dean as New President, CEO.
• Webinar: DkNET - “Precision Diabetes: Understanding and Managing Glucose Dysregulation Using Deep Data and Remote Monitoring” on Friday, Jan. 23, 2026.
• WE ARE RECRUITING! Tenure-Track/Tenured Faculty Position in Nutrition Research at Baylor College of Medicine, Children’s Nutrition Research Center.
• Wednesday, March 4, 2026, 9am - 3pm Event Location Live Webinar on Zoom - Annual Research Ethics Day Conference 2026: The Future of Research Ethics: Threats & Opportunities.
• Call for Abstracts: 12th Annual International Weight Stigma Conference.
• Registration Open: 43rd International Symposium on Diabetes and Nutrition. Tarragona, Spain; 15-18 June, 2026.