Featured

• Professor Richard DiMarchi and Professor Matthias Tschöp Receives the Rolf Luft Award 2026.
• Higher Protein Intakes Predict Leaner Body Composition in Weight-Loss Participants - Findings from the International Weight Control Registry.
• Uncoupling Insulin Sensitivity from Longevity: A Sex-Dependent Effect of Hepatic Glucagon Signaling.
• Grandmaternal Exercise Improves the Metabolic Health of Second-Generation Offspring Generated from F1 Females.

Headline vs Study

• Headline: Home-Delivered Food Boxes Improve Diabetes Control, Experts Say.
• Press Release: Home-Delivered Groceries Improve Blood Sugar Control for People with Diabetes Facing Food Insecurity.
• Study: A Single-Arm Prepost Study of Delivering Food Boxes with American Diabetes Association Create Your Plate Method. No Control; Causation Not Established.

Contrary or Null Findings

• RCT: "The intervention effectively reduced UPF consumption", yet "No significant differences were found for BMI or BMI/Age z-score (p>0.05)."
• RCT: No significant treatment assignment effects in "exploratory randomized controlled trial of a physical activity intervention for individuals with osteoarthritis (OA) involving telephone-delivered coaching, activity self-monitoring, and connection with resources to support activity (Osteoarthritis Physical Activity Care Pathway; OA-PCP)."
• RCT: No significant differences "of perioperative immunonutrition (IN) versus standard enteral nutrition (EN) on short-term postoperative outcomes in patients with head and neck cancer (HNC)."
• RCT: Mobile Instant Messaging "MIM-supported brief physical exercise intervention did not significantly increase smoking abstinence or physical activity compared with brief cessation advice alone."
• Caloric Restriction Attenuates Oxidative and Inflammatory Markers of Aging, While Compromising Germinative Epithelium Homeostasis in the Rat Aged Testis.
• RCT: "Acute whey protein supplementation did not induce a different bone or inflammatory response following exhaustive running exercise in young endurance runners compared to the control."
• No Indication of Histological Changes in Embryonic Somatosensory Cortex Development upon Maternal Aspartame Consumption in Mice.
• RCT: No Significant Differential Effects of Aspartame, Sucrose, and Water on Short-Term Cognitive Performance.
• RCT: "These findings suggest that 15 weeks of recreational football may not be sufficient to produce significant improvements in glycaemic control in inactive premenopausal women with mild hypertension..."

A Tiny Fraction of The Manifold Opinions on the Dietary Guidelines

• Dietary Guidelines for Americans, 2025-2030. (pdf)
• The Scientific Foundation for the Dietary Guidelines for Americans, 2025-2030. (pdf)
• The Scientific Foundation for the Dietary Guidelines for Americans Appendices. (pdf)
• Dietary Guidelines for Americans 2025-2030: Progress on added sugar, protein hype, saturated fat contradictions.
• Commentary: Ambiguous DGAs & the Rancher's Pyramid.
• Statement from the Academy of Nutrition and Dietetics on the Release of the Dietary Guidelines for Americans, 2025-2030.
• Commentary: Protein, Finally: From Minimums to Meaningful.
• Commentary: Dietary Guidelines, 2025 (Well, 6): The Blur, Where Baby Meets BATHWATER.
• Commentary: Kennedy Is Telling Americans How to Eat. It’s Not Crazy Advice.
• Commentary: The MAHA 2025-2030 Dietary Guidelines Have Arrived: Cheerful, Muddled, Contradictory, Ideological, Retro.
• American Society for Nutrition Calls for Strong Science in National Nutrition Guidance.
• Commentary: Dietary Guidelines in America: Misguided, or Guided Missiles?

Basic

• Gpx4 Deletion-Mediated Macrophage Ferroptosis Alleviates Obesity-Associated Insulin Resistance.
• COP9 Signalosome Is Required for Adipose Tissue Maintenance and Metabolic Health.
• Brown Adipose Tissue-Derived Exosomes Ameliorate Obesity-Related Hypertension Via HuR-Mediated Restoration of Endothelial Function.
• Endothelial IRE1α Promotes Thrombospondin-1 MRNA Decay and Supports Metabolic Stress Adaptation of Pancreatic Islets.
• Dietary Fat Disrupts a Commensal-Host Lipid Network That Promotes Metabolic Health.

Scientific Rigor & Scholarly Dialogue

• Letter: Concerns over Conclusions in an Ultra-Processed Food Trial.
• Letter: Concerns around Evidence That Food Processing Should Be Included in Dietary Guidance.
• Letter: Concerns About Attributing Weight Change to Processing in a Crossover Feeding Trial.
• Response: Reply to Ludwig, D. S. et al.; Robinson, E. & Forde, C. G.; Wang, Z. & Peng, C.
• PubPeer Comments On: The Effects of Omega-3 Supplementation on Stress, Anxiety, Depression, Sleep Quality, and Everyday Memory in Individuals with Psychological Distress: A Randomized, Double-Blind, Placebo-Controlled Trial.
• Author Correction: The Cold-Induced Lipokine 12,13-DiHOME Promotes Fatty Acid Transport Into Brown Adipose Tissue.
• Association between Cagemate Number and Risk of Death in Mice: A Time-Varying Covariate Analysis Using Cox Frailty Models.

Clinical

• RCT: Ectopic Fat Distribution and Its Correlation with Insulin Resistance Indices in Individuals without Obesity and with Type 2 Diabetes.
• Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults.
• The Public Health Burden of Diabetes Mellitus and Thyroid Disease: Twin Epidemics.

Children and Adolescents

• Meta-Analysis: Association of Childhood Obesity Phenotypes with Cardiometabolic Outcomes in Adulthood.
• Challenges and Management of Obesity in Young Adults: Perspectives from Low and Middle-Income Countries.
• Family Perceptions of Pediatric Metabolic and Bariatric Surgery in a Safety-Net Obesity Clinic.

Surgery

• "Bariatric surgery was associated with increased skeletal muscle mitochondrial respiration despite unchanged morphology and reduced mtDNA amount, whereas lifestyle-induced weight loss showed a transient downregulation of OXPHOS-related proteins with other mitochondrial markers remaining stable."
• Review: Prurigo Pigmentosa Following Bariatric Surgery.
• Prospective Evaluation of Surgical Site Infection Rates and Predictors Following Elective Abdominal Surgeries. (pdf)
• Midterm Outcomes of Laparoscopic Sleeve Gastrectomy for Gastroesophageal Reflux Disease in Patients with Obesity.

Drugs

• Commentary: GLP-1 Receptor Agonists for Obesity: Eligibility Across 99 Countries.
• Review: Nutrition Strategies for Next-Generation Incretin Therapies: A Systematic Scoping Review of the Current Evidence.
• Meta-Analysis: Weight Regain After Cessation of Medication for Weight Management.

Food & Diet

• Bioactive Oriented Discovery of Diterpenoids in Coffea Arabica Basing on 1D NMR and LC-MS/MS Molecular Network.
• Associations between Preservative Food Additives and Type 2 Diabetes Incidence in the NutriNet-Santé Prospective Cohort.

Caloric and Dietary Restriction

• Diet Quality and Nutritional Adequacy During a 2-Year Calorie Restriction Intervention: The CALERIE 2 Trial.
• Methionine Restriction, Not Cysteine Restriction, Is a Cancer-Specific Vulnerability.
• Integration of 12-H Time-Restricted Feeding with Exercise Training Potentiates Weight Loss and Attenuates MASLD in Diet-Induced Obese Mice.

Exercise & Physical Activity

• Cross-Sectional Associations between Overweight, Eating Behavior, and Physical Activity in Children and Adolescents: Differences Depending on Socio-Economic Status.
• Associations between Physical Activity and Nutrition Self-Efficacy and Self-Reported Physical Activity in Residents of Resource-Limited Neighborhoods.
• RCT: Once and Thrice Weekly Interval Training in Adults with Central Obesity.

Economics & Sociology

• Social Mobility of the Father and Relative Body Weight of Offspring: A Three-Generation Study.
• Dietary Patterns in Children: Associations with Ethnicity, Socioeconomic Position, BMI and Body Composition.
• Social Determinants of Health Influence Maternal Health Behaviors and Engagement in an Obesity Prevention Intervention.

Epidemiology

• Trends in Obesity-Related Cardiovascular and Cancer Mortality in Switzerland 1995-2019: An Analysis of Multiple Causes of Death.
• Investigating Multidimensional Associations between Obesity-Related Traits and Brain Health, and Identifying Potential Mechanisms.
• Prevalence and Trends of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease Among Adults in the United States.

Psychology & Neuroscience

• Comparative Analysis of Hypothalamic Responses to Stress and Glutamine Supplementation in Diet-Induced Obese Mice: A Study of Sex Differences.
• Review: The Addicted Brain: How Processed Foods Hijack Reward Pathways.

Differential Population Circumstances, Exposures, Outcomes, and Effects

• Municipal Deprivation and Cardiometabolic Outcomes in Mexican Adults: Findings from ENSANUT 2021-2023.
• Comment: Impact and Scope of Mexican Clinical Practice Guideline for Adult Overweight and Obesity on Weight Stigma.
• Domain-Specific Physical Activity and Obesity Risk Among Black Men in the United States: Evidence of a Physical Activity Paradox.

Stigma

• Changes to Weight Bias Internalization and Eating Behaviors in Adults Aged 50+ with Overweight or Obesity During a Structured 12-Week Behavioral Weight Management Intervention.
• Developing a Novel Weight Stigma Curriculum for Pediatric Residents Using Transformative Learning Theory.
• Structural Fatphobia in the Training and Practice of Primary Health Care Professionals in Brazil: A Mixed-Methods Study Grounded in Fat Studies.

Policy Related

• Identifying Synergistic Mechanisms of Community-Led Policy, Systems, and Environmental Change for Childhood Obesity Prevention in the Multi-Site Catalyzing Communities Initiative.
• The Estimated Impact of Mandatory Front-Of-Pack Nutrition Labelling Policies on Adult Obesity Prevalence and Obesity-Related Mortality in England: A Modelling Study.

Intergenerational Effects

• How Dad’s Fitness May Be Packaged and Passed Down in Sperm RNA.
• Protocol: Nutrition and Obesity in Under-Represented Population (NOURISH): Study Protocol to Examine the Effect of Restricted and Unrestricted Financial Benefits on Infant Food Insecurity, Growth, and Nutrition.
• RCT: Effect of a Pragmatic eHealth Behavioral Gestational Weight Gain Intervention on Household Chaos in Pregnant People of Lower Socioeconomic Status.

Ecology, Evolution, & Energetics

• Did Increasing Brain Size Place Early Humans at Risk of Extinction?
• Primate Gut Microbiota Induce Evolutionarily Salient Changes in Mouse Neurodevelopment.

Methods

• Unraveling the Genetic Association between Obesity-Related Anthropometric Indices and Foot Deformities in the European Population: A Two-Sample Mendelian Randomization Study.
• Distinct Genetic Profiles of Obesity Have Different Effects on Breast Cancer Risk: Leveraging Mendelian Randomisation to Interrogate Causal Pathways and Identify Mediating Proteins.

Mathematical and Quantitative

• Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) to Understand How Obesity Risk Varies According to Multiple Lifestyle Behavior Recommendations.

Commentary

• Transdermal "Natural GLP-1" Dietary Supplements Violate Law and Place Patients at Risk.
• Podcast: Protein Amount, Quality and Timing | Dr Luc Van Loon.
• RFK Jr.'s New Dietary Guidelines Go All in on Meat and Dairy.
• 4:3 Intermittent Fasting Shows Modestly Greater Weight Loss Than Daily Caloric Restriction.
• Physical Activity and Telomere Length in Early Childhood: Implications for Chronic Disease Prevention.
• Strength Training Boosts Brain Health, According to New Study.
• What Happens to Your Body When You Strength Train While Fasting.
• The Dumbest Headline of the Year About Obesity.
• Weight Loss Drugs are Effective, but Can Healthcare Systems Afford Them?

General

• Baylor College of Medicine Publishes Promising Safety and Efficacy Results of Multi-Antigen Targeted T Cells in Patients with Pancreatic Cancer.
• Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells.
• Sequentially Constrained Randomization in Preclinical Animal Studies.
• Self-Report of 24-Hour Urine Completeness Compared to PABA Recovery Does Not Bias Estimates of Dietary Salt Intake in the UK.
• Why Academics Should Do More Consulting - and How to Make It Work.
• Assessing the Evidence Transparency of Policies.
• What If the Idea of the Autism Spectrum Is Completely Wrong?
• Will Mpox Go Global Again? Research Shows It’s Evolving in Curious Ways.

Announcements

• Webinar: The Gut-Brain Axis and Psychosis - Jan 20.
• Joel Habener, Whose Research Led to Weight-Loss Drugs, Dies at 88.
• Indiana Academy of Sciences - Abstracts Due Feb 28^th.