01/02/26
Featured
- Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice.
- Gut-To-Brain Signaling Restricts Dietary Protein Intake During Recovery from Catabolic States.
- Reconciling Conflicting Evidence on Low- and No-Calorie Sweeteners and Cardiometabolic Outcomes: An Umbrella Review Using Naïve and Bias-Adjusted Methods.
- Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow.
- Habits at Home: How the Home Food Environment Shapes Caregivers' Eating Habits.
Headline vs Study
- Headline: A New Trial Investigates Whether the MIND Diet Can Be Scaled for Obesity Management.
- Study: Exploring the Interplay between Diet, Obesity, Mental Health, and the Gut Microbiota: The MIND-GUT Intervention Study... A Study Protocol. No Results Yet.
Contrary or Null Findings
- "Multimodal health behaviour-changing interventions may improve objectively-assessed physical activity at 12 months when delivered in healthcare settings and may slightly improve HRQoL at 24 months when delivered in the community, but they may have little to no effect on the other pre-defined critical outcomes, including physical and mental well-being, and anthropometry (BMI z-score)."
- Meta-Analysis: "LCD + EX [low-carbohydrate diet with exercise] did not demonstrate significant overall improvements in glycemic control or body composition compared to NRD + EX [non-carbohydrate-restricted diet with exercise] in adults with T2DM" in “Efficacy of a low-carbohydrate diet combined with exercise on glycemic control and metabolic health in type 2 diabetes mellitus.”
- Meta-Analysis: "Biotic supplementation has not been shown to consistently improve metabolic syndrome risk factors in overweight and obese children, except for a modest beneficial effect of prebiotics on weight and BMI (with very-low certainly of evidence)..."
- RCT: "Recreational soccer, whether in SSG [Small-Sided Soccer Games] or TSG [Traditional Soccer Group] formats, was insufficient to elicit significant improvements in physical literacy among adolescents with high cardiometabolic risk."
- Protein supplementation in pediatric oncology: a systematic review revealing a lack of evidence and insights from other chronically and critically ill children - "Evidence on the potential of protein supplementation is scarce and not available in children with cancer."
- RCT: "The findings of this trial did not indicate a clinically significant reduction in lipid profiles attributable to COS [Chitosan Oligosaccharide Supplementation]."
- "Higher BMI was associated with reduced in-hospital mortality in patients with COVID-19, with the BMI-based predictive model demonstrating strong predictive capabilities."
- "This study is the first to assess the causal effects of population-based BMI screening on long-term health outcomes in a Southeast Asian population. The findings suggest that merely informing individuals of their overweight or obese status and implementing light-touch interventions are insufficient to significantly reduce BMI or drive sustained behavior change."
Basic
- Essential Amino Acids Preserve Intestinal Barrier Integrity Via Mitochondrial Protection in Obesity and Gut Inflammation.
- The Role of Transmembrane Proton Transport Rates in Mild Mitochondrial Uncoupling by Arylamide Substituted Fatty Acids.
- Left Ventricular Myocardial Molecular Profile of Human Diabetic Ischaemic Cardiomyopathy.
- Inhibition of IRAK4 [interleukin-1 receptor-associated kinase 4] by Microbial Trimethylamine Blunts Metabolic Inflammation and Ameliorates Glycemic Control.
- Review: The Molecular Mechanisms of Muscle-Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes.
Scientific Rigor & Scholarly Dialogue
- Commentary: "the data do not justify eating large amounts of cheese or cream as protective foods against dementia or heart disease."
- Fraud Detection and Prevention in Online Research: Lessons Learned and Recommendations.
- Comment On: “Most Methodological Characteristics Do Not Exaggerate Effect Estimates in Nutrition RCTs: Findings from a Meta-Epidemiological Study”.
- Response to Letter On: “Most Methodological Characteristics Do Not Exaggerate Effect Estimates in Nutrition RCTs: Findings from a Meta-Epidemiological Study”.
Clinical
- Access to Kidney Transplantation in Adults with Severe Obesity: A Population-Based Retrospective Cohort Study.
- Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.
- RCT: Daily Almond Supplementation Improves Blood Pressure and Lipid Profile in Pregnant Women with Hypertension and Dyslipidemia.
- Review: Multimodal (Bio)Markers and Risk of Obesity.
- Obesity-Associated Gut Microbiome Influences Diet-Induced Metabolic and Cognitive Outcomes in Older Adults.
- RCT: Gut Microbiome Predicts Personalized Responses to Dietary Fiber in Prediabetes.
Children and Adolescents
- Association between Wearable Device Usage and Obesity Transition in Children and Adolescents.
- Systematic Review: The Association between Affect and Adiposity in Childhood and Adolescence.
- Pre-print: Adherence to Mediterranean Diet in Children and Adolescents with Obesity and Association with Anthropometrics as Well as Cardiometabolic Risk Factors.
- "Stimulant therapy for ADHD is associated with significant shifts in BMI classification among pediatric patients. While many children, especially younger with higher baseline BMI, experienced improvements in weight status, a notable minority exhibited weight gain."
Surgery
- Metabolic and Bariatric Surgery and Depression in US Adults.
- Meta-Analysis: Minimally Invasive Hypoabsorptive Bariatric Surgery.
- ADHD, Self-Reported Mental Health and Weight Loss 10 Years After Metabolic-Bariatric Surgery During Adolescence. (pdf)
Drugs
- Beyond the Prescription: Global Observations on the Social Implications of GLP-1 Receptor Agonists for Weight Loss.
- Meta-Analysis: The Efficacy and Safety of Danuglipron and Orforglipron in Patients with Type 2 Diabetes and Obesity.
- RCT: Combining Glucagon-Like Peptide 1 Analogues with Sodium-Glucose Cotransporter 2 Inhibitors to Treat Patients with Type 1 Diabetes, BMI > 25 kg/m2, and Chronic Kidney Disease.
- Meta-Analysis: Efficacy, Safety and Tolerability of Lisdexamfetamine Dimesylate Treatment Compared with Placebo in Adults with Binge-Eating Disorder.
- Meta-Analysis: Semaglutide Beyond Diabetes and Obesity.
Food & Diet
- Tempeh, a Fermented Soybean, Extends Lifespan Via MAPK Pathway and Improves Healthy Aging in Caenorhabditis elegans.
- Effect of Replacing Added Sugars with Sucralose on Gut Microbiome Composition Among Asian Indian Adults.
- Longitudinal Study on the Association between Salty Food Preference and Obesity Prevalence.
- Commentary: Can Ultraprocessed Foods Be Addictive? A Neuroscientist Weighs In.
Caloric and Dietary Restriction
- Dietary Methionine Depletion and Hydrogen Sulfide-Producing Genes in Perivascular Adipose Tissue of Male Wistar Rats.
- Dissertation: Intermittent Fasting vs Daily Caloric Restriction: Dietary Flexibility, Eating Behaviors, and Models of Energy Intake.
Exercise & Physical Activity
- Meta-Analysis: Comparative Efficacy of Exercise Interventions for Cognitive Health in Older Adults.
- Genetic Risk Scores for Obesity and the Effectiveness of a Diet and Exercise Intervention Program.
- Effect of High-Intensity Interval Training and Pre-Meal Water Consumption on Lipid Profile in Students with Overweight or Obesity.
- Review: Exercise Attenuates the Hallmarks of Aging.
- Systematic Review: Comparison of the Impact of Exercise Training Combined with Dietary Intervention Vs. Dietary Intervention Alone in Patients with Obesity and Metabolic Syndrome.
- Excessive Vigorous Exercise Impairs Cognitive Function Through a Muscle-Derived Mitochondrial Pretender.
Economics & Sociology
- Economic Evaluation of NHS England’s Type 2 Diabetes Path to Remission Pilot Scheme: Evidence from Real-World Data and Patient Simulation Modelling.
- Prevalence and Economic Burden of Obesity-Related Comorbidities in the Gulf Region: Results from the POEM-Gulf Study.
- Socioeconomic and Lifestyle Determinants of Obesity Among Turkish Women.
- Prevalence and Correlates of Dumping Syndrome After Bariatric Surgery in Saudi Adults: The Role of Social Determinants and Nutrition Knowledge.
Epidemiology
- Pre-print: "Folic acid supplementation during pregnancy was inversely associated with the incidence of HDP [hypertensive disorders of pregnancy]."
- BMI, Waist Circumference and Cognition over Time.
- Quantifying the Dementia Burden Attributable to Excess Weight in the United States.
Psychology & Neuroscience
- Rethinking the Obesity Paradox: BMI and Longitudinal Cognitive Decline in Older Adults.
- Systematic Review: Obesity, Olfaction and Cognition.
- Association between BMI and Depression/Anxiety.
Differential Population Circumstances, Exposures, Outcomes, and Effects
- Why Do Black Women Have a Higher Obesity Prevalence Than White Women in the United States?
- Trends and Disparities in Obesity and Atherosclerotic Cardiovascular Disease Mortality in a 25-Year Retrospective Analysis.
- Sex Disparities in Adult Obesity Prevalence Across 47 African Countries.
- Meta-Analysis: Racial Disparities, Comorbidities, and Low BMI Reduce Survival After Cardiopulmonary Resuscitation.
- Dyadic Associations of Physical Activity, Diet Quality, and BMI in Black Prostate Cancer Survivors and Their Spouses.
Stigma
- Sex Differences in the Influence of Weight Bias Internalization on Preferences for Telehealth Utilization Among People with Obesity.
- Dissertation: Assessing Healthcare Provider Perspectives and Experiences with Weight Management and Weight-Inclusive Care.
- Systematic Review: What Is the Felt Experience of Weight Stigma in Latin America and the Caribbean?
Policy Related
- A Scoping Review of Microsimulation Models on Obesity-Related Policy Evaluation.
- Review: Integrating Obesity Care Into Chronic Disease Management: Progress and Challenges in Health System Approaches.
- Review: Evaluating Policy and Industry-Based Interventions for Healthier Online Food-Away-From-Home Choices.
- Policies to Halt and Reverse the Rise in Ultra-Processed Food Production, Marketing, and Consumption.
- Supplemental Nutrition Assistance Program Policies and Food Insecurity.
- RCT: Creating Healthy Habits for Maryland Preschoolers (CHAMP).
Intergenerational Effects
- Targeted Next-Generation Sequencing of the Leptin-Melanocortin Pathway in Severe Obesity.
- Associations between Parental Mental Wellbeing and Adolescents’ Physical Activity, Sedentary Digital Media Use, and BMI.
- Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring.
- Association between Maternal Folic Acid Supplementation in Different Pregnancy and Infant Neurobehavioral Development at 6 and 18 Months.
Ecology, Evolution, & Energetics
- Five Hundred Million Years of Hunger: How Animals Evolved to Survive Essential Amino Acid Scarcity.
- Transfer to a Naturalistic Setting Restructures Fear Responses in Laboratory Mice.
- Adherence to the Mediterranean Diet and Sustainable Nutrition: The Role of Nutrition Literacy Across Generations.
- Review: Aquatic Plants for Blue Protein Innovation: Bridging Nutrition, Sustainability, and Food Security.
Methods
- Spatial Molecular Imaging of the Glycome Using Mass Spectrometry.
- Systematic Review: Machine Learning and Deep Learning Approaches for Obesity Prediction.
- Psychometric Validation of the Eating Behavior and Appetite Questionnaire (EBAQ) for Individuals with Obesity or Overweight.
- Review of Advanced Algorithms and Imaging Techniques in Food Analysis: A Path to the Future.
Commentary
- Can Aripiprazole Offer a Metabolic Advantage over Risperidone in Schizophrenia?
- Ozempic for Everyone? Pharmacological Dystopia, Inequality of Access and the Eternal Promise of Healing.
- Future Medical Doctors are Not Learning About Overweight and Obesity in Children.
- Ozempic Is Shrinking More Than Waistlines, It’s Slashing Americans’ Food Bills.
- A Gut-To-Brain Pathway That Limits Protein Intake.
- Plant-Based Protein for Older Adults with Obesity.
- How Much Protein Do You Need to Build Muscles? Here’s What You Need in Daily Diet.
- Single Exercise Session Shown to Slow Cancer Growth.
- Postbiotics: Emerging Regulatory Mechanisms and Therapeutic Applications in Obesity and Its Complications.
- Obesity Accelerates Aging: Mechanisms and Therapeutic Implications.
General
- Detecting Inconsistencies and Fraud in Research Data: Time for Authors to Share the Data Underlying Their Summary Statistics as a Matter of Course.
- Recent False Claims Act Settlement Highlights the Importance of Vetting Federal Grant Applications.
- Pig Study Could Improve Health of Premature Babies.
- The Yin and Yang of Cellular Senescence in Ischemia-Induced Myocardial Injury.
- Repurposing Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Neurodegenerative Disorders.
- Using Drone-Based Infrared Thermography for Monitoring Vital Signs in Dolphins.
- Pharmacologic Reversal of Advanced Alzheimer’s Disease in Mice and Identification of Potential Therapeutic Nodes in Human Brain.
- Aging-Induced Dysfunction of Adipose Tissue and Skeletal Muscle and Its Link to Insulin Resistance.
- How Can You Maintain Your Muscles and Health During Long Holidays When You Can't Go to the Gym?
- RFK Jr. Says He'll Work with Federal Agencies to Wind Down Animal Testing.