Featured
Headline vs Study
Contrary or Null Findings
Basic
Scientific Rigor & Scholarly Dialogue
Clinical
Children and Adolescents
Surgery
Drugs
Food & Diet
Caloric and Dietary Restriction
Exercise & Physical Activity
Economics & Sociology
Epidemiology
Psychology & Neuroscience
Differential Population Circumstances, Exposures, Outcomes, and Effects
Stigma
Policy Related
Intergenerational Effects
Ecology, Evolution, & Energetics
Methods
Mathematical and Quantitative
Commentary
General
Announcements
Featured
Headline vs Study
Contrary or Null Findings
Basic
Scientific Rigor & Scholarly Dialogue
Clinical
Children and Adolescents
Surgery
Drugs
Food & Diet
Caloric and Dietary Restriction
Exercise & Physical Activity
Economics & Sociology
Epidemiology
Psychology & Neuroscience
Differential Population Circumstances, Exposures, Outcomes, and Effects
Stigma
Policy Related
Intergenerational Effects
Ecology, Evolution, & Energetics
Methods
Commentary
- Podcast: Peter Attia - the Ketogenic Diet, Ketosis, and Hyperbaric Oxygen: Metabolic Therapies for Weight Loss, Cognitive Enhancement, Cancer, Alzheimer’s Disease, Brain Injuries, and More | Dominic D’Agostino, Ph.D.
- Podcast: The Science of Myostatin Inhibitors, GLP-1 Meds and Muscle Mass.
- Fat Cats are Taking Ozempic Now - and It Could Be the Solution to Terminal Feline Illnesses.
- Mapping Out Directions for Weight Bias Research.
- Dietary Fats, Blood Lipids and Atherosclerotic Cardiovascular Disease: Time for Food-Based Approach?
- WHO Issues First Global GLP‑1 Guideline for Obesity Treatment.
- "Muscle quality": rethinking an imprecise term.
- Gradually, Then Suddenly: Nutrition in an Era of Medically Induced Weight Loss.
General
Announcements
Featured
Headline vs Study
Contrary or Null Findings
Basic
Scientific Rigor & Scholarly Dialogue
Clinical
Children and Adolescents
Surgery
Drugs
Food & Diet
Caloric and Dietary Restriction
Exercise & Physical Activity
Economics & Sociology
Epidemiology
Psychology & Neuroscience
Differential Population Circumstances, Exposures, Outcomes, and Effects
Ethics
Stigma
Policy Related
Intergenerational Effects
Ecology, Evolution, & Energetics
Methods
Commentary
General
Video & Audio
Announcements
Featured
Headline vs Study
Contrary or Null Findings
- "Contrary to hypotheses, adolescent-reported family mealtime quality showed slight trending declines among both the intervention and control group" in "Examining Effects of a Cultural and Family Resilience Program on Improving Physical Activity and Eating Behaviors Among Overweight Black Adolescents".
- RCT: "the intervention did not outperform the control in reducing BMI" in A Multicomponent Family Treatment of Childhood Obesity Based on the Planetary Healthy Diet.
- RCT: Vitamin D Supplementation Has No Effect on Bone Mineral Density in Individuals with Chronic Spinal Cord Injury.
- "Despite evidence of positive and statistically significant education-obesity correlations, we cannot reject the null hypothesis that schooling has no overall causal impact on obesity in either study setting."
- "In conclusion, the study by De Jong and colleagues offers robust evidence that low-dose norepinephrine...at extubation is safe for both obese and non-obese patients, challenging the practice of delaying extubation solely due to vasopressor use."
- "Our findings demonstrate no discernible difference in rested-state nor, contrary to our hypothesis, exercise-induced iMyoPS rates between MA and OC. Furthermore, we observed no clear difference in the mTORC1-mediated signaling response to exercise between MA and OC. Taken together, these data suggest that despite divergent long-term exercise habits in MA, OC possess a similar capacity to upregulate intramuscular signaling and iMyoPS in response to unaccustomed exercise contraction."
- RCT: "Short-term probiotic supplementation was safe and well accepted among children but did not produce statistically significant improvements in oral health parameters over 30 days." in Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children.
- RCT: "There were no significant main effects of group and no significant baseline-by-group interactions for SWAN parent ratings of inattention, hyperactivity or total score" in Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD.
Basic
Scientific Rigor & Scholarly Dialogue
Clinical
Children and Adolescents
Surgery
Drugs
Food & Diet
Caloric and Dietary Restriction
Exercise & Physical Activity
Economics & Sociology
Epidemiology
Psychology & Neuroscience
Differential Population Circumstances, Exposures, Outcomes, and Effects
Stigma
Policy Related
Intergenerational Effects
Ecology, Evolution, & Energetics
Methods
Commentary
General
Announcements
Featured
Headline vs Study
Contrary or Null Findings
- RCT: No Effect on Diet Quality in Primary School-Based Food Environment Intervention.
- RCT: "There were no significant differences in sitting time …, standing or stepping time between groups" in "The Children – Sit Less, Move More (C-SLAMM) pilot intervention: Feasibility and acceptability of a multi-component school and home-based intervention to promote physical activity".
- RCT: "Surprisingly, the APC-SAS video-a short, animated story video promoting healthy eating-did significantly boost PsyCap, as well as happiness, and this effect was still visible 2 weeks later."
- RCT: "Despite acute glucose suppression, fasting glucose rose modestly after 10 days of high-dose KME supplementation, suggesting possible compensatory metabolic adaptation. This finding underscores the complexity of ketone-glucose interactions and highlights the need for further research into the long-term metabolic effects of chronic ketone supplement use."
- "Surprisingly, the diabetic status of the myoblast donor predicted myoblast fusion, with reduced fusion rates in diabetic myoblasts exposed to conditioned media from all adipose sources. This suggests that IMAT-myoblast signaling may be detrimental to regeneration in diabetes, but that the effect is driven in part by an intrinsic difference in diabetic myoblasts' sensitivity to IMAT secreted factors."
- "Contrary to our hypothesis, neonatal HO [hyperoxia] was associated with lower BP compared to control offspring from lean mothers (males: 105±1 vs. 111±1 mmHg; females: 102±0.4 vs. 108±0.4 mmHg); and also reduced BP and HR in hypertensive obese offspring from obese mothers..."
- Preprint: "Contrary to dogma, hepatic mTORC1 signaling was not elevated in response to diet-induced obesity associated with the phenotypes of type-2 diabetes, including hyperinsulinemia, systemic insulin resistance, and hyperglycemia, and blocking hepatic AKT-TSC-mTORC1 signaling did not prevent these metabolic impairments."
- "The MAD [Modified Atkins diet] was safe but not effective in the treatment of D/EE-SWAS [Developmental and Epileptic encephalopathy with spike-wave activation in sleep] in the short-term, with improvements only seen in seizure control. Its impact on EEG and cognition appears limited in the short-term and poor adherence poses significant challenges."
Basic
Scientific Rigor & Scholarly Dialogue
Clinical
Children and Adolescents
Surgery
Drugs
Food & Diet
Caloric and Dietary Restriction
Exercise & Physical Activity
Economics & Sociology
Epidemiology
Psychology & Neuroscience
Differential Population Circumstances, Exposures, Outcomes, and Effects
Stigma
Policy Related
Intergenerational Effects
Ecology, Evolution, & Energetics
Methods
Commentary
General
Video & Audio
Announcements
Pages