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- "This large prospective cross-sectional study found weak and inconsistent associations between the gut microbiome and premalignant colorectal neoplasia, with no robust microbial signatures. Findings suggest that previously reported microbial shifts may emerge later in disease progression, potentially as a consequence rather than a cause of CRC."
- Preprint: Large Increases in Resistance Training Volume Do Not Impair Skeletal Muscle Hypertrophy or Anabolic-Catabolic Molecular Signalling in Trained Individuals.
- RCT: No Differential Effect of a Chilean Diet Supplemented with Gevuina avellana molina Versus a Low-Fat Diet on Cardiometabolic, Oxidative Stress, and Inflammatory Biomarkers in Chilean Adults with Hypercholesterolemia.
- RCT: "Nevertheless, there were no significant differences between the two training groups in the mean values of SIRT1, NO, or systolic blood pressure..." in “Effects of low-load blood flow restriction resistance training on Sirtuin-1 and endothelial-related biochemical markers in men with type 2 diabetes.”
- RCT: "Based on this early terminated trial, a high-energy strategy for early nutrition in pancreatitis does not decrease mortality/severity, but potentially increases organ failure and pain relapse rate."
- RCT: "These findings suggest that supplementation with isolated leucine supplementation alone is insufficient to counteract cancer-related muscle waste and should be investigated as part of multimodal interventions addressing nutrition, inflammation, and physical activity." (pdf)
- RCT: "A 12-week run-walk training did not alter systemic CRP, TNF-α, or IL-8 in adults with chronic LBP. Improvements in pain intensity were not associated with changes in these inflammatory markers."
- RCT: Red rooibos "did not attenuate the changes to body composition, metabolic, or movement outcomes observed in the OVX (ovariectomized) group" [in mice].
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Contrary or Null Findings
- Supplementation with Mixed Nuts Does Not Improve Inflammatory Biomarkers or Dietary Inflammatory Potential in Post-Myocardial Infarction: A Secondary Analysis of the DICA-NUTS Trial.
- "Contrary to prediction of the aerobic model for endothermy evolution, we found near zero BMR-VO2max correlation on the between-individual level, suggesting null genetic co-variance, or its cancellation by among-individual maintenance-to-capacity trade-off."
- "Contrary to our hypothesis, %LML plateaus with greater weight loss. Moreover, men experience greater %LML than women."
- "Contrary to expectations, placing larvae in hypoxia a day before they reached the critical weight delayed the molt significantly, suggesting that hypoxia is not a trigger for the initiation of metamorphosis."
- "The results showed that, contrary to widespread concerns, FCR was no higher in more active flocks and that on average more active flocks tended to have lower (i.e. more efficient) FCR (p = 0.060)."
- "Bergmann's rule posits that animals tend to have larger body sizes at higher latitudes with colder climates,...Contrary to expectation, however, Bergmann's rule is not stronger at the population level (21% of species) than at the species level (24% of families or orders). Bergmann's rule is likely moderated by thermoregulatory strategy, as body size was negatively correlated with temperature along latitudinal clines in endotherms but not in ectotherms."
- RCT: Foods Fortified with Soybean or Palm Oil Show No Effect on Inflammation or Oxidized Low-Density Lipoprotein in Adults with Overweight or Obesity.
- RCT: "In summary, 30 days of greens-based supplementation led to selective changes in epigenetic aging markers and individual gut microbial taxa, without significant effects on overall microbiome diversity, metabolic health markers, or body composition."
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- RCT: "A moderate, fat-dominant preload consumed before a mixed meal did not alter nadir or overall postprandial glucose in adults without diabetes after SG."
- RCT: Limited to No Effects Detected in Preplanned Analyses of Primary Endpoints in the Effect of a Supervised Exercise Program Throughout Pregnancy on Longitudinal Lipid Profile Changes.
- RCT: "In this relatively small study, providing a modified, low-protein infant formula during the first months of life did not affect hormonal and metabolic markers during early childhood".
- "Contrary to expectations, placing larvae in hypoxia a day before they reached the critical weight delayed the molt significantly, suggesting that hypoxia is not a trigger for the initiation of metamorphosis. Nevertheless, an increase in lactate levels in the second half of the final instar, and the leveling off of metabolic rate, indicate that a metabolic shift occurs at the critical weight."
- "Contrary to the general belief of the dominance of Lactobacillus in the human endometrium, our study suggests that the endometrial microenvironment may be harbouring DNA fragments and/or cells of lactobacilli originating from the lower reproductive tract. Our study results indicate a need to re-consider/re-analyse the endometrial microbiome in health and disease."
- "Contrary to our hypothesis, we find dietary benefits in individuals with lower ADHD PGS, necessitating replication."
- "Contrary to the persistent assumption that hippos rest in water by day and graze on land all night, hippos in this study fed during only a quarter of the night and were active for a similar proportion of the day."
- "Strikingly, and in contrast to prevailing expectations based on metabolic improvements, this shortened lifespan in females occurred despite marked enhancements in metabolic health, including reduced body weight and adiposity, preferential glucose oxidation, elevated metabolic rate, and enhanced glucose tolerance and insulin sensitivity throughout adulthood."
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