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- Precision Nutrition for Better Clinical Outcomes.
- Podcast: To Mark Sigma Nutrition's Milestone 600th Episode (and 12-Year Anniversary), Danny and Alan Examine Several Areas in Which Their Views Have Changed, Softened, Strengthened, or Remained Stable over the Lifespan of the Podcast.
- Once- or Twice-Yearly Injection for Weight Loss?
- Addressing Childhood Obesity: Resources, Social Drivers of Health, and Pediatric Guidelines.
- Is Berberine Really “Nature’s Ozempic”?
- Cold Exposure and Metabolic Health: Therapeutic Potential for Obesity, Diabetes, and Beyond.
- How Animals Allocate Resources between Growth, Maintenance, and Reproduction Is a Fundamental Question. In This Issue of PLOS Biology, Pradhan and Colleagues Show That Maternal Nutrient Sensing Regulates Ribosome Deposition Into Embryos, Shaping the Early Growth Dynamics in the Next Generation.
- Tastiness Is Not Why People Overeat.
- Steak Night: How Healthy Is This Houston Staple?
- "What Dolphins Can Teach Us About Aging Better, According to a Surprising Navy Discovery."
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Headline vs Study
Contrary or Null Findings
- "Chia seed supplementation …did not impact primary obesity indicators under obesogenic conditions" [in rats].
- RCT: "among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, IRVR, or both did not result in statistically significant differences in improvements in cognitive function over 24 months."
- Dietary Inflammatory Index and Objective Disease Activity in IBD: No Association Found.
- "Contrary to earlier reports, our study demonstrates that neither GLS1 inhibition nor PD-1 blockade significantly reduced p16INK4a-positive cell burden or improved aging-related health parameters. Although we do not seek to discredit prior work, our results underscore the need for rigorous design, standardized protocols, and independent validation to ensure reliable senolytics before clinical translation."
- “Contrary to Expectation, HMTBa Did Not Alleviate MFD, nor Did It Cause Changes in Trans-10 FA Concentrations in Rumen and Milk or in Mammary De Novo FA Synthesis. …The Involvement of Cis-9 16:1 and Cis-11 18:1 in Marine Lipid-Induced MFD Is Therefore Challenged and the Previously Described Relationship Would Not Be Causative, but Probably a Confounding Effect” [in Sheep].
- Preprint: "The results of this study do not support the hypothesis that dietary iron supplementation increases infection severity in M. sexta" [Tobacco Hornworm].
- "Contrary to characterizations of the placenta as a transcriptomic void, we find transcriptional breadth and complexity comparable to adult tissues, with high splicing diversity of obesity- and growth-related gene transcripts, including 108 distinct CSH1 (placental lactogen) isoforms."
- "Contrary to expectations, meal consumption did not reduce isotonic lingual endurance."
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Headline vs Study
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- High Meat Consumption Linked to Lower Dementia Risk in APOE4 Carriers.
- RCT: "...long-term almond consumption (50 g/day) did not enhance cognitive performance in overweight/obese individuals with prediabetes. Moreover, brain vascular function was unaffected."
- Astaxanthin, Meclizine, Mitoglitazone, Pioglitazone, Alpha-Ketoglutarate, Mifepristone, Methotrexate, and Atorvastatin-Telmisartan Do Not Increase Lifespan in UM-HET3 Mice.
- RCT: "Wholegrain rye versus refined wheat foods as part of a hypocaloric diet did not result in larger weight loss."
- RCT: "Intention-to-treat and per-protocol analyses revealed no statistically significant between-group differences in any biomarker" in Effects of a Modified Otago Exercise Program on Metabolic, Cellular, and Epigenetic Biomarkers in People Living with Dementia.
- RCT: "There were no statistically significant differences found between those in the TRE and ER groups" in Relative Effects of Time-Restricted Eating, Energy-Restricted Eating, and Unrestricted Eating on Eating Patterns and Dietary Intake.
- RCT: "In people with HIV and obesity, switching from an INSTI+TAF/FTC regimen to DOR/FTC with either TAF [tenofovir alafenamide] or TDF [tenofovir disoproxil fumarate] did not produce clinically meaningful differences in weight change or metabolic health after 48 weeks."
- RCT: "Vitamin K2 supplementation had no effect on muscle strength, physical function, muscle soreness, or inflammatory responses in the recovery period after a bout of resistance exercise."
- RCT: "The findings of this study suggest that a 12-week 8-hour time-restricted eating intervention was not associated with reductions in body mass or body composition and sleep parameters evaluated by a portable monitoring device."
- "Maternal fat-soluble vitamin levels were not independently associated with birth weight, suggesting that vitamin status during mid-to late pregnancy may not be a major determinant of fetal growth in this metabolically high-risk [overweight or obesity] population."
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